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The interaction between national constitutions and transnational sources of law (foreign and international) has generated quite an active disagreement in the United States about what these bodies of law have to do with each other. This paper will explore these debates and the postures towards transnational law and its role in domestic constitutional adjudication which they express. It will identify three postures — of convergence, of resistance, and of engagement — that are manifest in the opinions of different justices of important high courts around the world, and will argue for a posture of ‘engagement’ at least in established constitutional systems like that of the United States.
Today is a time of retrogression in sustaining rights-protecting democracies, and of high levels of distrust in institutions. Of particular concern are threats to the institutions, including universities and the press, that help provide the information base for successful democracies. Attacks on universities, and university faculties, are rising. In Poland over the last four years, a world-renowned constitutional law theorist, Wojciech Sadurski, has been subject to civil and criminal prosecutions for defamation of the governing party. In Hungary, the Central European University (CEU) was ejected by the government, and had to partly relocate to Vienna, and other attacks on academic freedom followed. Faculty members in a number of countries have needed to relocate to other countries for their own safety.
Let ∑x be the (population) dispersion matrix, assumed well-estimated, of a set of non-homogeneous item scores. Finding the greatest lower bound for the reliability of the total of these scores is shown to be equivalent to minimizing the trace of ∑x by reducing the diagonal elements while keeping the matrix non-negative definite. Using this approach, Guttman's bounds are reviewed, a method is established to determine whether his λ4 (maximum split-half coefficient alpha) is the greatest lower bound in any instance, and three new bounds are discussed. A geometric representation, which sheds light on many of the bounds, is described.
Aspects of an entrenched constitution that were essential parts of founding compromises, and justified as necessary when a constitution was first adopted, may become less justifiable over time. Is this the case with respect to the structure of the United States Senate? The US Senate is hardwired in the Constitution to consist of an equal number of Senators from each state—the smallest of which currently has about 585,000 residents, and the largest of which has about 39.29 million. As this essay explains, over time, as population inequalities among states have grown larger, so too has the disproportionate voting power of smaller-population states in the national Senate. As a result of the ‘one-person, one-vote’ decisions of the 1960s that applied to both houses of state legislatures, each state legislature now is arguably more representative of its state population than the US Congress is of the US population. The ‘democratic deficit’ of the Senate, compared to state legislative bodies, also affects presidential (as compared to gubernatorial) elections. When founding compromises deeply entrenched in a constitution develop harder-to-justify consequences, should constitutional interpretation change responsively? Possible implications of the ‘democratic’ difference between the national and the state legislatures for US federalism doctrine are explored, especially with respect to the ‘pre-emption’ doctrine. Finally, the essay briefly considers the possibilities of federalism for addressing longer term issues of representation, polarisation and sustaining a single nation.
Bell’s palsy is acute facial palsy due to inflammation involving the facial nerve related to infections. Rates have not been noted to differ by ethnicity. We studied the lifetime prevalence in First Nations and all other Manitobans in people with type 2 diabetes mellitus aged 7 and older in 2013–2014 and 2016–2017. We found a crude lifetime prevalence of 9.9% [95% CI 9.4–10.4%] in the First Nations population versus 3.9% [95% CI 3.8–4.0%] in all other Manitobans. It is unknown if there were differences in glycemic control. The increased prevalence was found in all five provincial health regions. This study indicates that ethnicity may be an important risk factor for Bell’s palsy.
Geotechnical drilling for a tunnel between Port Moody and Burnaby, BC, Canada, uncovered a buried fjord. Its sedimentary fill has a thickness of at least 130 m and extends more than 37 m below present mean sea level. Recovered sediments record cyclical growth and decay of successive Cordilleran ice sheets. The oldest sediments comprise 58 m of almost stoneless silt conformably overlying ice-proximal sediments and till, which in turn overlie bedrock. These sediments may predate Marine Isotope Stage (MIS) 4. Glacial sediments assigned to MIS 4 overlie this basal succession and, in turn, are overlain by MIS 3 interstadial sediments and sediments from two MIS 2 glacial advances. Indicators of relative sea-level elevations that bracket glacial deposits of MIS 4 and 2 indicate the cyclic existence of moat-like isostatic depressions in the front of expanding ice sheets. Compared with present sea level, these depressions were at least 160 m during the onsets of MIS 4 and MIS 2. Assuming a maximum eustatic drawdown of 120 m during MIS 2, isostatic depression may have exceeded 200 m during retreat of glacial ice from the Evergreen tunnel area. This is consistent with region-specific low mantle viscosity and rapid Cordilleran Ice Sheet buildup and wasting.
Seven kaolins from Georgia (southeastern U.S.A.), ranging from high to low commercial grade, were characterized by X-ray powder diffraction and chemical techniques to establish that the variation in quality was caused by impurities. The Ca and Cs cation-exchange capacities (CEC) varied from 2.67 to 8.17 and from 3.29 to 8.77 meq/100g, respectively. Selective dissolution and correlation analyses strongly indicated that expandable 2:1 minerals, particularly smectite (1.2-5.9%), were responsible for most of the observed variations in Ca CEC (r = 0.85*). The external surface CEC of kaolinite ranged from 0 to 1 meq/ 100 g. The positive significant correlation (r = 0.90**) between the Ca CEC and the K-mica content (03.9%) suggested that Ca CEC may be related to the degree of mica weathering through an expandable mineral stage.
The Cs-retention capacity (0.19–1.14 meq/100 g) was closely related to Cs-measured vermiculite content (r = 0.80*), and this content plus specific surface (R = 0.93**) or mica content (R = 0.86*). The Cs retention appeared to be primarily related to the presence of interlayer wedges at mica/vermiculite XY interfaces.
The objective of this paper is to present flow sheets for a system of quantitative minera-logical analysis of clays of soils and sediments and to show representative results. Selective dissolution analysis by the Na2S2O7-HCl-NaOH procedure yields the quartz and feldspar contents (0 to 63%) and differentiates feldspar K from mica K. The NaOH-thermal system of selective dissolution yields the allophane plus gibbsite, kaolinite plus halloysite, and dickite contents (0 to 84% for the sediments; 1 to 25% for soil clays) Mica contents (0 to 92% for the rock specimens, 7 to 43% for soil clays) are determined by nonfeldspathic K (and Na). Vermiculite contents (1 to 97% of specimens; 3 to 21% for soil clays) are measured by blocking of interlayer CEC by drying at 110°C while K saturated and replacing with NH4Cl. Montmorillonite (and palygorskite) contents (0 to 85% of specimens; 3 to 36% of soil clays) are determined by the CEC not blocked by the K and NH4 sequence for vermiculite. Chlorite contents (0 to 85% for specimens; 0 to 37% for soil clays) are determined by thermal gravimetric analysis, after allocation of OH water lost between 300 and 950°C to other hydrous minerals determined.
The best evidence of the accuracy of the system of analysis lies in the consistent total recovery of 24 standard mineral samples averaging 100.4 ± 1.3 (± standard error of means) and of 22 soil clay samples averaging 99.5 ± 0.8. The different constituents were present in widely different proportions in the various samples, and were determined by independent methods. The complementary total of near 100% (maximum range 95 to 105% for specimens; 95 to 103% for soil clays) for the analyses is a significant measure of the specificity of the several determinations.
Deferration by reduction of free Fe2O3 with Na2S2O4 in the presence of Na citrate and NaHCO3 caused a change in valence state of 10 to 35 per cent of the total structural iron in micaceous vermiculites, soils, nontronite, and muscovite. An increase in Fe2+ on deferration was accompanied by an equivalent decrease in Fe3+. Subsequent treatment with H2O2 reoxidized the structural Fe2+ previously formed.
Sesquioxide coatings on micaceous vermiculites were examined electron microscopically. These coatings were composed predominantly of Fe2O3 with approximately 10 per cent by weight of Al2O3 and small amounts of SiO2, as determined by chemical analysis of the deferration extracts.
The cation exchange capacity (CEC) increased 10–60 per cent as a result of deferration of micaceous vermiculites and soils. Treatment of the deferrated sample with H2O2 restored the Fe3+ content to approximately the original value but the CEC was not affected. Consequently, the increase in CEC on deferration was attributed to the removal of the positively charged sesquioxide coating. The reversible change in valence of structural iron without an equivalent change in CEC was attributed to deprotonation-protonation of the structure (OH− ⇄ O2−) simultaneous with the oxidation-reduction of iron (Fe2+ ⇄ Fe3+) in the phyllosilicate layer.
When a viscous fluid partially fills a Hele-Shaw channel, and is pushed by a pressure difference, the fluid interface is unstable due to the Saffman–Taylor instability. We consider the evolution of a fluid region of finite extent, bounded between two interfaces, in the limit that the interfaces are close, that is, when the fluid region is a thin liquid filament separating two gases of different pressure. In this limit, we derive a second-order ‘thin-filament’ model that describes the normal velocity of the filament centreline, and evolution of the filament thickness, as functions of the thickness, centreline curvature and their derivatives. We show that the second-order terms in this model, that include the effect of transverse flow along the filament, are necessary to regularise the instability. Numerical simulation of the thin-filament model is shown to be in accordance with level-set computations of the complete two-interface model. Solutions ultimately evolve to form a bubble of rapidly increasing radius and decreasing thickness.
Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk.
Methods
Data came from the Collaborative Study on the Genetics of Alcoholism (n = 3681; ages 11–36). Alcohol transitions (first: drink, intoxication, alcohol use disorder [AUD] symptom, AUD diagnosis), internalizing, and externalizing phenotypes came from the Semi-Structured Assessment for the Genetics of Alcoholism. EF was measured with the Tower of London and Visual Span Tasks. Polygenic scores (PGS) were computed for alcohol-related and behavioral phenotypes. Cox models estimated associations among PGS, behavior, and alcohol milestones.
Results
Externalizing phenotypes (e.g. conduct disorder symptoms) were associated with future initiation and drinking problems (hazard ratio (HR)⩾1.16). Internalizing (e.g. social anxiety) was associated with hazards for progression from first drink to severe AUD (HR⩾1.55). Initiation and AUD were associated with increased hazards for later depressive symptoms and suicidal ideation (HR⩾1.38), and initiation was associated with increased hazards for future conduct symptoms (HR = 1.60). EF was not associated with alcohol transitions. Drinks per week PGS was linked with increased hazards for alcohol transitions (HR⩾1.06). Problematic alcohol use PGS increased hazards for suicidal ideation (HR = 1.20).
Conclusions
Behavioral markers of addiction vulnerability precede and follow alcohol transitions, highlighting dynamic, bidirectional relationships between behavior and emerging addiction.
A method using Li saturation and heating to 250°C to differentiate montmorillonite from beidellite and nontronite has been developed. The test utilizes three washings with 3 M LiCl and two washings with 0.01 M LiCl in 90% methanol to prevent dispersion. An 'infinitely thick’ sample (6–8 mg/cm2) on a glass slide is used to avoid the effects of the reaction of a thin clay film with sodium of the slide when it is heated at 250°C. Solvation with glycerol rather than ethylene glycol is used, because all of the Li smectites studied expanded to some extent in ethylene glycol after the heating. The smectites included several montmorillonites, a nontronite, and saponites. The presence of interstratified montmorillonite and beidellite layers was clearly shown by the test for several smectite samples, including the so-called beidellites from Beidell, Colorado, and Chen-yuan, Taiwan, and several soil clays. The test thereby provides more mineralogical information than the often-used arbitrary dividing point between montmorillonite and beidellite at 50% tetrahedral charge. Heating the Li-saturated clays at 250°C caused substitution of 35 to 125 meq/100 g of nonexchangeable Li. These amounts exceeded the changes in cation-exchange capacity plus Li by 4 to 21 meq/100 g, except for the end-member beidellite from the Black Jack mine, Idaho. Fusion with LiNO3 at 300°C could not be used to differentiate between smectites instead of washing with LiCl solution and heating to 250°C, because fused montmorillonite subsequently expanded to 18 Å with glycerol. Large increases in nonexchangeable Li were caused by the fusion of smectites, a vermiculite, and two partially expanded micas.
Clinical outcomes of repetitive transcranial magnetic stimulation (rTMS) for treatment of treatment-resistant depression (TRD) vary widely and there is no mood rating scale that is standard for assessing rTMS outcome. It remains unclear whether TMS is as efficacious in older adults with late-life depression (LLD) compared to younger adults with major depressive disorder (MDD). This study examined the effect of age on outcomes of rTMS treatment of adults with TRD. Self-report and observer mood ratings were measured weekly in 687 subjects ages 16–100 years undergoing rTMS treatment using the Inventory of Depressive Symptomatology 30-item Self-Report (IDS-SR), Patient Health Questionnaire 9-item (PHQ), Profile of Mood States 30-item, and Hamilton Depression Rating Scale 17-item (HDRS). All rating scales detected significant improvement with treatment; response and remission rates varied by scale but not by age (response/remission ≥ 60: 38%–57%/25%–33%; <60: 32%–49%/18%–25%). Proportional hazards models showed early improvement predicted later improvement across ages, though early improvements in PHQ and HDRS were more predictive of remission in those < 60 years (relative to those ≥ 60) and greater baseline IDS burden was more predictive of non-remission in those ≥ 60 years (relative to those < 60). These results indicate there is no significant effect of age on treatment outcomes in rTMS for TRD, though rating instruments may differ in assessment of symptom burden between younger and older adults during treatment.
Evidence from previous research suggests that frame-of-reference (FOR) training is effective at improving assessor ratings in many organizational settings. Yet no research has presented a thorough examination of systematic sources of variance (assessor-related effects, evaluation settings, and measurement design features) that might influence training effectiveness. Using a factorial ANOVA and variance components analyses on a database of four studies of frame-of-reference assessor training, we found that (a) training is most effective at identifying low levels of performance and (b) the setting of the training makes little difference with respect to training effectiveness. We also show evidence of the importance of rater training as a key determinant of the quality of performance ratings in general. Implications for FOR training theory and practice are discussed.
Diets deficient in fibre are reported globally. The associated health risks of insufficient dietary fibre are sufficiently grave to necessitate large-scale interventions to increase population intake levels. The Danish Whole Grain Partnership (DWP) is a public–private enterprise model that successfully augmented whole-grain intake in the Danish population. The potential transferability of the DWP model to Slovenia, Romania and Bosnia-Herzegovina has recently been explored. Here, we outline the feasibility of adopting the approach in the UK. Drawing on the collaborative experience of DWP partners, academics from the Healthy Soil, Healthy Food, Healthy People (H3) project and food industry representatives (Food and Drink Federation), this article examines the transferability of the DWP approach to increase whole grain and/or fibre intake in the UK. Specific consideration is given to the UK’s political, regulatory and socio-economic context. We note key political, regulatory, social and cultural challenges to transferring the success of DWP to the UK, highlighting the particular challenge of increasing fibre consumption among low socio-economic status groups – which were also most resistant to interventions in Denmark. Wholesale transfer of the DWP model to the UK is considered unlikely given the absence of the key ‘success factors’ present in Denmark. However, the DWP provides a template against which a UK-centric approach can be developed. In the absence of a clear regulatory context for whole grain in the UK, fibre should be prioritised and public–private partnerships supported to increase the availability and acceptability of fibre-rich foods.
This study investigated sex differences in Fe status, and associations between Fe status and endurance and musculoskeletal outcomes, in military training. In total, 2277 British Army trainees (581 women) participated. Fe markers and endurance performance (2·4 km run) were measured at the start (week 1) and end (week 13) of training. Whole-body areal body mineral density (aBMD) and markers of bone metabolism were measured at week 1. Injuries during training were recorded. Training decreased Hb in men and women (mean change (–0·1 (95 % CI –0·2, –0·0) and –0·7 (95 % CI –0·9, –0·6) g/dl, both P < 0·001) but more so in women (P < 0·001). Ferritin decreased in men and women (–27 (95 % CI –28, –23) and –5 (95 % CI –8, –1) µg/l, both P ≤ 0·001) but more so in men (P < 0·001). Soluble transferrin receptor increased in men and women (2·9 (95 % CI 2·3, 3·6) and 3·8 (95 % CI 2·7, 4·9) nmol/l, both P < 0·001), with no difference between sexes (P = 0·872). Erythrocyte distribution width increased in men (0·3 (95 % CI 0·2, 0·4)%, P < 0·001) but not in women (0·1 (95 % CI –0·1, 0·2)%, P = 0·956). Mean corpuscular volume decreased in men (–1·5 (95 % CI –1·8, –1·1) fL, P < 0·001) but not in women (0·4 (95 % CI –0·4, 1·3) fL, P = 0·087). Lower ferritin was associated with slower 2·4 km run time (P = 0·018), sustaining a lower limb overuse injury (P = 0·048), lower aBMD (P = 0·021) and higher beta C-telopeptide cross-links of type 1 collagen and procollagen type 1 N-terminal propeptide (both P < 0·001) controlling for sex. Improving Fe stores before training may protect Hb in women and improve endurance and protect against injury.
Premature mortality in people with depression is well established. A better understanding of the causes of death and the relative risks of death from each cause may help identify factors that contribute to the health inequalities between people with and without depression.
Objectives
To describe all-cause and cause-specific mortality of people with a hospital admission record for depression in Scotland, relative to the general population.
Methods
We used a linked population-based dataset of all psychiatric hospital admissions in Scotland to the national death dataset to identify 28,837 adults ≥18 years of age who had a hospital admission record of depression between 2000 and 2019. We obtained general population estimates and mortality data from the National Records of Scotland and quantified the relative difference in mortality by calculating the standardised mortality ratio (SMR), using indirect standardisation and stratifying by sex.
Results
During a median follow-up of 8.1 years, 7,931(27.5%) people who were hospitalised for depression died. Circulatory system diseases were the most common causes of death. Standardised all-cause mortality was more than three times higher than would be expected based on death rates in the general Scottish population. SMRs were similar in men and women for all-cause mortality and, in general, for cause-specific death (Table 1). The SMR for the suicide category was markedly higher in women than men, partly explained by the higher suicide mortality in males than females in the general population.Table 1
All-cause and cause-specific mortality of people hospitalised for depression in Scotland 2000-19
Observed deaths, n(All)
Expected deaths, n(All)
SMR (95% CI)(All)
Observed deaths, n(Male)
Expected deaths, n(Male)
SMR (95% CI)(Male)
Observed deaths, n(Female)
Expected deaths, n(Female
SMR (95% CI)(Female)
All-cause
7,931
2427
3.3(3.2-3.3)
3617
1052
3.4(3.3-3.5)
4314
1375
3.1(3.0-3.2)
Circulatory system diseases
2,020
806
2.5(2.4-2.6)
886
343
2.6(2.4-2.7)
1,134
463
2.4(2.3-2.6)
Neoplasms
1,153
682
1.7(1.6-1.8)
534
306
1.7(1.6-1.9)
619
376
1.6(1.5-1.8)
Respiratory system diseases
1,106
292
3.8(3.6-4.0)
453
112
4.0(3.7-4.4)
653
180
3.6(3.3-3.9)
Mental & behavioural disorders
835
131
6.4(5.9-6.8)
333
52
6.4(5.7-7.2)
502
79
6.3(5.8-6.9)
Accidents
395
69
5.7(5.2-6.3)
224
38
5.9(5.1-6.7)
171
31
5.5(4.7-6.3)
Suicide, self-harm & injuries of undetermined Intent
805
53
15.2(14.1-16.2)
485
39
12.4(11.3-13.5)
320
14
22.9(20.3-25.4)
Other external cause
28
6
4.7(2.9-6.4)
16
3
5.3 (2.7- 7.9)
12
3
4.0(1.7-6.3)
Other natural diseases
1,589
388
4.1(3.9-4.3)
686
159
4.3 (4.0-4.6)
903
229
3.9(3.7-4.2)
CI: Confidence interval; SMR: Standardised mortality ratio
Conclusions
People hospitalised for depression continue to have higher all-cause mortality than the general population in Scotland, with relative mortality varying by cause of death.