We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Spatially resolved transcriptomics (SRT) is a growing field that links gene expression to anatomical context. SRT approaches that use next-generation sequencing (NGS) combine RNA sequencing with histological or fluorescent imaging to generate spatial maps of gene expression in intact tissue sections. These technologies directly couple gene expression measurements with high-resolution histological or immunofluorescent images that contain rich morphological information about the tissue under study. While broad access to NGS-based spatial transcriptomic technology is now commercially available through the Visium platform from the vendor 10× Genomics, computational tools for extracting image-derived metrics for integration with gene expression data remain limited. We developed VistoSeg as a MATLAB pipeline to process, analyze and interactively visualize the high-resolution images generated in the Visium platform. VistoSeg outputs can be easily integrated with accompanying transcriptomic data to facilitate downstream analyses in common programing languages including R and Python. VistoSeg provides user-friendly tools for integrating image-derived metrics from histological and immunofluorescent images with spatially resolved gene expression data. Integration of this data enhances the ability to understand the transcriptional landscape within tissue architecture. VistoSeg is freely available at http://research.libd.org/VistoSeg/.
The cerebellum has been implicated in cognitive, affective and motor functions, including emotion regulation, executive control and sensorimotor processing. In schizophrenia, cerebellar dysfunction has been associated with treatment resistance and clinical features. However, few studies have been focused on delusional disorder (DD).
Objectives
Our main purpose was to review the evidence available on cerebellum abnormalities and dysfunctions in patients with DD.
Methods
A systematic review was conducted through PubMed, Scopus and ClinicalTrials.gov (inception-June 2022) according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) directives. The following search terms were used: cerebellum OR cerebellar AND (“delusional disorder” AND paranoia). Reference lists from included studies were hand-checked to find other potential relevant papers.
Results
Six studies were included from a total of 119 retrieved records (PubMed: 52, Scopus: 66, ClinicalTrials.gov: 1). Study 1:Patients with DD somatic type (n=14) presented a decreased gray matter volume in cerebellar lobules compared to healthy controls (HC) (n=32, left lobule VIIIa) and non-somatic DD (n=18, lobule V). Cerebellar volumes did not seem to differ between HC and non-somatic DD. Study 2:Abnormalities of voluntary saccadic eye movements, linking frontal and cerebellar functions, were found in DD patients (n=34) compared to HC (n=40). Study 3: Abnormal smooth pursuit eye movements in DD (n=15) compared with HC (n=40) and similar to schizophrenia (n=40). Case reports (n=3): DD associated with Dandy-Walker variant (partial vermian hypoplasia), unruptured intracerebral aneurysm of basilar artery, and megacisterna magna.
Conclusions
Cerebellar deficits in patients with DD has been reported, particularly in those presenting somatic delusional contents.
Contains 'Stagsden and Its Manors', by J. Steele Elliott. 'Three Records of the Alien Priory of Grove and the Manor of Leighton Buzzard', by Robert Richmond. 'Ancient Bedfordshire Deeds, no 3: Northill, Southill, Old Warden, etc', by F. A. Page-Turner. 'Harlington Churchwardens' Accounts', by Joseph Hight Blundell. 'Some Bedfordshire Assessments for the Taxation of a Ninth, 1297, by Mrs. Hilary Jenkinson. 'Institutions to Ecclesiastical Benefices in the County of Bedford, 1535-1660', by The Rev. Canon C. W. Foster.
Notes: I 'Declaration of Common Rights, Eaton Bray and Totternhoe, 1475', by Fred. Puttnam; II 'Catsbrook at Biscot near Luton', by William Austin; III 'Wingate of Streatley and Harlington', by Joseph Hight Blundell; IV 'Variant spelling of Thurleigh'; V 'The Meeting Place of Manshead Hundred', by G. Herbert Fowler.
In memoriam C. G. C. (Clifford Gore Chambers, d. 1913). 'The Bedfordshire Wills and Administrations Proved at Lambeth Palace and in the Archdeaconry of Huntingdon', by F. A. Page Turner. 'The Beauchamps, Barons of Eaton', by G. Herbert Fowler. 'Ancient Bedfordshire Deeds, No. 1', by F. A. Page Turner. 'Records of Northill College, No. 2', by C. Gore Chambers. 'Bedfordshire Charters in the Missenden Cartulary', by G. Herbert Fowler. 'The Browne Family of Arlesey', by F. A. Page Turner. 'Markets and Fairs of Luton', by William Austin. 'The Assessment of Knight Service in Bedfordshire, No. 1', by John E. Morris. 'Materies Genealogica, No. 1', by F. A. Page Turner. 'An early Bedfordshire taxation', by Mrs. Hilary Jenkinson. 'A Commutation of Villan (sic) services', by William Austin. 'Records of Knight Service in Bedfordshire’, by G. Herbert Fowler. 'Notes and replies – Ravensden and Chainhalle; Toddington place names 1453; Luton names in the xiith century; duties on bricks'.
Includes 'The Beauchamps, Barons of Bedford', by C. Gore Chambers and G. Herbert Fowler. 'Clerical Subsidies in the Archdeaconry of Bedford, 1390-2, 1400-1', by J. E. Brown. 'Domesday Notes', by G. Herbert Fowler. 'A Lease of Caddington Manor in 1299', by C. Gore Chambers. 'Sir William Harper, Knt.', by F. A. Page-Turner. 'Early Charters of the Priory of Chicksand', by G. Herbert Fowler. 'Notes on Two Trades: (i) Strawplaiting, (ii) Brickmaking', by William Austin. 'The Bedford Eyre, 1202', by G. Herbert Fowler. 'Records of Northill College, No. I', by C. Gore Chambers.
In a very interesting note on Eels and Eel-catching in Bedfordshire, Mr. Steele Elliott has criticised my suggested identification of these two manors, on the ground that the mill at Chainhalle paid as part rent in Domesday Book thirty shillings and a hundred eels:
“judging from its comparatively high rental [this mill] must have been one of the most important in the county. Therefore we can reasonably presume the position of this Manor was adjoining the Ouse, and not remote from any important stream.” The actual money rent is no doubt high, but we cannot now gauge the factors which produced that (accessibility, water-power, population, area under grain, etc.). As regards the eels, I venture to think that the criticism is not destructive. In the first place, a hundred eels was not an exceptional number, but about the average paid by eel-rented mills in Beds. (2610 eels ÷ 25 mills); nine out of the twenty-five mills paid less, six paid more. Again, Mr. Elliott does not seem to have made sufficient allowance for the general lowering of the water level all over the county due to the ‘ drayning and imbanking ‘ of the fens. What is now the inconsiderable stream on which presumably the Ravensden Mill stood, would be larger, and the area of which it can be said today “the ground is swampy and often covered by water from the overflow of the streams,” would then offer harbourage enough for eels.
That there was a mill at Ravensden in early times is shown by the inquisition post mortem of William de Beauchamp (II B) in 1262. To clinch the matter, the manor of Putenehou (Putnoe in Goldington), the position of which is not disputed, lay just on the other side of the stream from Ravensden, and similarly paid a rent of a hundred eels. The probable position of these mills is less than three miles from the Ouse.