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The National Institutes of Health (NIH) diversity supplements represent an opportunity to enhance diversity in the biomedical research workforce. Despite their potential impact, practical barriers prevent effective use of these resources. The Altman Clinical and Translational Research Institute (ACTRI) at the University of California San Diego (UCSD) developed and implemented of an institutional repository and support system to improve diversity supplement applications. The centralized repository and support system incorporated three strategies: (1) a secure web-based repository housing successful examples of supplements, (2) match making for diversity supplements and mentors, and (3) web-based resources for potential applicants. The repository was implemented in June 2021 and includes 51 supplement samples across 14 divisions of NIH as of November 2024. The repository has been accessed by 51 potential applicants since implementation in 2021. Few investigators have requested match making. Early indicators show a doubling in diversity supplement applications compared to pre-implementation period at UCSD. We outlined our approach to addressing some of the barriers in diversity supplement applications, which could provide a model for other institutions. Pending solutions to some of the lessons learned, coordinated efforts aimed at diversity supplements could be a practical approach toward a more diverse biomedical research workforce.
Let $(W,S)$ be a Coxeter system, and write $S=\{s_i:i\in I\}$, where I is a finite index set. Fix a nonempty convex subset $\mathscr {L}$ of W. If W is of type A, then $\mathscr {L}$ is the set of linear extensions of a poset, and there are important Bender–Knuth involutions$\mathrm {BK}_i\colon \mathscr {L}\to \mathscr {L}$ indexed by elements of I. For arbitrary W and for each $i\in I$, we introduce an operator $\tau _i\colon W\to W$ (depending on $\mathscr {L}$) that we call a noninvertible Bender–Knuth toggle; this operator restricts to an involution on $\mathscr {L}$ that coincides with $\mathrm {BK}_i$ in type A. Given a Coxeter element $c=s_{i_n}\cdots s_{i_1}$, we consider the operator $\mathrm {Pro}_c=\tau _{i_n}\cdots \tau _{i_1}$. We say W is futuristic if for every nonempty finite convex set $\mathscr {L}$, every Coxeter element c and every $u\in W$, there exists an integer $K\geq 0$ such that $\mathrm {Pro}_c^K(u)\in \mathscr {L}$. We prove that finite Coxeter groups, right-angled Coxeter groups, rank-3 Coxeter groups, affine Coxeter groups of types $\widetilde A$ and $\widetilde C$, and Coxeter groups whose Coxeter graphs are complete are all futuristic. When W is finite, we actually prove that if $s_{i_N}\cdots s_{i_1}$ is a reduced expression for the long element of W, then $\tau _{i_N}\cdots \tau _{i_1}(W)=\mathscr {L}$; this allows us to determine the smallest integer $\mathrm {M}(c)$ such that $\mathrm {Pro}_c^{{\mathrm {M}}(c)}(W)=\mathscr {L}$ for all $\mathscr {L}$. We also exhibit infinitely many non-futuristic Coxeter groups, including all irreducible affine Coxeter groups that are not of type $\widetilde A$, $\widetilde C$, or $\widetilde G_2$.
How can scholars conduct field research when there is limited access to the field? This article first identifies how limited and uncertain field access can affect field research and then provides recommendations to address these challenges. We focus on conducting field research in Japan because of our substantive expertise, but we believe that the problems and solutions outlined in this article are applicable to a broad range of countries. Our hope is that this article contributes to the developing literature on conducting research during times of emergency and to the larger literature on best practices for field research.
To nineteenth and early twentieth-century scholarship, the early modern expansion of powers like Spain, Portugal, England and Holland, was a necessary preliminary step towards Europe's ultimate domination of the Asian and African continents. Moreover, the relative ease with which colonial powers manhandled regions like North Africa and the Indo-Pak subcontinent suggested that their early modern ‘pioneering’ counterparts must have shared similar experiences. While some historians highlighted superior business concepts (joint-stock companies, profit-sharing) or superior shipbuilding and navigation techniques as the means with which trading powers like the Estado da India and the English East India Company penetrated and overwhelmed Indian Ocean commerce, other scholars boiled it down to the European affinity for using ‘men-of-war, gun, and shot’. The critical underlying assumption of any of these teleological explanations s i that ‘encountered’ cultures were unable to adequately respond to European technology, of course hinting at some deeper and more profound deficiency. Scholarship in recent decades has shorn such confidence and begun to scrutinise this seedling period of interaction between Europe and non-Europe, suggesting that the initial playing ground between ‘encounterer’ and ‘encountered’ was perhaps more level than previously portrayed.
We used pollen and high-resolution charcoal analysis of lake sediment to reconstruct a 7600 yr vegetation and fire history from Anthony Lake, located in the Blue Mountains of northeastern Oregon. From 7300 to 6300 cal yr BP, the forest was composed primarily of Populus, and fire was common, indicating warm, dry conditions. From 6300 to 3000 cal yr BP, Populus declined as Pinus and Picea increased in abundance and fire became less frequent, suggesting a shift to cooler, wetter conditions. From 3000 cal yr BP to present, modern-day forests composed of Pinus and Abies developed, and from 1650 cal yr BP to present, fires increased. We utilized the modern climate-analogue approach to explain the potential synoptic climatological processes associated with regional fire. The results indicate that years with high fire occurrence experience positive 500 mb height anomalies centered over the Great Basin, with anomalous southerly component of flow delivering dry air into the region and with associated sinking motions to further suppress precipitation. It is possible that such conditions became more common over the last 1650 cal yr BP, supporting an increase in fire despite the shift to more mesic conditions.
Global climate change poses significant threats to the Caribbean islands. Yet, little is known about the long-term disturbance regimes in island ecosystems. This research investigates 2000 yr of natural and anthropogenic fire disturbance through the analysis of a latitudinal transect of sediment records from coastal salt ponds in the British Virgin Islands (BVI). The two research objectives in this study are (1) to determine the fire regime history for the BVI over the last 2000 yr and (2) to explore ecological impacts from anthropogenic landscape modification pre- and post-European settlement. The magnitude of anthropogenic landscape modification, including the introduction of agriculture, was investigated through a multiproxy approach using sedimentary records of fossil pollen and charcoal. Our results suggest fire regimes from Belmont Pond, Thatch Island, and Skeleton Pond have been influenced by human activity, particularly during the postsettlement era, from 500 cal yr BP to modern. Our results suggest that fire regimes during the Medieval Climate Anomaly were responding to changes in climate via dominant atmospheric drivers. The presettlement fire regimes from these islands suggest that fires occurred every 90 to 120 yr. This research represents a significant data contribution to a region with little disturbance and vegetation data available.
High-resolution charcoal and pollen analyses were used to reconstruct a 12,000-yr-long fire and vegetation history of the Tumalo Lake watershed and to examine the short-term effects that tephra deposition have on forest composition and fire regime. The record suggests that, from 12,000 to 9200 cal yr BP, the watershed was dominated by an open Pinus forest with Artemisia as a common understory species. Fire episodes occurred on average every 115 yr. Beginning around 9200 cal yr BP, and continuing to the present, Abies became more common while Artemisia declined, suggesting the development of a closed forest structure and a decrease in the frequency of fire episodes, occurring on average every 160 yr. High-resolution pollen analyses before and after the emplacement of three distinct tephra deposits in the watershed suggest that nonarboreal species were most affected by tephra events and that recovery of the vegetation community to previous conditions took between 40 and 100 yr. Changes in forest composition were not associated with tephra depositional events or changes in fire-episode frequency, implying that the regional climate is the more important control on long-term forest composition and structure of the vegetation in the Cascade Range.
As noted by Rudi Matthee in his 2010 article ‘Was Safavid Iran an Empire?’, there is a conspicuous absence of comparative studies of early modern empires and political systems across Europe and Asia that engage the Safavid dynasty of Iran (r. 1501–1722). However, what is particularly lacking within the field of Safavid studies is a conversation which addresses the thematic concerns that are currently shaping the study of the Mamluk, Ottoman and Mughal states. Marshall Hodgson, in his seminal study The Venture of Islam, argued that the model of military patronage state best represented the political reality of the post-Mongol Islamic world. Indeed, this notion of military patronage state (MPS) served as the underpinning for the historiographical leviathan of the ‘gunpowder empire’ paradigm. Keen to nuance Hodgson's ideas for a Mamluk setting, Van Steenbergen argues that the model of the MPS does not accept the notion of a unitary state which exists independently of its surrounding constituencies, elite or otherwise. Rather, politics is not conducted on the basis of static institutions, but rather through constituency membership and the act of patronage. Farhat Hasan argued similarly against overly structuralist approaches when examining the political landscape of Mughal India, and he explicitly rejected Stephen Blake's Weberian ‘patrimonial-bureaucratic’ model in favour of a methodology which understood state power in a much more reflexive and fluid manner. In recent years, there have been lively debates regarding how we can look to seemingly quotidian institutions – chanceries, judiciaries, bureaucracies – to understand better the exercise and articulation of power in pre-modern settings. This chapter contributes to these debates by examining the secretarial culture of the seventeenth-century Safavid Empire, in particular the changing roles and fortunes of the ‘state-secretary’ (munshi al-mamalik).
Admittedly, Safavid historians face a number of issues which prevent the ready acceptance of such military or household-specific models, which seem to thrive in Mamluk historiography and other contexts. First and foremost, the Safavid ‘royal’ dynasts came into existence as the spiritual leaders of a militarised millenarian Sufi Order.
The United Kingdom is a leader in genomics research, and the presence of numerous types of biobanks and the linking of health data and research within the UK evidences the importance of biobank-based research in the UK. There is no biobank-specific law in the UK and research on biobank materials is governed by a confusing set of statutory law, common law, regulations, and guidance documents. Several layers of applicable law, from European to local, further complicate an understanding of privacy protections. Finally, biobanks frequently contain data in addition to the samples; the legal framework in the UK generally differentiates between data and samples and the form of the data affects the applicability of legal provisions. Biobanks must be licensed by the Human Tissue Authority; certain projects must be reviewed by Research Ethics Committees, and all projects are encouraged to be reviewed by them. Data Access Committees in biobanks are also common in the UK. While this confusing array of legal provisions leaves privacy protections in biobanking somewhat unclear, changes at the EU level may contribute to harmonization of approaches to privacy.
We present the results of an approximately 6 100 deg2 104–196 MHz radio sky survey performed with the Murchison Widefield Array during instrument commissioning between 2012 September and 2012 December: the MWACS. The data were taken as meridian drift scans with two different 32-antenna sub-arrays that were available during the commissioning period. The survey covers approximately 20.5 h < RA < 8.5 h, − 58° < Dec < −14°over three frequency bands centred on 119, 150 and 180 MHz, with image resolutions of 6–3 arcmin. The catalogue has 3 arcmin angular resolution and a typical noise level of 40 mJy beam− 1, with reduced sensitivity near the field boundaries and bright sources. We describe the data reduction strategy, based upon mosaicked snapshots, flux density calibration, and source-finding method. We present a catalogue of flux density and spectral index measurements for 14 110 sources, extracted from the mosaic, 1 247 of which are sub-components of complexes of sources.
Significant new opportunities for astrophysics and cosmology have been identified at low radio frequencies. The Murchison Widefield Array is the first telescope in the southern hemisphere designed specifically to explore the low-frequency astronomical sky between 80 and 300 MHz with arcminute angular resolution and high survey efficiency. The telescope will enable new advances along four key science themes, including searching for redshifted 21-cm emission from the EoR in the early Universe; Galactic and extragalactic all-sky southern hemisphere surveys; time-domain astrophysics; and solar, heliospheric, and ionospheric science and space weather. The Murchison Widefield Array is located in Western Australia at the site of the planned Square Kilometre Array (SKA) low-band telescope and is the only low-frequency SKA precursor facility. In this paper, we review the performance properties of the Murchison Widefield Array and describe its primary scientific objectives.