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The performance of the wavy leading edge (WLE) on the self-noise from a cambered NACA 65(12)-10 airfoil at a Reynolds number of 100 000 is investigated in this paper. The self-noise from the airfoils is measured in an anechoic wind tunnel while the flow details are obtained from both planar particle image velocimetry measurements and the wall-resolved large eddy simulations. It turns out that the WLE is effective in reducing both the tonal and the broadband separation noise in the mid-to-low-frequency range from the baseline airfoil. The underlying mechanisms of the noise reduction are also examined carefully from both the tonal and the broadband aspects. By introducing the WLE, the generated streamwise vortices can modify the boundary-layer development and reduce the spanwise coherence of the flow structures. As a consequence, the acoustic feedback loop responsible for the tonal noise from the baseline airfoil is disturbed. Additionally, the WLE decreases the convection velocity and generates less coherent wall pressure fluctuations in the low-to-mid-frequency range, leading to broadband separation noise reduction.
Pronounced variations in suicide mortality persist across Europe. Understanding long-term temporal patterns through age, period and cohort (APC) effects, alongside suicide means, is essential for tailored prevention. This study aims to determine how suicide mortality rates in Europe have changed across APC dimensions at national and subregional levels.
Methods
Our analysis was restricted to European countries with complete age- and sex-specific suicide mortality data from 1990 to 2019 within the World Health Organization mortality database. The analysis comprised two components. The first component disentangled long-term suicide mortality trends (1990–2019) into APC dimensions using an age-period-cohort model via the National Cancer Institute’s APC Web Tool. The second component involved an assessment of suicide means, restricted to 2010–2019 and to countries with detailed International Classification of Diseases, 10th Revision (ICD-10) cause-of-death data.
Results
In 2019, Europe recorded 47,793 male and 13,111 female suicide deaths. Overall suicide mortality rates declined in most subregions from 1990 to 2019, with the largest reductions among Eastern European men, from 77.81 (95% CI: 77.17–78.45) per 100,000 in the mid-1990s to 22.93 (95% CI: 22.58–23.28) per 100,000 by 2019, although this region retained the highest male suicide burden. Age-specific risk patterns differed markedly: among men, risk peaked in early adulthood and then declined in Eastern Europe, while in Western and Southern Europe, it was lower and more stable but rose after age 60; for women, risk was generally lower, with peaks in early adulthood in Eastern Europe and in midlife elsewhere. Period reflected continued improvement, especially in Eastern Europe where the period risk in 2015–2019 was approximately 60% lower than 2000–2004. Cohort effects similarly showed progressive declines. However, upward trends emerged among younger generations. In Northern Europe, the cohort relative risk for females increased from 0.73 (95% CI: 0.68–0.78) in the 1980 cohort to 0.90 (95% CI: 0.70–1.04) in the 2000 cohort. While the completeness of suicide means analysis varied by subregion, the primary data indicated that hanging was the predominant means for both sexes during 2010–2019.
Conclusions
Despite an overall decline, suicide mortality in Europe exhibits persistent regional and demographic differences. This study reveals emerging risks among younger cohorts, specifically Northern European women and Southern European men, signalling shifting patterns that are not apparent from overall temporal trends alone. This evolving risk profile calls for sustained surveillance and research to investigate the drivers of these population-specific vulnerabilities.
An experimental study was conducted to investigate the characteristics of unsteady oblique shock trains in a constant-area rectangular duct under an asymmetric incoming boundary layer. High-speed schlieren techniques and high-frequency pressure measurements were utilised in this study. The results indicate that the oblique shock train mainstream leans significantly towards the thin-boundary-layer side. Under downstream periodic excitation, the shock train moves periodically, and its shape changes during the movement. This phenomenon occurs to match the downstream pressure by altering the relative Mach number in front of the shock train, with the average pressure rise slope along the thick-boundary-layer side changing periodically. Additionally, unlike a normal shock train, the pressure rise distribution along the thick-boundary-layer side is nearly linear, and the correlation coefficients between the transducers on this side and the most downstream transducer are higher than those on the thin-boundary-layer side. Due to differences in flow structure and pressure rise distribution, the existing amplitude prediction model proposed by Xiong et al. (J. Fluid Mech. vol. 846, 2018, pp. 240–262) for the unsteady normal shock train is no longer applicable to the unsteady oblique shock train. Therefore, a new prediction model is derived and verified by experiments. Moreover, it is found that using only the downstream pressure transducer information on the thick-boundary-layer side can effectively predict the amplitude of the shock-train motion. Combined with the prediction model, a novel method is proposed to estimate the amplitude of the shock-train motion conveniently.
Blastocyst formation represents an essential requirement for subsequent implantation. Successful embryo implantation depends on adequate endometrial receptivity and appropriate embryo-maternal communication. Uterus-derived extracellular vesicles (EVs), as biological nanoscale particles carrying non-coding RNAs (nc-RNAs), DNAs, proteins and lipids, play a crucial role in promoting cellular interactions and regulating maternal-foetal dialogue.
Method
This article systematically searched the PubMed database and used the following keyword combinations for literature screening : (exosome * OR ‘extracellular vesicle’) AND (uter OR blastocysti) AND (blastocyst OR embryo*).
Result
The composition of uterus-derived EVs exhibits variation across different physiological periods and plays different roles. Compared with the proliferative phase, EVs during the peri-implantation period contain more molecules related to cell differentiation, cell cycle, cell migration and invasion, apoptosis and antioxidant activity. The EVs discovered from uterine fluid, primary human endometrial epithelial cells (EECs), endometrial stromal cell and so forth have been shown to be internalised by embryos and trophoblast cell. The cargoes carried by EVs, mainly miRNA and proteins, regulate embryonic development and invasion-related pathways or molecules, supporting blastocyst formation and implantation. Similarly, EVs collected from dysfunctional uterus have been proved to disrupt critical reproductive processes, impairing both embryo development and implantation potential.
Conclusion
This review summarises the multiple effects of uterus-derived EVs on successful embryo implantation, including the effects on pre-implantation embryo development and embryo implantation ability.
Constant-force mechanisms (CFMs) are attractive for mechanical energy storage owing to their distinctive force–displacement characteristics, particularly under conditions with limited external load capacity and restricted space. However, conventional CFMs often suffer from short constant-force strokes and inefficient space utilization, which hinder their broader application. To address these limitations, this study exploits the buckling of compliant beams and increases the structural degrees of freedom by adopting a less constrained configuration, which extends the constant-force stroke and space utilization while reducing the required external load, thus improving energy storage efficiency for the same stored elastic energy. A novel catapult was developed through NSGA-II multi-objective optimization, achieving a high energy-to-cost ratio and an extended constant-force stroke. This work presents an effective design approach for motion mechanisms that demand high energy-storage efficiency and high-power output.
Bemisia tabaci is one of the most important agricultural pests worldwide, and the combined application of multiple natural enemies such as predators and parasitoids can potentially control B. tabaci. The study examined whether the predator Orius similis and the parasitoid Encarsia formosa can synergistically control B. tabaci (crop: kidney bean). The greenhouse cage method was used to release O. similis and E. formosa alone or in combination in different ratios. The combined release of O. similis and E. formosa synergistically decreased the B. tabaci population when compared with O. similis or E. formosa alone. Additionally, O. similis + E. formosa decreased the number of E. formosa black pupae and adults in each crop stage. However, the niche overlap index of E. formosa with B. tabaci nymphs in the O. similis + E. formosa group was higher than in the E. formosa group. Grey correlation analysis revealed that the correlation degree between natural enemies and B. tabaci was the highest when the O. similis and E. formosa release ratio was 1:3. These findings indicate that the combined release of O. similis and E. formosa synergistically controlled B. tabaci with the release ratio 1:3 being optimal for field application.
The treatment response for the negative symptoms of schizophrenia is not ideal, and the efficacy of antidepressant treatment remains a matter of considerable controversy. This systematic review and meta-analysis aimed to assess the efficacy of adjunctive antidepressant treatment for negative symptoms of schizophrenia under strict inclusion criteria.
Methods
A systematic literature search (PubMed/Web of Science) was conducted to identify randomized, double-blind, effect-focused trials comparing adjuvant antidepressants with placebo for the treatment of negative symptoms of schizophrenia from database establishment to April 16, 2025. Negative symptoms were examined as the primary outcome. Data were extracted from published research reports, and the overall effect size was calculated using standardized mean differences (SMD).
Results
A total of 15 articles, involving 655 patients, were included in this review. Mirtazapine (N = 2, n = 48, SMD −1.73, CI −2.60, −0.87) and duloxetine (N = 1, n = 64, SMD −1.19, CI −2.17, −0.21) showed significantly better efficacy for negative symptoms compared to placebo. In direct comparisons between antidepressants, mirtazapine showed significant differences compared to reboxetine, escitalopram, and bupropion, but there were no significant differences between other antidepressants or between antidepressants and placebo. No publication bias for the prevalence of this condition was observed.
Conclusions
These findings suggest that adjunctive use of mirtazapine and duloxetine can effectively improve the negative symptoms of schizophrenia in patients who are stably receiving antipsychotic treatment. Therefore, incorporating antidepressants into future treatment plans for negative symptoms of schizophrenia is a promising strategy that warrants further exploration.
This study presents a novel investigation into the vortex dynamics of flow around a near-wall rectangular cylinder based on direct numerical simulation at $Re=1000$, marking the first in-depth exploration of these phenomena. By varying aspect ratios ($L/D = 5$, $10$, $15$) and gap ratios ($G/D = 0.1$, $0.3$, $0.9$), the study reveals the vortex dynamics influenced by the near-wall effect, considering the incoming laminar boundary layer flow. Both $L/D$ and $G/D$ significantly influence vortex dynamics, leading to behaviours not observed in previous bluff body flows. As $G/D$ increases, the streamwise scale of the upper leading edge (ULE) recirculation grows, delaying flow reattachment. At smaller $G/D$, lower leading edge (LLE) recirculation is suppressed, with upper Kelvin–Helmholtz vortices merging to form the ULE vortex, followed by instability, differing from conventional flow dynamics. Larger $G/D$ promotes the formation of an LLE shear layer. An intriguing finding at $L/D = 5$ and $G/D = 0.1$ is the backward flow of fluid from the downstream region to the upper side of the cylinder. At $G/D = 0.3$, double-trailing-edge vortices emerge for larger $L/D$, with two distinct flow behaviours associated with two interactions between gap flow and wall recirculation. These interactions lead to different multiple flow separations. For $G/D = 0.9$, the secondary vortex (SV) from the plate wall induces the formation of a tertiary vortex from the lower side of the cylinder. Double-SVs are observed at $L/D = 5$. Frequency locking is observed in most cases, but is suppressed at $L/D = 10$ and $G/D = 0.9$, where competing shedding modes lead to two distinct evolutions of the SV.
This study employs direct numerical simulations to examine the effects of varying backpressure conditions on the turbulent atomisation of impinging liquid jets. Using the incompressible Navier–Stokes equations, and a volume-of-fluid approach enhanced by adaptive mesh refinement and an isoface-based interface reconstruction algorithm, we analyse spray characteristics in the environments with ambient gas densities ranging from 1 to 40 times the atmospheric pressure under five different backpressure scenarios. We investigate the behaviour of turbulent jets, incorporate realistic orifice geometries and identify significant variations in the atomisation patterns depending on backpressure. Two distinct atomisation types emerge, namely jet-sheet-ligament-droplet at lower backpressures and jet-sheet-fragment-droplet at higher ones, alongside a transition from dilute to dense spray patterns. This variation affects the droplet size distribution and spray dynamics, with increased backpressure reducing the spray's spreading angle and breakup length, while increasing the droplet size variation. Furthermore, these conditions promote distributions that induce rapid, nonlinear wavy motion in liquid sheets. Topological analysis of the atomisation field using velocity-gradient tensor invariants reveals significant variations in topology volume fractions across different regions. Downstream, the droplet Sauter mean diameter increases and then stabilises, reflecting the continuous breakup and coalescence processes, notably under higher backpressures. This research underscores the substantial impact of backpressure on impinging-jet atomisation and provides essential insights for nozzle design to optimise droplet distributions.
The large number of patients with ankle injuries and the high incidence make ankle rehabilitation an urgent health problem. However, there is a certain degree of difference between the motion of most ankle rehabilitation robots and the actual axis of the human ankle. To achieve more precise ankle joint rehabilitation training, this paper proposes a novel 3-PUU/R parallel ankle rehabilitation mechanism that integrates with the human ankle joint axis. Moreover, it provides comprehensive ankle joint motion necessary for effective rehabilitation. The mechanism has four degrees of freedom (DOFs), enabling plantarflexion/dorsiflexion, eversion/inversion, internal rotation/external rotation, and dorsal extension of the ankle joint. First, based on the DOFs of the human ankle joint and the variation pattern of the joint axes, a 3-PUU/R parallel ankle joint rehabilitation mechanism is designed. Based on the screw theory, the inverse kinematics inverse, complete Jacobian matrix, singular characteristics, and workspace analysis of the mechanism are conducted. Subsequently, the motion performance of the mechanism is analyzed based on the motion/force transmission indices and the constraint indices. Then, the performance of the mechanism is optimized according to human physiological characteristics, with the motion/force transmission ratio and workspace range as optimization objectives. Finally, a physical prototype of the proposed robot was developed, and experimental tests were performed to evaluate the above performance of the proposed robot. This study provides a good prospect for improving the comfort and safety of ankle joint rehabilitation from the perspective of human-machine axis matching.
This study investigates the flow structures and combustion regimes in an axisymmetric cavity-based scramjet combustor with a total temperature of 1800 K and a high Reynolds number of approximately 1 × 107. The hydroxyl planar laser-induced fluorescence technique, along with the broadband flame emission and CH* chemiluminescence, is employed to visualize the instantaneous flame structure in the optically accessible cavity. The jet-wake flame stabilization mode is observed, with intense heat release occurring in the jet wake upstream of the cavity. A hybrid Reynolds-averaged Navier–Stokes/large-eddy simulation approach is performed for the 0.18-equivalent-ratio case with a pressure-corrected flamelet/progress variable model. The combustion regime is identified mainly in the corrugated or wrinkled flamelet regime (approximately 102 < Da < 104, 103 < Ret < 105 where $Da$ is the Damköhler number and $Re_t$ is the turbulent Reynolds number). The combustion process is jointly dominated by supersonic combustion (which accounts for approximately 58 %) and subsonic combustion, although subsonic combustion has a higher heat release rate (peak value exceeding 1 × 109 J (m3s)−1). A partially premixed flame is observed, where the diffusion flame packages a considerable quantity of twisted premixed flame. The shockwave plays a critical role in generating vorticity by strengthening the volumetric expansion and baroclinic torque term, and it can facilitate the chemical reaction rates through the pressure and temperature surges, thereby enhancing the combustion. Combustion also shows a remarkable effect on the overall flow structures, and it drives alterations in the vorticity of the flow field. In turn, the turbulent flow facilitates the combustion and improves the flame stabilization by enhancing the reactant mixing and increasing the flame surface area.
Toroidal bubbles (TBs) represent cases of vortex rings with a gas–liquid interface where a gas vortex ring is encased within a liquid vortex ring, and can serve as effective media for mass conveyance, process mixing, noise reduction and reaction regulation. In this study, we carry out a systematic study on the interaction between a TB and a free surface. According to the high-speed photographic images from the experiments, we identify strong and weak interactions in terms of the normalized maximum free surface deformation $h_{max}^*$. Then, we perform numerical simulations based on the volume of fluid (VOF) method in the OpenFOAM platform. Based on both the experimental and the numerical results, we conclude that the Froude number, $Fr$, determines the main characteristics during the interaction process. The TB–free surface interaction is essentially the interaction between the liquid vortex ring enveloping the TB and the free surface, supplemented by the TB's complex behaviour. Next, we establish the scaling law of $h_{max}^*$ based on the energy balance condition. Based on this, we provide the critical $Fr$ and the slenderness of the TB, $\eta$, for identifying the strong and weak interactions, and a parametric plot of the interactions in terms of $Fr$ and $\eta$.
MicroRNAs (miRNAs) are endogenous, non-coding RNAs, which are functional in a variety of biological processes through post-transcriptional regulation of gene expression. However, the role of miRNAs in the interaction between Bacillus thuringiensis and insects remains unclear. In this study, small RNA libraries were constructed for B. thuringiensis-infected (Bt) and uninfected (CK) Spodoptera exigua larvae (treated with double-distilled water) using Illumina sequencing. Utilising the miRDeep2 and Randfold, a total of 233 known and 726 novel miRNAs were identified, among which 16 up-regulated and 34 down-regulated differentially expressed (DE) miRNAs were identified compared to the CK. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that potential target genes of DE miRNAs were associated with ABC transporters, fatty acid metabolism and MAPK signalling pathway which are related to the development, reproduction and immunity. Moreover, two miRNA core genes, SeDicer1 and SeAgo1 were identified. The phylogenetic tree showed that lepidopteran Dicer1 clustered into one branch, with SeDicer1 in the position closest to Spodoptera litura Dicer1. A similar phylogenetic relationship was observed in the Ago1 protein. Expression of SeDicer1 increased at 72 h post infection (hpi) with B. thuringiensis; however, expression of SeDicer1 and SeAgo1 decreased at 96 hpi. The RNAi results showed that the knockdown of SeDicer1 directly caused the down-regulation of miRNAs and promoted the mortality of S. exigua infected by B. thuringiensis GS57. In conclusion, our study is crucial to understand the relationship between miRNAs and various biological processes caused by B. thuringiensis infection, and develop an integrated pest management strategy for S. exigua via miRNAs.
Motivated by the work initiated by Chapman [‘Determinants of Legendre symbol matrices’, Acta Arith.115 (2004), 231–244], we investigate some arithmetical properties of generalised Legendre matrices over finite fields. For example, letting $a_1,\ldots ,a_{(q-1)/2}$ be all the nonzero squares in the finite field $\mathbb {F}_q$ containing q elements with $2\nmid q$, we give the explicit value of the determinant $D_{(q-1)/2}=\det [(a_i+a_j)^{(q-3)/2}]_{1\le i,j\le (q-1)/2}$. In particular, if $q=p$ is a prime greater than $3$, then
We explore the transition to chaos in a prototypical hydrodynamic oscillator, namely a globally unstable low-density jet subjected to external time-periodic forcing. As the forcing strengthens at an off-resonant frequency, we find that the jet exhibits a sequence of nonlinear states: period-1 limit cycle $\rightarrow $ quasiperiodicity $\rightarrow$ intermittency $\rightarrow$ low-dimensional chaos. We show that the intermittency obeys type-II Pomeau–Manneville dynamics by analysing the first return map and the scaling properties of the quasiperiodic lifetimes between successive chaotic epochs. By providing experimental evidence of the type-II intermittency route to chaos in a globally unstable jet, this study reinforces the idea that strange attractors emerge via universal mechanisms in open self-excited flows, facilitating the development of instability control strategies based on chaos theory.
We experimentally investigate the forced synchronization of a self-excited chaotic thermoacoustic oscillator with two natural frequencies, $f_1$ and $f_2$. On increasing the forcing amplitude, $\epsilon _f$, at a fixed forcing frequency, $f_f$, we find two different types of synchronization: (i) $f_f/f_1 = 1:1$ or $2:1$ chaos-destroying synchronization (CDS), and (ii) phase synchronization of chaos (PSC). En route to $1:1$ CDS, the system transitions from an unforced chaotic state (${\rm {CH}}_{1,2}$) to a forced chaotic state (${\rm {CH}}_{1,2,f}$), then to a two-frequency quasiperiodic state where chaos is destroyed ($\mathbb {T}^2_{2,f}$), and finally to a phase-locked period-1 state (${\rm {P1}}_f$). The route to $2:1$ CDS is similar, but the quasiperiodic state hosts a doubled torus $(2\mathbb {T}^2_{2,f})$ that transforms into a phase-locked period-2 orbit $({\rm {P2}}_f)$ when CDS occurs. En route to PSC, the system transitions to a forced chaotic state (${\rm {CH}}_{1,2,f}$) followed by a phase-locked chaotic state, where $f_1$, $f_2$ and $f_f$ still coexist but their phase difference remains bounded. We find that the maximum reduction in thermoacoustic amplitude occurs near the onset of CDS, and that the critical $\epsilon _f$ required for the onset of CDS does not vary significantly with $f_f$. We then use two unidirectionally coupled Anishchenko–Astakhov oscillators to phenomenologically model the experimental synchronization dynamics, including (i) the route to $1:1$ CDS, (ii) various phase dynamics, such as phase drifting, slipping and locking, and (iii) the thermoacoustic amplitude variations in the $f_f/f_1$–$\epsilon _f$ plane. This study extends the applicability of open-loop control further to a chaotic thermoacoustic system, demonstrating (i) the feasibility of using an existing actuation strategy to weaken aperiodic thermoacoustic oscillations, and (ii) the possibility of developing new active suppression strategies based on both established and emerging methods of chaos control.
The numerical investigation focuses on the flow patterns around a rectangular cylinder with three aspect ratios ($L/D=5$, $10$, $15$) at a Reynolds number of $1000$. The study delves into the dynamics of vortices, their associated frequencies, the evolution of the boundary layer and the decay of the wake. Kelvin–Helmholtz (KH) vortices originate from the leading edge (LE) shear layer and transform into hairpin vortices. Specifically, at $L/D=5$, three KH vortices merge into a single LE vortex. However, at $L/D=10$ and $15$, two KH vortices combine to form a LE vortex, with the rapid formation of hairpin vortex packets. A fractional harmonic arises due to feedback from the split LE shear layer moving upstream, triggering interaction with the reverse flow. Trailing edge (TE) vortices shed, creating a Kármán-like street in the wake. The intensity of wake oscillation at $L/D=5$ surpasses that in the other two cases. Boundary layer transition occurs after the saturation of disturbance energy for $L/D=10$ and $15$, but not for $L/D=5$. The low-frequency disturbances are selected to generate streaks inside the boundary layer. The TE vortex shedding induces the formation of a favourable pressure gradient, accelerating the flow and fostering boundary layer relaminarization. The self-similarity of the velocity defect is observed in all three wakes, accompanied by the decay of disturbance energy. Importantly, the decrease in the shedding frequency of LE (TE) vortices significantly contributes to the overall decay of disturbance energy. This comprehensive exploration provides insights into complex flow phenomena and their underlying dynamics.
Let H be a complex separable Hilbert space with $\dim H \geq 2$. Let $\mathcal {N}$ be a nest on H such that $E_+ \neq E$ for any $E \neq H, E \in \mathcal {N}$. We prove that every 2-local isometry of $\operatorname {Alg}\mathcal {N}$ is a surjective linear isometry.
We present experimental evidence of multifractality and scale-free network topology in a noise-perturbed laminar jet operated in a globally stable regime, prior to the critical point of a supercritical Hopf bifurcation and prior to the saddle-node point of a subcritical Hopf bifurcation. For both types of bifurcation, we find that (i) the degree of multifractality peaks at intermediate noise intensities, (ii) the conditions for peak multifractality produce a complex network whose node degree distribution obeys an inverse power-law scaling with an exponent of $2 < \gamma < 3$, indicating scale-free topology and (iii) the Hurst exponent and the global clustering coefficient can serve as early warning indicators of global instability under specific operating and forcing conditions. By characterising the noise-induced dynamics of a canonical shear flow, we demonstrate that the multifractal and scale-free network dynamics commonly observed in turbulent flows can also be observed in laminar flows under certain stochastic forcing conditions.