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This study explored mental workload recognition methods for carrier-based aircraft pilots utilising multiple sensor physiological signal fusion and portable devices. A simulation carrier-based aircraft flight experiment was designed, and subjective mental workload scores and electroencephalogram (EEG) and photoplethysmogram (PPG) signals from six pilot cadets were collected using NASA Task Load Index (NASA-TLX) and portable devices. The subjective scores of the pilots in three flight phases were used to label the data into three mental workload levels. Features from the physiological signals were extracted, and the interrelations between mental workload and physiological indicators were evaluated. Machine learning and deep learning algorithms were used to classify the pilots’ mental workload. The performances of the single-modal method and multimodal fusion methods were investigated. The results showed that the multimodal fusion methods outperformed the single-modal methods, achieving higher accuracy, precision, recall and F1 score. Among all the classifiers, the random forest classifier with feature-level fusion obtained the best results, with an accuracy of 97.69%, precision of 98.08%, recall of 96.98% and F1 score of 97.44%. The findings of this study demonstrate the effectiveness and feasibility of the proposed method, offering insights into mental workload management and the enhancement of flight safety for carrier-based aircraft pilots.
Posttraumatic stress disorder (PTSD) is a heterogenous disorder with frequent diagnostic comorbidity. Research has deciphered this heterogeneity by identifying PTSD subtypes and their neural biomarkers. This review summarizes current approaches, symptom-based group-level and data-driven approaches, for generating PTSD subtypes, providing an overview of current PTSD subtypes and their neural correlates. Additionally, we systematically assessed studies to evaluate the influence of comorbidity on PTSD subtypes and the predictive utility of biotypes for treatment outcomes. Following the PRISMA guidelines, a systematic search was conducted to identify studies employing brain imaging techniques, including functional magnetic resonance imaging (fMRI), structural MRI, diffusion-weighted imaging (DWI), and electroencephalogram (EEG), to identify biomarkers of PTSD subtypes. Study quality was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. We included 53 studies, with 44 studies using a symptom-based group-level approach, and nine studies using a data-driven approach. Findings suggest biomarkers across the default-mode network (DMN) and the salience network (SN) throughout multiple subtypes. However, only six studies considered comorbidity, and four studies tested the utility of biotypes in predicting treatment outcomes. These findings highlight the complexity of PTSD’s heterogeneity. Although symptom-based and data-driven methods have advanced our understanding of PTSD subtypes, challenges remain in addressing the impact of comorbidities and the limited validation of biotypes. Future studies with larger sample sizes, brain-based data-driven approaches, careful account for comorbidity, and rigorous validation strategies are needed to advance biologically grounded biotypes across mental disorders.
Cargo carrying by a spring connected chiral micro-swimmer in a square channel is numerical studied by the three-dimensional lattice Boltzmann method and a chiral squirmer model. The effects of the driving type (β), swimming Reynolds number (Rep), spin coefficient (ξ) and diameter ratio (S) on the changes of the cargo-carrying velocity, spring length and motion modes are investigated, respectively. Four kinds of interesting motion modes are observed. When the chirality is not considered, the optimal combination for maximising swimming velocity are the pusher–cargo and cargo–puller configurations when Rep = 0.1 ∼ 1. When Rep is enhanced, the swimming velocities of the pusher–cargo, puller–cargo and cargo–pusher are increased, while the velocity of the cargo–puller is gradually decreased. When considering the chirality, only the swimming velocity of cargo–pusher and cargo–puller keep an interesting increment, and the reverse motion mode for the pusher-cargo and puller-cargo is firstly found in the present work when ξ exceeds a certain value. The impact of S on the cargo-carrying behaviour is complex, three kinds of oscillatory trajectories will appear under different ξ and S. The swimming velocity is reduced and even zero velocity will be observed when S is large. This work reveals key factors on the movement of microorganisms, offering guidance for improving cargo-carrying capabilities.
We investigate the statistical properties of kinetic and thermal dissipation rates in two-dimensional/three-dimensional vertical convection of liquid metal ($Pr = 0.032$) within a square cavity. Two situations are specifically discussed: (i) classical vertical convection with no external forces and (ii) vertical magnetoconvection with a horizontal magnetic field. Through an analysis of dissipation fields and a reasonable approximation of buoyancy potential energy sourced from vertical heat flux, the issue of the ‘non-closure of the dissipation balance relation’, which has hindered the application of the GL theory in vertical convection, is partially resolved. The resulting asymptotic power laws are consistent with existing laminar scaling theories and even show certain advantages in validating simulations with large Prandtl number ($Pr$). Additionally, a full-parameter model and prefactors applicable to low-$Pr$ fluids are provided. The extension to magnetoconvection naturally introduces the approximate expression for total buoyancy potential energy and necessitates adjustments to the contributions of kinetic dissipation in both the bulk and boundary layer. The flow dimensionality and boundary layer thickness are key considerations in this analysis. The comprehension of Joule dissipation has been updated: the Lorentz force generates positive dissipation in the bulk by suppressing convection, while in the Hartmann layer, shaping the exponential boundary layer requires the fluid to perform positive work to accelerate, leading to negative dissipation. Finally, the proposed transport equations for magnetoconvection are supported by current direct numerical simulation (DNS) and literature data, and the applicability of the model is discussed.
Objectives/Goals: Mathematical models of airborne virus transmission lack supporting field and clinical data such as viral aerosol emission rates and airborne infectious doses. Here, we aim to measure inhalation exposure to influenza aerosols in a room shared with persons with community-acquired influenza and estimate the infectious dose via inhalation. Methods/Study Population: We recruited healthy volunteer recipients and influenza donors with polymerase chain reaction (PCR)-confirmed community-acquired infection. On admission to a hotel quarantine, recipients provided sera to determine baseline immunity to influenza virus, and donor infections were confirmed by quantitative real-time polymerase chain reaction. Donors and recipients were housed in separate rooms and interacted in an “event room” with controlled ventilation (0.2 – 0.5 air changes/hour) and relative humidity (20–40%). We collected ambient bioaerosol exposure samples using NIOSH BC-251 samplers. Donors provided exhaled breath samples collected by a Gesundheit-II (G-II). We analyzed aerosol samples using dPCR and fluorescent focus assays for influenza A and sera by hemagglutinin inhibition assay (HAI) against donor viruses and vaccine strains. Results/Anticipated Results: Among two cohorts (24b and 24c), we exposed 11 recipients (mean age: 36; 55% female) to 5 donors (mean age: 21; 80% female) infected with influenza A H1N1 or H3N2. Eight G-II and two NIOSH bioaerosol samples (1–4 µm and ≥4 µm) were PCR positive. We cultured virus from one G-II sample. Based on previous literature, we hypothesized that ~50% of immunologically naïve people (HAI Discussion/Significance of Impact: We demonstrated that it is feasible to recruit donors with community-acquired influenza and expose recipients to measurable virus quantities under controlled conditions. However, baseline immunity was high among volunteers. Our work sets the stage for designing studies with increased sample sizes comprising immunologically naïve volunteers.
The reflection of multiple incident shock waves that converge to a single point on the reflecting surface is studied in this paper. The number of the incident shocks, denoted $K$, is arbitrary. The interaction between the reflected shock of one incident shock and the other incident shocks may produce various possible configurations, such as type-I, type-II and type-IV shock interferences. The number of possible reflection configurations is shown to be an exponential function of ($K-1$) with base 2. The possibility of pre-, middle- and post-Mach reflections, which means Mach reflection occurs for the first, middle and last incident shock, is revealed through numerical simulation for $K=3$. For the particular case where the incident shocks are produced by equal variation of wedge surface deflection, the conventional von Neumann condition and detachment condition for the $k\mathrm{th}$ incident shock to have Mach reflection are derived. It is shown that the von Neumann condition for regular reflection is lowered and the detachment condition for Mach reflection is elevated as $k$ increases. The shock reflection patterns for $ K=1,2,\ldots ,10$ are obtained by numerical simulations. We observe a shock interaction train structure, where we have pre-Mach reflection followed by ($K-1$) type-I or type-II shock interferences. We also observe that the Mach stem height decreases with $K$ well above the von Neumann condition and becomes non-monotonic near the von Neumann condition.
Numerous supraglacial lakes form on the Greenland Ice Sheet (GrIS) during the summer, and accurately estimating their depth is crucial for understanding GrIS water storage. In this study, we estimate the depth of 35 representative GrIS supraglacial lakes using ICESat-2, Sentinel-2 imagery and ArcticDEM data. ICESat-2-derived lake depth is used to validate the performance of three remote sensing methods, namely empirical formula method (EFM), radiative transfer method (RTM) and depression topography method (DTM). EFM relies on ICESat-2-derived lake depth to construct empirical formulas, while RTM and DTM do not. The results show that (1) the green band EFM performs best; the DTM performs secondarily but tends to consistently underestimate depths; the green-band RTM has lower accuracy and overestimates depths, while the red-band RTM also has lower accuracy but underestimates depths. (2) Temporal changes of depression topography have limited impacts on the performance of DTM, whereas the uncertainties caused by lake shoreline height estimates should be considered. (3) The performance of RTM is significantly influenced by the spectral attenuation coefficient. We further identify the factors that affect spatiotemporal extrapolation of these methods and recommend prioritizing the use of the EFM when near-simultaneous ICESat-2 data are available; otherwise, DTM is recommended, yet an underestimation ratio should be used.
This paper provides an overview of the current status of ultrafast and ultra-intense lasers with peak powers exceeding 100 TW and examines the research activities in high-energy-density physics within China. Currently, 10 high-intensity lasers with powers over 100 TW are operational, and about 10 additional lasers are being constructed at various institutes and universities. These facilities operate either independently or are combined with one another, thereby offering substantial support for both Chinese and international research and development efforts in high-energy-density physics.
The rural-oriented tuition-waived medical education program in China, started in 2010, provides free medical education to students committed to serving in rural areas to address medical staff shortages. Despite its success in training and deploying graduates, retaining them post-obligation remains challenging. This study explores the mechanisms behind the turnover intentions of rural-oriented medical students in Western China, offering insights for their retention.
Methods:
Semi-structured interviews were conducted with 47 rural-oriented medical students and 30 health clinic directors in Nanning City. Interview data were analysed using grounded theory, and open, axial and selective coding was applied.
Results:
Through three levels of coding analysis, 34 tree nodes, 13 sub-categories and 3 main categories were identified from the interviews with rural-oriented medical students and health clinic directors. 3 main categories were Subjective Norms, Behavioural Attitudes, and Perceived Behavioural Control.
Conclusion:
A model of turnover intention among rural-oriented medical students was developed. This model can serve as a valuable reference for future policy optimization concerning China’s rural order-directed medical students.
Knowledge of the critical periods of crop–weed competition is crucial for designing weed management strategies in cropping systems. In the Lower Yangtze Valley, China, field experiments were conducted in 2011 and 2012 to study the effect of interference from mixed natural weed populations on cotton growth and yield and to determine the critical period for weed control (CPWC) in direct-seeded cotton. Two treatments were applied: allowing weeds to infest the crop or keeping plots weed-free for increasing periods (0, 1, 2, 4, 6, 8, 10, 12, 14, and 20 wk) after crop emergence. The results show that mixed natural weed infestations led to 35- to 55-cm shorter cotton plants with stem diameters 10 to 13 mm smaller throughout the season, fitting well with modified Gompertz and logistic models, respectively. Season-long competition with weeds reduced the number of fruit branches per plant by 65% to 82%, decreasing boll number per plant by 86% to 96% and single boll weight by approximately 24%. Weed-free seed cotton yields ranged from 2,900 to 3,130 kg ha−1, while yield loss increased with the duration of weed infestation, reaching up to 83% to 96% compared with permanent weed-free plots. Modified Gompertz and logistic models were used to analyze the impact of increasing weed control duration and weed interference on relative seed cotton yield (percentage of season-long weed-free cotton), respectively. Based on a 5% yield loss threshold, the CPWC was found to be from 145 to 994 growing degree days (GDD), corresponding to 14 to 85 d after emergence (DAE). These findings emphasize the importance of implementing effective weed control measures from 14 to 85 DAE in the Lower Yangtze Valley to prevent crop losses exceeding a 5% yield loss threshold.
Accurate characterization of high-power laser parameters, especially the near-field and far-field distributions, is crucial for inertial confinement fusion experiments. In this paper, we propose a method for computationally reconstructing the complex amplitude of high-power laser beams using modified coherent modulation imaging. This method has the advantage of being able to simultaneously calculate both the near-field (intensity and wavefront/phase) and far-field (focal-spot) distributions using the reconstructed complex amplitude. More importantly, the focal-spot distributions at different focal planes can also be calculated. To verify the feasibility, the complex amplitude optical field of the high-power pulsed laser was measured after static aberrations calibration. Experimental results also indicate that the near-field wavefront resolution of this method is higher than that of the Hartmann measurement. In addition, the far-field focal spot exhibits a higher dynamic range (176 dB) than that of traditional direct imaging (62 dB).
The betatron radiation source features a micrometer-scale source size, a femtosecond-scale pulse duration, milliradian-level divergence angles and a broad spectrum exceeding tens of keV. It is conducive to the high-contrast imaging of minute structures and for investigating interdisciplinary ultrafast processes. In this study, we present a betatron X-ray source derived from a high-charge, high-energy electron beam through a laser wakefield accelerator driven by the 1 PW/0.1 Hz laser system at the Shanghai Superintense Ultrafast Laser Facility (SULF). The critical energy of the betatron X-ray source is 22 ± 5 keV. The maximum X-ray flux reaches up to 4 × 109 photons for each shot in the spectral range of 5–30 keV. Correspondingly, the experiment demonstrates a peak brightness of 1.0 × 1023 photons·s−1·mm−2·mrad−2·0.1%BW−1, comparable to those demonstrated by third-generation synchrotron light sources. In addition, the imaging capability of the betatron X-ray source is validated. This study lays the foundation for future imaging applications.
The Early-Middle Jurassic impression/compression macroflora and the palynoflora from the Qaidam Basin in the northeastern Qinghai-Xizang (Tibetan) Plateau have been well studied; however, fossil wood from this region has not been previously documented systematically. Here, we describe an anatomically well-preserved fossil wood specimen from the Lower Jurassic Huoshaoshan Formation at the Dameigou section in northern Qinghai Province, northwestern China. This fossil exhibits typical Metapodocarpoxylon Dupéron-Laudoueneix et Pons anatomy with usually araucarian radial tracheid pits and variable cross-field pits, representing a new record for Metapodocarpoxylon in the Qaidam Basin. This discovery indicates that trees with this type of wood anatomy were not confined to northern Gondwana but also grew in more northerly regions in Laurasia. The wood displays distinct growth rings, with abundant, well-formed earlywood and narrow latewood. This observation, along with previous interpretations based on macroflora, palynoflora and sedimentological data, suggests that a warm and humid climate with mild seasonality prevailed in the region during the Early Jurassic.
Post-traumatic stress disorder (PTSD) is a mental health condition caused by the dysregulation or overgeneralization of memories related to traumatic events. Investigating the interplay between explicit narrative and implicit emotional memory contributes to a better understanding of the mechanisms underlying PTSD.
Methods
This case–control study focused on two groups: unmedicated patients with PTSD and a trauma-exposed control (TEC) group who did not develop PTSD. Experiments included real-time measurements of blood oxygenation changes using functional near-infrared spectroscopy during trauma narration and processing of emotional and linguistic data through natural language processing (NLP).
Results
Real-time fNIRS monitoring showed that PTSD patients (mean [SD] Oxy-Hb activation, 0.153 [0.084], 95% CI 0.124 to 0.182) had significantly higher brain activity in the left anterior medial prefrontal cortex (L-amPFC) within 10 s after expressing negative emotional words compared with the control group (0.047 [0.026], 95% CI 0.038 to 0.056; p < 0.001). In the control group, there was a significant time-series correlation between the use of negative emotional memory words and activation of the L-amPFC (latency 3.82 s, slope = 0.0067, peak value = 0.184, difference = 0.273; Spearman’s r = 0.727, p < 0.001). In contrast, the left anterior cingulate prefrontal cortex of PTSD patients remained in a state of high activation (peak value = 0.153, difference = 0.084) with no apparent latency period.
Conclusions
PTSD patients display overactivity in pathways associated with rapid emotional responses and diminished regulation in cognitive processing areas. Interventions targeting these pathways may alleviate symptoms of PTSD.
The emotion regulation network (ERN) in the brain provides a framework for understanding the neuropathology of affective disorders. Although previous neuroimaging studies have investigated the neurobiological correlates of the ERN in major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns in the ERN and whether the abnormal FC in the ERN can serve as a therapeutic response signature remain unclear.
Methods
A large functional magnetic resonance imaging dataset comprising 709 patients with MDD and 725 healthy controls (HCs) recruited across five sites was analyzed. Using a seed-based FC approach, we first investigated the group differences in whole-brain resting-state FC of the 14 ERN seeds between participants with and without MDD. Furthermore, an independent sample (45 MDD patients) was used to evaluate the relationship between the aforementioned abnormal FC in the ERN and symptom improvement after 8 weeks of antidepressant monotherapy.
Results
Compared to the HCs, patients with MDD exhibited aberrant FC between 7 ERN seeds and several cortical and subcortical areas, including the bilateral middle temporal gyrus, bilateral occipital gyrus, right thalamus, calcarine cortex, middle frontal gyrus, and the bilateral superior temporal gyrus. In an independent sample, these aberrant FCs in the ERN were negatively correlated with the reduction rate of the HAMD17 score among MDD patients.
Conclusions
These results might extend our understanding of the neurobiological underpinnings underlying unadaptable or inflexible emotional processing in MDD patients and help to elucidate the mechanisms of therapeutic response.
In this paper, we study the rapid transition in Richtmyer–Meshkov instability (RMI) with reshock through three-dimensional double-layer swirling vortex rings. The rapid transition in RMI with reshock has an essential influence on the evolution of supernovas and the ignition of inertial confinement fusion, which has been confirmed in numerical simulations and experiments in shock-tube and high-energy-density facilities over the past few years. Vortex evolution has been confirmed to dominate the late-time nonlinear development of the perturbed interface. However, few studies have investigated the three-dimensional characteristics and nonlinear interactions among vortex structures during the transition to turbulent flows. The coexistence of co-rotating and counter-rotating vortices is hypothesized to induce successive large-scale strain fields, which are the main driving sources for rapid development. The three-dimensional effect is reflected in the presence of local swirling motion in the azimuthal direction, and it decreases the translation velocity of a vortex ring. Large-, middle- and small-scale strain fields are employed to describe the development process of RMI with reshock, e.g. vorticity deposited by the reshock, formation of the coexistence of the co-rotating and counter-rotating vortices, iterative cascade under the amplification of the strain fields and viscous dissipation to internal energy. This provides theoretical suggestions for designing practical applications, such as the estimation of the hydrodynamic instability and mixing during the late-time acceleration phase of the inertial confinement fusion.
Biped wall-climbing robots (BWCRs) serve as viable alternatives to human workers for inspection and maintenance tasks within three-dimensional (3D) curtain wall environments. However, autonomous climbing in such environments presents significant challenges, particularly related to localization and navigation. This paper presents a pioneering navigation framework tailored for BWCRs to navigate through 3D curtain wall environments. The framework comprises three essential stages: Building Information Model (BIM)-based map extraction, 3D climbing path planning (based on our previous work), and path tracking. An algorithm is developed to extract a detailed 3D map from the BIM, including structural elements such as walls, frames, and ArUco markers. This generated map is input into a proposed path planner to compute a viable climbing motion. For path tracking during actual climbing, an ArUco marker-based global localization method is introduced to estimate the pose of the robot, enabling adjustments to the target foothold by comparing desired and actual poses. The conducted experiments validate the feasibility and efficacy of the proposed navigation framework and associated algorithms, aiming to enhance the autonomous climbing capability of BWCRs.