This article discusses Abdullahi Ahmed an-Na‘im's Islam and the Secular State from the perspective of Marsilius of Padua's political theory. Both authors share similar concepts of the relationship between religion, state policy, and the state, and allow for the integration of religious doctrines into state law. Nonetheless, the Marsilian conception provides stronger protection of unbelievers' and religious dissenters' civic rights. In the broader discourse on political theory of rights, Marsilius argues in favors of individual rights and a protection of minority rights, while an-Na‘im's theory of Shari‘a reform suggests a preference for a people's self-determination.

It has been shown that treatment of rats with clofibrate, a synthetic agonist of PPARα, increases mRNA concentration of organic cation transporters (OCTN)-1 and -2 and concentration of carnitine in the liver. Since oxidised fats have been demonstrated in rats to activate hepatic PPARα, we tested the hypothesis that they also up regulate OCTN. Eighteen rats were orally administered either sunflower-seed oil (control group) or an oxidised fat prepared by heating sunflower-seed oil, for 6 d. Rats administered the oxidised fat had higher mRNA concentrations of typical PPARα target genes such as acyl-CoA oxidase, cytochrome P450 4A1 and carnitine palmitoyltransferases-1A and -2 in liver and small intestine than control rats (P < 0·05). Furthermore, rats treated with oxidised fat had higher hepatic mRNA concentrations of OCTN1 (1·5-fold) and OCTN2 (3·1-fold), a higher carnitine concentration in the liver and lower carnitine concentrations in plasma, gastrocnemius and heart muscle than control rats (P < 0·05). Moreover, rats administered oxidised fat had a higher mRNA concentration of OCTN2 in small intestine (2·4-fold; P < 0·05) than control rats. In conclusion, the present study shows that an oxidised fat causes an up regulation of OCTN in the liver and small intestine. An increased hepatic carnitine concentration in rats treated with the oxidised fat is probably at least in part due to an increased uptake of carnitine into the liver which in turn leads to reduced plasma and muscle carnitine concentrations. The present study supports the hypothesis that nutrients acting as PPARα agonists influence whole-body carnitine homeostasis.

Marsilius of Padua: The Defender of the Peace, Annabel Brett, ed. and trans., Cambridge: Cambridge University Press, 2005, pp. lxi, 569.

Marsilius of Padua's Defensor Pacis is one of the key texts of medieval political theory. His thought forms a cornerstone of the transition from medieval to modern political reasoning and is one of the Western classics in the history of political ideas. This early fourteenth-century thinker is not only well known for his secular political thought but also for a theory of the Church that foreshadows the Reformation. The importance of Marsilius of Padua is demonstrated by a continuing and increasing scholarly interest in his ideas. Moreover, the growing number of translations and re-translations of Marsilius's writings indicates his significance for graduate and undergraduate education as well as for scholars whose primary expertise is not in medieval political thought.