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Prenatal maternal stress is a known risk factor for later emotional problems, yet not all exposed offspring develop psychopathology. Executive functioning and prefrontal cortex structure and activity may buffer these effects, but it remains unclear whether genetic predispositions in these domains moderate associations with adolescent internalizing symptoms.
Methods
We examined 3,111 adolescents (1,881 females, 1,230 males). Prenatal stress was measured via a cumulative index across four domains. Internalizing symptoms were self-reported at ages 14 and 16. Genetic predisposition for executive functioning was indexed using a polygenic score (PGS) derived from adult samples, applied here to estimate genetic predisposition for executive functioning in adolescence. We also estimated a prefrontal cortex PGS based on cortical thickness and activation in six prefrontal regions, with a composite index derived from the first principal axis summarizing these measures.
Results
Higher prenatal stress was significantly associated with more internalizing symptoms in adolescence. Female sex and maternal genetic risk for internalizing symptoms were also associated with higher symptom levels. Neither genetic disposition for executive functioning nor prefrontal cortex moderated this association overall. However, a weak interaction emerged at age 16, indicating that a genetic disposition for higher executive functioning was associated with greater internalizing symptoms under high stress exposure.
Conclusions
Prenatal maternal stress predicted increased adolescent internalizing symptoms, with limited evidence for moderation by genetic predisposition for executive functioning. Higher genetic potential for executive functioning may confer increased sensitivity to early stress under certain developmental conditions.
To assess whether wind-driven natural ventilation in the Infectious Diseases Treatment Module (IDTM) can achieve ventilation performance consistent with airborne precaution requirements [160 liters per second (L/s)] and to estimate associated pathogen-specific infection risks.
Methods:
An experimental campaign of air velocity measurements and CO2 decays were conducted to validate the developed computational fluid dynamics (CFD) model. The validated CFD model simulated wind-driven natural ventilation (1–4 m/s) for an L-shaped IDTM configuration under four structural scenarios defined by the presence or absence of patient porches and mosquito nets. Airborne infection risk was estimated using a Wells–Riley quanta-based model for seven representative airborne pathogens under short-duration healthcare worker exposure and prolonged patient co-exposure.
Results:
Ventilation performance varied widely based on wind speed and structural configuration. Airflow ranged from 7 L/s in the most restricted configuration (porch and mosquito nets present at 1 m/s) to over 3,100 L/s when mosquito nets were removed at 4 m/s.
When mapped to infection-risk estimates, ventilation rates at 160 L/s substantially reduced short-duration healthcare worker infection risk for all pathogens (≤1%), whereas prolonged co-exposure remained associated with high risk for high-emission pathogens despite high ventilation.
Conclusion:
Under favorable wind conditions and optimized configurations, the IDTM can achieve ventilation rates consistent with the 160 L/s recommendation for airborne precautions. While this provides substantial protection for healthcare workers, individual-room isolation remains essential for patient management. Operationally, removing window-mounted nets is the most effective way to ensure safety targets are met; hybrid ventilation measures should be considered during low-wind conditions.
This article examines how linguistics instructors can invoke the concept of impact in preparing students for a career, arguing that this way of thinking underscores the value of identifying and articulating transferable skills in engaging with community to pursue meaningful challenges. Drawing on initiatives in the UK and US, the authors present models of embedding partnership building, applied projects, and reflective practices into teaching, from an Applied Sociolinguistics module to scalable interventions for classrooms and beyond. Finally, reframing career preparation as critical engagement with capitalism, the article explores how this lens brings focus to choicefulness in careers and students’ capacity to effect change through work.
We present 29 successfully recovered Civ time lags in Active Galactic Nuclei from the complete Dark Energy Survey Reverberation Mapping campaign. The AGN in this sample span a redshift range of $1.9\lt z\lt 3.5$. We successfully measure the velocity dispersion from the Civ spectral linewidth for 25 of these 29 sources, and use these to calculate new high-redshift black hole mass estimates, finding masses between 0.8 and 1.3 billion solar masses. We also identify a selection effect due to the duration of the survey that can impact the radius-luminosity relation derived from this and other (high-redshift) data. This paper represents the culmination of the OzDES Civ campaign.
Over the last decade, the Australian Dark Energy (OzDES) collaboration has used Reverberation Mapping to measure the masses of high redshift supermassive black holes. Here we present the final review and analysis of this OzDES reverberation mapping campaign. These observations use $6-7$ years of photometric and spectroscopic observations of 735 Active Galactic Nuclei (AGN) in the redshift range $z\in [0.13, 3.85]$ and bolometric luminosity range $\log_{10}(L_{\mathrm{bol}})\in [44.3, 47.5] \; \mathrm{erg/s}$. Both photometry and spectra are observed in visible wavelengths, allowing for the physical scale of the AGN broad line region to be estimated from reverberations of the H$\beta$, MgII and CIV emission lines. We successfully use reverberation mapping to constrain the masses of 62 super-massive black holes, and combine with existing data to fit a power law to the lag-luminosity relation for the H$\beta$ and MgII lines with a scatter of $\sim0.25$ dex, the tightest yet identified, fit specifically for consistency with high redshift AGN. We fit a similarly constrained relation for CIV, resolving a tension with the low luminosity literature AGN by accounting for selection effects arising from finite survey length. We also examine the impact of emission line width and luminosity (related to accretion rate) in reducing the scatter of these scaling relationships and find no significant improvement over the lag-only approach for any of the three lines. Using these relations, we further estimate the masses and accretion rates of 246 AGN with single epoch methods. We also use these relations to estimate the relative sizes of the H$\beta$, MgII and CIV emitting regions, and find evidence that the MgII emission may occur further out than H$\beta$. In short, we provide a comprehensive benchmark of high redshift AGN reverberation mapping at the close of this most recent generation of surveys, including light curves, time-delays, and a set of significantly improved radius-luminosity relations for use with high-redshift populations.
The receptor for advanced glycation end-products (RAGE) is a unique multi-ligand member of the immunoglobulin superfamily that exists in both membrane-bound and soluble forms. Under physiological conditions, RAGE expression is low in most tissues; however, it is markedly upregulated in response to tissue injury, inflammation or metabolic stress. Ligand-induced activation of RAGE initiates complex intracellular signalling cascades that regulate inflammation, extracellular matrix remodelling, cell proliferation, survival and migration.
Methods
While the contribution of RAGE to diabetes and chronic inflammatory diseases is well established, its role in gynaecological disorders remains insufficiently characterized.
Results
This comprehensive review summarizes current evidence on the involvement of RAGE in the pathogenesis of benign gynaecological disorders, such as endometriosis and polycystic ovary syndrome (PCOS), pregnancy-related complications and malignant neoplasms of the female reproductive tract.
Conclusions
It also discusses emerging therapeutic strategies aimed at targeting the RAGE pathway, highlighting their potential translational relevance in gynaecological practice.
People with affective psychotic disorders often face diagnostic delays and presentations are under-recognised at first contact with early intervention services (EIS). Despite their clinical significance, most research and service models for first-episode psychosis (FEP) have focused on non-affective psychoses.
Aims
We sought to clarify the relative prevalence of affective psychoses in EIS.
Method
A systematic review and random-effects meta-analysis of observational studies reporting proportion of affective psychotic disorders among individuals presenting to EIS with FEP was conducted. Eligible studies included treated FEP populations diagnosed using DSM/ICD criteria. Searches were conducted in Web of Science, Medline and PsycINFO (inception to July 2025). The primary outcome was pooled proportion of affective psychotic disorders. Heterogeneity was assessed using Q-statistics and I2-statistics. Meta-regressions examined potential moderators, including urbanicity, national income level and geographical region.
Results
Eighty-three studies (N = 30 946; mean age 24.95 years; 34.78% female) were included. Random-effects pooled proportion was 18.0% (95% CI 15.4–20.6; 95% prediction interval 3.6–39.4%; I2 = 95.6%). Schizoaffective disorder represented 7.4% (k = 49; 95% CI 5.8–9.2). Schizophrenia was the most frequent diagnosis, with a pooled proportion of 45.5% (k = 79; 95% CI 40.3–50.7). Meta-regression analyses identified that affective psychoses were less common in Asia and more common in North America compared with Europe. Higher urbanicity was also associated with increased prevalence. Associations with national income level (NIL) were limited by small subgroup sizes.
Conclusions
Affective psychotic disorders constitute a meaningful subgroup within EIS. This suggests better screening, targeted treatments and adaptive service models of care.
All linguistic research has the potential to reproduce or challenge racial notions.
—Linguistic Society of America Statement on Race (2019)
The LSA Statement on Race stems from a larger conversation around undertheorized treatment of race and ethnicity in linguistics research and practice. In this commentary, we define racial identity and ethnicity and explain their relevance for linguistic research. We discuss considerations that linguistic researchers should take prior to research, during study design, and following research, and we offer specific recommendations when soliciting or using race and ethnicity data. These recommendations aim to help researchers avoid social harm, ensure ethical compliance and research integrity, and improve descriptive accuracy, especially for undersampled groups, by balancing research transparency with generalizability. We consider issues germane to collecting self-disclosures of ethnicity and racial identity in a range of study types spanning several subfields of linguistics. We give concrete examples of questions that may arise in planning studies in computational and corpus-based linguistics, formal linguistics, experimental linguistics, and qualitative linguistics. We speak to ethical considerations, including the importance of using locally constructed labels, analyst positionality, and respect for communities. Our goals are to provide linguistic researchers with a firmer basis for conceptualizing racial identity and ethnicity particularly as pertains to linguistics, and to supply a guide that aids linguists in reflecting on their own study design, positionality, and responsibility to participants and communities.
The Radio Neutrino Observatory-Greenland (RNO-G, at Summit Station) experiment comprises an extensive fat-dipole antenna array deployed into ice boreholes over an eventual area of approximately 35 km2. Since the RNO-G experimental sensitivity depends on the radio-frequency properties of the firn, which are known to vary laterally on sub-km distance scales and vertically on sub-meter distance scales, a technique for quickly extracting information on firn ice properties with depth ($n(z)$) during drilling and deployment is desirable. Given that a dipole’s resonant wavelength is fixed by geometry, the resonant frequency $f_{res}$ (measured as an S-parameter reflection coefficient [‘$S_{11}$’] minimum) scales inversely with the local refractive index, allowing a translation of a depth-dependent $S_{11}$(z) profile into $n(z)$. $S_{11}$(z) data were initially taken in August 2024 using a dipole lowered into a newly drilled 98 ± 1 mm diameter, 350 m deep borehole at Summit Station, Greenland, approximately 1 km from the site of the original GISP-2 core; improved measurements were subsequently made in May 2025. We conclude that $S_{11}$(z) data can be used to estimate $n(z)$, on 50 cm vertical scales, at the per cent level of accuracy required by experiments such as RN0-G.
Fences are increasingly fragmenting landscapes and curtailing the movement of terrestrial wildlife. In arid and semi-arid ecosystems, where herbivores rely on movement to access patchily distributed resources, fences may cause behavioural changes with consequences for energy balance and fitness. Here, we investigate the fine-scale behavioural responses of the highly mobile springbok antelope (Antidorcas marsupialis) to encounters with a veterinary cordon fence in northern Namibia. Using supervised machine learning on tri-axial accelerometer data from collared individuals, we trained a classifier capable of identifying 12 behavioural categories with up to 91% accuracy. Applying this model to over 29,000 accelerometer records from eight free-ranging springbok, we examined behaviour in relation to fence encounters. We found significant changes in behaviour in response to fences, which depended on whether the fence was successfully crossed or not. Fence crossings were associated with shifts from grazing to browsing during crossings, as well as increased walking during and after crossings, suggesting altered foraging and increased movement. Behavioural changes were less pronounced in the case of non-crossing encounters. Our results show how accelerometry can reveal behavioural responses to anthropogenic barriers and emphasise the importance of maintaining ecological connectivity for migratory ungulates.
Specialised forms of social cognition enable primates to manage the stresses of group living by allowing for flexible and intentional communication. This is used to increase the predictability of conspecifics’ behaviour for both signallers and receivers. Intentional communication helps to overcome the stimulus-driven processing that may occur due to stress, enhancing attention allocation in receivers.
eSource – particularly EHR-to-EDC – is an emerging paradigm in clinical research that enables automated transfer of electronic health record (EHR) data into electronic data capture (EDC) systems, with the potential to reduce site burden, improve data quality and accelerate oncology clinical trial workflows. However, widespread implementation remains limited due to technical, regulatory and operational barriers. To address these challenges, the European Institute for Innovation through Health Data (i~HD) launched the eSource Scale-Up Task Force in 2024. This multi-stakeholder initiative brings together leading oncology centres and pharmaceutical sponsors to establish a consensus-driven roadmap for eSource adoption. Central to this effort are three foundational resources: readiness criteria for early adopters, a performance indicator framework for monitoring success and an operational playbook to guide implementation. This article provides a structured overview of the Task Force’s objectives, collaborative model and outputs, with specific attention to its focus on interoperability, regulatory alignment and real-world validation. While initially developed for oncology, the Task Force’s framework is applicable across therapeutic areas characterized by data-intensive workflows.
Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement.
Methods
We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry [EUR], 10,231 of African ancestry, and 3,746 of East Asian ancestry) and compared the results to other nicotine-related phenotypes.
Results
We replicated the well-known association at the CHRNA5 locus (lead single-nucleotide polymorphism [SNP]: rs147144681, p = 1.27E−11 in EUR; lead SNP = rs2036527, p = 6.49e−13 in cross-ancestry analysis). DSM-NicDep showed strong positive genetic correlations with cannabis use disorder, opioid use disorder, problematic alcohol use, lung cancer, material deprivation, and several psychiatric disorders, and negative correlations with respiratory function and educational attainment. A polygenic score of DSM-NicDep predicted DSM-5 tobacco use disorder criterion count and all 11 individual diagnostic criteria in the independent National Epidemiologic Survey on Alcohol and Related Conditions-III sample. In genomic structural equation models, DSM-NicDep loaded more strongly on a previously identified factor of general addiction liability than a “problematic tobacco use” factor (a combination of cigarettes per day and nicotine dependence defined by the Fagerström Test for Nicotine Dependence). Finally, DSM-NicDep showed a strong genetic correlation with a GWAS of tobacco use disorder as defined in electronic health records (EHRs).
Conclusions
Our results suggest that combining the wide availability of diagnostic EHR data with nuanced criterion-level analyses of DSM tobacco use disorder may produce new insights into the genetics of this disorder.
Artificial intelligence is dramatically reshaping scientific research and is coming to play an essential role in scientific and technological development by enhancing and accelerating discovery across multiple fields. This book dives into the interplay between artificial intelligence and the quantum sciences; the outcome of a collaborative effort from world-leading experts. After presenting the key concepts and foundations of machine learning, a subfield of artificial intelligence, its applications in quantum chemistry and physics are presented in an accessible way, enabling readers to engage with emerging literature on machine learning in science. By examining its state-of-the-art applications, readers will discover how machine learning is being applied within their own field and appreciate its broader impact on science and technology. This book is accessible to undergraduates and more advanced readers from physics, chemistry, engineering, and computer science. Online resources include Jupyter notebooks to expand and develop upon key topics introduced in the book.
The theory of kernels offers a rich mathematical framework for the archetypical tasks of classification and regression. Its core insight consists of the representer theorem that asserts that an unknown target function underlying a dataset can be represented by a finite sum of evaluations of a singular function, the so-called kernel function. Together with the infamous kernel trick that provides a practical way of incorporating such a kernel function into a machine learning method, a plethora of algorithms can be made more versatile. This chapter first introduces the mathematical foundations required for understanding the distinguished role of the kernel function and its consequence in terms of the representer theorem. Afterwards, we show how selected popular algorithms, including Gaussian processes, can be promoted to their kernel variant. In addition, several ideas on how to construct suitable kernel functions are provided, before demonstrating the power of kernel methods in the context of quantum (chemistry) problems.
In this chapter, we change our viewpoint and focus on how physics can influence machine learning research. In the first part, we review how tools of statistical physics can help to understand key concepts in machine learning such as capacity, generalization, and the dynamics of the learning process. In the second part, we explore yet another direction and try to understand how quantum mechanics and quantum technologies could be used to solve data-driven task. We provide an overview of the field going from quantum machine learning algorithms that can be run on ideal quantum computers to kernel-based and variational approaches that can be run on current noisy intermediate-scale quantum devices.
In this chapter, we introduce the field of reinforcement learning and some of its most prominent applications in quantum physics and computing. First, we provide an intuitive description of the main concepts, which we then formalize mathematically. We introduce some of the most widely used reinforcement learning algorithms. Starting with temporal-difference algorithms and Q-learning, followed by policy gradient methods and REINFORCE, and the interplay of both approaches in actor-critic algorithms. Furthermore, we introduce the projective simulation algorithm, which deviates from the aforementioned prototypical approaches and has multiple applications in the field of physics. Then, we showcase some prominent reinforcement learning applications, featuring some examples in games; quantum feedback control; quantum computing, error correction and information; and the design of quantum experiments. Finally, we discuss some potential applications and limitations of reinforcement learning in the field of quantum physics.
Distinguishing early domesticates from their wild progenitors presents a significant obstacle for understanding human-mediated effects in the past. The origin of dogs is particularly controversial because potential early dog remains often lack corroborating evidence that can provide secure links between proposed dog remains and human activity. The Tumat Puppies, two permafrost-preserved Late Pleistocene canids, have been hypothesized to have been littermates and early domesticates due to a physical association with putatively butchered mammoth bones. Through a combination of osteometry, stable isotope analysis, plant macrofossil analysis, and genomic and metagenomic analyses, this study exploits the unique properties of the naturally mummified Tumat Puppies to examine their familial relationship and to determine whether dietary information links them to human activities. The multifaceted analysis reveals that the 14,965–14,046 cal yr BP Tumat Puppies were littermates who inhabited a dry and relatively mild environment with heterogeneous vegetation and consumed a diverse diet, including woolly rhinoceros in their final days. However, because there is no evidence of mammoth consumption, these data do not establish a link between the canids and ancient humans.