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Reliable population estimates are one of the most elementary needs for the management of wildlife, particularly for introduced ungulates on oceanic islands. We aimed to produce accurate and precise density estimates of Philippine deer (Rusa marianna) and wild pigs (Sus scrofa) on Guam using motion-triggered cameras combined with distance sampling to estimate densities from observations of unmarked animals while accounting for imperfect detection. We used an automated digital data processing pipeline for species recognition and to estimate the distance to detected species. Our density estimates were slightly lower than published estimates, consistent with management to reduce populations. We estimated the number of camera traps needed to obtain a 0.1 coefficient of variation was substantial, requiring > ten-fold increase in camera traps, while estimates with precision of 0.2 or 0.3 were more achievable, requiring doubling to quadrupling the number of camera traps. We provide best practices for establishing and conducting distance sampling with camera trap surveys for density estimation based on lessons learned during this study. Future studies should consider distance sampling with camera traps to efficiently survey and monitor unmarked animals, particularly medium-sized ungulates, in tropical, oceanic island ecosystems.
Understanding how well critical source areas of water or sediment are connected to receiving surface waters, is an essential step towards improvement of land management. For this, it is important to quantify connectivity beyond the conceptual and proportional evaluation that most studies use connectivity for. Most studies measure only the potential of a landscape to allow connectivity to occur; or the connectivity that occurs at a given moment. This fact shows the two opportunities that will make it possible to monitor connectivity: assess the potential connectivity and the water and sediment fluxes through those landscapes. These components finally may result in the desired knowledge on the connectivity of the research area. In this chapter, we identify three spatial levels of connectivity: soil, hillslopes and catchments. In addition, to be able to measure and monitor connectivity the stocks and flow within every spatial level is introduced to allow for the identification of available techniques to actually assess connectivity at the given scale. The chapter ends with a set of key questions that need answering to make measuring connectivity on different scales reliable and useful.
To evaluate the impact of a mobile-app-based central line-associated bloodstream infection (CLABSI) prevention program in oncology clinic patients with peripherally inserted central catheters (PICCs).
Design:
Pre-post prospective cohort study with baseline (July 2015–December 2016), phase-in (January 2017–April 2017), and intervention (May 2017–November 2018). Generalized linear mixed models compared intervention with baseline frequency of localized inflammation/infection and dressing peeling. Cox proportional hazards models compared days-to-removal of lines with localized inflammation/infection. Chi-square test compared bacteremia rates before and after intervention.
Setting:
Oncology clinic at a large medical center.
Patients:
Oncology clinic adult patients with PICCs.
Intervention:
CLABSI prevention program consisting of an actionable scoring system for identifying insertion site infection/inflammation coupled with a mobile-app enabling photo-assessments and automated physician alerting for remote response.
Results:
We completed 5,343 assessments of 569 PICCs in 401 patients (baseline: 2,924 assessments, 300 PICCs, 216 patients; intervention: 2,419 assessments, 269 PICCs, 185 patients). The intervention was associated with a 92% lower likelihood of having a dressing with peeling (OR 0.08, 95%CI 0.04-0.17, P < 0.001), 53% lower local inflammation/infection (OR 0.47, 95%CI 0.27-0.84, P < 0.011), and 24% (non-significant) lower CLABSI rates (P = .63). Physician mobile-app alerting and response enabled 80% lower risk of lines remaining in place after inflammation/infection was identified (HR 0.20, 95%CI:0.14-0.30, P < 0.001) and 85% faster removal of infected lines from mean (SD) 11.1 (9.7) to 1.7 (2.4) days.
Conclusions:
A mobile-app-based CLABSI prevention program decreased frequency of inflamed/infected central line insertion sites and increased speed of removal when inflammation/infection was found.
Glacier ice flux is a key indicator of mass balance; therefore, accurate monitoring of ice dynamics is essential. Satellite-based methods are widely used for glacier velocity measurements but are limited by satellite revisit frequency. This study explores using seismic station internal GPS data to track glacier movement. While less accurate than differential GPS, this method offers high-temporal resolution as a by-product where seismic stations are deployed. Using a seismic station on Borebreen, Svalbard, we show that internal GPS provides reliable surface velocity measurements. When compared with satellite-inferred velocities, the results show a strong correlation, suggesting that the internal GPS, despite its inherent uncertainty, can serve as an efficient tool for glacier velocity monitoring. The high-temporal sampling reveals short-term dynamics of speed-up events and underscores the role of meltwater in driving these processes. This approach augments glacier observation networks at no additional cost.
This article investigates the use of standard econometric models for quantal choice to study equilibria of extensive form games. Players make choices based on a quantal-choice model and assume other players do so as well. We define an agent quantal response equilibrium (AQRE), which applies QRE to the agent normal form of an extensive form game and imposes a statistical version of sequential rationality. We also define a parametric specification, called logit-AQRE, in which quantal-choice probabilities are given by logit response functions. AQRE makes predictions that contradict the invariance principle in systematic ways. We show that these predictions match up with some experimental findings by Schotter et al. (1994) about the play of games that differ only with respect to inessential transformations of the extensive form. The logit-AQRE also implies a unique selection from the set of sequential equilibria in generic extensive form games. We examine data from signaling game experiments by Banks et al. (1994) and Brandts and Holt(1993). We find that the logit-AQRE selection applied to these games succeeds in predicting patterns of behavior observed in these experiments, even when our prediction conflicts with more standard equilibrium refinements, such as the intuitive criterion. We also reexamine data from the McKelvey and Palfrey (1992) centipede experiment and find that the AQRE model can account for behavior that had previously been explained in terms of altruistic behavior.
We investigate, in an experimental setting, the effect of private information on the Coase theorem's predictions of efficiency and allocative neutrality. For a two-person bargaining game, we find significantly more inefficiency and allocative bias in the case of private information compared with the case of complete information. We also find substantial bargaining breakdown, which is not predicted by the Coase theorem. For the case of private information, we reject the Coase theorem in favor of the alternative of a generalized version of the Myerson- Satterthwaite theorem, which predicts inefficiency, allocative bias in the direction of the disagreement point, and some bargaining breakdown.
Children with CHD are at increased risk for neurodevelopmental disabilities and neuropsychological impairments throughout their life span. The purpose of this report is to share our experience building a sustainable, novel, inpatient, interdisciplinary Neurocardiac Critical Care Program to mitigate risks and optimize outcomes during the ICU stay.
Material and methods:
A descriptive review was chosen to identify meaningful characteristics, challenges and lessons learned related to the establishment, expansion of and sustainability of Neurocardiac Critical Care Program in a 26-bed pediatric cardiac ICU.
Results:
We successfully launched, expanded, and sustained an interdisciplinary Neurocardiac Critical Care Program. Here, we share the foundation, framework, challenges, and lessons learned as we established and sustained the Neurocardiac Critical Care Program. The key elements of our program are (1) consistent engagement by pediatric neurologists in the cardiac ICU, (2) comprehensive education initiatives, (3) evidence-based clinical practice changes, and (4) quality improvement and research projects.
Discussion:
The development of a pediatric Neurocardiac Critical Care Program is feasible and sustainable. This program was informed by recent research related to perioperative and psychosocial risk factors that impact brain development and neurodevelopmental outcomes in this vulnerable population. By aligning our efforts, our multidisciplinary team is helping shift the paradigm in pediatric cardiac critical care to actively manage complex heart disease, while simultaneously and proactively mitigating risks to the developing brain and family unit.
Converting knowledge from basic research into innovations that improve clinical care requires a specialized workforce that converts a laboratory invention into a product that can be developed and tested for clinical use. As the mandate to demonstrate more real-world impact from the national investment in research continues to grow, the demand for staff that specialize in product development and clinical trials continues to outpace supply. In this study, two academic medical institutions in the greater Houston–Galveston region termed this population the “bridge and clinical research professional” (B + CRP) workforce and assessed its turnover before and after the onset of the COVID-19 pandemic . Both institutions realized growth (1.2 vs 2.3-fold increase) in B + CRP-specific jobs from 2017 to 2022. Turnover increased 1.5–2-fold after the onset of the pandemic but unlike turnover in the larger clinical and translational research academic workforce, the instability did not resolve by 2022. These results are a baseline measurement of the instability of our regional B + CRP workforce and have informed the development of a regional alliance of universities, academic medical centers, and economic development organizations in the greater Houston–Galveston region to increase this highly specialized and skilled candidate pool.
This chapter gives an overview of data-driven methods applied to turbulence closure modeling for coarse graining. A non-exhaustive introduction of the various data-driven approaches that have been used in the context of closure modeling is provided which includes a discussion of model consistency, which is the ultimate indicator of a successful model, and other key concepts. More details are then presented for two specific methods, one a neural-network representative of nontransparent black-box approaches and one specific type of evolutionary algorithm representative of transparent approaches yielding explicit mathematical expressions. The importance of satisfying physical constraints is emphasized and methods to choose the most relevant input features are suggested. Several recent applications of data-driven methods to subgrid closure modeling are discussed, both for nonreactive and reactive flow configurations. The chapter is concluded with current trends and an assessment of what can be realistically expected of data-driven methods for coarse graining.
Bathing intensive care unit (ICU) patients with chlorhexidine gluconate (CHG) decreases healthcare-associated infections (HAIs). The optimal method of CHG bathing remains undefined.
Methods:
Prospective crossover study comparing CHG daily bathing with 2% CHG-impregnated cloths versus 4% CHG solution. In phase 1, from January 2020 through March 2020, 1 ICU utilized 2% cloths, while the other ICU utilized 4% solution. After an interruption caused by the coronavirus disease 2019 pandemic, in phase 2, from July 2020 through September 2020, the unit CHG bathing assignments were reversed. Swabs were performed 3 times weekly from patients’ arms and legs to measure skin microbial colonization and CHG concentration. Other outcomes included HAIs, adverse reactions, and skin tolerability.
Results:
411 assessments occurred after baths with 2% cloth, and 425 assessments occurred after baths with 4% solution. Average microbial colonization was 691 (interquartile range 0, 30) colony-forming units per square centimeter (CFU/cm2) for patients bathed with 2% cloths, 1,627 (0, 265) CFUs/cm2 for 4% solution, and 8,519 (10, 1130) CFUs/cm2 for patients who did not have a CHG bath (P < .001). Average CHG skin concentration (parts per million) was 1300.4 (100, 2000) for 2% cloths, 307.2 (30, 200) for 4% solution, and 32.8 (0, 20) for patients without a recorded CHG bath. Both CHG bathing methods were well tolerated. Although underpowered, no difference in HAI was noted between groups.
Conclusions:
Either CHG bathing method resulted in a significant decrease in microbial skin colonization with a greater CHG concentration and fewer organisms associated with 2% CHG cloths.
Focusing on practical application, this textbook provides clear and concise explanations of statistical tests and techniques that students can apply in real-world situations. It has a dual emphasis: firstly, on doing statistics, and secondly, on understanding statistics, to do away with the mindset that statistics is difficult. Procedural explanations are provided so students know how to apply particular statistical tests and techniques in practical research situations. Conceptual understanding is encouraged to ensure students know not only when and how to apply appropriate techniques, but also why they are using them. Ancillary resources are available including sample answers to exercises, PowerPoint teaching slides, instructor manual, and a test bank. Illustrative figures, real-world data, practice exercises, and software instruction make this an essential resource for mastering statistics for undergraduate and graduate students in the social and behavioral sciences.
Psychologists and other behavioral scientists are frequently interested in whether a questionnaire measures a latent construct. Attempts to address this issue are referred to as construct validation. We describe and extend nonparametric hypothesis testing procedures to assess matrix structures, which can be used for construct validation. These methods are based on a quadratic assignment framework and can be used either by themselves or to check the robustness of other methods. We investigate the performance of these matrix structure tests through simulations and demonstrate their use by analyzing a big five personality traits questionnaire administered as part of the Health and Retirement Study. We also derive rates of convergence for our overall test to better understand its behavior.
We present a cognitive process model of response choice and response time performance data that has excellent psychometric properties and may be used in a wide variety of contexts. In the model there is an accumulator associated with each response option. These accumulators have bounds, and the first accumulator to reach its bound determines the response time and response choice. The times at which accumulator reaches its bound is assumed to be lognormally distributed, hence the model is race or minima process among lognormal variables. A key property of the model is that it is relatively straightforward to place a wide variety of models on the logarithm of these finishing times including linear models, structural equation models, autoregressive models, growth-curve models, etc. Consequently, the model has excellent statistical and psychometric properties and can be used in a wide range of contexts, from laboratory experiments to high-stakes testing, to assess performance. We provide a Bayesian hierarchical analysis of the model, and illustrate its flexibility with an application in testing and one in lexical decision making, a reading skill.
The subject of factor indeterminacy has a vast history in factor analysis (Guttman, 1955; Lederman, 1938; Wilson, 1928). It has lead to strong differences in opinion (Steiger, 1979). The current paper gives necessary and sufficient conditions for observability of factors in terms of the parameter matrices and a finite number of variables. Five conditions are given which rigorously define indeterminacy. It is shown that (un)observable factors are (in)determinate. Specifically, the indeterminacy proof by Guttman is extended to Heywood cases. The results are illustrated by two examples and implications for indeterminacy are discussed.
Human abilities in perceptual domains have conventionally been described with reference to a threshold that may be defined as the maximum amount of stimulation which leads to baseline performance. Traditional psychometric links, such as the probit, logit, and t, are incompatible with a threshold as there are no true scores corresponding to baseline performance. We introduce a truncated probit link for modeling thresholds and develop a two-parameter IRT model based on this link. The model is Bayesian and analysis is performed with MCMC sampling. Through simulation, we show that the model provides for accurate measurement of performance with thresholds. The model is applied to a digit-classification experiment in which digits are briefly flashed and then subsequently masked. Using parameter estimates from the model, individuals’ thresholds for flashed-digit discrimination is estimated.
The majority of studies of mental health interventions for young adolescents have only evaluated short-term benefits. This study evaluated the longer-term effectiveness of a non-specialist delivered group-based intervention (Early Adolescent Skills for Emotions; EASE) to improve young adolescents’ mental health.
Methods
In this single-blind, parallel, controlled trial, Syrian refugees aged 10-14 years in Jordan who screened positive for psychological distress were randomised to receive either EASE or enhanced usual care (EUC). Primary outcomes were scores on the Paediatric Symptom Checklist (PSC) assessed at Week 0, 8-weeks, 3-months, and 12 months after treatment. Secondary outcomes were disability, posttraumatic stress, school belongingness, wellbeing, and caregivers’ reports of distress, parenting behaviour, and their perceived children’s mental health.
Results
Between June, 2019 and January, 2020, 185 adolescents were assigned to EASE and 286 to EUC, and 149 (80.5%) and 225 (78.7%) were retained at 12 months, respectively. At 12 months there were no significant differences between treatment conditions, except that EASE was associated with less reduction in depression (estimated mean difference -1.6, 95% CI –3.2 to -0.1; p=.03; effect size, -0.3), and a greater sense of school belonging (estimated mean difference -0.3, 95% CI –5.7 to -0.2; p=.03; effect size, 5.0).
Conclusions
Although EASE led to significant reductions in internalising problems, caregiver distress, and harsh disciplinary parenting at 3-months, these improvements were not maintained at 12 months relative to EUC. Scalable psychological interventions for young adolescents need to consider their ongoing mental health needs. Prospectively registered: ACTRN12619000341123.
Experiments in engineering are typically conducted in controlled environments where parameters can be set to any desired value. This assumes that the same applies in a real-world setting, which is often incorrect as many experiments are influenced by uncontrollable environmental conditions such as temperature, humidity, and wind speed. When optimizing such experiments, the focus should be on finding optimal values conditionally on these uncontrollable variables. This article extends Bayesian optimization to the optimization of systems in changing environments that include controllable and uncontrollable parameters. The extension fits a global surrogate model over all controllable and environmental variables but optimizes only the controllable parameters conditional on measurements of the uncontrollable variables. The method is validated on two synthetic test functions, and the effects of the noise level, the number of environmental parameters, the parameter fluctuation, the variability of the uncontrollable parameters, and the effective domain size are investigated. ENVBO, the proposed algorithm from this investigation, is applied to a wind farm simulator with eight controllable and one environmental parameter. ENVBO finds solutions for the entire domain of the environmental variable that outperform results from optimization algorithms that only focus on a fixed environmental value in all but one case while using a fraction of their evaluation budget. This makes the proposed approach very sample-efficient and cost-effective. An off-the-shelf open-source version of ENVBO is available via the NUBO Python package.
Today, there are an increasing number of procedures requiring moderate and deep sedation being performed outside the surgical suite. As a result, qualified non-anesthesia providers are administering varying levels of sedation to patients for a variety of diagnostic, therapeutic, and/or surgical procedures. Practitioners should provide patients with the benefits of sedation and/or analgesia while minimizing the associated risks. To do so, providers should understand the pharmacology of the agents being administered as well as the role of pharmacologic antagonists for opioids and benzodiazepines. Today’s practitioners are equipped with an abundance of versatile sedative agents that can be used alone and in combination. Furthermore, combinations of sedative and analgesics should be administered as appropriate for the procedure being performed and the condition of the patient. Policies and standards regarding administration of sedation and analgesia by non-anesthesia providers are addressed elsewhere in the book. This chapter focuses on the pharmacology of the drugs most used to provide moderate and deep sedation and their available reversal agents.