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Objective: Children’s growing digital engagement exposes them to risks such as cyberbullying, privacy breaches, and harmful content. Digital literacy, the ability to critically and responsibly navigate technology, has emerged as a key protective strategy. This review synthesizes evidence on the effectiveness and challenges of digital literacy interventions for children.
Objectives
This review synthesizes evidence on the effectiveness and challenges of digital literacy interventions for children.
Methods
Following PRISMA guidelines, we systematically searched PubMed, Scopus, Web of Science, ERIC, and PsycINFO for studies published between 2012 and 2024. Eligible studies evaluated digital literacy interventions among children aged 6–14 years-old, reporting outcomes on online risk reduction and safer digital behaviors. Data were synthesized narratively and, where possible, meta-analytically.
Results
Thirty-four studies met inclusion criteria, including randomized trials, quasi-experimental designs, and qualitative research. Most interventions were delivered in schools or through interactive online platforms. Findings showed that strengthened digital literacy skills consistently reduced cyber bullying incidents, privacy violations, and exposure to harmful content. Effective strategies involved age-appropriate, experiential learning, parental and teacher involvement, and gamified or scenario-based content. Common pitfalls included limited teacher training, lack of cultural adaptation, and inequities in access and participation. Sustained improvements were most evident in programs with longitudinal reinforcement and ongoing support.
Conclusions
Digital literacy is an evidence-based approach to safeguarding children online; however, its effectiveness depends on context-sensitive strategies and overcoming barriers such as unequal access and educator preparedness. Future work should prioritize scalable, adaptive interventions and cross-sector partnerships to close the digital safety gap.
There is presently limited information on the sexual experiences of women with type 2 diabetes (T2DM) in Iran.
Objectives
This study aimed to determine the effectiveness of couples’ relationship enrichment counseling on sexual function and sexual satisfaction, sexual shame and sexual self-compassion in women with T2DM.
Methods
A quasi-experimental design with pretest-posttest and control group was employed. A purposive sample of 68 Iranian women with T2DM was randomly assigned to two groups: an intervention group (n = 34) and a control group (n = 34). The intervention group received six 90-minute sessions of couples’ relationship enrichment counseling, while the control group did not receive any training. Data were collected using self-report scales on women’s Sexual Function Index, Sexual Satisfaction Questionnaire, Sexual Shame, and Sexual Self-Compassion. Then they were analyzed using multivariate analysis of variance with repeated measurements.
Results
Before the intervention, there was no significant difference between the intervention and control groups in the scores obtained by the scales (p >.05). After the intervention, the mean scores on all scales except sexual shame were significantly different between the two groups, with the intervention group scoring significantly higher (p < .05).
Conclusions
Therefore, the findings provide evidence that couples’ relationship enrichment counseling may be useful for improving sexual function, sexual satisfaction, and sexual self-compassion among women with T2DM in Iran.
Type 2 diabetes (T2DM) imposes substantial economic burdens on healthcare systems.
Objectives
This study aimed to evaluate the cost-benefit of a gamification-based intervention delivered through the ERES mobile application by examining its impact on healthcare utilization patterns and patient activation among Iranian women with T2DM.
Methods
A quasi-experimental cost-benefit analysis was conducted with a pretest-posttest control group design. A purposive sample of 98 Iranian women with T2DM was randomly assigned to an intervention group (n = 49) that received eight 90-minute sessions of the ERES-based gamification intervention or a control group (n = 49) that received routine care. Data were collected using the Patient Activation Measure (PAM-13), healthcare utilization records (emergency visits, hospitalizations, outpatient consultations), and cost documentation. Analysis employed multivariate analysis of variance with repeated measures and cost-benefit calculation
Results
Baseline analysis showed no significant differences between groups in activation or healthcare utilization (p > .05). Post-intervention results demonstrated significantly greater improvement in patient activation scores in the intervention group compared to controls (p < .01). More notably, the intervention group showed a 42% reduction in diabetes-related emergency visits and a 31% reduction in hospitalizations compared to the control group. Cost-benefit analysis revealed a 2.8:1 return on investment, indicating that for every $1 invested in the intervention, $2.80 was saved in avoided healthcare costs.
Conclusions
The ERES gamification intervention not only enhanced patient activation but also significantly reduced healthcare utilization and generated substantial cost savings. These findings position digital gamification strategies as both clinically effective and economically advantageous for T2DM management. Healthcare policymakers and insurers should consider implementing such interventions to reduce the economic burden of diabetes while improving patient outcomes
The role of personality factors in explaining individual difference factors in mental health is well-documented.
Objectives
The present study aimed to investigate the relationship between online gaming addiction and the Big-Five personality traits through the mediating role of mental health, while also examining the moderating role of gender in university students.
Methods
This applied study employed a correlational design using structural equation modeling. The statistical population included all students at the University of Tehran during the 2024–2025 academic year. A total of 306 participants were selected using convenience sampling. The data were collected using the Internet Gaming Disorder Scale, the short form of the Big Five Inventory, and the Cognitive Emotion Regulation Questionnaire. Data analysis was conducted using path analysis in SPSS-24 and LISREL.
Results
The findings revealed significant gender differences in gaming frequency, game types, and gaming platforms. Emotional stability and agreeableness also varied significantly between genders. A significant positive correlation was found between online gaming addiction and the use of maladaptive emotion regulation strategies (p < .001). No significant correlation was observed between online gaming addiction and any of the Big-Five personality dimensions (p > .05). The indirect effects of personality traits on gaming addiction were not significant, and no significant gender differences were found in the paths from emotion regulation strategies to gaming addiction or from personality traits to emotion regulation strategies (p > .05).
Conclusions
These findings may serve as a foundation for developing psychological interventions aimed at preventing and treating online gaming addiction and offer deeper insight into the role of personality traits and emotion regulation in students’ mental health.
There is comparatively only modest research that has examined psychological factors on distress tolerance among women with breast cancer, and associated mediating factors.
Objectives
This study aimed to investigate the effect of wisdom and self-empowerment on distress tolerance among women with breast cancer, considering the mediating roles of coping styles and emotion management
Methods
In this cross-sectional, descriptive-correlational study, 128 women with breast cancer were selected via convenience sampling from the Cancer Research Center at Hospital in Mashhad. Data were collected using validated questionnaires measuring wisdom, self-empowerment, distress tolerance, coping styles, and emotion management. The proposed relationships were analyzed using Pearson’s correlation, multivariate regression, and structural equation modeling (SEM) in SPSS and Smart-PLS.
Results
The findings indicated that wisdom had a significant direct effect on distress tolerance. Furthermore, coping styles served as a significant mediator in the relationship between wisdom and distress tolerance. However, self-empowerment did not exhibit a statistically significant direct effect on distress tolerance, and emotion management did not mediate the relationship between wisdom and distress tolerance.
Conclusions
The results suggest that enhancing wisdom and improving adaptive coping strategies can effectively increase distress tolerance in women with breast cancer. These findings highlight the importance of psychological interventions focused on these constructs in supportive care for cancer patients.
Body dissatisfaction is becoming more common among adolescents and is a putative risk factor for adverse mental (e.g., eating disorder and depressive symptoms) and physical health outcomes (e.g., excessive weight gain), both of which have also been increasing. Targeting body dissatisfaction through preventative interventions might improve these outcomes, however robust evidence of causal associations is limited.
Objectives
To investigate the association between body dissatisfaction at age 16 and eating disorder symptoms at age 21, as well as depressive symptoms and BMI at ages 21 and 26 using a co-twin control design.
Methods
We used data from the Twins Early Development Study (TEDS) and validated self-report measures. We fitted univariable and multivariable linear mixed effect models adjusting for a comprehensive list of confounding factors (Figure 1) to investigate the association between body dissatisfaction, eating disorder and depressive symptoms, and BMI in the full twin sample. We then repeated these analyses using a co-twin control design, which allows to fully and partially control for genetic confounding in monozygotic (MZ) and dizygotic (DZ) twins, respectively, and for any shared measured and unmeasured environmental factors. We conducted primary analyses in imputed datasets for participants with complete exposure data.
Results
The analytical sample included 2,183 twins (60.2% females, 61.7% DZ twins). In the full twin sample, one unit increase in body dissatisfaction at age 16 was associated with: (i) a 1.80-point increase in eating disorder symptoms at age 21 (95%CI: 1.49 to 2.11), (ii) a 0.59-point increase in depressive symptoms (95%CI: 0.46 to 0.72), and (iii) a 0.20-point BMI increase (95%CI: 0.08 to 0.32) across age 21 and 26 years. In co-twin control analyses, the association between body dissatisfaction and eating disorder symptoms was larger in DZ twins (N=661; 1.72, 95%CI: 1.11 to 2.33) than in MZ twins (N=414, 0.96, 95%CI: 0.15 to 1.77), whereas effect sizes for depressive symptoms were comparable [DZ: (0.56, 95%CI: 0.33 to 0.78); MZ: (0.50, 95%CI: 0.15 to 0.85)]. Associations with BMI were smaller in DZ (0.20, 95%CI: 0.00 to 0.40), and null in MZ twins (0.07, 95%CI: -0.21 to 0.35).
Image 1:
Conclusions
Our findings suggest that greater body dissatisfaction might be a causal risk factor for eating disorders and depression in young people, as associations seen in the full sample persisted in co-twin control analyses. This indicates that body dissatisfaction could be a modifiable target to reduce the risk of these mental health problems in adolescents and young adults. Evidence of associations between body dissatisfaction and increased BMI was weaker in co-twin control analyses than in the full sample. This might be due to larger proportions of shared genetic risk and thus require larger sample sizes to detect.
The health benefits of the long-chain omega-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been known for over 50 years and underpin the UK population recommendation to consume >450 mg EPA + DHA per day. These recommendations, last revised in 2004, are based mainly on epidemiological evidence. Much research has been conducted in the interim. Most randomised controlled trials (RCT) use doses of EPA + DHA of 840 mg/d or more. For anti-inflammatory, triacylglycerol-lowering and anti-hypertensive effects, >1.5 g EPA + DHA per day is needed. Cognitive benefits are also likely to require these higher intakes. Farmed salmon now contains considerably less EPA + DHA relative to farmed fish of 20 years ago, meaning one portion per week will no longer provide the equivalent of 450 mg EPA + DHA per day. Oily fish alone can only provide a fraction of the EPA + DHA required to meet global needs. Furthermore, there is low global oily fish consumption, with typical intakes of <200 mg EPA + DHA per day, and limited intakes in vegans and vegetarians. Therefore, there is an urgent need for affordable, acceptable, alternative EPA + DHA sources, including vegan/vegetarian friendly options, such as bio-enriched poultry, red meat and milk products; fortified foods; enriched oilseeds (for example, genetically modified Camelina sativa); algae and algal oils; and approaches which enhance endogenous EPA/DHA synthesis. In this narrative review, we suggest that current EPA + DHA intake recommendations are too low, consider EPA/DHA from a holistic health-sustainability perspective and identify research, policy and knowledge mobilisation areas which need attention.
To examine if the current taught undergraduate psychiatry syllabus at an Irish University relates to what doctors in psychiatry consider to be clinically relevant and important.
Methods:
Doctors of different clinical grades were invited to rate their views on 216 items on a 10-point Likert scale ranging from ‘0 = not relevant’ to ‘10 = very relevant’. Participants were invited to comment on topics that should be excluded or included in a new syllabus. Thematic analysis was conducted on this free-text to identify particular themes.
Results:
The doctors surveyed rated that knowledge of diagnostic criteria was important for medical students. This knowledge attained high scores across all disorders with particularly high scores for a number of disorders including major depressive disorder (mean = 9.64 (SD = 0.86)), schizophrenia (mean = 9.55 (SD = 0.95)) and attention deficit hyperactivity disorder (Attention Deficit Hyperactivity Disorder (ADHD); mean = 9.26 (SD = 1.40)). Lower scores were noted for less frequently utilised management strategies (transcranial magnetic stimulation (mean = 4.97 (SD = 2.60)), an awareness of the difference in criteria for use disorder and dependence from psychoactive substances (mean = 5.56 (SD = 2.26)), and some theories pertaining to psychotherapy (i.e. Freud’s drive theory (mean = 4.59 (SD = 2.42)).
Conclusions:
This study highlights the importance of an undergraduate programme that is broad based, practical and relevant to student’s future medical practice. An emphasis on diagnosis and management of major psychiatry disorders, and knowledge of the interface between mental health services, other medical specialities and support services was also deemed important.
Fifty-three tests designed to measure aspects of creative thinking were administered to 410 air cadets and student officers. The scores were intercorrelated and 16 factors were extracted. Orthogonal rotations resulted in 14 identifiable factors, a doublet, and a residual. Nine previously identified factors were: verbal comprehension, numerical facility, perceptual speed, visualization, general reasoning, word fluency, associational fluency, ideational fluency, and a factor combining Thurstone's closure I and II. Five new factors were identified as originality, redefinition, adaptive flexibility, spontaneous flexibility, and sensitivity to problems.
Several neural networks have been proposed in the general literature for pattern recognition and clustering, but little empirical comparison with traditional methods has been done. The results reported here compare neural networks using Kohonen learning with a traditional clustering method (K-means) in an experimental design using simulated data with known cluster solutions. Two types of neural networks were examined, both of which used unsupervised learning to perform the clustering. One used Kohonen learning with a conscience and the other used Kohonen learning without a conscience mechanism. The performance of these nets was examined with respect to changes in the number of attributes, the number of clusters, and the amount of error in the data. Generally, the K-means procedure had fewer points misclassified while the classification accuracy of neural networks worsened as the number of clusters in the data increased from two to five.
The association between cannabis and psychosis is established, but the role of underlying genetics is unclear. We used data from the EU-GEI case-control study and UK Biobank to examine the independent and combined effect of heavy cannabis use and schizophrenia polygenic risk score (PRS) on risk for psychosis.
Methods
Genome-wide association study summary statistics from the Psychiatric Genomics Consortium and the Genomic Psychiatry Cohort were used to calculate schizophrenia and cannabis use disorder (CUD) PRS for 1098 participants from the EU-GEI study and 143600 from the UK Biobank. Both datasets had information on cannabis use.
Results
In both samples, schizophrenia PRS and cannabis use independently increased risk of psychosis. Schizophrenia PRS was not associated with patterns of cannabis use in the EU-GEI cases or controls or UK Biobank cases. It was associated with lifetime and daily cannabis use among UK Biobank participants without psychosis, but the effect was substantially reduced when CUD PRS was included in the model. In the EU-GEI sample, regular users of high-potency cannabis had the highest odds of being a case independently of schizophrenia PRS (OR daily use high-potency cannabis adjusted for PRS = 5.09, 95% CI 3.08–8.43, p = 3.21 × 10−10). We found no evidence of interaction between schizophrenia PRS and patterns of cannabis use.
Conclusions
Regular use of high-potency cannabis remains a strong predictor of psychotic disorder independently of schizophrenia PRS, which does not seem to be associated with heavy cannabis use. These are important findings at a time of increasing use and potency of cannabis worldwide.
Charged particle acceleration and heating in the heliosphere requires detailed observa-tions of the velocity distribution functions (VDFs) of these particles across a range of mass and charge states. Such particle energization is often observed concurrent with transient phenom-ena. Proper characterization of such energization processes and their impact on charged particles requires careful consideration of instrument observation timing and the timing at which a tran-sient phenomenon is observed. Solar Orbiter’s Heavy Ion Sensor (HIS) observes the composition of the solar wind along with suprathermal and pickup ions. As such, it provides the observations necessary to resolve the mass and charge states appropriate for properly characterizing charged particle energization. In this work, we describe the current status of data aggregation at vari-able time intervals and how that enables proper characterization of charged particle energization concurrent with transient phenomena.
Background: Efgartigimod, a human immunoglobulin G (IgG)1 antibody Fc fragment, blocks the neonatal Fc receptor, decreasing IgG recycling and reducing pathogenic IgG autoantibody levels. ADHERE assessed the efficacy and safety of efgartigimod PH20 subcutaneous (SC; co-formulated with recombinant human hyaluronidase PH20) in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: ADHERE enrolled participants with CIDP (treatment naive or on standard treatments withdrawn during run-in period) and consisted of open-label Stage A (efgartigimod PH20 SC once weekly [QW]), and randomized (1:1) Stage B (efgartigimod or placebo QW). Primary outcomes were clinical improvement (assessed with aINCAT, I-RODS, or mean grip strength; Stage A) and time to first aINCAT score deterioration (relapse; Stage B). Secondary outcomes included treatment-emergent adverse events (TEAEs) incidence. Results: 322 participants entered Stage A. 214 (66.5%) were considered responders, randomized, and treated in Stage B. Efgartigimod significantly reduced the risk of relapse (HR: 0.394; 95% CI: 0.25–0.61) versus placebo (p=0.000039). Reduced risk of relapse occurred in participants receiving corticosteroids, intravenous or SC immunoglobulin, or no treatment before study entry. Most TEAEs were mild to moderate; 3 deaths occurred, none related to efgartigimod. Conclusions: Participants treated with efgartigimod PH20 SC maintained a clinical response and remained relapse-free longer than those treated with placebo.
Edited by
Ben Kiernan, Yale University, Connecticut,T. M. Lemos, Huron University College, University of Western Ontario,Tristan S. Taylor, University of New England, Australia
General editor
Ben Kiernan, Yale University, Connecticut
William I’s ‘Harrying of the North’ was a military expedition against local rebels and a Danish invasion force in the winter of 1069–70. It has been regarded since the 1870s as a uniquely savage treatment of the English inhabitants of northern England, wantonly destructive of life and the means of sustenance, and tantamount to genocide. Such views derive from the two fullest medieval accounts, by the early twelfth-century historians Symeon of Durham and Orderic Vitalis. However, neither was an eye-witness, both were at work two generations later, and both had their own agenda in describing the destruction of the North and William I’s cruelty. The Harrying should instead be seen as a routine military operation which took place, unusually, in the depths of winter, and so had unusually severe consequences. More strictly contemporary accounts from Evesham and Beverley reveal a regional but probably localized famine and a refugee crisis. Further, the record in Domesday Book (1086) of many Yorkshire villages as ‘waste’ should be read as referring not to physical destruction but to the absence of surplus values accruing to landlords, and not caused by the Harrying alone. The Harrying of the North was no genocide.
It has been shown that, in small groups of intact male domestic turkeys, supplementary ultraviolet (UV-A) radiation, visual barriers, and added straw (environmental enrichment) minimize the incidence of injurious pecking under incandescent light at 5 lux. This paper describes two experiments, each involving eight groups of 100 non beak-trimmed birds up to 5 weeks of age, that assessed the effectiveness of these procedures at higher light intensities and with fluorescent light. Experiment 1 examined 5 or 10 lux of incandescent or fluorescent light. Experiment 2 studied responses to 5, 10, 36 or 70 lux of fluorescent light. Individual inspections of the birds, for wing, tail and head injuries due to pecking, were conducted daily.
Fluorescent light significantly reduced the incidence of tail injuries (P = 0.03), and tended to reduce those to the wings (P = 0.08), compared with incandescent light. No difference was observed between 5 and 10 lux for either tail or wing injuries. In Experiment 2, the incidence of tail and wing injuries was significantly and positively correlated with light intensity (tail, P = 0.05; wing, P = 0.02). Injuries to the head were minimal in all treatments. These results suggest that turkey poults may be kept with minimal injurious pecking, under fluorescent light at an intensity of 10 lux, with appropriate environmental enrichment.
We present WALLABY pilot data release 1, the first public release of H i pilot survey data from the Wide-field ASKAP L-band Legacy All-sky Blind Survey (WALLABY) on the Australian Square Kilometre Array Pathfinder. Phase 1 of the WALLABY pilot survey targeted three $60\,\mathrm{deg}^{2}$ regions on the sky in the direction of the Hydra and Norma galaxy clusters and the NGC 4636 galaxy group, covering the redshift range of $z \lesssim 0.08$. The source catalogue, images and spectra of nearly 600 extragalactic H i detections and kinematic models for 109 spatially resolved galaxies are available. As the pilot survey targeted regions containing nearby group and cluster environments, the median redshift of the sample of $z \approx 0.014$ is relatively low compared to the full WALLABY survey. The median galaxy H i mass is $2.3 \times 10^{9}\,{\rm M}_{{\odot}}$. The target noise level of $1.6\,\mathrm{mJy}$ per 30′′ beam and $18.5\,\mathrm{kHz}$ channel translates into a $5 \sigma$ H i mass sensitivity for point sources of about $5.2 \times 10^{8} \, (D_{\rm L} / \mathrm{100\,Mpc})^{2} \, {\rm M}_{{\odot}}$ across 50 spectral channels (${\approx} 200\,\mathrm{km \, s}^{-1}$) and a $5 \sigma$ H i column density sensitivity of about $8.6 \times 10^{19} \, (1 + z)^{4}\,\mathrm{cm}^{-2}$ across 5 channels (${\approx} 20\,\mathrm{km \, s}^{-1}$) for emission filling the 30′′ beam. As expected for a pilot survey, several technical issues and artefacts are still affecting the data quality. Most notably, there are systematic flux errors of up to several 10% caused by uncertainties about the exact size and shape of each of the primary beams as well as the presence of sidelobes due to the finite deconvolution threshold. In addition, artefacts such as residual continuum emission and bandpass ripples have affected some of the data. The pilot survey has been highly successful in uncovering such technical problems, most of which are expected to be addressed and rectified before the start of the full WALLABY survey.
Clinical trials continue to disproportionately underrepresent people of color. Increasing representation of diverse backgrounds among clinical research personnel has the potential to yield greater representation in clinical trials and more efficacious medical interventions by addressing medical mistrust. In 2019, North Carolina Central University (NCCU), a Historically Black College and University with a more than 80% underrepresented student population, established the Clinical Research Sciences Program with support from the Clinical and Translational Science Awards (CTSA) program at neighboring Duke University. This program was designed to increase exposure of students from diverse educational, racial, and ethnic backgrounds to the field of clinical research, with a special focus on health equity education. In the first year, the program graduated 11 students from the two-semester certificate program, eight of whom now hold positions as clinical research professionals. This article describes how leveraging the CTSA program helped NCCU build a framework for producing a highly trained, competent, and diverse workforce in clinical research responsive to the call for increased diversity in clinical trial participation.