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Motor neuron disease (MND) is a progressive, fatal, neurodegenerative condition that affects motor neurons in the brain and spinal cord, resulting in loss of the ability to move, speak, swallow and breathe. Acceptance and commitment therapy (ACT) is an acceptance-based behavioural therapy that may be particularly beneficial for people living with MND (plwMND). This qualitative study aimed to explore plwMND’s experiences of receiving adapted ACT, tailored to their specific needs, and therapists’ experiences of delivering it.
Method:
Semi-structured qualitative interviews were conducted with plwMND who had received up to eight 1:1 sessions of adapted ACT and therapists who had delivered it within an uncontrolled feasibility study. Interviews explored experiences of ACT and how it could be optimised for plwMND. Interviews were audio recorded, transcribed and analysed using framework analysis.
Results:
Participants were 14 plwMND and 11 therapists. Data were coded into four over-arching themes: (i) an appropriate tool to navigate the disease course; (ii) the value of therapy outweighing the challenges; (iii) relevance to the individual; and (iv) involving others. These themes highlighted that ACT was perceived to be acceptable by plwMND and therapists, and many participants reported or anticipated beneficial outcomes in the future, despite some therapeutic challenges. They also highlighted how individual factors can influence experiences of ACT, and the potential benefit of involving others in therapy.
Conclusions:
Qualitative data supported the acceptability of ACT for plwMND. Future research and clinical practice should address expectations and personal relevance of ACT to optimise its delivery to plwMND.
Key learning aims
(1) To understand the views of people living with motor neuron disease (plwMND) and therapists on acceptance and commitment therapy (ACT) for people living with this condition.
(2) To understand the facilitators of and barriers to ACT for plwMND.
(3) To learn whether ACT that has been tailored to meet the specific needs of plwMND needs to be further adapted to potentially increase its acceptability to this population.
Digital Mental Health Interventions (DMHIs) that meet the definition of a medical device are regulated by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK. The MHRA uses procedures that were originally developed for pharmaceuticals to assess the safety of DMHIs. There is recognition that this may not be ideal, as is evident by an ongoing consultation for reform led by the MHRA and the National Institute for Health and Care Excellence.
Aims
The aim of this study was to generate an experts’ consensus on how the medical regulatory method used for assessing safety could best be adapted for DMHIs.
Method
An online Delphi study containing three rounds was conducted with an international panel of 20 experts with experience/knowledge in the field of UK digital mental health.
Results
Sixty-four items were generated, of which 41 achieved consensus (64%). Consensus emerged around ten recommendations, falling into five main themes: Enhancing the quality of adverse events data in DMHIs; Re-defining serious adverse events for DMHIs; Reassessing short-term symptom deterioration in psychological interventions as a therapeutic risk; Maximising the benefit of the Yellow Card Scheme; and Developing a harmonised approach for assessing the safety of psychological interventions in general.
Conclusion
The implementation of the recommendations provided by this consensus could improve the assessment of safety of DMHIs, making them more effective in detecting and mitigating risk.
We recently reported on the radio-frequency attenuation length of cold polar ice at Summit Station, Greenland, based on bi-static radar measurements of radio-frequency bedrock echo strengths taken during the summer of 2021. Those data also allow studies of (a) the relative contributions of coherent (such as discrete internal conducting layers with sub-centimeter transverse scale) vs incoherent (e.g. bulk volumetric) scattering, (b) the magnitude of internal layer reflection coefficients, (c) limits on signal propagation velocity asymmetries (‘birefringence’) and (d) limits on signal dispersion in-ice over a bandwidth of ~100 MHz. We find that (1) attenuation lengths approach 1 km in our band, (2) after averaging 10 000 echo triggers, reflected signals observable over the thermal floor (to depths of ~1500 m) are consistent with being entirely coherent, (3) internal layer reflectivities are ≈–60$\to$–70 dB, (4) birefringent effects for vertically propagating signals are smaller by an order of magnitude relative to South Pole and (5) within our experimental limits, glacial ice is non-dispersive over the frequency band relevant for neutrino detection experiments.
The U.S. Department of Agriculture–Agricultural Research Service (USDA-ARS) has been a leader in weed science research covering topics ranging from the development and use of integrated weed management (IWM) tactics to basic mechanistic studies, including biotic resistance of desirable plant communities and herbicide resistance. ARS weed scientists have worked in agricultural and natural ecosystems, including agronomic and horticultural crops, pastures, forests, wild lands, aquatic habitats, wetlands, and riparian areas. Through strong partnerships with academia, state agencies, private industry, and numerous federal programs, ARS weed scientists have made contributions to discoveries in the newest fields of robotics and genetics, as well as the traditional and fundamental subjects of weed–crop competition and physiology and integration of weed control tactics and practices. Weed science at ARS is often overshadowed by other research topics; thus, few are aware of the long history of ARS weed science and its important contributions. This review is the result of a symposium held at the Weed Science Society of America’s 62nd Annual Meeting in 2022 that included 10 separate presentations in a virtual Weed Science Webinar Series. The overarching themes of management tactics (IWM, biological control, and automation), basic mechanisms (competition, invasive plant genetics, and herbicide resistance), and ecosystem impacts (invasive plant spread, climate change, conservation, and restoration) represent core ARS weed science research that is dynamic and efficacious and has been a significant component of the agency’s national and international efforts. This review highlights current studies and future directions that exemplify the science and collaborative relationships both within and outside ARS. Given the constraints of weeds and invasive plants on all aspects of food, feed, and fiber systems, there is an acknowledged need to face new challenges, including agriculture and natural resources sustainability, economic resilience and reliability, and societal health and well-being.
The aim of this study was to observe the level of alcohol-based sanitizer, mask use, and physical distancing across indoor community settings in Guelph, ON, Canada, and to identify potential barriers to practicing these behaviors.
Methods:
Shoppers were observed in June 2022 across 21 establishments. Discrete in-person observations were conducted and electronically recorded using smartphones. Multilevel logistic regression models were fitted to identify possible covariates for the 3 behavioral outcomes.
Results:
Of 946 observed shoppers, 69% shopped alone, 72% had at least 1 hand occupied, 26% touched their face, 29% physically distanced ≥ 2 m, 6% used hand sanitizer, and 29% wore masks. Sanitizer use was more commonly observed among people who wore masks and in establishments with coronavirus disease (COVID-19) signage posted at the entrance. Mask use was more commonly observed during days without precipitation and in establishments with some or all touch-free entrances. Shoppers more commonly physically distanced ≥ 2 m when they were shopping alone.
Conclusions:
This supports evidence for environmental context influencing COVID-19 preventive behaviors. Intervention efforts aimed at visible signage, tailored messaging, and redesigning spaces to facilitate preventive behaviors may be effective at increasing adherence during outbreaks.
Water plays a critical role in the production of food and preparation of nutritious meals, yet few studies have examined the relationship between water and food insecurity. The primary objective of this study, therefore, was to examine how experiences of household water insecurity (HWI) relate to experiences of household food insecurity (HFI) among a pastoralist population living in an arid, water-stressed region of northern Kenya.
Design:
We implemented the twelve-item Household Water Insecurity Experiences (HWISE, range 0–36) Scale and the nine-item Household Food Insecurity Access Scale (HFIAS, range 0–27) in a cross-sectional survey to measure HWI and HFI, respectively. Data on socio-demographic characteristics and intake of meat and dairy in the prior week were collected as covariates of interest.
Setting:
Northern Kenya, June–July 2019.
Participants:
Daasanach pastoralist households (n 136) from seven communities.
Results:
In the prior 4 weeks, 93·4 % and 98·5 % of households had experienced moderate-to-severe HWI and HFI, respectively. Multiple linear regression analyses indicated a strong association between HWI and HFI. Each point higher HWISE score was associated with a 0·44-point (95 % CI: 0·22, 0·66, P = 0·003) higher HFIAS score adjusting for socio-economic status and other covariates.
Conclusions:
These findings demonstrate high prevalence and co-occurrence of HWI and HFI among Daasanach pastoralists in northern Kenya. This study highlights the need to address HWI and HFI simultaneously when developing policies and interventions to improve the nutritional well-being of populations whose subsistence is closely tied to water availability and access.
Previous studies using resting-state functional neuroimaging have revealed alterations in whole-brain images, connectome-wide functional connectivity and graph-based metrics in groups of patients with schizophrenia relative to groups of healthy controls. However, it is unclear which of these measures best captures the neural correlates of this disorder at the level of the individual patient.
Methods
Here we investigated the relative diagnostic value of these measures. A total of 295 patients with schizophrenia and 452 healthy controls were investigated using resting-state functional Magnetic Resonance Imaging at five research centres. Connectome-wide functional networks were constructed by thresholding correlation matrices of 90 brain regions, and their topological properties were analyzed using graph theory-based methods. Single-subject classification was performed using three machine learning (ML) approaches associated with varying degrees of complexity and abstraction, namely logistic regression, support vector machine and deep learning technology.
Results
Connectome-wide functional connectivity allowed single-subject classification of patients and controls with higher accuracy (average: 81%) than both whole-brain images (average: 53%) and graph-based metrics (average: 69%). Classification based on connectome-wide functional connectivity was driven by a distributed bilateral network including the thalamus and temporal regions.
Conclusion
These results were replicated across the three employed ML approaches. Connectome-wide functional connectivity permits differentiation of patients with schizophrenia from healthy controls at single-subject level with greater accuracy; this pattern of results is consistent with the ‘dysconnectivity hypothesis’ of schizophrenia, which states that the neural basis of the disorder is best understood in terms of system-level functional connectivity alterations.
Childhood maltreatment is one of the strongest predictors of adulthood depression and alterations to circulating levels of inflammatory markers is one putative mechanism mediating risk or resilience.
Aims
To determine the effects of childhood maltreatment on circulating levels of 41 inflammatory markers in healthy individuals and those with a major depressive disorder (MDD) diagnosis.
Method
We investigated the association of childhood maltreatment with levels of 41 inflammatory markers in two groups, 164 patients with MDD and 301 controls, using multiplex electrochemiluminescence methods applied to blood serum.
Results
Childhood maltreatment was not associated with altered inflammatory markers in either group after multiple testing correction. Body mass index (BMI) exerted strong effects on interleukin-6 and C-reactive protein levels in those with MDD.
Conclusions
Childhood maltreatment did not exert effects on inflammatory marker levels in either the participants with MDD or the control group in our study. Our results instead highlight the more pertinent influence of BMI.
Declaration of interest
D.A.C. and H.W. work for Eli Lilly Inc. R.N. has received speaker fees from Sunovion, Jansen and Lundbeck. G.B. has received consultancy fees and funding from Eli Lilly. R.H.M.-W. has received consultancy fees or has a financial relationship with AstraZeneca, Bristol-Myers Squibb, Cyberonics, Eli Lilly, Ferrer, Janssen-Cilag, Lundbeck, MyTomorrows, Otsuka, Pfizer, Pulse, Roche, Servier, SPIMACO and Sunovian. I.M.A. has received consultancy fees or has a financial relationship with Alkermes, Lundbeck, Lundbeck/Otsuka, and Servier. S.W. has sat on an advisory board for Sunovion, Allergan and has received speaker fees from Astra Zeneca. A.H.Y. has received honoraria for speaking from Astra Zeneca, Lundbeck, Eli Lilly, Sunovion; honoraria for consulting from Allergan, Livanova and Lundbeck, Sunovion, Janssen; and research grant support from Janssen. A.J.C. has received honoraria for speaking from Astra Zeneca, honoraria for consulting with Allergan, Livanova and Lundbeck and research grant support from Lundbeck.
Lithium-ion batteries featuring electrodes of silicon nanoparticles, conductive carbon, and polymer binders were constructed with electrolyte containing 1.2 M LiPF6 in ethylene carbonate and diethyl carbonate (1:1, w/w). Material binders used include polyvinylidene difluoride (PVdF), polyacrylic acid (PAA), sodium carboxymethyl cellulose (CMC), and a mixture of equal masses of CMC and PAA (CMCPAA). Hard X-ray photoelectron spectroscopy (HAXPES) was performed on the electrodes when fresh, cycled at reduced potential, and cycled one full time to study how substrate material binders affect the early formation of the solid electrolyte interphase (SEI) layer. Electrodes cycled 5, 10, and 20 times were also analyzed to discern what changes to the SEI occur after initial formation. We also present estimates of the SEI thickness by cycle count, indicating that PAA develops the thinnest SEI, followed by CMCPAA, CMC, and PVdF in order of increasing layer thickness.
Objectives: Amphetamine improves vigilance as assessed by continuous performance tests (CPT) in children and adults with attention deficit hyperactivity disorder (ADHD). Less is known, however, regarding amphetamine effects on vigilance in healthy adults. Thus, it remains unclear whether amphetamine produces general enhancement of vigilance or if these effects are constrained to the remediation of deficits in patients with ADHD. Methods: We tested 69 healthy adults (35 female) on a standardized CPT (Conner’s CPT-2) after receiving 10- or 20-mg d-amphetamine or placebo. To evaluate potential effects on learning, impulsivity, and perseveration, participants were additionally tested on the Iowa Gambling Task (IGT) and Wisconsin Card Sorting Task (WCST). Results: Participants receiving placebo exhibited the classic vigilance decrement, demonstrated by a significant reduction in attention (D’) across the task. This vigilance decrement was not observed, however, after either dose of amphetamine. Consistent with enhanced vigilance, the 20-mg dose also reduced reaction time variability across the task and the ADHD confidence index. The effects of amphetamine appeared to be selective to vigilance since no effects were observed on the IGT, WCST, or response inhibition/perseveration measures from the CPT. Conclusions: The present data support the premise that amphetamine improves vigilance irrespective of disease state. Given that amphetamine is a norepinephrine/dopamine transporter inhibitor and releaser, these effects are informative regarding the neurobiological substrates of attentional control. (JINS, 2018, 24, 283–293)
As researchers and land managers increasingly seek to understand plant invasions and the external (climate) and internal (plant genetics) conditions that govern the process, new insight is helping to answer the elusive question of what makes some invasions successful and others not. Plant invasion success or failure is based on a combination of evolutionary and ecological processes. Abiotic (e.g., climate) and biotic (e.g., plant competition) conditions in the environment and plant genetics (e.g., fitness) combine in either decreasing or increasing invasion, yet it has proven challenging to know exactly which of these conditions leads to success for a given species, even when a wealth of empirical data is available. Further, current regional distribution models for invasive plant species rarely consider biotic and fitness interactions, instead focusing primarily on abiotic conditions. The crucial role of all three factors (climate dynamics, invader fitness, and ecosystem resistance) must not be ignored. Here we construct a three-factor invasion framework from which we develop conceptual models using empirical studies for yellow starthistle, nonnative common reed, and musk thistle, three dissimilar but commonly occurring invasive plant species in North America. We identify how components of the invasion process—rapid population increase, established local dominance, and rapid range expansion—are influenced by ecosystem resistance, invader fitness, and/or climate dynamics, a set of broadly defined factors for each of the three invasive plant species. Our framework can be used to (1) establish research priorities, (2) address gaps in theoretical understanding, and (3) identify invasion process components that can be targeted to improve management. Building on previous models, our unifying framework, which can be used for assessing any invasive plant species having sufficient empirical data, simultaneously shows the influence of ecosystem resistance, invader fitness, and climate dynamics factors on the invasion process.
People with pancreatic cancer have poor survival, and management is challenging. Pancreatic cancer patients' perceptions of their care coordination and its association with their outcomes have not been well-studied. Our objective was to determine if perception of care coordination is associated with patient-reported outcomes or survival.
Methods:
People with pancreatic cancer who were 1–8 months postdiagnosis (52 with completed resection and 58 with no resection) completed a patient-reported questionnaire that assessed their perceptions of care coordination, quality of life, anxiety, and depression using validated instruments. Mean scores for 15 care-coordination items were calculated and then ranked from highest (best experience) to lowest (worst experience). Associations between care-coordination scores (including communication and navigation domains) and patient-reported outcomes and survival were investigated using general linear regression and Cox regression, respectively. All analyses were stratified by whether or not the tumor had been resected.
Results:
In both groups, the highest-ranked care-coordination items were: knowing who was responsible for coordinating care, health professionals being informed about their history, and waiting times. The worst-ranked items related to: how often patients were asked about visits with other health professionals and how well they and their family were coping, knowing the symptoms they should monitor, having sufficient emotional help from staff, and access to additional specialist services. For people who had a resection, better communication and navigation scores were significantly associated with higher quality of life and less anxiety and depression. However, these associations were not statistically significant for those with no resection. Perception of cancer care coordination was not associated with survival in either group.
Significance of results:
Our results suggest that, while many core clinical aspects of care are perceived to be done well for pancreatic cancer patients, improvements in emotional support, referral to specialist services, and self-management education may improve patient-reported outcomes.
In the greenhouse, glyphosate [N-(phosphonomethyl)glycine] at 0.6 kg ae/ha applied directly to seeds alone or seeds on the soil surface reduced germination and shoot dry weight of common rye (Secale cereale L. ♯3 SECCE). Paraquat (1,1′-dimethyl-4,4′-bipyridinium ion) applied similarly at 0.6 kg ai/ha reduced germination and shoot dry weight of downy brome (Bromus tectorum L. ♯ BROTE) and wheat (Triticum aestivum L. ‘Daws' ♯ TRZAX). Metribuzin [4-amino-6-tert-butyl-3-(methylthio)-as-triazin-5 (4H)-one] at 0.6 kg ai/ha applied to seeds, soil, or seeds and soil had very little effect on germination, but significantly reduced shoot dry weight of common rye, downy brome, wheat, and jointed goatgrass (Aegilops cylindrica Host. ♯ AEGCY). Pronamide [3,5-dichloro(N-1,1-dimethyl-2-propynyl)benzamide] at 0.6 kg ai/ha, and propham (isopropyl carbanilate) at 3.4 kg ai/ha plus extender (p-chlorophenyl-N-methylcarbamate) at 0.4 kg ai/ha substantially reduced shoot height and dry weight of all species, regardless of application method, with pronamide completely inhibiting shoot elongation and dry-weight production in three of the four species.
Mayweed (Anthemis cotula L. # ANTCO) achenes and seed were germinated in the laboratory at constant temperatures ranging from 5 to 30 C. Maximum percent germination occurred at 20 C for both achenes and seed. Under all conditions tested, achene germination was less than seed germination. Both acid scarification for 15 min and soaking in 14 mM gibberellic acid (GA3) more than doubled achene germination. Pericarp leachate inhibited achene and seed germination only at high concentrations, indicating that inhibitors in the pericarp are not a primary cause of low germination in achenes. Optimum germination of achenes and seed occurred at pH 4.5 and over a range from pH 3 to pH 6. Achene germination was inhibited to a greater degree by moisture stress than was seed germination. It appears that structural integrity of the pericarp is the predominant factor affecting mayweed germination.
A seed remover using a modified water-spray system was constructed to separate weed seeds rapidly and effectively from a silt loam soil A 1-kg soil sample can be washed through the seed remover in 6 min. Using a 500-μ mesh sieve, only 70% of small shepherdspurse seeds were recovered, while 100% of larger seeds of henbit, curly dock, wild oats, and downy brome were recovered. The modified seed remover system reduced the required man-hours by more than 50% compared to previous systems.
Greenhouse and field experiments were conducted to evaluate the efficacy of chlorsulfuron {2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino] carbonyl] benzenesulfonamide} on Russian thistle (Salsola iberica Sennen and Pau # SASKR) in a spring wheat (Triticum aestivum L.) summer-fallow rotation. In the greenhouse, when chlorsulfuron was applied to Russian thistle at three stages of growth, shoot dry weight was reduced similarly with either 4.4 g ai/ha plus surfactant or 140 g ai/ha plus surfactant. In the field, postharvest control (1981) of Russian thistle with 17.5 to 140 g/ha of chlorsulfuron ranged from 35 to 60% without surfactant and from 76 to 93% with surfactant. During the summer-fallow year (1982), Russian thistle treated in the preflowering stage of growth was not effectively controlled with 17.5 or 35 g/ha. In contrast, residual control from postharvest treatments 1 yr after application ranged from 90 to 100%. Chlorsulfuron applied in the crop (1983) controlled Russian thistle throughout the growing season. All treatments of chlorsulfuron applied in 1981, 1982, and 1983 increased wheat yield at least 75%.
Fruit and vegetable (FV) intake is associated with reduced risk of a number of non-communicable diseases. Research tends to focus on antioxidants, flavonoids and polyphenols contained in FV as the main beneficial components to health; however, increasing FV may also alter overall diet profile. Extra FV may be substituted for foods thought to be less healthy, therefore altering the overall macronutrient and/or micronutrient content in the diet. This analysis merged dietary data from four intervention studies in participants with varying health conditions and examined the effect of increased FV consumption on diet profile. Dietary intake was assessed by either diet diaries or diet histories used in four FV randomised intervention studies. All food and drink intake recorded was analysed using WISP version 3.0, and FV portions were manually counted using household measures. Regression analysis revealed significant increases in intakes of energy (172 kJ (+41 kcal)), carbohydrate (+3·9 g/4184 kJ (1000 kcal)), total sugars (+6·0 g/4184 kJ (1000 kcal)) and fibre (+0·8 g/4184 kJ (1000 kcal)) and significant decreases in intakes of total fat (−1·4 g/4184 kJ (1000 kcal)), SFA (−0·6 g/4184 kJ (1000 kcal)), MUFA (−0·6 g/4184 kJ (1000 kcal)), PUFA (−0·1 g/4184 kJ (1000 kcal)) and starch (−2·1 g/4184 kJ (1000 kcal)) per one portion increase in FV. Significant percentage increases were also observed in vitamin C (+24 %) and -carotene (+20 %) intake, per one portion increase in FV. In conclusion, pooled analysis of four FV intervention studies, that used similar approaches to achieving dietary change, in participants with varying health conditions, demonstrated an increase in energy, total carbohydrate, sugars and fibre intake, and a decrease in fat intake alongside an expected increase in micronutrient intake.
A segment of the debate surrounding the commercialization of genetically
engineered (GE) crops, such as glyphosate-resistant (GR) crops, focuses on
the theory that implementation of these traits is an extension of the
intensification of agriculture that will further erode the biodiversity of
agricultural landscapes. A large field-scale study was conducted in 2006 in
the United States on 156 different field sites with a minimum 3-yr history
of GR corn, cotton, or soybean in the cropping system. The impact of
cropping system, crop rotation, frequency of using the GR crop trait, and
several categorical variables on emerged weed density and diversity was
analyzed. Species richness, evenness, Shannon's H′, proportion of forbs,
erect growth habit, and C3 species diversity were all greater in
agricultural sites that lacked crop rotation or were in a continuous GR crop
system. Rotating between two GR crops (e.g., corn and soybean) or rotating
to a non-GR crop resulted in less weed diversity than a continuous GR crop.
The composition of the weed flora was more strongly related to location
(geography) than any other parameter. The diversity of weed flora in
agricultural sites with a history of GR crop production can be influenced by
several factors relating to the specific method in which the GR trait is
integrated (cropping system, crop rotation, GR trait rotation), the specific
weed species, and the geographical location. The finding that fields with
continuous GR crops demonstrated greater weed diversity is contrary to
arguments opposing the use of GE crops. These results justify further
research to clarify the complexities of crops grown with
herbicide-resistance traits, or more broadly, GE crops, to provide a more
complete characterization of their culture and local adaptation.
In 2010, a grower survey was administered to 1,299 growers in 22 states to determine changes in weed management in the United States from 2006 to 2009. The majority of growers had not changed weed management practices in the previous 3 yr; however, 75% reported using weed management practices targeted at glyphosate-resistant (GR) weeds. Growers were asked to rate their efforts at controlling GR weeds and rate the effectiveness of various practices for controlling/preventing GR weeds regardless of whether they were personally using them. Using the herbicide labeled rate, scouting fields, and rotating crops were among the practices considered by growers as most effective in managing GR weeds. Sixty-seven percent of growers reported effective management of GR weeds. Between the 2005 and 2010 Benchmark surveys, the frequency of growers using specific actions to manage GR weeds increased markedly. Although the relative effectiveness of practices, as perceived by growers, remained the same, the effectiveness rating of tillage and the use of residual and POST herbicides increased.
Corn and soybean growers in Illinois, Indiana, Iowa, Mississippi, Nebraska, and North Carolina, as well as cotton growers in Mississippi and North Carolina, were surveyed about their views on changes in problematic weeds and weed pressure in cropping systems based on a glyphosate-resistant (GR) crop. No growers using a GR cropping system for more than 5 yr reported heavy weed pressure. Over all cropping systems investigated (continuous GR soybean, continuous GR cotton, GR corn/GR soybean, GR soybean/non-GR crop, and GR corn/non-GR crop), 0 to 7% of survey respondents reported greater weed pressure after implementing rotations using GR crops, whereas 31 to 57% felt weed pressure was similar and 36 to 70% indicated that weed pressure was less. Pigweed, morningglory, johnsongrass, ragweed, foxtail, and velvetleaf were mentioned as their most problematic weeds, depending on the state and cropping system. Systems using GR crops improved weed management compared with the technologies used before the adoption of GR crops. However, the long-term success of managing problematic weeds in GR cropping systems will require the development of multifaceted integrated weed management programs that include glyphosate as well as other weed management tactics.