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Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults
- Charlotte Debras, Reynalda Cordova, Ana-Lucia Mayén, Kim Maasen, Viktoria Knaze, Simone J. P. M. Eussen, Casper G. Schalkwijk, Inge Huybrechts, Anne Tjønneland, Jytte Halkjær, Verena Katzke, Rashmita Bajracharya, Matthias B. Schulze, Giovanna Masala, Valeria Pala, Fabrizio Pasanisi, Alessandra Macciotta, Dafina Petrova, Jazmin Castañeda, Carmen Santiuste, Pilar Amiano, Conchi Moreno-Iribas, Yan Borné, Emily Sonestedt, Ingegerd Johansson, Anders Esberg, Elom Kouassivi Aglago, Mazda Jenab, Heinz Freisling
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- Journal:
- British Journal of Nutrition , First View
- Published online by Cambridge University Press:
- 22 February 2024, pp. 1-13
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Dicarbonyl compounds are highly reactive precursors of advanced glycation end products (AGE), produced endogenously, present in certain foods and formed during food processing. AGE contribute to the development of adverse metabolic outcomes, but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO) and 3-deoxyglucosone (3-DG), and body weight changes in European adults. Dicarbonyl intakes were estimated using food composition database from 263 095 European Prospective Investigation into Cancer and Nutrition–Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home in Relation to Anthropometry participants with two body weight assessments (median follow-up time = 5·4 years). Associations between dicarbonyls and 5-year body-weight changes were estimated using mixed linear regression models. Stratified analyses by sex, age and baseline BMI were performed. Risk of becoming overweight/obese was assessed using multivariable-adjusted logistic regression. MGO intake was associated with 5-year body-weight gain of 0·089 kg (per 1-sd increase, 95 % CI 0·072, 0·107). 3-DG was inversely associated with body-weight change (–0·076 kg, −0·094, −0·058). No significant association was observed for GO (0·018 kg, −0·002, 0·037). In stratified analyses, GO was associated with body-weight gain among women and older participants (above median of 52·4 years). MGO was associated with higher body-weight gain among older participants. 3-DG was inversely associated with body-weight gain among younger and normal-weight participants. MGO was associated with a higher risk of becoming overweight/obese, while inverse associations were observed for 3-DG. No associations were observed for GO with overweight/obesity. Dietary dicarbonyls are inconsistently associated with body weight change among European adults. Further research is needed to clarify the role of these food components in overweight and obesity, their underlying mechanisms and potential public health implications.
Structural brain abnormalities in schizophrenia in adverse environments: examining the effect of poverty and violence in six Latin American cities
- Nicolas A. Crossley, Andre Zugman, Francisco Reyes-Madrigal, Leticia S. Czepielewski, Mariana N. Castro, Ana M. Diaz-Zuluaga, Julian A. Pineda-Zapata, Ramiro Reckziegel, Ary Gadelha, Andrea Jackowski, Cristiano Noto, Luz M. Alliende, Barbara Iruretagoyena, Tomas Ossandon, Juan P. Ramirez-Mahaluf, Carmen P. Castañeda, Alfonso Gonzalez-Valderrama, Ruben Nachar, Pablo León-Ortiz, Juan Undurraga, Carlos López-Jaramillo, Salvador M. Guinjoan, Clarissa S. Gama, Camilo de la Fuente-Sandoval, Rodrigo A. Bressan
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- Journal:
- The British Journal of Psychiatry / Volume 218 / Issue 2 / February 2021
- Published online by Cambridge University Press:
- 18 August 2020, pp. 112-118
- Print publication:
- February 2021
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Background
Social and environmental factors such as poverty or violence modulate the risk and course of schizophrenia. However, how they affect the brain in patients with psychosis remains unclear.
AimsWe studied how environmental factors are related to brain structure in patients with schizophrenia and controls in Latin America, where these factors are large and unequally distributed.
MethodThis is a multicentre study of magnetic resonance imaging in patients with schizophrenia and controls from six Latin American cities. Total and voxel-level grey matter volumes, and their relationship with neighbourhood characteristics such as average income and homicide rates, were analysed with a general linear model.
ResultsA total of 334 patients with schizophrenia and 262 controls were included. Income was differentially related to total grey matter volume in both groups (P = 0.006). Controls showed a positive correlation between total grey matter volume and income (R = 0.14, P = 0.02). Surprisingly, this relationship was not present in patients with schizophrenia (R = −0.076, P = 0.17). Voxel-level analysis confirmed that this interaction was widespread across the cortex. After adjusting for global brain changes, income was positively related to prefrontal cortex volumes only in controls. Conversely, the hippocampus in patients with schizophrenia, but not in controls, was relatively larger in affluent environments. There was no significant correlation between environmental violence and brain structure.
ConclusionsOur results highlight the interplay between environment, particularly poverty, and individual characteristics in psychosis. This is particularly important for harsh environments such as low- and middle-income countries, where potentially less brain vulnerability (less grey matter loss) is sufficient to become unwell in adverse (poor) environments.