Dietary n-3 PUFA may have potential benefits in preventing peptic ulcer disease (PUD). However, data from observational epidemiological studies are limited. Thus, we conducted a Mendelian randomisation analysis to reveal the causal impact of n-3 PUFA on PUD. Genetic variants strongly associated with plasma levels of total or individual n-3 PUFA including plant-derived α-linolenic acid and marine-derived EPA, DPA and DHA were enrolled as instrumental variables. Effect size estimates of the n-3 PUFA-associated genetic variants with PUD were evaluated using data from the UK biobank. Per one sd increase in the level of total n-3 PUFA in plasma was significantly associated with a lower risk of PUD (OR = 0·91; 95 % CI 0·85, 0·99; P = 0·020). The OR were 0·81 (95 % CI 0·67, 0·97) for EPA, 0·72 (95 % CI 0·58, 0·91) for DPA and 0·87 (95 % CI 0·80, 0·94) for DHA. Genetically predicted α-linolenic acid levels in plasma had no significant association with the risk of PUD (OR = 5·41; 95 % CI 0·70, 41·7). Genetically predicted plasma levels of n-3 PUFA were inversely associated with the risk of PUD, especially marine-based n-3 PUFA. Such findings may have offered an effective and feasible strategy for the primary prevention of PUD.

In this paper, we study the Dirichlet problem of Hessian quotient equations of the form $S_k(D^2u)/S_l(D^2u)=g(x)$ in exterior domains. For $g\equiv \mbox {const.}$, we obtain the necessary and sufficient conditions on the existence of radially symmetric solutions. For g being a perturbation of a generalized symmetric function at infinity, we obtain the existence of viscosity solutions by Perron’s method. The key technique we develop is the construction of sub- and supersolutions to deal with the non-constant right-hand side g.

This study is designed to explore the association between dietary betaine intake and risk of all-cause and cardiovascular death in patients with coronary artery diseases (CAD). In this cohort study, 1292 patients with CAD were followed up for a median of 9·2 years. Baseline dietary betaine intake was collected using a paper-based semi-quantitative FFQ and assessed according to the US Department of Agriculture (USDA) database and the data of betaine in common foods. Cox proportional hazards regression models were used to analyse the association between dietary betaine intake and risks of all-cause and cardiovascular mortality. During the follow-up periods, 259 deaths recorded in 1292 participants, of which 167 died of CVD. Patients in the highest tertile of dietary betaine intake had a lower risk of all-cause (P = 0·007) and cardiovascular death (P < 0·001) than those in the lowest tertile after adjusting for age and sex, traditional cardiovascular risk factors and other potential confounders. After further adjusting for plasma methionine metabolites and vitamins, hazard ratio across tertiles of dietary betaine intake were 1·00, 0·84 and 0·72 for all-cause mortality (P for trend = 0·124), and 1·00, 0·77 and 0·55 for cardiovascular mortality (P for trend = 0·021). Higher dietary betaine intake was associated with a decreased risk of cardiovascular death after fully adjustment for cardiovascular risk factors, other potential confounders and plasma methionine metabolites and vitamins. However, the association between dietary betaine intake and risk of all-cause mortality was not statistically significant after further adjusting for plasma methionine metabolites and vitamins.

Spatial profiles of impurity emission measurements in the extreme ultraviolet (EUV) spectroscopic range in radiofrequency (RF)-heated discharges are combined with one-dimensional and three-dimensional transport simulations to study the effects of resonant magnetic perturbations (RMPs) on core impurity accumulation at EAST. The amount of impurity line emission mitigation by RMPs appears to be correlated with the ion Z for lithium, carbon, iron and tungsten monitored, i.e. stronger suppression of accumulation for heavier ions. The targeted effect on the most detrimental high-Z impurities suggests a possible advantage using RMPs for impurity control. Profiles of transport coefficients are calculated with the STRAHL one-dimensional impurity transport code, keeping $\nu /D$ fixed and using the measured spatial profiles of $\textrm{F}{\textrm{e}^{20 + }}$, $\textrm{F}{\textrm{e}^{21 + }}$ and $\textrm{F}{\textrm{e}^{22 + }}$ to disentangle the transport coefficients. The iron diffusion coefficient ${D_{\textrm{Fe}}}$ increases from $1.0- 2.0\;{\textrm{m}^2}\;{\textrm{s}^{ - 1}}$ to $1.5- 3.0\;{\textrm{m}^2}\;{\textrm{s}^{ - 1}}$ from the core region to the edge region $(\rho \gt 0.5)$ after the onset of RMPs. Meanwhile, an inward pinch of iron convective velocity ${\nu _{\textrm{Fe}}}$ decreases in magnitude in the inner core region and increases significantly in the outer confined region, simultaneously contributing to preserving centrally peaked $\textrm{Fe}$ profiles and exhausting the impurities. The ${D_{\textrm{Fe}}}$ and ${\nu _{\textrm{Fe}}}$ variations lead to reduced impurity contents in the plasma. The three-dimensional edge impurity transport code EMC3-EIRENE was also applied for a case of RMP-mitigated high-Z accumulation at EAST and compared to that of low-Z carbon. The exhaust of ${\textrm{C}^{6 + }}$ toward the scrape-off layer accompanying an overall suppression of heavier ${\textrm{W}^{30 + }}$ is observed when using RMPs.

Accurate disparity prediction is a hot spot in computer vision, and how to efficiently exploit contextual information is the key to improve the performance. In this paper, we propose a simple yet effective non-local context attention network to exploit the global context information by using attention mechanisms and semantic information for stereo matching. First, we develop a 2D geometry feature learning module to get a more discriminative representation by taking advantage of multi-scale features and form them into the variance-based cost volume. Then, we construct a non-local attention matching module by using the non-local block and hierarchical 3D convolutions, which can effectively regularize the cost volume and capture the global contextual information. Finally, we adopt a geometry refinement module to refine the disparity map to further improve the performance. Moreover, we add the warping loss function to help the model learn the matching rule of the non-occluded region. Our experiments show that (1) our approach achieves competitive results on KITTI and SceneFlow datasets in the end-point error and the fraction of erroneous pixels $({D_1})$; (2) our proposed method particularly has superior performance in the reflective regions and occluded areas.

In inertial confinement fusion experiments that involve short-laser pulses such as fast ignition (FI), diagnosis of neutrons is usually very challenging because high-intensity γ rays generated by short-laser pulses would mask the much weaker neutron signal. In this paper, fast-response scintillators with low afterglow and gated microchannel plate photomultiplier tubes are combined to build neutron time-of-flight (nTOF) spectrometers for such experiments. Direct-drive implosion experiments of deuterium-gas-filled capsules were performed at the Shenguang-II Upgrade (SG-II-UP) laser facility to study the compressed fuel areal density (〈ρR〉) and evaluate the performance of such nTOF diagnostics. Two newly developed quenched liquid scintillator detectors and a gated ultrafast plastic scintillator detector were used to measure the secondary DT neutrons and primary DD neutrons, respectively. The secondary neutron signals were clearly discriminated from the γ rays from (n, γ) reactions, and the compressed fuel areal density obtained with the yield-ratio method agrees well with the simulations. Additionally, a small scintillator decay tail and a clear DD neutron signal were observed in an integrated FI experiment as a result of the low afterglow of the oxygen-quenched liquid scintillator.

A detailed history of volcanism covering the last 2840 years is reconstructed from the top 100.42 m of a 109.91 m ice core from Dome A (DA2005 ice core), East Antarctica. Using two known volcanic stratigraphic markers, the mean accumulation rate during the period AD 1260-1964 is found to be 23.2 mmw.e. a-1, consistent with the previously reported accumulation rate at Dome A. This mean accumulation rate is used to date the entire core. Volcanic eruptions in the period 840 BC-AD1998 are detected as outstanding sulphate events. Seventy-eight eruptions are identified, with a mean of 2.7 eruptions per century. Comparisons with previous Antarctic ice-core volcanic records are made to assess the quality of this new DA2005 record. In terms of dates for volcanic events, the DA2005 record is in good agreement with previous records in the second millennium ad (ad 1000-1998). A series of volcanic signatures found in both the DA2005 record and several other Antarctic ice-core records in the first millennium ad (ad 1-1000) appear to validate the DA2005 record during this time period. For the older periods, direct comparisons are difficult between the DA2005 record and other Antarctic ice-core records due to the lack of well-dated stratigraphic horizons.

A novel dual-band planar antenna with a low profile for mobile communication system is proposed in this paper. The antenna is composed of one shorted patch with two radiating notches for low frequency resonance and one square patch for high frequency resonance. The low profile is achieved via the shorting patch, which introduces the parallel electrical field between the reflector and antenna. A step-impedance microstrip line is used to feed the antenna. The coupling between the square patch and microstrip line cancels out the inductance of shorting probe, which increases the working bandwidth of proposed antenna. A prototype with a low profile of 0.0286λ is fabricated and measured. The antenna achieves dual impedance bandwidths of 1.6% for the low frequency band and 60% for the high frequency band, covering the frequency range 851–865 MHz and 1.97–3.65 GHz, respectively. The measured results show good agreements with the simulated ones.

Based on the finite-differences approach, we study the electronic properties of two-dimensional electron gas under an inhomogeneous magnetic field. Such structure can be realized by deposition of ferromagnetic strips on the surface of a semiconductor heterostructure. It is found that the system exhibits rich band structures. Many bound states are twofold degenerate for θ = π/2, which defines the magnetization direction in the ferromagnetic strips, while few degenerate state exist for θ = 0. Despite of this, there are three kinds of electronic states in our system: the extended, localized and intermediate ones, which is very different from the case of absence of magnetic field.

The critically endangered Sichuan Hill-partridge Arborophila rufipectus occupies a restricted range in south-central China. Field surveys within this range were undertaken using line transects in 1996 and 1997. Calling males were recorded from nine subtropical forest tracts within an area totalling 1,793 km2 and consisting of primary, natural secondary and replanted broadleaf forest between 1,100 and 2,235 m elevation. The only sightings obtained were in primary forest. The mean density of calling males estimated from data collected during transect surveys was 0.48 ± 0.06 and 0.24 ± 0.16 calling birds km−2 in 1996 and 1997 respectively. There was no difference in density estimates for calling males between primary forest and secondary/replanted broadleaf forest. The principal threat to the continued survival of the species is clear-felling of primary forest, but clear-felled areas are often replanted with native broadleaf trees and records of Sichuan Hill-partridge calls in such plantations offers hope for its future survival. Forest management should be modified to make forestry practices more sympathetic to the conservation of the Sichuan Hill-partridge.

A number of former forest farms in southern Sichuan province, south-west China have been designated as protected areas following the 1998 logging ban in the upper Yangtze basin. These are within the range of the endemic Sichuan Partridge Arborophila rufipectus which has a fragmented distribution in the remnant broadleaf forests of this region, and is currently listed as ‘Endangered’ by IUCN. The design of a robust conservation plan for this species has been hampered by a lack of knowledge about its habitat preferences in a heavily modified environment. To remedy this, ranging behaviour and habitat utilization by this species was studied through a combination of a call count method and radio tracking of individual birds. The results indicate that A. rufipectus significantly prefers primary and older planted secondary broadleaf forest compared to forest degraded by human activity or scrub. Individual birds were found on the upper parts of slopes and made particular use of areas with a dense canopy and open understorey, whilst avoiding the lower slopes and areas close to trails where human disturbance is likely to be greater. The ongoing conservation programme for this partridge species is based on these findings and includes further protected area designations and management plans, the establishment of new forest corridors, and better control of hunting and other forms of forest exploitation.

The present study was designed to evaluate the feasibility of producing pig transgenic blastocysts expressing enhanced green fluorescent protein (GFP) and to examine the effects of shape and preparation methods of donor cells on in vitro developmental ability of pig nuclear transferred embryos (NTEs). In experiment 1, the effect of GFP transfection on development of pig NTEs was evaluated. The cleavage and blastocyst rates showed no significant difference between NTEs derived from transfected and non-transfected donors. In experiment 2, the effect of different nuclear donor preparation methods on in vitro development of NTEs was examined. The cleavage rate showed no statistically significant differences among three preparation methods. The blastocyst rates of donor cells treated once at −4 °C and those of freshly digested cells were similar to each other (26.3% vs 17.9%). The lowest blastocyst rates (5.88%) were observed when cells cryopreserved at −196 °C were used as donors. In experiment 3, the effect of different cell cycle synchronization methods on the in vitro development potential of pig NTEs was evaluated. The cleavage rate of NTEs derived from cycling cells was much better than that of NTEs derived from serum-starved cells (64.4% vs 50.5%, p < 0.05), but no significant difference was observed between the the blastocyst rates of the two groups. In experiment 4, the effect of different shapes of cultured fibroblast cells on the in vitro development of pig NTEs was examined. The fusion rate for couplets derived from rough cells was poorer than that observed in couplets derived from round smooth cells (47.8% vs 76.8%, p < 0.05). However, there were no significant differences observed in the cleavage rate and blastocyst rate. In conclusion, the present study indicated that (i) refrigerated pig GFP-transfected cells could be used as donors in nuclear transfer and these NTEs could be effectively developed to blastocyst stage; (ii) serum starvation of GFP-transfected cells is not required for preimplantation development of pig NTEs; and (iii) a rough surface of GFP-transfected donor cells affects fusion rate negatively but has no influence on the cleavage rate or blastocyst rate of pig NTEs.

This paper has been retracted by Dai Mei-Xue