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Knowledge of sex differences in risk factors for posttraumatic stress disorder (PTSD) can contribute to the development of refined preventive interventions. Therefore, the aim of this study was to examine if women and men differ in their vulnerability to risk factors for PTSD.
Methods
As part of the longitudinal AURORA study, 2924 patients seeking emergency department (ED) treatment in the acute aftermath of trauma provided self-report assessments of pre- peri- and post-traumatic risk factors, as well as 3-month PTSD severity. We systematically examined sex-dependent effects of 16 risk factors that have previously been hypothesized to show different associations with PTSD severity in women and men.
Results
Women reported higher PTSD severity at 3-months post-trauma. Z-score comparisons indicated that for five of the 16 examined risk factors the association with 3-month PTSD severity was stronger in men than in women. In multivariable models, interaction effects with sex were observed for pre-traumatic anxiety symptoms, and acute dissociative symptoms; both showed stronger associations with PTSD in men than in women. Subgroup analyses suggested trauma type-conditional effects.
Conclusions
Our findings indicate mechanisms to which men might be particularly vulnerable, demonstrating that known PTSD risk factors might behave differently in women and men. Analyses did not identify any risk factors to which women were more vulnerable than men, pointing toward further mechanisms to explain women's higher PTSD risk. Our study illustrates the need for a more systematic examination of sex differences in contributors to PTSD severity after trauma, which may inform refined preventive interventions.
Medical Emergencies in A Mental Health Setting (MEAMS) was a proposed high-fidelity simulation training course specifically designed for the mental health multidisciplinary team (MDT). A team of resus officers, mental health nurses and psychiatric doctors worked to create scenarios reflecting the emergencies encountered in mental health. It aimed to gives staff simulated experience in approaching and managing a verity of complex emergencies, including physical health, as well as communication scenarios. Specifically the aims were: (1) Determine if course was perceived to benefit staff, (2) Determine if course subjectively increased staff knowledge and confidence in mental health emergencies, (3) Review for continued areas of improvement
Methods
The full day sessions were carried out in the Electroconvulsive therapy (ECT) suite, with it being modified into an immersive environment similar to wards or clinics. The faculty of medical resus officers, mental health nurses and psychiatric consultants ran the courses, with participants joining from across the MDT including nursing staff, junior doctors, consultants, students and nursing assistants.
The morning program, run by resus officers, provided education in life support, initial assessment of the unwell patient and intraosseous access. The afternoon contained various scenarios, including for example managing neuroleptic malignant syndrome. Scenarios were observed via video link by faculty, with constructive feedback and debriefs provided.
Quantitative data of knowledge and confidence was obtained pre and post sessions using Likert scales. Qualitative information regarding future proposed scenarios, areas of improvement and areas of notable value was gathered.
Results
36 staff attended the program, run over 4 days. Average knowledge and confidence (scored out of 10) improved from 4.9 pre-session to 8.1 post-session. All 36 staff felt the session was beneficial. Particular positive feedback on scenario realism, MDT working, safe/ supportive teaching and the resus faculty teaching was highlighted.
Areas for improvement highlighted included running sessions more often, widening accessibility to more staff and teaching on resus medications and fluids. A variety of further scenarios were suggested, for example management of withdrawal seizure.
Conclusion
MEAMS was felt to achieve its aims, and demonstrated clear subjective increase in staff knowledge and confidence regarding common emergencies seen in mental health settings. Further sessions and wider accessibility to the mental health MDT is anticipated to continually benefit staff. Taking on qualitative feedback, the faculty aims to continually adapt the program to provide the best possible training and education, adapting and creating new relevant scenarios.
In recent work, Peter Hanks and Scott Soames argue for the type view, according to which propositions are types whose tokens are acts, states, or events. Hanks and Soames think that one of the virtues of the type view is that it allows them to explain why propositions have semantic properties. But, in this paper, we argue that their explanations aren't satisfactory.
Most of the discovered exoplanets are close to our sun. Usually their host star is with large proper motions, which is an important parameter for exoplanet searching. The first version of absolute proper motions catalog achieved based on Digitized Sky Survey Schmidt plate where outside the galactic plane |b|≥27° is presented, resulting in a zero point error less than ± 0.3 mas/yr, and the overall accuracy better than ± 4.5 mas/yr for objects brighter than RF=18.5, and ranging from 4.5 to 9.0 mas/yr for objects with magnitude 18.5<RF<20.5. The systematic errors of absolute proper motions related to the position, magnitude and color are practically all removed. The sky cover of this catalog is 22,525 degree2, the mean density is 6444 objects/degree2 and the magnitude limit is around RF=20.5.
The formal commissioning of the IRWG occurred at the 1991 Buenos Aires General Assembly, following a Joint Commission meeting at the IAU GA in Baltimore in 1988 that identified the problems with ground-based infrared photometry. The meeting justification, papers, and conclusions, can be found in Milone (1989). In summary, the challenges involved how to explain the failure to achieve the milli-magnitude precision expected of infrared photometry and an apparent 3% limit on system transformability. The proposed solution was to redefine the broadband Johnson system, the passbands of which had proven so unsatisfactory that over time effectively different systems proliferated, although bearing the same “JHKLMNQ” designations; the new system needed to be better positioned and centered in the spectral windows of the Earth's atmosphere, and the variable water vapour content of the atmosphere needed to be measured in real time to better correct for atmospheric extinction.
Structural framing is the reference to initial material at the end of a formal unit; this formal unit might be a theme, section, movement or even a multi-movement work. Structural framing is a special kind of thematic restatement that is fundamentally distinct from recapitulation or apotheosis. Whereas a recapitulation associates the beginning of one section with the beginning of another section, a structural frame associates the beginning of one section with its end. Thus a recapitulation is a re-beginning, an apotheosis is a triumphant arrival, and a structural frame is a closing gesture – a parting ‘adieu’ that assists the listener in the conceptual encompassment of a formal unit.
We have observed a gate-bias stress induced instability in both the threshold voltage of SiC MOSFETs and the flatband voltage of SiC MOS capacitors. The magnitude of this bias stress-induced instability generally increases linearly with log time, with no saturation of the effect observed, even out to 100,000 seconds. The magnitude also increases with increasing gate field. A positive gate-bias stress causes a positive shift and a negative gate-bias stress causes a negative shift, consistent with electron tunneling into or out of oxide traps near the SiC / SiO2 interface as opposed to mobile ions drifting across the gate oxide. The effect is repeatable.
Mutants in the Drosophila crooked neck
(crn) gene show an embryonic lethal phenotype
with severe developmental defects. The unusual crn protein
consists of sixteen tandem repeats of the 34 amino acid
tetratricopeptide (TPR) protein recognition domain. Crn-like
TPR elements are found in several RNA processing proteins,
although it is unknown how the TPR repeats or the crn protein
contribute to Drosophila development. We have
isolated a Saccharomyces cerevisiae gene, CLF1,
that encodes a crooked neck-like factor.
CLF1 is an essential gene but the lethal phenotype
of a clf1::HIS3 chromosomal null mutant can be
rescued by plasmid-based expression of CLF1 or the Drosophila
crn open reading frame. Clf1p is required in vivo and
in vitro for pre-mRNA 5′ splice site cleavage. Extracts
depleted of Clf1p arrest spliceosome assembly after U2
snRNP addition but prior to productive U4/U6.U5 association.
Yeast two-hybrid analyses and in vitro binding studies
show that Clf1p interacts specifically and differentially
with the U1 snRNP-Prp40p protein and the yeast U2AF65 homolog,
Mud2p. Intriguingly, Prp40p and Mud2p also bind the phylogenetically
conserved branchpoint binding protein (BBP/SF1). Our results
indicate that Clf1p acts as a scaffolding protein in spliceosome
assembly and suggest that Clf1p may support the cross-intron
bridge during the prespliceosome-to-spliceosome transition.
The extensively studied Markarian sample of 1500 ultraviolet excess galaxies contains many Seyfert, starburst, and peculiar galaxies. Using the 20 minute V plates obtained for the construction of the Hubble Space Telescope Guide Star Catalog, we have investigated the morphologies of the Markarian galaxies and the environments in which they are located. This paper reports on the relationship between the types of nuclear activity and the morphologies and environments of the Markarian galaxies.
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