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The field of cultural evolution has long emphasized forms of social learning where learners are “blind” to payoffs of cultural traits, while neglecting “sighted” processes like guided variation. We review new insights that could inform psychologically enriched models of social learning. These insights reveal new ways that blindness creeps into selection, even when agents appraise the payoffs of cultural traits.
In 250 men (21·4 (sd 2·9) years; BMI 24·2 (sd 3·0) kg·m–2) commencing arduous military training during winter, we investigated the effect of 12 weeks of vitamin D supplementation on lower body (pelvic girdle, sacrum, coccyx and lower limb) overuse musculoskeletal injury risk in a randomised, placebo-controlled trial. Participants received either simulated sunlight (1·3 × standard erythemal dose in T-shirt and shorts, three times per week for 4 weeks and then once per week for 8 weeks), oral vitamin D3 (1000 IU · d–1 for 4 weeks and then 400 IU · d–1 for 8 weeks) or placebo for each intervention. Serum vitamin D metabolites and bone metabolism biomarkers were measured at baseline, week 5 and week 12. At baseline, 29 % of participants were vitamin D sufficient (25-hydroxyvitamin D ≥ 50 nmol·L–1). Vitamin D supplementation achieved vitamin D sufficiency in 95 % of participants after 4 weeks. During 6 months of training and subsequent 3 years of military service, 100 lower body overuse musculoskeletal injuries were diagnosed by clinicians. Frailty models indicated no difference in injury risk between vitamin D and placebo during military training (HRplacebo:vitamin D = 1·23 (95 % CI 0·57, 2·66), P = 0·597) or military service (HRplacebo:vitamin D = 0·94 (95 % CI 0·60, 1·46), P = 0·782). Both safe simulated sunlight and oral vitamin D3 were effective in achieving and maintaining vitamin D sufficiency in almost all. There was no clear evidence that vitamin D affects the risk of lower body overuse musculoskeletal injury during 6 months of military training or subsequent 3 years of military service.
Given the paradoxical media environment for gay athletes and the struggle they face in shaping their own stories, the sports autobiography offers a rich and understudied site to trace the evolution of gay athlete stories in the media. This chapter analyzes five of the most prominent gay athlete autobiographies to date, told over a three-decade time period from 1977 to 2007, to reveal the discourses athletes use to construct their identities surrounding sport, sexuality, athleticism, and identity. The project offers a comparative analysis of the major themes that emerged in gay athlete autobiographies and how these stories were shaped over time and across different cultural and sporting contexts.
Results of an experimental study investigating issues of Coriolis effects on the fluid dynamics associated with vortex rings propagating through a rotating fluid are presented. The vortex rings are generated at the top of a large, water-filled rotating tank and they propagate downwards along the axis of rotation. The motion and the decay of the rings in a rotating fluid are expected to be accompanied by an inertial-wave field being established in the fluid surrounding the rings. However, the existence of this inertial-wave field had previously never been verified experimentally. Particle image velocimetry measurements were performed with the goal of demonstrating the existence of the inertial-wave field. Datasets were processed to extract individual inertial-wave modes and, for the first time, experimentally construct the dispersion relation for the inertial waves associated with vortex rings. For rotation rates when Coriolis forces dominate the dynamics, the experimental data are found to be in very good agreement with the well-established theoretical dispersion relation for inertial waves. The generation of inertial waves implies that kinetic energy is radiated away from the vortex rings. First results relating to the redistribution process of the kinetic energy are briefly discussed.
This study investigated changes in serum folate and B12, and associations with endurance performance and bone outcomes, in women during military training. Women (n 137) had serum folate and B12, haematological markers and endurance performance (2·4 km run) measured at the start (week 1) and end (week 13) of British Army basic training. Whole-body areal bone mineral density and markers of bone metabolism were measured at week 1. Training decreased serum folate (mean change (95 % CI), −2·3 (−3·0, −1·6) nmol ∙ l−1, P < 0·001), B12 (−16 (−32, 0) pmol ∙ l−1, P = 0·042), Hb (−0·7 (−0·9, −0·5) g ∙ dl−1, P < 0·001) and erythrocyte count (−0·2 (−0·3, −0·2) × 10^9 ∙ l−1, P < 0·001), but had no effect on mean corpuscular volume (P = 0·438) or erythrocyte distribution width (P = 0·088). There was no association between serum folate, serum B12, Hb or erythrocyte count with run time (P ≥ 0·518). Serum B12 was not associated with areal bone mineral density or bone metabolism at week 1 (P ≥ 0·152). Higher serum folate was associated with lower plasma c-telopeptide cross-links of type I collagen (standardised β (95 % CI) = −0·31 (−0·48, −0·15), P < 0·001), but not whole-body bone mineral density or plasma procollagen type I N-terminal propeptide (P ≥ 0·152). Serum folate and B12 decreased after military training in women, resulting in a high prevalence of folate deficiencies at the end of training. Low serum folate may contribute to increased bone resorption, the implications of which are unclear.
Glacier ice melt, a key driver of sea level rise, depends on how the ocean currents interact with ice. The roughness and shape of the ice on scales smaller than 10 m are important and remain poorly understood due to a lack of observations. We investigate submarine ice roughness using fine-resolution multibeam sonar measurements from 13 grounded icebergs and a drone survey of a recently capsized floating iceberg in the temperate tidewater glacial fjord Xeitl Geeyi’ (LeConte Bay), Alaska. From these 14 icebergs, 55 gridded iceberg surfaces (20–40 cm resolution) were derived. We apply a spectral, scale-resolved approach to quantify iceberg roughness. Spectral analysis shows that 40 of these surfaces were dominated by vertically oriented channels with wavelengths ranging from 0.9 m to 3.7 m, likely shaped by buoyancy-driven meltwater plumes. Statistical analyses reveal a mean peak wavelength of 1.9 m, RMS height of 0.3 m, skewness of -0.3 and kurtosis of 4.3. Roughness at medium- to small-scales $\mathcal{O}$(0.5-5 m) can nearly double the ice–ocean boundary surface area and, when combined with iceberg-scale morphology $\mathcal{O}$(10 m), underscores the need to integrate realistic roughness and morphology parameters into melt models, which may improve melt predictions.
More than five million individuals in North America experience an episode of critical illness annually, and among those who survive, as many as a third experience substantial cognitive impairment, which often lasts long after discharge and can be permanent. While cognitive impairment after critical illness has been widely studied for two decades, much remains unknown, and the insights that have been generated by research often fail to inform clinical care. Key issues germane to understanding and optimally treating ICU survivors with cognitive deficits include: improving methods of early detection and screening, honing and implementing cognitive rehabilitation strategies, and better understanding the trajectories of impairments observed in patients. Prioritizing the brain health of individuals after critical care both through prevention and thoughtful interventional efforts remains a key public health goal and one that can only be accomplished through careful and deliberate interdisciplinary efforts.
The nonlinear Schrödinger equation is a second-order nonlinear, integrable partial differential equation describing the propagation of nonlinear waves in a variety of media, including light propagation in optical fibres. Inspired by recently reported experiments, here we consider its generalization to higher, even orders, of derivatives corresponding in optics to higher orders of dispersion. We show that none of these equations are integrable and investigate the nature of singularities that cause the equations to fail the Painlevé test.
Substance use and mental health problems commonly co-occur. Yet, people experiencing both problems commonly face barriers to getting the support they need and experience increased physical morbidity and premature mortality, compared to those with only one problem. In the UK, current guidance on treatment of co-occurring alcohol and mental health problems exist which set out standards for ways of working with this population, and how and where treatments should be offered.
Objectives
Through a secondary qualitative analysis and a systematic review, we aimed to determine the extent to which the UK guidance for care for people with co-occurring problems is being implemented.
Methods
A secondary qualitative analysis was conducted of interview transcripts from people with co-occurring depression and hazardous/harmful alcohol (N = 39). In addition, a systematic review was conducted to identify studies published in the UK since 2017 which focueds on treatment for adults with co-occurring substance use and mental health problems. For both data sources, a deductive coding framework was developed based upon the UK guidance and a thematic analysis was applied.
Results
The qualitative analysis identified four key themes from the service user perspective: Wrong doors and stigma; Responsibility and coordination of care; ‘Don’t discharge me’ and Impacts of gaps between services. The review identified three main themes: Challenges to care for co-occurring conditions; Integration of care; and System and structural level barriers. Both studies showed that making initial contact with services was challenging, as was continued engagement with treatment. Staff attitudes and knowledge were important, because the therapeutic alliance had a significant impact on treatment outcomes and recovery. Stigma, both intrinsic and extrinsic, was identified as a barrier to accessing, engaging with, and delivering support. Both studies found evidence of inconsistent treatment offerings and conflicting advice or support, especially around the most appropriate way to treat co-occurring conditions. Barriers and facilitators were evident across individual, organisational and systems levels. Findings indicate that people are often not receiving the care they need in the ways in which guidance recommends.
Conclusions
The results suggest that despite existence of current guidance in the UK, implementation is inconsistent. This work has identified specific areas for improvement around access to treatment and a need for better coordination and integration of care. It highlights the need to explore how guidance can be better embedded in current practice to improve experiences and outcomes for this population.
In recent years, the authority of the press and universities as knowledge institutions has increasingly come under scrutiny – and not just from rising populists. Critics question the dedication of these institutions to producing knowledge, their commitment to open inquiry and intellectual rigor, the ethical norms they espouse and whether they adhere to them, and their degree of independence from influential funders and other powerful forces.
This chapter sketches some tentative responses to these questions. It considers how the press and universities are similar as knowledge institutions and how they differ. It explores the nature of journalistic and academic topics and judgments, their independence in the pursuit of knowledge, the time frames of their work, and their ethics. It draws attention to how these two institutions use overlapping but not identical tools to develop new knowledge and test knowledge claims, and how sustaining the independent competencies necessary towards this goal is challenged by rising polarization and mistrust and by diminishing public and private financial support. It closes with some reflections on the interdependence among knowledge institutions and their longstanding roles in constitutional democracy.
Background: Nipocalimab is a human IgG1 monoclonal antibody targeting FcRn that selectively reduces IgG levels without impacting antigen presentation, T- and B-cell functions. This study describes the effect of nipocalimab on vaccine response. Methods: Open-label, parallel, interventional study randomized participants 1:1 to receive intravenous 30mg/kg nipocalimab at Week0 and 15mg/kg at Week2 and Week4 (active) or no drug (control). On Day 3, participants received Tdap and PPSV®23 vaccinations and were followed through Wk16. Results: Twenty-nine participants completed the study and are included (active, n=15; control, n=14). Participants with a positive anti-tetanus IgG response was comparable between groups at Wk2 and Wk16, but lower at Wk4 (nipocalimab 3/15 [20%] vs control 7/14 [50%]; P=0.089). All maintained anti-tetanus IgG above the protective threshold (0.16IU/mL) through Wk16. While anti-pneumococcal-capsular-polysaccharide (PCP) IgG levels were lower during nipocalimab treatment, the percent increase from baseline at Wk2 and Wk16 was comparable between groups. Post-vaccination, anti-PCP IgG remained above 50mg/L and showed a 2-fold increase from baseline throughout the study in both groups. Nipocalimab co-administration with vaccines was safe and well-tolerated. Conclusions: These findings suggest that nipocalimab does not impact the development of an adequate IgG response to T-cell–dependent/independent vaccines and that nipocalimab-treated patients can follow recommended vaccination schedules.
New South Wales (NSW) Health is committed to enhancing child health and development during the first 2000 days (conception to 5 years)(1). However, in Australia current child health behaviours indicate the need for further improvements. For example, discretionary foods (contributing high amounts of saturated fat, energy, added sodium and sugar) account for approximately 30% of total energy intakes in 2–3 years olds including the consumption of sugar sweetened beverages (SSB)(2). There remains a need to provide all parents raising children with direct and sustained support from birth to maximise health behaviours during this important life stage. Healthy Beginnings for HNEKids (HB4HNEKids) is an innovative text messaging program designed to be integrated into the usual care provided by Child and Family Health Nursing (CFHN) services. The messages were co-designed with key stakeholders to provide age-and-stage relevant preventive health information to parents/carers during the first 2000 days. HB4HNEKids has been piloted within five diverse CFHN services within the Hunter New England (HNE) local health district of NSW, reaching over 6000 families since its launch. However, the efficacy of the program on child health behaviours has not yet been explored. The aim of this study is to explore if families that received the HB4HNEKids program report reduced frequency of child discretionary food intake and a lower prevalence of SSB exposure, compared to families who did not receive the program. A cross-sectional survey of mothers 12–14 months post-partum was conducted between August 2023 and July 2024 including participants that received HB4HNEKids and a concurrent non-randomised comparison group, located in HNE. Mothers were asked to report on the frequency of child discretionary food intake per week, and whether their child had ever received SSB (including sweetened water, cordial, fruit drink, and soft-drinks). We conducted linear regression and logistic regression analyses to explore differences between the intervention and comparison participants. A total of 283 participants completed the survey, including 104 (37%) participants that had received the HB4HNEKids program. In infants aged 12–14 months, the frequency of discretionary food intake was approximately 1 serve per week and was unchanged based on if the family had received the HB4HNEKids program or not. Despite a 6-point prevalence difference in SSB exposure reported between groups (HB4HNEKids: 19.42% vs Comparison: 26.26%), this difference was not statistically significant (OR: 0.68 (95% CI: 0.37, 1.23), p = 0.2). Australian infant feeding guidelines suggest that the consumption of nutrient poor discretionary foods and sugar sweetened beverages should be avoided or limited(3). The HB4HNEKids program demonstrates some promise for improving infant feeding behaviours, however a larger effectiveness trial is required to ensure the evaluation is adequately powered.
The interaction between national constitutions and transnational sources of law (foreign and international) has generated quite an active disagreement in the United States about what these bodies of law have to do with each other. This paper will explore these debates and the postures towards transnational law and its role in domestic constitutional adjudication which they express. It will identify three postures — of convergence, of resistance, and of engagement — that are manifest in the opinions of different justices of important high courts around the world, and will argue for a posture of ‘engagement’ at least in established constitutional systems like that of the United States.
Today is a time of retrogression in sustaining rights-protecting democracies, and of high levels of distrust in institutions. Of particular concern are threats to the institutions, including universities and the press, that help provide the information base for successful democracies. Attacks on universities, and university faculties, are rising. In Poland over the last four years, a world-renowned constitutional law theorist, Wojciech Sadurski, has been subject to civil and criminal prosecutions for defamation of the governing party. In Hungary, the Central European University (CEU) was ejected by the government, and had to partly relocate to Vienna, and other attacks on academic freedom followed. Faculty members in a number of countries have needed to relocate to other countries for their own safety.
Let ∑x be the (population) dispersion matrix, assumed well-estimated, of a set of non-homogeneous item scores. Finding the greatest lower bound for the reliability of the total of these scores is shown to be equivalent to minimizing the trace of ∑x by reducing the diagonal elements while keeping the matrix non-negative definite. Using this approach, Guttman's bounds are reviewed, a method is established to determine whether his λ4 (maximum split-half coefficient alpha) is the greatest lower bound in any instance, and three new bounds are discussed. A geometric representation, which sheds light on many of the bounds, is described.
Aspects of an entrenched constitution that were essential parts of founding compromises, and justified as necessary when a constitution was first adopted, may become less justifiable over time. Is this the case with respect to the structure of the United States Senate? The US Senate is hardwired in the Constitution to consist of an equal number of Senators from each state—the smallest of which currently has about 585,000 residents, and the largest of which has about 39.29 million. As this essay explains, over time, as population inequalities among states have grown larger, so too has the disproportionate voting power of smaller-population states in the national Senate. As a result of the ‘one-person, one-vote’ decisions of the 1960s that applied to both houses of state legislatures, each state legislature now is arguably more representative of its state population than the US Congress is of the US population. The ‘democratic deficit’ of the Senate, compared to state legislative bodies, also affects presidential (as compared to gubernatorial) elections. When founding compromises deeply entrenched in a constitution develop harder-to-justify consequences, should constitutional interpretation change responsively? Possible implications of the ‘democratic’ difference between the national and the state legislatures for US federalism doctrine are explored, especially with respect to the ‘pre-emption’ doctrine. Finally, the essay briefly considers the possibilities of federalism for addressing longer term issues of representation, polarisation and sustaining a single nation.
Bell’s palsy is acute facial palsy due to inflammation involving the facial nerve related to infections. Rates have not been noted to differ by ethnicity. We studied the lifetime prevalence in First Nations and all other Manitobans in people with type 2 diabetes mellitus aged 7 and older in 2013–2014 and 2016–2017. We found a crude lifetime prevalence of 9.9% [95% CI 9.4–10.4%] in the First Nations population versus 3.9% [95% CI 3.8–4.0%] in all other Manitobans. It is unknown if there were differences in glycemic control. The increased prevalence was found in all five provincial health regions. This study indicates that ethnicity may be an important risk factor for Bell’s palsy.
Geotechnical drilling for a tunnel between Port Moody and Burnaby, BC, Canada, uncovered a buried fjord. Its sedimentary fill has a thickness of at least 130 m and extends more than 37 m below present mean sea level. Recovered sediments record cyclical growth and decay of successive Cordilleran ice sheets. The oldest sediments comprise 58 m of almost stoneless silt conformably overlying ice-proximal sediments and till, which in turn overlie bedrock. These sediments may predate Marine Isotope Stage (MIS) 4. Glacial sediments assigned to MIS 4 overlie this basal succession and, in turn, are overlain by MIS 3 interstadial sediments and sediments from two MIS 2 glacial advances. Indicators of relative sea-level elevations that bracket glacial deposits of MIS 4 and 2 indicate the cyclic existence of moat-like isostatic depressions in the front of expanding ice sheets. Compared with present sea level, these depressions were at least 160 m during the onsets of MIS 4 and MIS 2. Assuming a maximum eustatic drawdown of 120 m during MIS 2, isostatic depression may have exceeded 200 m during retreat of glacial ice from the Evergreen tunnel area. This is consistent with region-specific low mantle viscosity and rapid Cordilleran Ice Sheet buildup and wasting.
Seven kaolins from Georgia (southeastern U.S.A.), ranging from high to low commercial grade, were characterized by X-ray powder diffraction and chemical techniques to establish that the variation in quality was caused by impurities. The Ca and Cs cation-exchange capacities (CEC) varied from 2.67 to 8.17 and from 3.29 to 8.77 meq/100g, respectively. Selective dissolution and correlation analyses strongly indicated that expandable 2:1 minerals, particularly smectite (1.2-5.9%), were responsible for most of the observed variations in Ca CEC (r = 0.85*). The external surface CEC of kaolinite ranged from 0 to 1 meq/ 100 g. The positive significant correlation (r = 0.90**) between the Ca CEC and the K-mica content (03.9%) suggested that Ca CEC may be related to the degree of mica weathering through an expandable mineral stage.
The Cs-retention capacity (0.19–1.14 meq/100 g) was closely related to Cs-measured vermiculite content (r = 0.80*), and this content plus specific surface (R = 0.93**) or mica content (R = 0.86*). The Cs retention appeared to be primarily related to the presence of interlayer wedges at mica/vermiculite XY interfaces.
The objective of this paper is to present flow sheets for a system of quantitative minera-logical analysis of clays of soils and sediments and to show representative results. Selective dissolution analysis by the Na2S2O7-HCl-NaOH procedure yields the quartz and feldspar contents (0 to 63%) and differentiates feldspar K from mica K. The NaOH-thermal system of selective dissolution yields the allophane plus gibbsite, kaolinite plus halloysite, and dickite contents (0 to 84% for the sediments; 1 to 25% for soil clays) Mica contents (0 to 92% for the rock specimens, 7 to 43% for soil clays) are determined by nonfeldspathic K (and Na). Vermiculite contents (1 to 97% of specimens; 3 to 21% for soil clays) are measured by blocking of interlayer CEC by drying at 110°C while K saturated and replacing with NH4Cl. Montmorillonite (and palygorskite) contents (0 to 85% of specimens; 3 to 36% of soil clays) are determined by the CEC not blocked by the K and NH4 sequence for vermiculite. Chlorite contents (0 to 85% for specimens; 0 to 37% for soil clays) are determined by thermal gravimetric analysis, after allocation of OH water lost between 300 and 950°C to other hydrous minerals determined.
The best evidence of the accuracy of the system of analysis lies in the consistent total recovery of 24 standard mineral samples averaging 100.4 ± 1.3 (± standard error of means) and of 22 soil clay samples averaging 99.5 ± 0.8. The different constituents were present in widely different proportions in the various samples, and were determined by independent methods. The complementary total of near 100% (maximum range 95 to 105% for specimens; 95 to 103% for soil clays) for the analyses is a significant measure of the specificity of the several determinations.