Greenland's marine- and land-terminating glaciers are retreating inland due to climate warming, reconfiguring the way the ice sheet interacts with its proglacial environment. Here we use three decades of satellite imagery to determine whether the ice-sheet margin is becoming more or less exposed to marine and lacustrine processes. During our 1990–2019 study period, we find that the length of ice-sheet perimeter in contact with the ocean shrank by 12.3 ± 3.8% (196.2 ± 10.4 km), due to the retreat of marine-terminating glaciers into narrower fjords. On the other hand, we find that the length of the ice-sheet perimeter in contact with freshwater lakes exhibited more divergent trends that is better explored at regional scales. The length of ice–lake boundaries increased in southwest, north and northwest Greenland but declined in southeast and central east Greenland. The magnitude of change we document during our study period leads us to conclude that the ice sheet is poised for further, substantial reconfiguration in the coming decades with consequences for the flux of fresh water, nutrients and primary productivity in Greenland's terrestrial and oceanic environment.

The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery (WCPCCS) will be held in Washington DC, USA, from Saturday, 26 August, 2023 to Friday, 1 September, 2023, inclusive. The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery will be the largest and most comprehensive scientific meeting dedicated to paediatric and congenital cardiac care ever held. At the time of the writing of this manuscript, The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery has 5,037 registered attendees (and rising) from 117 countries, a truly diverse and international faculty of over 925 individuals from 89 countries, over 2,000 individual abstracts and poster presenters from 101 countries, and a Best Abstract Competition featuring 153 oral abstracts from 34 countries. For information about the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery, please visit the following website: [www.WCPCCS2023.org]. The purpose of this manuscript is to review the activities related to global health and advocacy that will occur at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery.

Acknowledging the need for urgent change, we wanted to take the opportunity to bring a common voice to the global community and issue the Washington DC WCPCCS Call to Action on Addressing the Global Burden of Pediatric and Congenital Heart Diseases. A copy of this Washington DC WCPCCS Call to Action is provided in the Appendix of this manuscript. This Washington DC WCPCCS Call to Action is an initiative aimed at increasing awareness of the global burden, promoting the development of sustainable care systems, and improving access to high quality and equitable healthcare for children with heart disease as well as adults with congenital heart disease worldwide.

Let k be an algebraically closed field of prime characteristic p. Let $kGe$ be a block of a group algebra of a finite group G, with normal defect group P and abelian $p'$ inertial quotient L. Then we show that $kGe$ is a matrix algebra over a quantised version of the group algebra of a semidirect product of P with a certain subgroup of L. To do this, we first examine the associated graded algebra, using a Jennings–Quillen style theorem.

As an example, we calculate the associated graded of the basic algebra of the nonprincipal block in the case of a semidirect product of an extraspecial p-group P of exponent p and order $p^3$ with a quaternion group of order eight with the centre acting trivially. In the case of $p=3$ , we give explicit generators and relations for the basic algebra as a quantised version of $kP$ . As a second example, we give explicit generators and relations in the case of a group of shape $2^{1+4}:3^{1+2}$ in characteristic two.

Background: Carbapenem-resistant Enterobacteriaceae (CRE) are endemic in the Chicago region. We assessed the regional impact of a CRE control intervention targeting high-prevalence facilities; that is, long-term acute-care hospitals (LTACHs) and ventilator-capable skilled nursing facilities (vSNFs). Methods: In July 2017, an academic–public health partnership launched a regional CRE prevention bundle: (1) identifying patient CRE status by querying Illinois’ XDRO registry and periodic point-prevalence surveys reported to public health, (2) cohorting or private rooms with contact precautions for CRE patients, (3) combining hand hygiene adherence, monitoring with general infection control education, and guidance by project coordinators and public health, and (4) daily chlorhexidine gluconate (CHG) bathing. Informed by epidemiology and modeling, we targeted LTACHs and vSNFs in a 13-mile radius from the coordinating center. Illinois mandates CRE reporting to the XDRO registry, which can also be manually queried or generate automated alerts to facilitate interfacility communication. The regional intervention promoted increased automation of alerts to hospitals. The prespecified primary outcome was incident clinical CRE culture reported to the XDRO registry in Cook County by month, analyzed by segmented regression modeling. A secondary outcome was colonization prevalence measured by serial point-prevalence surveys for carbapenemase-producing organism colonization in LTACHs and vSNFs. Results: All eligible LTACHs (n = 6) and vSNFs (n = 9) participated in the intervention. One vSNF declined CHG bathing. vSNFs that implemented CHG bathing typically bathed residents 2–3 times per week instead of daily. Overall, there were significant gaps in infection control practices, especially in vSNFs. Also, 75 Illinois hospitals adopted automated alerts (56 during the intervention period). Mean CRE incidence in Cook County decreased from 59.0 cases per month during baseline to 40.6 cases per month during intervention (P < .001). In a segmented regression model, there was an average reduction of 10.56 cases per month during the 24-month intervention period (P = .02) (Fig. 1), and an estimated 253 incident CRE cases were averted. Mean CRE incidence also decreased among the stratum of vSNF/LTACH intervention facilities (P = .03). However, evidence of ongoing CRE transmission, particularly in vSNFs, persisted, and CRE colonization prevalence remained high at intervention facilities (Table 1). Conclusions: A resource-intensive public health regional CRE intervention was implemented that included enhanced interfacility communication and targeted infection prevention. There was a significant decline in incident CRE clinical cases in Cook County, despite high persistent CRE colonization prevalence in intervention facilities. vSNFs, where understaffing or underresourcing were common and lengths of stay range from months to years, had a major prevalence challenge, underscoring the need for aggressive infection control improvements in these facilities.

Funding: The Centers for Disease Control and Prevention (SHEPheRD Contract No. 200-2011-42037)

Disclosures: M.Y.L. has received research support in the form of contributed product from OpGen and Sage Products (now part of Stryker Corporation), and has received an investigator-initiated grant from CareFusion Foundation (now part of BD).

Sediments that accumulate in high-latitude lakes serve as valuable environmental archives of changing conditions in a region currently undergoing rapid change. A previously unexplored sedimentary sequence reaching back 16,000 years from Lakes Peters and Schrader (Neruokpuk Lakes) in the northeastern Brooks Range (69°N), Alaska, shows distinct changes in accumulation rates and biophysical properties including bulk density (BD), organic matter (OM) content, and grain-size distribution at five widely distributed core sites. The oldest sediments contain little OM and accumulated rapidly as glaciers retreated around 15 ka. OM peaked between 12 and 10 ka along with Northern Hemisphere summer insolation. BD increased and OM decreased until around 5 ka, possibly reflecting a decrease in river-transported terrestrial OM. From 5–2 ka, OM consistently increased, suggesting a rise in river discharge, or a rise in summer temperatures, which led to higher productivity, or both. After 2 ka, sediments increased in BD and decreased in OM, suggesting glacier growth. Evidence for glacier expansion late during the Little Ice Age is weak, but increased sedimentation rates may reflect glacier retreat during the last century. This study provides a framework for future paleoenvironmental research of a rare archive in a relatively pristine Arctic setting.

With few exceptions, today's tidal trees near Washington's Pacific coast postdate an earthquake that lowered the region by 1 m or more. The earthquake, which occurred in A.D. 1700, is the most recent to have ruptured much of the plate boundary at this central part of the Cascadia subduction zone. Because of the coseismic subsidence, lowland forests became tidal flats where thousands of trees died. Most of the trees killed were Sitka spruce (Picea sitchensis). In the centuries since the earthquake, tidal deposits have built new land that has been colonized by new Sitka spruce. All but several tens of the region's tidal spruce consequently postdate 1700, as shown by counts of annual rings in 121 of the largest spruce in tidal forests at Copalis River, Grays Harbor, and Willapa Bay. Forests began to return to each of these estuaries in the early 1700s and spread seaward in the late 1700s and 1800s. Annual rings in the oldest of the trees thus record a large fraction of the earthquake-recurrence interval that began with the 1700 earthquake.