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We introduce three families of vectors $|\underline {\lambda }^{so}\rangle $, $|\underline {\lambda }^{sp}\rangle $ and $|\underline {\lambda }^{o}\rangle $ parametrized by partitions in the Fock space by using products of adjoint vertex operators. We show that the quotient space of the dual vacuum vector is spanned by the partition vectors indexed by a special family of partitions. The partition-indexed vectors also help us to derive the dual Littlewood identities of types B, C, and D in a new manner associated to the special family of partitions. As an application, we obtain a new free fermionic construction to show that the measures related to dual Littlewood identities introduced by Rains [33, Section 7] and Betea [6, Section 3] are determinantal with respect to some explicit correlation kernels.
Furthermore, we establish a number of generalized Littlewood identities summed over certain restricted partitions by computing the inner products with elements indexed by one-column partitions or generalized partitions $(0^m)$ in the complete dual Fock space. In particular, for each positive integer n, we obtain generalized Littlewood identities for $(-n)$-asymmetric partitions. We show that these generalized Littlewood identities contain several well-known Littlewood-type identities as special cases. Consequently we also give a new proof of the generalized Littlewood identity [28, (5.25)] for Lie superalgebras.
Replacing soiled bed linens is a common practice in intensive care units . We identified dust-driven transmission of carbapenem-resistant Acinetobacter baumannii correlated with changing bed linens by air sampling and genome-based analysis. This uncovers a hidden airborne route, which needs to be considered to design countermeasures against multidrug-resistant organisms.
High-power terahertz (THz) pulses are important for material analysis and ultrafast spectroscopy, but existing sources barely achieve high field strength and average power simultaneously. Tilted-pulse-front pumping (TPFP) improves THz conversion efficiency, but its optimal configuration is highly dependent on pump parameters. Focusing on high single-pulse energy (millijoule level) and a short pulse duration (226 fs), this study systematically evaluates two TPFP configurations: the reflective grating and echelon mirror. Experimental results show that the echelon mirror configuration achieves a 0.4% conversion efficiency and a 51.7 mW average THz power, exceeding the performance of the grating configuration, which reaches 0.26% and 41.8 mW, respectively. These results confirm that combining short pulses with the echelon mirror enhances both conversion efficiency and average THz power under high-power pumping, providing experimental guidance for high-power strong-field THz sources for material manipulation and biomedical imaging.
The ryanodine receptor 2 gene mutation associated with catecholaminergic polymorphic ventricular tachycardia is one of the aetiologies of cardiac syncope and has the risk of sudden cardiac death. This study reported two novel ryanodine receptor 2 gene variants.
Case description:
We described two 9-year-old girls with recurrent syncope during exercise or stress presenting two novel ryanodine receptor 2 gene variants (c.6938T>G/p. Val2313Gly and c.12263A>C/p. His4088Pro) associated with catecholaminergic polymorphic ventricular tachycardia through a comprehensive review of medical history, examination findings and genetic testing. Propranolol was used for treatment, and the two patients didn’t experience episodes of syncope during follow-up for 6 months. Besides, literature associated with catecholaminergic polymorphic ventricular tachycardia and ryanodine receptor 2 mutations was reviewed.
Conclusions:
Recurrent syncope during exertion or stress should be focused on catecholaminergic polymorphic ventricular tachycardia caused by ryanodine receptor 2 gene mutations. The genetic testing is a crucial tool in confirming the mutation of catecholaminergic polymorphic ventricular tachycardia. Early recognition of this disease, timely diagnosis of ryanodine receptor 2 gene mutations, and administration of appropriate pharmacological agents or ICD implantation are critical to ensure favourable clinical outcomes.
Currently, quadruped robots are widely used in diverse scenarios due to their high mobility, creating a demand for more advanced interaction capabilities. This study proposes a whole-body planning and control framework that integrates adaptive control into a hierarchical model predictive control (MPC) and whole-body control (WBC) structure, enhancing the environmental adaptability and interaction performance of quadruped mobile manipulators. Key innovations include: a recursive least squares and feedforward compensation strategy for accurate end-effector force estimation; relaxed barrier functions embedded in the MPC to combine dynamic obstacle avoidance with adaptive control; and a WBC-based priority hierarchy to enforce critical constraints. Validated in Gazebo simulation and on the B1-Z1 platform, the method allows the robot to handle unknown loads up to 3 kg and maintain tracking errors under 2 cm despite 35 N external disturbances. It also demonstrates strong adaptability in non-uniform object transportation, providing a reliable solution for unstructured environments.
Schizophrenia progresses through high-risk, first-episode, and chronic stages, each associated with altered spontaneous brain activity. Resting state functional MRI studies highlight these changes, but inconsistencies persist, and the genetic basis remains unclear.
Methods
A neuroimaging meta-analysis was conducted to assess spontaneous brain activity alterations in each schizophrenia stage. The largest available genome-wide association study (GWAS) summary statistics for schizophrenia (N = 53,386 cases, 77,258 controls) were used, followed by Hi-C-coupled multimarker analysis of genomic annotation (H-MAGMA) to identify schizophrenia-associated genes. Transcriptome-neuroimaging association and gene prioritization analyses were performed to identify genes consistently linked to brain activity alterations. Biological relevance was explored by functional enrichment.
Results
Fifty-two studies met the inclusion criteria, covering the high-risk (Nhigh-risk = 409, Ncontrol = 475), first-episode (Ncase = 1842, Ncontrol = 1735), and chronic (Ncase = 1242, Ncontrol = 1300) stages. High-risk stage showed reduced brain activity in the right median cingulate and paracingulate gyri. First-episode stage revealed increased activity in the right putamen and decreased activity in the left gyrus rectus and right postcentral gyrus. Chronic stage showed heightened activity in the right inferior frontal gyrus and reduced activity in the superior occipital gyrus and right postcentral gyrus. Across all stages, 199 genes were consistently linked to brain activity changes, involved in biological processes such as nervous system development, synaptic transmission, and synaptic plasticity.
Conclusions
Brain activity alterations across schizophrenia stages and genes consistently associated with these changes highlight their potential as universal biomarkers and therapeutic targets for schizophrenia.
Remote injury assessment during natural disasters poses major challenges for healthcare providers due to the inaccessibility of disaster sites. This study aimed to explore the feasibility of using artificial intelligence (AI) techniques for rapid assessment of traumatic injuries based on gait analysis.
Methods
We conducted an AI-based investigation using a dataset of 4500 gait images across 3 species: humans, dogs, and rabbits. Each image was categorized as either normal or limping. A deep learning model, YOLOv5—a state-of-the-art object detection algorithm—was trained to identify and classify limping gait patterns from normal ones. Model performance was evaluated through repeated experiments and statistical validation.
Results
The YOLOv5 model demonstrated high accuracy in distinguishing between normal and limp gaits across species. Quantitative performance metrics confirmed the model’s reliability, and qualitative case studies highlighted its potential application in remote, fast traumatic assessment scenarios.
Conclusions
The use of AI, particularly deep convolutional neural networks like YOLOv5, shows promise in enabling fast, remote traumatic injury assessment during disaster response. This approach could assist healthcare professionals in identifying injury risks when physical access to patients is restricted, thereby improving triage efficiency and early intervention.
Patients with mental disorders often engage in extreme and unpredictable violent behaviors that seriously endanger the public security and stability of the society. Violence risk is commonly assessed by subjective judgement, which may lead to bias and uncertainty in the appraisal results. Existing expression recognition and analysis techniques have limitations in identifying the emotional states of patients with mental disorders.
Objectives
The study aimed to explore the association between violent behaviors and facial expression in patients with mental disorders by machine learning algorithm, to evaluate the application value of facial expression analysis system in violence risk assessment of individuals with mental disorders.
Methods
Thirty-nine patients with mental disorders were enrolled and assessed by using Modified Overt Aggression Scale (MOAS), positive and negative syndrome scale (PANSS) and brief psychiatric rating scale (BPRS). An emotional arousal paradigm was performed and the intensity of baisc emotions and expression action units was recorded before, during and after the paradigm. The processed quantitative data was used to generate one-dimensional waveform maps and two-dimensional time-frequency maps and then quantized feature data were extracted. A machine learning model with high accuracy was trained using these feature data, which can accurately determine the violence risk states of patients and output the probability. All individuals participated voluntarily and provided informed consent. This study was approved by the ethics committee of the Academy of Forensic Science.
Results
The intensity difference of sadness, surprise and fear in different time periods was statistically significant. The intensity of the left medial eyebrow lift action unit was found significantly different before and after the emotional arousal. The intensity of anger and disgust was positively correlated with the MOAS scores, PANSS scores and BPRS scores. The features of time-frequency diagrams of 5 expression action units (medial eyebrow raise, eyebrow lowering, slightly open lips, chin drop and eye closure) and 8 basic emotions were selected and then support vector machine was used for triple classification, which is a classifier that can well distinguish the three stages of non-violence risk period, violence risk period, and post-violence risk period. In the 4:1 training-testing grouping, the classification accuracy reaches 91.2%.
Conclusions
Featured expressive action units and various baisc emotions might be used to capture information associated with violent behaviors. The facial expression analysis system mentioned above can be used as an auxiliary tool to assess the potential risk of violence in patients with mental disorders.
Disclosure of Interest
X. Ling: None Declared, S. Wang: None Declared, X. Zhou: None Declared, N. Li: None Declared, W. Cai: None Declared, H. Li Grant / Research support from: This study was supported by National Key R & D Program of China [grant number 2022YFC3302001], National Natural Science Foundation of China [grant number 81801881], Science and Technology Committee of Shanghai Municipality [grant numbers 20DZ1200300, 21DZ2270800, 19DZ2292700].
Cryphodera guangdongensis n. sp. was collected from the soil and roots of Schima superba in Guangdong province, China. The new species is characterised by having a nearly spherical female, with dimensions of length × width = 532.3 (423.8–675.3) × 295.6 (160.0–381.2) μm, stylet length of 35.7 (31.1–42.1) μm, protruding vulval lips, a vulval slit measuring 54.2 (47.4–58.9) μm, an area between the vulva and anus that is flat to concave, and a vulva–anus distance 49.3 (41.1–57.6) μm. The male features two lip annules, a stylet length of 31.7 (27.4–34.8) μm and basal knobs that are slightly projecting anteriorly, while lateral field is areolated with three incisures and spicules length of 27.1 (23.7–31.0) μm. The second stage juvenile is characterised by a body length of 506.1 (441.8–564.4) μm long, two to three lip annules, a stylet length 31.2 (29.7–33.2) μm which is well developed, basal knobs projecting anteriorly, a lateral field that is areolate with three incisures, and a narrow rounded tail measuring 63.2 (54.2–71.3) μm long, with a hyaline region of 35.6 (27.4–56.6) μm long that is longer than the stylet. Based on morphology and morphometrics, the new species is closely related to C. sinensis and C. japonicum within the genus Cryphodera. The phylogenetic trees constructed based on the ITS-rRNA, 28S-rRNA D2–D3 region, and the partial COI gene sequences indicate that the new species clusters with other Cryphodera species but maintains in a separated subgroup. A key to the species of the genus Cryphodera is also provided in this study.
Previous studies have reported co-morbidities of autoimmune thyroid disorders (AITD), including Hashimoto’s disease and Graves’ disease and celiac disease (CeD), as well as the possible beneficial effects of a gluten-free diet (GFD) on AITD. Nonetheless, it remains uncertain whether there is a genetic causal relationship between AITD and CeD, while the beneficial effects of a GFD are controversial. This study aims to explore the causal relationship between CeD and AITD, particularly with Hashimoto’s disease, and to determine whether a GFD is beneficial for AITD. We performed a two-sample Mendelian randomisation analysis on data from the largest meta-analysis summary statistics of AITD, CeD and GFD. Genetic instrumental variables were established by pinpointing SNP that relate to corresponding factors. In assessing sensitivity and heterogeneity, we conducted examinations of MR Egger, weighted median, simple mode, weighted mode and MR Egger intercept tests. Hashimoto’s disease was found to play a pathogenic role in increasing the risk of CeD (ORIVW = 1·544 (95 % CI 1·153, 2·068), P = 0·00355), and our Mendelian randomisation study does not support genetic liability related to CeD with Graves’ disease and GFD with AITD. This study supports the positive correlation between Hashimoto’s disease risk and CeD risk, while GFD has no protective effect on AITD and may exert its effect through other mechanisms. These findings provide valuable insights into potential targets for disease intervention and treatment at the genetic level.
Milk fat is a crucial component for evaluating the production performance and nutritional value of goat milk. Previous research indicated that the composition of ruminal microbiota plays a significant role in regulating milk fat percentage in ruminants. Thus, this study aimed to identify key ruminal microorganisms and blood metabolites relevant to milk fat synthesis in dairy goats as a mean to explore their role in regulating milk fat synthesis. Sixty clinically healthy Xinong Saanen dairy goats at mid-lactation and of similar body weight, and similar milk yield were used in a feeding study for 15 days. Based on daily milk yield of dairy goats and the results of milk component determination on the 1st and 8th days, five goats with the highest milk fat content (H group) and five goats with the lowest milk fat content (L group) were selected for further analysis. Before the morning feeding on the 15th day of the experiment, samples of milk, blood and ruminal fluid were collected for analyses of components, volatile fatty acids, microbiota and metabolites. Results revealed that acetate content in the rumen of H group was greater compared with L group. H group had abundant beneficial bacteria including Ruminococcaceae_UCG-005, Saccharofermentans, Ruminococcaceae-UCG-002 and Prevotellaceae_UCG-3, which were important for plant cellulose and hemicellulose degradation and immune regulation. Metabolomics analysis revealed H group had greater relative concentrations of 4-acetamidobutanoic acid and azelaic acid in serum, and had lower relative concentrations of Arginyl-Alanine, SM(d18:1/12:0) and DL-Tryptophan. These altered metabolites are involved in the sphingolipid signaling pathway, arginine and proline metabolism. Overall, this study identified key ruminal microorganisms and serum metabolites associated with milk fat synthesis in dairy goats. These findings offer insights for enhancing the quality of goat milk and contribute to a better understanding of the regulatory mechanisms involved in milk fat synthesis in dairy goats.
Fitting propensity (FP) analysis quantifies model complexity but has been impeded in item response theory (IRT) due to the computational infeasibility of uniformly and randomly sampling multinomial item response patterns under a full-information approach. We adopt a limited-information (LI) approach, wherein we generate data only up to the lower-order margins of the complete item response patterns. We present an algorithm that builds upon classical work on sampling contingency tables with fixed margins by implementing a Sequential Importance Sampling algorithm to Quickly and Uniformly Obtain Contingency tables (SISQUOC). Theoretical justification and comprehensive validation demonstrate the effectiveness of the SISQUOC algorithm for IRT and offer insights into sampling from the complete data space defined by the lower-order margins. We highlight the efficiency and simplicity of the LI approach for generating large and uniformly random datasets of dichotomous and polytomous items. We further present an iterative proportional fitting procedure to reconstruct joint multinomial probabilities after LI-based data generation, facilitating FP evaluation using traditional estimation strategies. We illustrate the proposed approach by examining the FP of the graded response model and generalized partial credit model, with results suggesting that their functional forms express similar degrees of configural complexity.
The underwater target detection is affected by image blurring caused by suspended particles in water bodies and light scattering effects. To tackle this issue, this paper proposes a reparameterized feature enhancement and fusion network for underwater blur object recognition (REFNet). First, this paper proposes the reparameterized feature enhancement and gathering (REG) module, which is designed to enhance the performance of the backbone network. This module integrates the concepts of reparameterization and global response normalization to enhance the network’s feature extraction capabilities, addressing the challenge of feature extraction posed by image blurriness. Next, this paper proposes the cross-channel information fusion (CIF) module to enhance the neck network. This module combines detailed information from shallow features with semantic information from deeper layers, mitigating the loss of image detail caused by blurring. Additionally, this paper replace the CIoU loss function with the Shape-IoU loss function improves target localization accuracy, addressing the difficulty in accurately locating bounding boxes in blurry images. Experimental results indicate that REFNet achieves superior performance compared to state-of-the-art methods, as evidenced by higher mAP scores on the underwater robot professional competitionand detection underwater objects datasets. REFNet surpasses YOLOv8 by approximately 1.5% in $mAP_{50:95}$ on the URPC dataset and by about 1.3% on the DUO dataset. This enhancement is achieved without significantly increasing the model’s parameters or computational load. This approach enhances the precision of target detection in challenging underwater environments.
A new fossil of Lycidae, Domipteron gaoi n. gen. n. sp., is described from Miocene Dominican amber. The fossil exhibits a combination of characteristics found in both Calopterini and Eurrhacini. To determine its systematic placement, we conducted phylogenetic analyses based on adult morphological features. Our analyses indicate that the new fossil belongs to Calopterini.
This paper presents an investigation of the secondary saturation characteristics of a HfTe2 saturable absorber. Pulse energies of 5.85 and 7.4 mJ were demonstrated with a high-order Hermite–Gaussian (HG) laser and a vortex laser, respectively, using alexandrite as the gain medium. To the best of our knowledge, these are the highest pulse energies directly generated with HG and vortex lasers. To broaden the applications of high-energy pulsed HG and vortex lasers, wavelength tuning in the region of 40 nm was achieved using an etalon.
The data volumes generated by theWidefield ASKAP L-band Legacy All-sky Blind surveY atomic hydrogen (Hi) survey using the Australian Square Kilometre Array Pathfinder (ASKAP) necessitate greater automation and reliable automation in the task of source finding and cataloguing. To this end, we introduce and explore a novel deep learning framework for detecting low signal-to-noise ratio (SNR) Hi sources in an automated fashion. Specifically, our proposed method provides an automated process for separating true Hi detections from false positives when used in combination with the source finding application output candidate catalogues. Leveraging the spatial and depth capabilities of 3D convolutional neural networks, our method is specifically designed to recognize patterns and features in three-dimensional space, making it uniquely suited for rejecting false-positive sources in low SNR scenarios generated by conventional linear methods. As a result, our approach is significantly more accurate in source detection and results in considerably fewer false detections compared to previous linear statistics-based source finding algorithms. Performance tests using mock galaxies injected into real ASKAP data cubes reveal our method’s capability to achieve near-100% completeness and reliability at a relatively low integrated SNR $\sim3-5$. An at-scale version of this tool will greatly maximise the science output from the upcoming widefield Hi surveys.
With decades of advance research and recent developments in the drug and medical device regulatory approval process, patient-reported outcomes (PROs) are becoming increasingly important in clinical trials. While clinical trial analyses typically treat scores from PROs as observed variables, the potential to use latent variable models when analyzing patient responses in clinical trial data presents novel opportunities for both psychometrics and regulatory science. An accessible overview of analyses commonly used to analyze longitudinal trial data and statistical models familiar in both psychometrics and biometrics, such as growth models, multilevel models, and latent variable models, is provided to call attention to connections and common themes among these models that have found use across many research areas. Additionally, examples using empirical data from a randomized clinical trial provide concrete demonstrations of the implementation of these models. The increasing availability of high-quality, psychometrically rigorous assessment instruments in clinical trials, of which the Patient-Reported Outcomes Measurement Information System (PROMIS®) is a prominent example, provides rare possibilities for psychometrics to help improve the statistical tools used in regulatory science.
Item response theory scoring based on summed scores is employed frequently in the practice of educational and psychological measurement. Lord and Wingersky (Appl Psychol Meas 8(4):453–461, 1984) proposed a recursive algorithm to compute the summed score likelihood. Cai (Psychometrika 80(2):535–559, 2015) extended the original Lord–Wingersky algorithm to the case of two-tier multidimensional item factor models and called it Lord–Wingersky algorithm Version 2.0. The 2.0 algorithm utilizes dimension reduction to efficiently compute summed score likelihoods associated with the general dimensions in the model. The output of the algorithm is useful for various purposes, for example, scoring, scale alignment, and model fit checking. In the research reported here, a further extension to the Lord–Wingersky algorithm 2.0 is proposed. The new algorithm, which we call Lord–Wingersky algorithm Version 2.5, yields the summed score likelihoods for all latent variables in the model conditional on observed score combinations. The proposed algorithm is illustrated with empirical data for three potential application areas: (a) describing achievement growth using score combinations across adjacent grades, (b) identification of noteworthy subscores for reporting, and (c) detection of aberrant responses.
Motivated by Gibbons et al.’s (Appl. Psychol. Meas. 31:4–19, 2007) full-information maximum marginal likelihood item bifactor analysis for polytomous data, and Rijmen, Vansteelandt, and De Boeck’s (Psychometrika 73:167–182, 2008) work on constructing computationally efficient estimation algorithms for latent variable models, a two-tier item factor analysis model is developed in this research. The modeling framework subsumes standard multidimensional IRT models, bifactor IRT models, and testlet response theory models as special cases. Features of the model lead to a reduction in the dimensionality of the latent variable space, and consequently significant computational savings. An EM algorithm for full-information maximum marginal likelihood estimation is developed. Simulations and real data demonstrations confirm the accuracy and efficiency of the proposed methods. Three real data sets from a large-scale educational assessment, a longitudinal public health survey, and a scale development study measuring patient reported quality of life outcomes are analyzed as illustrations of the model’s broad range of applicability.