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Small-scale shear layers arising from the turbulent motion of viscoelastic fluids are investigated through direct numerical simulations of statistically steady, homogeneous isotropic turbulence in a fluid described by the FENE-P model. These shear layers are identified via a triple decomposition of the velocity gradient tensor. The viscoelastic effects are examined through the Weissenberg number ($Wi$), representing the ratio of the longest polymer relaxation time scale to the Kolmogorov time scale. The mean flow around these shear layers is analysed within a local reference frame that characterises shear orientation. In both Newtonian and viscoelastic turbulence, shear layers appear in a straining flow, featuring stretching in the shear vorticity direction and compression in the layer normal direction. Polymer stresses are markedly influenced by the shear and strain, which enhance kinetic energy dissipation due to the polymers. The shear layers in viscoelastic turbulence exhibit a high aspect ratio, undergoing significant characteristic changes once $Wi$ exceeds approximately 2. As $Wi$ increases, the extensive strain weakens, diminishing vortex stretching. This change coincides with an imbalance between extension and compression in the straining flow. In the shear layer, the interaction between vorticity and polymer stress causes the destruction and production of enstrophy at low and high $Wi$ values, respectively. Enstrophy production at high $Wi$ is induced by normal polymer stress oriented along the shear flow, associated with the diminished extensive strain. The $Wi$-dependent behaviour of these shear layers aligns with the overall flow characteristics, underscoring their pivotal roles in vorticity dynamics and kinetic energy dissipation in viscoelastic turbulence.
The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery (WCPCCS) will be held in Washington DC, USA, from Saturday, 26 August, 2023 to Friday, 1 September, 2023, inclusive. The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery will be the largest and most comprehensive scientific meeting dedicated to paediatric and congenital cardiac care ever held. At the time of the writing of this manuscript, The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery has 5,037 registered attendees (and rising) from 117 countries, a truly diverse and international faculty of over 925 individuals from 89 countries, over 2,000 individual abstracts and poster presenters from 101 countries, and a Best Abstract Competition featuring 153 oral abstracts from 34 countries. For information about the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery, please visit the following website: [www.WCPCCS2023.org]. The purpose of this manuscript is to review the activities related to global health and advocacy that will occur at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery.
Acknowledging the need for urgent change, we wanted to take the opportunity to bring a common voice to the global community and issue the Washington DC WCPCCS Call to Action on Addressing the Global Burden of Pediatric and Congenital Heart Diseases. A copy of this Washington DC WCPCCS Call to Action is provided in the Appendix of this manuscript. This Washington DC WCPCCS Call to Action is an initiative aimed at increasing awareness of the global burden, promoting the development of sustainable care systems, and improving access to high quality and equitable healthcare for children with heart disease as well as adults with congenital heart disease worldwide.
Direct numerical simulations (DNS) of turbulent fronts spreading into an irrotational flow region are used to analyse the turbulent entrainment mechanism for viscoelastic fluids. The simulations use the FENE-P fluid model and are initiated from DNS of isotropic turbulence with Weissenberg and turbulence Reynolds numbers varying in the ranges $1.30 \le Wi \le 3.46$ and $206 \le Re_{\lambda }^{0} \le 404$, respectively. The enstrophy dynamics near the turbulent/non-turbulent interface (TNTI) layer, that separates regions of turbulent and irrotational flow, includes a new mechanism – the viscoelastic production – caused by the interaction between the vorticity field and the polymer stresses. This term can be a sink or a source of enstrophy in the turbulent core region of the flow, depending on the Weissenberg number, and contributes to the initial growth of the enstrophy in the viscous superlayer, together with the viscous diffusion, which is the only mechanism present for Newtonian fluids. For low and moderate Weissenberg numbers the scaling of the TNTI layer is similar to the scaling of TNTI layers for Newtonian fluids, but this is no longer the case at high Weissenberg numbers where the enstrophy tends to be concentrated into thin vortex sheets instead of vortex tubes. Finally, it is shown that the substantial decrease of the entrainment rates observed in turbulent flows of viscoelastic fluids, compared with Newtonian fluids, is caused by a reduction of the surface area and fractal dimension of the irrotational boundary, originated by the depletion of ‘active’ scales of motion in the fluid solvent caused by the viscoelasticity.
We describe system verification tests and early science results from the pulsar processor (PTUSE) developed for the newly commissioned 64-dish SARAO MeerKAT radio telescope in South Africa. MeerKAT is a high-gain (
${\sim}2.8\,\mbox{K Jy}^{-1}$
) low-system temperature (
${\sim}18\,\mbox{K at }20\,\mbox{cm}$
) radio array that currently operates at 580–1 670 MHz and can produce tied-array beams suitable for pulsar observations. This paper presents results from the MeerTime Large Survey Project and commissioning tests with PTUSE. Highlights include observations of the double pulsar
$\mbox{J}0737{-}3039\mbox{A}$
, pulse profiles from 34 millisecond pulsars (MSPs) from a single 2.5-h observation of the Globular cluster Terzan 5, the rotation measure of Ter5O, a 420-sigma giant pulse from the Large Magellanic Cloud pulsar PSR
$\mbox{J}0540{-}6919$
, and nulling identified in the slow pulsar PSR J0633–2015. One of the key design specifications for MeerKAT was absolute timing errors of less than 5 ns using their novel precise time system. Our timing of two bright MSPs confirm that MeerKAT delivers exceptional timing. PSR
$\mbox{J}2241{-}5236$
exhibits a jitter limit of
$<4\,\mbox{ns h}^{-1}$
whilst timing of PSR
$\mbox{J}1909{-}3744$
over almost 11 months yields an rms residual of 66 ns with only 4 min integrations. Our results confirm that the MeerKAT is an exceptional pulsar telescope. The array can be split into four separate sub-arrays to time over 1 000 pulsars per day and the future deployment of S-band (1 750–3 500 MHz) receivers will further enhance its capabilities.
Mental disorders can have a major impact on brain development. Peripheral blood concentrations of brain-derived neurotrophic factor (BDNF) are lower in adult psychiatric disorders. Serum BDNF concentrations and BDNF genotype have been associated with cortical maturation in children and adolescents. In 2 large independent samples, this study tests associations between serum BDNF concentrations, brain structure, and psychopathology, and the effects of BDNF genotype on BDNF serum concentrations in late childhood and early adolescence.
Methods
Children and adolescents (7-14 years old) from 2 cities (n = 267 in Porto Alegre; n = 273 in São Paulo) were evaluated as part of the Brazilian high-risk cohort (HRC) study. Serum BDNF concentrations were quantified by sandwich ELISA. Genotyping was conducted from blood or saliva samples using the SNParray Infinium HumanCore Array BeadChip. Subcortical volumes and cortical thickness were quantified using FreeSurfer. The Development and Well-Being Behavior Assessment was used to identify the presence of a psychiatric disorder.
Results
Serum BDNF concentrations were not associated with subcortical volumes or with cortical thickness. Serum BDNF concentration did not differ between participants with and without mental disorders, or between Val homozygotes and Met carriers.
Conclusions
No evidence was found to support serum BDNF concentrations as a useful marker of developmental differences in brain and behavior in early life. Negative findings were replicated in 2 of the largest independent samples investigated to date.
It has been hypothesised that refugees have an increased risk of suicide.
Aims
To investigate whether risk of suicide is higher among refugees compared with non-refugee migrants from the same areas of origin and with the Swedish-born population, and to examine whether suicide rates among migrants converge to the Swedish-born population over time.
Method
A population-based cohort design using linked national registers to follow 1 457 898 people born between 1 January 1970 and 31 December 1984, classified by migrant status as refugees, non-refugee migrants or Swedish-born. Participants were followed from their 16th birthday or date of arrival in Sweden until death, emigration or 31 December 2015, whichever came first. Cox regression models estimated adjusted hazard ratios for suicide by migrant status, controlling for age, gender, region of origin and income.
Results
There were no significant differences in suicide risk between refugee and non-refugee migrants (hazard ratio 1.28, 95% CI 0.93–1.76) and both groups had a lower risk of suicide than Swedish born. During their first 5 years in Sweden no migrants died by suicide; however, after 21–31 years their suicide risk was equivalent to the Swedish-born population (hazard ratio 0.94, 95% CI 0.79–1.22). After adjustment for income this risk was significantly lower for migrants than the Swedish-born population.
Conclusions
Being a refugee was not an additional risk factor for suicide. Our findings regarding temporal changes in suicide risk suggest that acculturation and socioeconomic deprivation may account for a convergence of suicide risk between migrants and the host population over time.
Congenital and acquired heart diseases are highly prevalent in developing countries despite limited specialised care. Namibia established a paediatric cardiac service in 2009 with significant human resource and infrastructural constraints. Therefore, patients are referred for cardiac interventions to South Africa.
Objectives
To describe the diagnoses, clinical characteristics, interventions, post-operative morbidity and mortality, and follow-up of patients referred for care.
Methods
Demographics, diagnoses, interventions, intra- and post-operative morbidity and mortality, as well as longitudinal follow-up data of all patients referred to South Africa, were recorded and analysed.
Results
The total cohort constituted 193 patients of which 179 (93%) had CHD and 7% acquired heart disease. The majority of patients (78.8%) travelled more than 400 km to Windhoek before transfer. There were 28 percutaneous interventions. Palliative and definitive surgery was performed in 27 and 129 patients, respectively. Out of 156 patients, 80 (51.3%) had post-operative complications, of which 15 (9.6%) were a direct complication of surgery. Surgical mortality was 8/156 (5.1%, 95% confidence interval 2.2–9.8), with a 30-day mortality of 3.2%. Prolonged ICU stay was associated with a 5% increased risk of death with hazard ratio 1.05, 95% confidence interval 1.02–1.08, p=0.001. Follow-up was complete in 151 (78%) patients for more than 7 years.
Conclusions
Despite the challenges associated with a cardiac programme for referring patients seeking intervention in a neighbouring country and the adverse characteristics of multiple lesions and complexity associated with late presentation, we report good surgical and interventional outcomes. Our goal remains to develop a comprehensive sustainable cardiac service in Namibia.
An outbreak of invasive Mycobacterium chimaera infections associated with heater-cooler devices (HCDs) has now affected patients in several countries on different continents. Clinical infections are characterized by delayed diagnosis, inadequate treatment response to antimicrobial agents, and poor prognosis. Outbreak investigators found M. chimaera in HCD water circuits and air samples while HCDs were running, suggesting that transmission from the HCD to the surgical site occurs via the airborne route. New HCDs at the manufacturing site were also contaminated with M. chimaera, and recent whole-genome sequencing data suggest a point source. Some guidance on screening for M. chimaera colonization in HCD water and exhaust air is available. In contrast, reliable disinfection procedures are not well described, and it is not yet known whether eradication of M. chimaera from a contaminated HCD can be achieved. Meanwhile, strict separation of the HCD from operating room air is necessary to ensure patient safety, and these efforts may require engineering solutions. While our understanding of the causes and the extent of the M. chimaera outbreak is growing, several aspects of patient management, device handling, and risk mitigation still require clarification.
We explore the evolution of the gravest internal Kelvin wave in a two-layer rotating cylindrical basin, using direct numerical simulations (DNS) with a hyper-viscosity/diffusion approach to illustrate different dynamic and energetic regimes. The initial condition is derived from Csanady’s (J. Geophys. Res., vol. 72, 1967, pp. 4151–4162) conceptual model, which is adapted by allowing molecular diffusion to smooth the discontinuous idealized solution over a transition scale, ${\it\delta}_{i}$, taken to be small compared to both layer thicknesses $h_{\ell },\ell =1,2$. The different regimes are obtained by varying the initial wave amplitude, ${\it\eta}_{0}$, for the same stratification and rotation. Increasing ${\it\eta}_{0}$ increases both the tendency for wave steepening and the shear in the vicinity of the density interface. We present results across several regimes: from the damped, linear–laminar regime (DLR), for which ${\it\eta}_{0}\sim {\it\delta}_{i}$ and the Kelvin wave retains its linear character, to the nonlinear–turbulent transition regime (TR), for which the amplitude ${\it\eta}_{0}$ approaches the thickness of the (thinner) upper layer $h_{1}$, and nonlinearity and dispersion become significant, leading to hydrodynamic instabilities at the interface. In the TR, localized turbulent patches are produced by Kelvin wave breaking, i.e. shear and convective instabilities that occur at the front and tail of energetic waves within an internal Rossby radius of deformation from the boundary. The mixing and dissipation associated with the patches are characterized in terms of dimensionless turbulence intensity parameters that quantify the locally elevated dissipation rates of kinetic energy and buoyancy variance.
Increased recognition of the business case for managing corporate impacts on the environment has helped drive increasingly detailed and quantified corporate environmental goals. Foremost among these are goals of no net loss (NNL) and net positive impact (NPI). We assess the scale and growth of such corporate goals. Since the first public, company-wide NNL/NPI goal in 2001, 32 companies have set similar goals, of which 18 specifically include biodiversity. Mining companies have set the most NNL/NPI goals, and the majority of those that include biodiversity, despite the generally lower total global impact of the mining industry on biodiversity compared to the agriculture or forestry industries. This could be linked to the mining industry's greater participation in best practice bodies, high-profile impacts, and higher profit margins per area of impact. The detail and quality of present goals vary widely. We examined specific NNL/NPI goals and assessed the extent to which their key components were likely to increase the effectiveness of these goals in benefiting biodiversity and managing business risk. Nonetheless, outcomes are more important than goals, and we urge conservationists to work with companies to both support and monitor their efforts to achieve increasingly ambitious environmental goals.
To examine the micronutrient status of disadvantaged pre-schoolers from Northeast Brazil, following the introduction of pro-poor policies, by assessing the prevalence of anaemia and micronutrient deficiencies and the role of sociodemographic factors, genetic Hb disorders and parasitic infections.
Design
In a cross-sectional study, data on sociodemographic status, health, growth, genetic Hb disorders, parasites and nutrient supply from day-care meals were obtained. Fasting blood samples were collected and analysed for Hb, serum ferritin, transferrin receptor, folate, vitamin B12, retinol, Zn and Se.
Pre-schoolers aged 3–6 years from disadvantaged households.
Results
Of the 376 sampled children, 94 % were of black or mixed race; 33 % and 29 % had at least one genetic Hb disorder and intestinal parasite, respectively. Stunting and underweight were ≤5 %; 14 % were overweight. Day-care centres supplied micronutrient-dense meals and snacks each weekday. Less than 10 % of pre-schoolers had anaemia and micronutrient deficiencies. Predictors (P < 0·05) of Hb were α3·7 thalassaemia, Se and retinol (but not ferritin). Micronutrient predictors (P < 0·05) were: elevated α1-glycoprotein for ferritin, Hb AS and BMI Z-score >1 for transferrin receptor, Zn and elevated α1-glycoprotein for retinol, sex and helminths for Se, helminths for vitamin B12, and Giardia intestinalis infection for serum folate.
Conclusions
Impaired growth, anaemia and micronutrient deficiencies were uncommon among these disadvantaged pre-schoolers attending day care. A range of interventions including provision of micronutrient-dense, fortified day-care meals, deworming and vitamin A supplementation likely contributed to improved micronutrient status, suggesting expanded coverage of these programmes.
We performed numerical simulations of mergers between gas-rich disc galaxies, which result in the formation of late-type galaxies. Stars formed during the merger end up in a thick disc that is partially supported by velocity dispersion and has high [α/Fe] ratios at all metallicities. Stars formed later end up in a thin, rotationally supported disc which has lower [α/Fe] ratios. While the structural and kinematical properties of the merger remnants depend strongly upon the orbital parameters of the mergers, we find a clear chemical signature of gas-rich mergers.
In this work, we analyze observations of the solar radius at 22 and 43 GHz obtained with the 13.7 m antenna of the Itapetinga Radio Observatory (Atibaia, Brazil) and at submillimeter-wave frequencies, 212 and 405 GHz, obtained by the Solar Submillimeter-wave Telescope (SST) (El Leoncito, San Juan, Argentina). The radius is defined as the limb position where the intensity is equal to half of the quiet Sun value. These measured radii are then compared with those predicted by a model of the solar atmosphere proposed by Selhorst, Silva, and Costa (2005). The results show that at 22 and 43 GHz, the emission comes from regions high in the chromosphere. Furthermore, the Itapetinga observations yield radii of 985” ± 5” and 981” ± 6”, at 22 and 43 GHz respectively, consistent with the theoretical positions in the atmosphere. On other hand, the submillimeter observations resulted in a mean radius of 972” ± 3” and 975” ± 5” at 212 and 405 GHz, respectively, considered equal within the uncertainties. The latter results can be explained by the origin of the emission being very close to the region of minimum temperature, between the photosphere and chromosphere. This is a dynamic region largely affected by many solar features, like spicules and plages.
The Program Group for World-wide Development of Astronomy (PG-WWDA) is one of nine Commission 46 program groups engaged with various aspects of astronomical education or development of astronomy education and research in the developing world. In the case of PG-WWDA, its goals are to promote astronomy education and research in the developing world through a variety of activities, including visiting astronomers in developing countries and interacting with them by way of giving encouragement and support.
The Program Group for the World-wide Development of Astronomy (PG-WWDA) is one of nine Commission 46 program groups engaged with various aspects of astronomical education or development of astronomy education and research in the developing world. In the case of PG-WWDA, its goals are to promote astronomy education and research in the developing world through a variety of activities, including visiting astronomers in developing countries and interacting with them by way of giving encouragement and support.
Our natural world is on the verge of a profound loss of biological diversity (Crooks and Sanjayan Chapter 1). Although the economic, cultural, and spiritual costs of this ecological impoverishment are enormous and irreversible, from a human point of view extinction's denouement appears to be “slow-motion.” This slow-motion results in a limited recognition of its urgency and the very little time we have to prevent it from occurring. As evident in this volume, the threats cut across multiple scales of ecological organization, from genes and species all the way to ecological processes. To face this complex challenge, action plans to avoid extinction must become more comprehensive, including strategies to preserve both areas and ecological and evolutionary processes, as well as those targeted to avoid the foreseeable extinction of particular threatened species.
One comprehensive regional-scale approach with great promise for effective conservation is based on the concept of “biodiversity conservation corridors,” a large-scale planning region where actions are taken to integrate representation and viability of species, ecosystems, and ecological and evolutionary processes in a scenario of explicitly defined human needs. The biodiversity conservation corridor approach shifts focus from a local to a regional scale, and represents an ambitious attempt to make protected area networks that are sufficient for species survival besides promoting an optimum allocation of resources to conserve biodiversity at the least economic cost to society (Salwasser et al. 1987).