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Knowledge of the magnetic properties of minerals is used in diverse research fields, including the Earth, planetary, environmental, biological, and materials sciences, and nanotechnology. This book is intended for advanced students, researchers and professionals working in these fields. Part I introduces readers to the essentials of mineralogy and, using high-school mathematics and physics, demonstrates how minerals record magnetic information. After laying these foundations, along with a treatment of the essential methods used to study mineral magnetism, the chapters in Part II each focus on the magnetic properties of a major magnetic mineral, with “minor” minerals treated together in a single chapter. This essential 'from the ground up' introduction to the topic, with in-depth treatment of each magnetic mineral and a guide to the extensive technical literature, is an invaluable resource for beginners and experts alike.
Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.
Posttraumatic stress disorder (PTSD) has been associated with advanced epigenetic age cross-sectionally, but the association between these variables over time is unclear. This study conducted meta-analyses to test whether new-onset PTSD diagnosis and changes in PTSD symptom severity over time were associated with changes in two metrics of epigenetic aging over two time points.
Methods
We conducted meta-analyses of the association between change in PTSD diagnosis and symptom severity and change in epigenetic age acceleration/deceleration (age-adjusted DNA methylation age residuals as per the Horvath and GrimAge metrics) using data from 7 military and civilian cohorts participating in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup (total N = 1,367).
Results
Meta-analysis revealed that the interaction between Time 1 (T1) Horvath age residuals and new-onset PTSD over time was significantly associated with Horvath age residuals at T2 (meta β = 0.16, meta p = 0.02, p-adj = 0.03). The interaction between T1 Horvath age residuals and changes in PTSD symptom severity over time was significantly related to Horvath age residuals at T2 (meta β = 0.24, meta p = 0.05). No associations were observed for GrimAge residuals.
Conclusions
Results indicated that individuals who developed new-onset PTSD or showed increased PTSD symptom severity over time evidenced greater epigenetic age acceleration at follow-up than would be expected based on baseline age acceleration. This suggests that PTSD may accelerate biological aging over time and highlights the need for intervention studies to determine if PTSD treatment has a beneficial effect on the aging methylome.
Objectives/Goals: Magnetic resonance imaging (MRI) reports are stored as unstructured text in the electronic health record (EHR), rendering the data inaccessible. Large language models (LLM) are a new tool for analyzing and generating unstructured text. We aimed to evaluate how well an LLM extracts data from MRI reports compared to manually abstracted data. Methods/Study Population: The University of California, San Francisco has deployed a HIPAA-compliant internal LLM tool utilizing GPT-4 technology and approved for PHI use. We developed a detailed prompt instructing the LLM to extract data elements from prostate MRI reports and to output the results in a structured, computer-readable format. A data pipeline was built using the OpenAI Application Programming Interface (API) to automatically extract distinct data elements from the MRI report that are important in prostate cancer care. Each prompt was executed five times and data were compared with the modal responses to determine variability of responses. Accuracy was also assessed. Results/Anticipated Results: Across 424 prostate MRI reports, GPT-4 response accuracy was consistently above 95% for most parameters. Individual field accuracies were 98.3% (96.3–99.3%) for PSA density, 97.4% (95.4–98.7%) for extracapsular extension, 98.1% (96.3–99.2%) for TNM Stage, had an overall median of 98.1% (96.3–99.2%), a mean of 97.2% (95.2–98.3%), and a range of 99.8% (98.7–100.0%) to 87.7% (84.2–90.7%). Response variability over five repeated runs ranged from 0.14% to 3.61%, differed based on the data element extracted (p Discussion/Significance of Impact: GPT-4 was highly accurate in extracting data points from prostate cancer MRI reports with low upfront programming requirements. This represents an effective tool to expedite medical data extraction for clinical and research use cases.
We show that the group $ \langle a,b,c,t \,:\, a^t=b,b^t=c,c^t=ca^{-1} \rangle$ is profinitely rigid amongst free-by-cyclic groups, providing the first example of a hyperbolic free-by-cyclic group with this property.
This is the first history to grapple with the vast project of British imperial investigation in the years between the Battle of Waterloo in 1815 and the Great Reform Act. Beginning in 1819, commissions of inquiry were sent to examine law, governance, and economy from New South Wales and the Caribbean to Malta and West Africa. They left behind a matchless record of colonial life in the form of papers, reports and more than 200 volumes of testimonies and correspondence. Inquiring into Empire taps this under-used archive to develop a new understanding of imperial reform. The authors argue that, far from being a first step in the march towards liberalism, the commissions represented a deeply pragmatic, messy but concerted effort to chart a middle way between reaction and revolution which was constantly buffeted by the politics of colonial encounter.
Cervical cancer remains a significant public health concern in sub-Saharan Africa, with treatment modalities such as chemoradiotherapy impacting patients’ quality of life (QoL). This study assessed the QoL of cervical cancer patients undergoing definitive chemoradiotherapy.
Methods:
This cross-sectional study was conducted at the National Radiotherapy, Oncology and Nuclear Medicine Centre, Korle-Bu Teaching Hospital, Accra, between February and May 2023. A total of 120 adult female cervical cancer patients, treated with definitive chemoradiotherapy, were purposively recruited. Data were collected using the FACT-Cx questionnaire, which assessed physical, social, emotional and functional well-being as well as additional concerns. Statistical analysis included descriptive and inferential methods with Spearman Rho used to examine correlations.
Results:
The mean age of participants was 53·5 years (SD 15·6), with most (77%) employed and half (50%) married. QoL scores were highest in social well-being (mean = 17·3/24·0) and emotional well-being (mean = 16·8/24·0), but lower in physical (mean = 15·4/28·0) and functional well-being (mean = 12·3/24·0). Most participants (66·7%) reported a good QoL, while 6·7% reported poor QoL. Key challenges included fatigue, pain and dissatisfaction with sex life, although participants received strong emotional support from their families. Correlations between age and QoL domains were statistically insignificant (p > 0·05).
Conclusions:
The findings suggest that despite the physical and functional challenges faced during chemoradiotherapy, most participants reported good overall QoL, largely attributed to strong family and social support. Future studies should incorporate longitudinal designs with baseline data collection to better understand treatment-related changes in QoL.
We investigate the effects of heterogeneity and incomplete information on aggregate contributions to a public good using the voluntary contribution mechanism. The non-linear laboratory environment has three-person groups as partners under varying conditions of information and communication. Bergstrom, Blum and Varian predict that increasing heterogeneity will have no effect on aggregate contributions in a no-communication environment. Ledyard conjectures a positive effect of incomplete information, a negative effect of heterogeneity, and a positive interaction of heterogeneity and incomplete information. We find that incomplete information has a small but significant negative effect. Heterogeneity has a positive effect on aggregate contributions, but its effects interact unexpectedly with communication. In a no-communication environment, heterogeneity in two dimensions (endowment and preferences) increases contributions substantially while heterogeneity in a single dimension (endowment or preferences) has little effect. In the communication environment we find the reverse. We also find a positive interaction between heterogeneity and incomplete information. Thus we reject the Bergstrom, Blume and Varian invariance result and provide mixed evidence on Ledyard's conjectures.
The Bigge Inquiry into New South Wales from 1819 demonstrates how inquiry in some respects mirrored Britain’s own counterrevolutionary project of restoring social and political hierarchies by sponsoring elites and limiting convict opportunity. But Bigge also modelled the power of commissions to bend their reports to suit local claims. In the course of his inquiries, Bigge was convinced by local elites to recommend the opening of frontiers to free capitalist farmers and pastoralists. He also proposed that elites should have a strong say in local government but was less convinced by calls to introduce an independent judiciary. The evidence he gathered prompted Earl Bathurst’s Colonial Office to compromise by limiting gubernatorial autocracy and expanding judicial authority. The resultant New South Wales Act set the parameters for conservative constitutional reform, which, by 1825, Bathurst planned to roll out in every crown colony in the empire.
The Commission of Legal Enquiry into the Caribbean (1822-1826) showcases the careful colonial politics of conservative inquiry into law and legal administration. The commissioners worked to keep planters onside in a successful effort to build consensus for sweeping law reforms. Their inquiries produced a bold (yet widely supported) endorsement of legal modernisation and professionalisation which garnered remarkable bipartisan support that swayed legal reform across the empire. Updating law and, most importantly, creating independent and professional Supreme Courts, formed key strategies of conservative reform here and elsewhere in the 1820s. In the Caribbean, law reforms promised not only to better manage trans-imperial business (by protecting creditors and heirs), they also formed the most important and consistent conservative strategy for ameliorating slavery. In the end these reforms failed because of a combination of penury, indecision and, ultimately, the fall of the conservative government.
In a brief discussion of our key primary sources, we outline the necessary limits of our own investigation into an enormous and understudied archive, suggest ways in which the structure of the archive shaped our analysis and offer reflections that we hope will inspire future scholars to launch inquiries of their own.
We explore the limits of conservative reform by unpacking the efforts of bonded labourers in the Cape between 1823 and 1826 to mobilise the Commission of Eastern Inquiry against the elaborate rules that governed the lives of people of colour. Hundreds of unfree people called on the commissioners to complain of systemic and personal abuse – more than any other colonial inquiry. And the commissioners opened their doors, recording unfree testimony and following up on most of the complaints that came before them. In the process, they performed a very important function of commissions everywhere – as emissaries of the king intimately supervising colonial governments and forging connections with new and old imperial subjects. Though they went to extraordinary efforts to follow up bonded complaint, Eastern Inquiry into the Cape failed, until extremely late in the day, to report their findings.
This introduction sets up our core findings about imperial inquiry and the British world in the second quarter of the nineteenth century. It places imperial inquiry in the overlapping contexts of transforming modes of governmentality in Britain and changing ideas and practices of colonialism in the Age of Revolution. We outline the limitations of previous scholarly understandings both of this period and of the imperial commissions themselves. We also introduce the notion of ‘constructive conservatism’ as an entry point to understanding the vexed relationship between reform and reaction that characterised not only the Liverpool Administration (1812 – 1827) but also the wider context of Britain’s imperial meridian that would usher in a new phase of global history.
The commission of inquiry into Ceylon (1829–31) which reported after the 1830 general election in England is a significant outlier in the broader story of imperial commissions called during the period of Liverpool’s administration. Changing metropolitan politics had enormous ramifications for the relatively new colonial subjects of Ceylon who, even more so than bonded labourers in the Cape, inundated commissioner Colebrooke with complaints about personal injustice and the failures of British rule. Commissioners Colebrooke and Cameron turned these complaints into a report for the times – the most Benthamite, uncompromising and radical recommendations given anywhere. Tellingly, significant reforms were implemented in Ceylon despite the trenchant opposition of Robert Wilmot Horton, former undersecretary of state in the Colonial Office, who, after Liverpool’s stroke, took it upon himself to hold the conservative line as Governor in Ceylon.
It is by comprehending domestic parliamentary politics in Britain itself that the origins of the commissions of enquiry into empire in 1819 can be best explained. This chapter tracks these beginnings through the power struggles that lay at the heart of Prime Minister Lord Liverpool’s fraught period in office (1812 – 1827). As we explore the parliamentary machinations that led to the calling of each commission, we come to a new understanding of the tension between politics and reform that has so long absorbed historians. These inquiries were always more than diversions to control Parliament, even if this was a key goal in their establishment. They also exemplified the very peculiar cast of the Liverpool regime, which had its own part-genuine and part-defensive commitments to imperial reform.
In this chapter, we track the interplay between domestic British politics and empire through the 1823 and 1824 scandals surrounding the deportation of two free businessmen of colour, Louis Celeste Lecesne and John Escoffery, from Jamaica, and the grievances of Bishop Burnett who was deported from the Cape. These cases not only demonstrate the explosive potential of empire in 1820s parliamentary politics, they also bring to the fore a key function of inquiries ‘on the ground’, as the struggling Liverpool ministry tried (and largely failed) to use colonial commissions to keep Parliament (as much as possible) out of the serious business of governing and reforming empire.