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The reduction of the hydrodynamic forces exerted on a bluff body in an incoming flow has been an issue of interest in fluid mechanics for many years. However, the Magnus effect indicates possible drag reduction but with the lift being increased significantly. This study is aimed at the simultaneous lift and drag reduction for which we consider a constant incoming flow past a circular cylinder or a sphere in the $x$-direction. Force element analysis (FEA) indicates the possibility of reducing the drag exerted on a circular cylinder or a sphere by rotating (say, clockwise about the $z$-axis) only the front half of the circular cylinder or the sphere. More precisely, we rotate the object but with the rear half covered by a closely spaced hood. Numerical simulations show that by increasing the dimensionless rotational speed $\alpha$: (i) the flow can be quickly stabilised to a steady state; (ii) the mean drag steadily decreases to zero and then becomes negative as $\alpha$ is further increased across the critical $\alpha _I = 4.11$ for the circular cylinder at $Re$ = 200, $\alpha _I = 4.81$ for the sphere at $Re$ = 200 and $\alpha _I = 4.92$ for the sphere at $Re$ = 300; (iii) the mean value of the lift decreases from zero to negative and then increases beyond zero, and in addition, the amplitude of the lift gradually decreases for the circular cylinder; the mean value of the lift decreases from zero to negative for the sphere; (iv) the side force is almost zero – the flow over the sphere is plane-symmetric about the $x{-}y$ plane. These features are compared with the flow past a rotating circular cylinder or a rotating sphere (Magnus effect). Notably, there is a range of flows that can be of practical use for: (a) the circular cylinder where the drag is greatly reduced while the lift is small in magnitude and (b) the sphere where the drag is greatly reduced while the lift is negative in magnitude and the side force is close to 0.
This study examined the impact of coherent structures on the aerodynamic forces exerted on a NACA0012 aerofoil with angles of attack $7.5^{\circ }$ and $10^{\circ }$, and a chord-based Reynolds number $50\,000$. The study utilized the spectral proper orthogonal decomposition (SPOD) algorithm to identify the coherent structures, and vorticity force analysis to quantify their impact on lift and drag forces. Results showed that at $10^{\circ }$, the zeroth frequency of the first SPOD mode had a significant impact on drag and lift forces due to a large vortex structure that caused a strong flow along the suction side of the aerofoil. The first and second frequencies of the first SPOD mode represented asymmetric vortex pairs and a series of vortex pairs that determined the leading-edge separation, respectively. At $7.5^{\circ }$, the zeroth frequency of the first mode corresponded to an oscillating near-wall stream that followed the reattachment flow pattern, while the first frequency corresponded to a counter-rotating vortex pair that originated where the flow reattaches. Finally, the second frequency of the first mode corresponded to smaller counter-rotating vortex pairs at the shear layer originated near the reattachment point. These findings suggest that coherent structures have a significant impact on aerodynamic forces exerted on aerofoils, and can be identified and quantified using the SPOD algorithm and vorticity force analysis.
In this study, a novel, cost-effective miniaturized tag antenna was developed for applications on the human body. To achieve impedance matching with the complex conjugate impedance of the Monza-4 tag chip (7.17–j74.22 Ω at 915 MHz), the proposed structure was configured by coarsely tuning the positions of vias and fine-tuning the small gaps of its coupled patches. For further reducing the profile and dimensions of the antenna, a design technique based on the three-dimensional dipole antenna current distribution was used. The proposed antenna configuration was not only miniaturized but also achieved a long stable reading distance (>5.0 m) and a wide impedance bandwidth of 71 MHz or 7.65% (covering the ultrahigh frequency radio frequency identification ranges in most regions), regardless of the location of the tag on the human body. Experiments were conducted to validate the simulated results, and adequate agreement was found between the simulated results and the measured results.
Youth suicide rates have increased markedly in some countries. This study aimed to estimate the population-attributable risk of psychiatric disorders associated with suicide among Taiwanese youth aged 10–24 years.
Methods
Data were obtained from the National Death Registry and National Health Insurance (NHI) claims database between 2007 and 2019. Youth who died by suicide were included, and comparisons, 1:10 matched by age and sex, were randomly selected from the Registry for NHI beneficiaries. We used multivariable logistic regression to estimate suicide odds ratios for psychiatric disorders. The population-attributable fractions (PAF) were calculated for each psychiatric disorder.
Results
A total of 2345 youth suicide and 23 450 comparisons were included. Overall, 44.8% of suicides had a psychiatric disorder, while only 7.9% of the comparisons had a psychiatric disorder. The combined PAF for all psychiatric disorders was 55.9%. The top three psychiatric conditions of the largest PAFs were major depressive disorder, dysthymia, and sleep disorder. In the analysis stratified by sex, the combined PAF was 45.5% for males and 69.2% for females. The PAF among young adults aged 20–24 years (57.0%) was higher than among adolescents aged 10–19 years (48.0%).
Conclusions
Our findings of high PAF from major depressive disorder, dysthymia, and sleep disorder to youth suicides suggest that youth suicide prevention that focuses on detecting and treating mental illness may usefully target these disorders.
The risk of antipsychotic-associated cardiovascular and metabolic events may differ among countries, and limited real-world evidence has been available comparing the corresponding risks among children and young adults. We, therefore, evaluated the risks of cardiovascular and metabolic events in children and young adults receiving antipsychotics.
Methods
We conducted a multinational self-controlled case series (SCCS) study and included patients aged 6–30 years old who had both exposure to antipsychotics and study outcomes from four nationwide databases of Taiwan (2004–2012), Korea (2010–2016), Hong Kong (2001–2014) and the UK (1997–2016) that covers a total of approximately 100 million individuals. We investigated three antipsychotics exposure windows (i.e., 90 days pre-exposure, 1–30 days, 30–90 days and 90 + days of exposure). The outcomes were cardiovascular events (stroke, ischaemic heart disease and acute myocardial infarction), or metabolic events (hypertension, type 2 diabetes mellitus and dyslipidaemia).
Results
We included a total of 48 515 individuals in the SCCS analysis. We found an increased risk of metabolic events only in the risk window with more than 90-day exposure, with a pooled IRR of 1.29 (95% CI 1.20–1.38). The pooled IRR was 0.98 (0.90–1.06) for 1–30 days and 0.88 (0.76–1.02) for 31–90 days. We found no association in any exposure window for cardiovascular events. The pooled IRR was 1.86 (0.74–4.64) for 1–30 days, 1.35 (0.74–2.47) for 31–90 days and 1.29 (0.98–1.70) for 90 + days.
Conclusions
Long-term exposure to antipsychotics was associated with an increased risk of metabolic events but did not trigger cardiovascular events in children and young adults.
To estimate the risks of depressive symptoms for developing frailty, accounting for baseline robust or pre-frailty status.
Design:
An incident cohort study design.
Setting:
Community dwellers aged 55 years and above from urban and rural areas in seven regions in Taiwan.
Participants:
A total of 2,717 participants from the Healthy Aging Longitudinal Study in Taiwan (HALST) were included. Subjects with frailty at baseline were excluded. The average follow-up period was 5.9 years.
Measurements:
Depressive symptoms were measured by the 20-item Center for Epidemiological Studies Depression (CES-D) Scale. Frailty was assessed using the Fried frailty measurement. Participants were stratified by baseline robust or pre-frailty status to reduce the confounding effects of the shared criteria between depressive symptoms and frailty. Overall and stratified survival analyses were conducted to assess risks of developing frailty as a result of baseline depressive symptoms.
Results:
One hundred individuals (3.7%) had depressive symptoms at baseline. Twenty-seven individuals (27.0%) with depressive symptoms developed frailty, whereas only 305 out of the 2,617 participants (11.7%) without depressive symptoms developed frailty during the follow-up period. After adjusting for covariates, depressive symptoms were associated with a 2.6-fold (95% CI 1.6, 4.2) increased hazard of incident frailty. The patterns of increased hazard were also observed when further stratified by baseline robust or pre-frailty status.
Conclusions:
Depressive symptoms increased the risk of developing frailty among the older Asian population. The impact of late-life depressive symptoms on physical health was notable. These findings also replicated results from Western populations. Future policies on geriatric public health need to focus more on treatment and intervention against geriatric depressive symptoms to prevent incident frailty among older population.
Cellulitis is a common infection of the skin and soft tissue. Susceptibility to cellulitis is related to microorganism virulence, the host immunity status and environmental factors. This retrospective study from 2001 to 2013 investigated relationships between the monthly incidence rate of cellulitis and meteorological factors using data from the Taiwanese Health Insurance Dataset and the Taiwanese Central Weather Bureau. Meteorological data included temperature, hours of sunshine, relative humidity, total rainfall and total number of rainy days. In otal, 195 841 patients were diagnosed with cellulitis and the incidence rate was strongly correlated with temperature (γS = 0.84, P < 0.001), total sunshine hours (γS = 0.65, P < 0.001) and total rainfall (γS = 0.53, P < 0.001). The incidence rate of cellulitis increased by 3.47/100 000 cases for every 1° elevation in environmental temperature. Our results may assist clinicians in educating the public of the increased risk of cellulitis during warm seasons and possible predisposing environmental factors for infection.
The purpose of this study was to investigate the effects of 8-week green tea extract (GTE) supplementation on promoting postexercise muscle glycogen resynthesis and systemic energy substrate utilisation in young college students. A total of eight healthy male participants (age: 22·0 (se 1·0) years, BMI: 24·2 (se 0·7) kg/m2, VO2max: 43·2 (se 2·4) ml/kg per min) participated in this study. GTE (500 mg/d for 8 weeks) was compared with placebo in participants in a double-blind/placebo-controlled and crossover study design with an 8-week washout period. Thereafter, all participants performed a 60-min cycling exercise (75 % VO2max) and consumed a carbohydrate-enriched meal immediately after exercise. Vastus lateralis muscle samples were collected immediately (0 h) and 3 h after exercise, and blood and gaseous samples were collected during the 3-h postexercise recovery period. An 8-week oral GTE supplementation had no effects on further promoting muscle glycogen resynthesis in exercised human skeletal muscle, but the exercise-induced muscle GLUT type 4 (GLUT4) protein content was greater in the GTE supplementation trial (P<0·05). We observed that, during the postexercise recovery period, GTE supplementation elicited an increase in energy reliance on fat oxidation compared with the placebo trial (P<0·05), although there were no differences in blood glucose and insulin responses between the two trials. In summary, 8-week oral GTE supplementation increases postexercise systemic fat oxidation and exercise-induced muscle GLUT4 protein content in response to an acute bout of endurance exercise. However, GTE supplementation has no further benefit on promoting muscle glycogen resynthesis during the postexercise period.
This paper reports a novel means of integrating a high-performance dual-modal ZnO piezoelectric transducer with a flexible stainless steel substrate (SUS304) to construct dual-modal vibration-power transducers. To fabricate vibration-power transducers, the off-axis RF magnetron sputtering method for the growth of ZnO piezoelectric thin films is adopted. The stainless steel substrate has a higher Young’s modulus than those of the other substrates, and behaves the long-term stability under vibration. The transducer includes a ZnO piezoelectric thin film deposited on the stainless steel substrate combined with Pt/Ti layers at room temperature, which is fabricated by an RF magnetron two-step sputtering system. In this report, the ZnO piezoelectric thin films deposited with the tilting angle of 34° are set by controlling the deposition parameters. Scanning electron microscopy and X-ray diffraction of ZnO piezoelectric thin films reveal a rigid surface structure and a high dual-modal orientation. To investigate the generating characteristics of the dual-modal transducer, two basic experiments of longitudinal and shear modes are carried out. Based on cantilever vibration theory, the cantilever length of 1 cm and a vibration area of 1 cm2 are used to fabricate a transducer with a low resonant-frequency of 65 Hz for the natural vibration. A mass loading at the front-end of the cantilever is critical to increase the amplitude of vibration and the power generated by the piezoelectric transducer. The maximum open circuit voltage of the power transducer is 19.4 V.
A novel allergy biosensor is designed and fabricated by using thin film bulk acoustic resonator (TFBAR) devices with shear mode ZnO piezoelectric thin films. To fabricate TFBAR devices, the off-axis RF magnetron sputtering method for the growth of piezoelectric ZnO piezoelectric thin films is adopted. The influences of the relative distance and sputtering parameters are investigated. In this report, the piezoelectric ZnO thin films with tilting angle are set by controlling the deposition parameters. The properties of the shear mode ZnO thin films are investigated by X-ray diffraction and scanning electron microscopy. The frequency response is measured using an HP8720 network analyzer with a CASCADE probe station. The resonance frequency of the shear mode is 796.75 MHz. The sensitivity of the shear mode is calculated to be 462.5 kHz·cm2/ng.
Numerical simulations and laboratory experiments were jointly conducted to investigate a bathtub vortex under the influence of a protruding cylinder in a rotating tank. In the set-up, a central drain hole is placed at the bottom of the tank and a top-down cylinder is suspended from the rigid top lid, with fluid supplied from the sidewall for mass conservation. The cylinder is protruded to produce the Taylor column effect. The flow pattern depends on the Rossby number ($\mathit{Ro}= U/ fR$), the Ekman number ($\mathit{Ek}= \nu / f{R}^{2} )$ and the height ratio, $h/ H$, where $R$ is the radius of the cylinder, $f$ is the Coriolis parameter, $\nu $ is the kinematic viscosity of the fluid, $h$ is the vertical length of the cylinder and $H$ is the height of the tank. It is found appropriate to choose $U$ to be the average inflow velocity of fluid entering the column beneath the cylinder. Steady-state solutions obtained by numerically solving the Navier–Stokes equations in the rotating frame are shown to have a good agreement with flow visualizations and particle tracking velocimetry (PTV) measurements. It is known that at $\mathit{Ro}\sim 1{0}^{- 2} $, the central downward flow surrounded by the neighbouring Ekman pumping forms a classic one-celled bathtub vortex structure when there is no protruding cylinder ($h/ H= 0$). The influence of a suspended cylinder ($h/ H\not = 0$) leads to several findings. The bathtub vortex exhibits an interesting two-celled structure with an inner Ekman pumping (EP) and an outer up-drafting motion, termed Taylor upwelling (TU). The two regions of up-drafting motion are separated by a notable finite-thickness structure, identified as a (thin-walled) Taylor column. The thickness ${ \delta }_{T}^{\ast } $ of the Taylor column is found to be well correlated to the height ratio and the Ekman number by ${\delta }_{T} = { \delta }_{T}^{\ast } / R= {(1- h/ H)}^{- 0. 32} {\mathit{Ek}}^{0. 095} $. The Taylor column presents a barrier to the fluid flow such that the fluid from the inlet may only flow into the inner region through the narrow gaps, one above the Taylor column and one beneath it (conveniently called Ekman gaps). As a result, five types of routes along which the fluid may flow to and exit at the drain hole could be identified for the multi-celled vortex structure. Moreover, the flow rates associated with the five routes were calculated and compared to help understand the relative importance of the component flow structures. The weaker influence of the Taylor column effect on the bathtub vortex at $\mathit{Ro}\sim 1$ or even higher $\mathit{Ro}\sim 1{0}^{2} $ is also discussed.
We report herein the crystal growth of ZnO nanoparticles by the foam fractionation method. In this study, the vertical column height of the foam was fixed and the velocity of the sparging air was varied, and the effect of foam flow rate on the synthesis of ZnO was investigated. The obtained ZnO consisted of aggregated platelets and had differing ultraviolet absorbances. The as-synthesized ZnO was hydrophobic because of the interaction between the anionic head groups of sodium dodecyl sulfate (SDS) and the ZnO under the precipitation conditions. The long chain of the SDS molecule was the cause of hydrophobicity. The contact angle of water was in the range of 95–105° for the obtained ZnO/SDS surface. The photocatalytic degradation efficiency of the as-synthesized (ZnO/SDS) and the calcined ZnO was investigated for methylene blue, and the calcined ZnO retained its activity even after three recycles.
In this study, we consider various contributions to the forces on an impulsively started finite plate from the perspective of a diagnostic vorticity force theory. The wing plate has an aspect ratio (AR) between 1 and 3, and is placed at low and high angles of attack ( and ), while the Reynolds number is either 100 or 300. The theory enables us to quantify the contributions to the forces exerted on the plate in terms of all of the fluid elements with non-zero vorticity, such as in the tip vortices (TiVs), leading- and trailing-edge vortices (LEV and TEV) as well on the plate surface. This line of force analysis has been pursued for two-dimensional flow in our previous studies. In contrast to the pressure force analysis (PFA), the vorticity force analysis (VFA) reveals new salient features in its applications to three-dimensional flow by examining sectional force contributions along the spanwise direction. In particular, at a large aspect ratio (), the force distributions of PFA and VFA show close agreements with each other in the middle sections, while at a lower aspect ratio (), the force distribution of PFA is substantially larger than that of VFA in most of the sections. The difference is compensated for by the contributions partly by the edge sections and mainly by the vortices in the outer regions. Further investigation is made fruitful by decomposing the vorticity into the spanwise (longitudinal) component (the only one in two-dimensional flow) and the other two orthogonal (transverse) components. The relative importance of the force contributions credited to the transverse components in the entire flow regions as well as in the two outer regions signifies the three-dimensional nature of the flow over a finite plate. The interplay between the LEV and the TiVs at various time stages is shown to play a key role in distinguishing the force contributions for the plate with a smaller aspect ratio and that with a larger aspect ratio. The present VFA provides a better perspective for flow control by relating the forces directly to the various sources of vorticity (or vortex structures) on or near the wing plate.
Insects perform their multitude of flight skills at frequencies of tens to hundreds of Hertz, and the aerodynamics of these skills are fundamentally unsteady. Intuitively, unsteadiness may come from unsteady wing motion, unsteady surface vorticity or vorticity being shed into the rear and front wakes. In this study, we propose to investigate the aerodynamics of dragonfly using a simplified wing–wing model from the perspective of many-body force decomposition and the associated force elements. Insect flight usually operates at Reynolds numbers of the order of several hundreds, at which the surface vorticity is shown to play a substantial role. There are important cases where the added mass effect is non-negligible. Nevertheless, the major contribution to the forces comes from the vorticity within the flow. This study focused on the effects of mutual interactions due to phase differences between the fore- and hindwings in the translational as well as rotational motions. It is well known that the dynamic stall vortex is an important mechanism for an unsteady wing to gain lift. In analysing the life cycles of lift and thrust elements, we also associate some high lift and thrust with the mechanisms identified as ‘riding on’ lift elements, ‘driven by’ thrust elements and ‘sucked by’ thrust elements, by which a wing makes use of a shed or fused vortex below, in front of, and behind it, respectively. In addition, a shear layer attaching to each wing may also provide significant thrust elements.
Few studies have been conducted to investigate the influence of recombinant human erythropoietin (rhEPO) on the long-term prognosis of end-stage renal disease (ESRD).
Design
A retrospective cohort study.
Setting
The largest regional hospital renowned for haemodialysis in northern Taiwan.
Subjects
A total of 702 ESRD patients undergoing haemodialysis between 1993 and 2002 were evaluated.
Results
The rate of overall use of rhEPO, vitamin D3 or Fe therapy was 62 %. The 10-year survival rate in patients with rhEPO supplementation was statistically more favourable than that in patients without rhEPO (hazard ratio (HR) = 0·38, 95 % CI 0·30, 0·47, P < 0·0001). Similar findings were noted for patients receiving vitamin D3 (HR = 0·36, 95 % CI 0·21, 0·64, P = 0.0004) and Fe (HR = 0·45, 95 % CI 0·33, 0·61, P < 0·0001). After adjusting for age, education and aetiology, the administration of rhEPO resulted in statistically significant improvements in long-term survival rate either with (HR = 0·30, 95 % CI 0·22, 0·42) or without (HR = 0·48, 95 % CI 0·38, 0·61) combined use of Fe or vitamin D3.
Conclusions
We demonstrated a reduction in long-term mortality related to supplementation therapy with rhEPO, vitamin D3 and Fe. The findings provide a justification for the administration of combined supplement therapy in patients undergoing haemodialysis.
In this study, we revisit two simplified models of hovering motion for fruit fly and dragonfly from the perspective of force decomposition. The unsteady aerodynamics are analysed by examining the lift force and its four constituent components, each of which is directly related to a physical effect. These force components include one from the vorticity within the flow, one from the surface vorticity and two contributions credited to the motion of the insect wing. According to the phase difference in the models, a hovering motion can be classified into one of three types: symmetric, advanced and delayed rotations. The relative importance of the force components under various flow conditions are carefully analysed. It is shown that the symmetric rotation has the maximum vorticity lift (from volume and surface vorticity), but the optimal average lift is attained for an advanced rotation, which, compared to the symmetric rotation, increases the force contribution due to the unsteady surface motion at the expense of sacrificing contribution from the vorticity. By identifying the variations of the vorticity lift with flow characteristics, we may further explore the detailed mechanisms associated with the unsteady aerodynamics at different phases of hovering motion. For the different types of rotation, the insect wing shares the same mechanism of gaining lift when in the phase of driving with a fuller speed but exhibits different mechanisms at turning from one phase of motion to another. Moreover, we also examine the effects of the Reynolds number in an appropriate range and evaluate the performance of different wing profiles from symmetric to largely cambered.
Coordinating and collecting satellite data of changing polar environments is one of the prime activities of International Polar Year (IPY) 2007–08 (Rapley et al. 2004). Within this framework, the requirements to obtain spaceborne snapshots of the Polar Regions and key high latitude processes have been prepared by the international cryospheric community under the auspices of the approved IPY project titled the Global Inter-agency IPY Polar Snapshot Year (GIIPSY). Earlier efforts in manoeuvring Radarsat-1 in a special mode provided radar images with a spatial resolution of 30 m over the entirety of Antarctica during September–October 1997 (Jezek et al. 1998). Limited to their altitude (AL), swath (SW) and pointing capability (PC), however, the operation of optical satellites with high-spatial-resolution sensors is generally restricted to certain latitudes. For example, Landsat (AL:705 km/SW:185 km/PC:0°) mission has been able to provide high-spatial-resolution optical imagery only to ~81°N to ~81°S since the 1980s. The coverage is now extended to ~86° by ASTER (AL:705 km/SW:60 km/PC:24°) (Kargel et al. 2005), but there has been no availability of space-borne optical image of the polar regions with a resolution equivalent or higher than Landsat type sensors with latitudes higher than 86°, until the successful operation of Formosat-2 (AL:891 km/SW:24 km/PC: ± 45° across and along track). Equipped with two-axes high torque reaction wheels, Formosat-2 is able to point not only to ± 45° across track, but also to ± 45° along track (Liu et al. 2007). Figure 1 shows the accessible areas (longer lines: along track ± 0°, across track ± 45°; shorter lines: along track ± 0°, across track ± 30°) and the corresponding ground tracks (solid curves) of Formosat-2 in the Polar Regions. Note that the accessible areas would be even greater if the pointing direction is also set to ± 45° along track. The detailed comparison of Formosat-2 with other similar sensors, including the multi-spectral bands and imaging repeat period, can be found in table I in Liu et al. (2007). To support IPY 2007–08, the National Space Organization (NSPO) of Taiwan launched a Polar Imaging Campaign (PIC) in March 2006. Up to September 2007, a total of 1 131 624 km2 in the North Polar Region and a total of 57 408 km2 in the South Polar Region had been imaged by Formosat-2. All Formosat-2 images taken during the NSPO PIC are available from the authors.
We investigated a cluster of postoperative febrile episodes and episodes of Acinetobacter baumannii bacteremia in obstetrics and gynecology wards after an electrical blackout and loss of the water supply. The use of patient-controlled analgesia was the only independent risk factor associated with postoperative fever, and A. baumannii isolates recovered from the blood of patients who had received patient-controlled analgesia were genetically related to an isolate recovered from the diluted morphine solution used for this procedure. After inappropriate preparation of the morphine solution was identified and stopped, the outbreak ended.
We report two cases of carcinoma in situ in the external auditory canal (EAC), presenting with symptoms such as pain, long-term itching of the ear, easy contact bleeding, canal otorrhea and hearing loss. Otoscopic examination revealed granulation tissue and a greyish-black tumour with irregular surface. The first patient had previously been diagnosed with otitis externa with persistent ear itching for the past three years. The second patient had received tympanoplasty for treatment of chronic otitis media on the right ear ten years ago. The first case was treated with wide excision, whereas the second patient received resection of the skin of the EAC together with its adjacent soft tissue, followed by skin grafting. No tumour recurrence was noted in the fourth and third post-operative year for the first and second patient respectively. We suggest that EAC carcinoma can be detected early and treated.