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Internationally, there is a growing drive to integrate patient preference information (PPI) into health technology assessment (HTA) decision-making. However, it is unclear how PPI is used in real-world contexts and the extent to which it can reshape and influence HTA decisions. Understanding how PPI can be meaningfully used in HTA is fundamental for supporting its practical application and increasing trust in its use.
Methods
The aim was to enhance understanding of how HTA committees interpret and incorporate PPI into decision-making. Mock deliberation workshops were conducted by members of the HTAi Patient Preference Project Subcommittee with experts from four HTA agencies. For the workshops, a mock evidence package was developed that included PPI evidence alongside key clinical and economic evidence to simulate decision-making processes. The mock deliberations were analyzed using thematic analysis.
Results
The mock deliberation workshops (25 participants) highlighted both opportunities and challenges in integrating PPI into HTA processes. While PPI was acknowledged as valuable evidence, its influence on decision-making in the scenarios varied from being cited by a few participants as informing the decision to most participants indicating the evidence was not persuasive. Participants pointed out the need for more structured guidance on how to incorporate PPI alongside clinical and economic evidence. The findings highlighted the importance of standardizing the path to integration, as well as the content and format of PPI, to support consistent interpretation and application in HTA.
Conclusions
By examining how PPI is weighed alongside clinical and economic evidence, the project offered valuable insights for stakeholders aiming to generate more pertinent PPI studies for incorporation into the decision-making process. The key takeaways for HTA agencies included strategies for effectively balancing PPI with clinical and economic evidence, highlighting a shift toward incorporating more diverse and inclusive forms of evidence.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that. Topics covered include correlation inequalities, Lee-Yang theorems, the Peierls method, the Hohenberg-Mermin-Wagner method, infrared bounds, random cluster methods, random current methods and BKT transition. The final section outlines major open problems to inspire future work. This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that.
Topics covered include correlation inequalities, Lee–Yang theorems, the Peierls method, the Hohenberg–Mermin–Wagner method, infrared bounds, random cluster methods, random current methods, and BKT transition. The final section outlines major open problems to inspire future work.
This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that.
Topics covered include correlation inequalities, Lee–Yang theorems, the Peierls method, the Hohenberg–Mermin–Wagner method, infrared bounds, random cluster methods, random current methods, and BKT transition. The final section outlines major open problems to inspire future work.
This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that.
Topics covered include correlation inequalities, Lee–Yang theorems, the Peierls method, the Hohenberg–Mermin–Wagner method, infrared bounds, random cluster methods, random current methods, and BKT transition. The final section outlines major open problems to inspire future work.
This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that.
Topics covered include correlation inequalities, Lee–Yang theorems, the Peierls method, the Hohenberg–Mermin–Wagner method, infrared bounds, random cluster methods, random current methods, and BKT transition. The final section outlines major open problems to inspire future work.
This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that.
Topics covered include correlation inequalities, Lee–Yang theorems, the Peierls method, the Hohenberg–Mermin–Wagner method, infrared bounds, random cluster methods, random current methods, and BKT transition. The final section outlines major open problems to inspire future work.
This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that.
Topics covered include correlation inequalities, Lee–Yang theorems, the Peierls method, the Hohenberg–Mermin–Wagner method, infrared bounds, random cluster methods, random current methods, and BKT transition. The final section outlines major open problems to inspire future work.
This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that.
Topics covered include correlation inequalities, Lee–Yang theorems, the Peierls method, the Hohenberg–Mermin–Wagner method, infrared bounds, random cluster methods, random current methods, and BKT transition. The final section outlines major open problems to inspire future work.
This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that.
Topics covered include correlation inequalities, Lee–Yang theorems, the Peierls method, the Hohenberg–Mermin–Wagner method, infrared bounds, random cluster methods, random current methods, and BKT transition. The final section outlines major open problems to inspire future work.
This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
The intersection of statistical mechanics and mathematical analysis has proved a fertile ground for mathematical physics and probability, and in the decades since lattice gases were first proposed as a model for describing physical systems at the atomic level, our understanding of them has grown tremendously. A book that provides a comprehensive account of the methods used in the study of phase transitions for Ising models and classical and quantum Heisenberg models has been long overdue. This book, written by one of the masters of the subject, is just that.
Topics covered include correlation inequalities, Lee–Yang theorems, the Peierls method, the Hohenberg–Mermin–Wagner method, infrared bounds, random cluster methods, random current methods, and BKT transition. The final section outlines major open problems to inspire future work.
This is a must-have reference for researchers in mathematical physics and probability and serves as an entry point, albeit advanced, for students entering this active area.
Growing evidence has linked both the onset and symptoms of various mental disorders to lifestyle factors such as diet, exercise and sleep. The link between diet and mental health, in particular in depressive disorders, has gained interest in recent years. Previous reviews assessing the link between the Mediterranean diet (MedDiet) and mental health predominantly focused on depression, whilst others failed to integrate a summary of possible underlying mechanisms related to a link between MedDiet and mental health to complement their findings. In the present review, we provide a comprehensive synthesis of evidence on the MedDiet and diverse mental health outcomes complemented by narration of the potential mechanisms involved. A literature search was conducted across MEDLINE, PsycINFO, Scopus, Cochrane library, Google Scholar, CINAHL and Embase databases. A total of 10 249 articles were found through the primary literature search and 104 articles (88 observational and 16 interventional studies) were eligible for inclusion. The MedDiet has been associated with favourable mental health outcomes in adult populations, including reduced depressive and anxiety symptoms, lower perceived stress, and improved quality of life and overall wellbeing, both in healthy individuals and those with comorbidities, across diverse geographical settings. Mechanisms involved include the antioxidant, anti-inflammatory potential of the MedDiet and its effect on gut microbiota. Further research is warranted to rigorously establish causal inferences and to guide the optimal incorporation of Mediterranean diet principles into comprehensive prevention and treatment strategies aimed at improving mental health outcomes.
It remains unclear which individuals with subthreshold depression benefit most from psychological intervention, and what long-term effects this has on symptom deterioration, response and remission.
Aims
To synthesise psychological intervention benefits in adults with subthreshold depression up to 2 years, and explore participant-level effect-modifiers.
Method
Randomised trials comparing psychological intervention with inactive control were identified via systematic search. Authors were contacted to obtain individual participant data (IPD), analysed using Bayesian one-stage meta-analysis. Treatment–covariate interactions were added to examine moderators. Hierarchical-additive models were used to explore treatment benefits conditional on baseline Patient Health Questionnaire 9 (PHQ-9) values.
Results
IPD of 10 671 individuals (50 studies) could be included. We found significant effects on depressive symptom severity up to 12 months (standardised mean-difference [s.m.d.] = −0.48 to −0.27). Effects could not be ascertained up to 24 months (s.m.d. = −0.18). Similar findings emerged for 50% symptom reduction (relative risk = 1.27–2.79), reliable improvement (relative risk = 1.38–3.17), deterioration (relative risk = 0.67–0.54) and close-to-symptom-free status (relative risk = 1.41–2.80). Among participant-level moderators, only initial depression and anxiety severity were highly credible (P > 0.99). Predicted treatment benefits decreased with lower symptom severity but remained minimally important even for very mild symptoms (s.m.d. = −0.33 for PHQ-9 = 5).
Conclusions
Psychological intervention reduces the symptom burden in individuals with subthreshold depression up to 1 year, and protects against symptom deterioration. Benefits up to 2 years are less certain. We find strong support for intervention in subthreshold depression, particularly with PHQ-9 scores ≥ 10. For very mild symptoms, scalable treatments could be an attractive option.