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A history of high-power laser research and development in the United Kingdom
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- Colin N. Danson, Malcolm White, John R. M. Barr, Thomas Bett, Peter Blyth, David Bowley, Ceri Brenner, Robert J. Collins, Neal Croxford, A. E. Bucker Dangor, Laurence Devereux, Peter E. Dyer, Anthony Dymoke-Bradshaw, Christopher B. Edwards, Paul Ewart, Allister I. Ferguson, John M. Girkin, Denis R. Hall, David C. Hanna, Wayne Harris, David I. Hillier, Christopher J. Hooker, Simon M. Hooker, Nicholas Hopps, Janet Hull, David Hunt, Dino A. Jaroszynski, Mark Kempenaars, Helmut Kessler, Sir Peter L. Knight, Steve Knight, Adrian Knowles, Ciaran L. S. Lewis, Ken S. Lipton, Abby Littlechild, John Littlechild, Peter Maggs, Graeme P. A. Malcolm, OBE, Stuart P. D. Mangles, William Martin, Paul McKenna, Richard O. Moore, Clive Morrison, Zulfikar Najmudin, David Neely, Geoff H. C. New, Michael J. Norman, Ted Paine, Anthony W. Parker, Rory R. Penman, Geoff J. Pert, Chris Pietraszewski, Andrew Randewich, Nadeem H. Rizvi, Nigel Seddon, MBE, Zheng-Ming Sheng, David Slater, Roland A. Smith, Christopher Spindloe, Roy Taylor, Gary Thomas, John W. G. Tisch, Justin S. Wark, Colin Webb, S. Mark Wiggins, Dave Willford, Trevor Winstone
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- Journal:
- High Power Laser Science and Engineering / Volume 9 / 2021
- Published online by Cambridge University Press:
- 27 April 2021, e18
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The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.
4 - Five Decades of Modeling Supporting the Systems Ecology Paradigm
- Edited by Robert G. Woodmansee, Colorado State University, John C. Moore, Colorado State University, Dennis S. Ojima, Colorado State University, Laurie Richards, Colorado State University
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- Natural Resource Management Reimagined
- Published online:
- 25 February 2021
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- 11 March 2021, pp 90-130
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Summary
Ecosystem modeling, a pillar of the systems ecology paradigm (SEP), addresses questions such as, how much carbon and nitrogen are cycled within ecological sites, landscapes, or indeed the earth system? Or how are human activities modifying these flows? Modeling, when coupled with field and laboratory studies, represents the essence of the SEP in that they embody accumulated knowledge and generate hypotheses to test understanding of ecosystem processes and behavior. Initially, ecosystem models were primarily used to improve our understanding about how biophysical aspects of ecosystems operate. However, current ecosystem models are widely used to make accurate predictions about how large-scale phenomena such as climate change and management practices impact ecosystem dynamics and assess potential effects of these changes on economic activity and policy making. In sum, ecosystem models embedded in the SEP remain our best mechanism to integrate diverse types of knowledge regarding how the earth system functions and to make quantitative predictions that can be confronted with observations of reality. Modeling efforts discussed are the Century ecosystem model, DayCent ecosystem model, Grassland Ecosystem Model ELM, food web models, Savanna model, agent-based and coupled systems modeling, and Bayesian modeling.
Early development and unstable genes in schizophrenia: preliminary results
- Agnes Ayton, Alex G. Morris, Philip J. Tyson, David Hunt, Ann M. Mortimer, David Cottrell
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- European Psychiatry / Volume 17 / Issue 6 / October 2002
- Published online by Cambridge University Press:
- 16 April 2020, pp. 332-338
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Background.
Trinucleotide repeats have been associated with schizophrenia, but the evidence, based on cross-sectional clinical information, is equivocal.
Aims.To examine the relationship between genomic CAG/CTG repeat size and premorbid development in schizophrenia.
Method.Early development and premorbid functioning of 22 patients with DSM-IV diagnosis of schizophrenia were assessed by parental interviews. Repeat expansion detection (RED) technique was used to measure genomic CAG/CTG repeat size, and PCR for CAG repeat size at the ERDA-1 and CTG 18.1 loci.
Results.There was an inverse association between CAG/CTG size and perinatal complications. Patients with speech and motor developmental delay had larger repeats. The results were not due to expansion in the ERDA-1 and CTG 18.1 genes.
Conclusions.CAG/CTG repeat expansion is associated with speech and motor developmental delay in schizophrenia. We propose that the developmental model may be useful for research into the genetics of schizophrenia.
“Why and how did this happen?”: development and evaluation of an information resource for parents of children with CHD
- Alexis V. Hunt, Desiree C. K. Hilton, Charlotte E. Verrall, Kristine K. Barlow-Stewart, Jane Fleming, David S. Winlaw, Gillian M. Blue
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- Journal:
- Cardiology in the Young / Volume 30 / Issue 3 / March 2020
- Published online by Cambridge University Press:
- 10 January 2020, pp. 346-352
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Background:
The causes of CHD are complex and often unknown, leading parents to ask how and why this has happened. Genetic counselling has been shown to benefit these parents by providing information and support; however, most parents currently do not receive this service. This study aimed to develop a brochure to determine whether an information resource could improve parents’ knowledge about CHD causation and inheritance and increase psychosocial functioning.
Methods:In development, the resource was assessed against several readability scales and piloted. Parents of children attending preadmission clinic for surgery were included. Assessments occurred pre- and post-receiving the information resource using a purpose-designed knowledge measure and validated psychological measures.
Results:Participant’s (n = 52) knowledge scores increased significantly from the pre-questionnaire ( ${\overline x}\, = \,5/10$ , sd = 2.086) to post-questionnaire ( $\overline x\, = \,7.88/10$ , sd = 2.094, p < 0.001), with all aware that CHD can be caused by genetic factors after reading the brochure. Perceived personal control also increased from pre- ( $\overline x\, = \,11.856/18$ , sd = 4.339) to post-brochure ( $\overline x\, = \,14.644/18$ , sd = 3.733, p < 0.001), and many reported reduced feelings of guilt. No negative emotional response to the brochure was reported. The information provided was considered relevant (88%), reassuring (86%), and 88% would recommend the brochure to other parents. However, some wanted more emotional support and assistance in what to tell their child.
Conclusions:Use of the information resource significantly enhanced parents’ knowledge of CHD causation and increased their psychosocial functioning. It is a valuable resource in the absence of genetic counselling; however, it should not replace formal genetic counselling when required.
Flux Densities at 8400 MHz for a Large Sample of Parkes Radio Sources
- Alan E. Wright, Robin M. Wark, Euan Troup, Robina Otrupcek, Andrew Hunt, David J. Cooke
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- Publications of the Astronomical Society of Australia / Volume 8 / Issue 3 / 1990
- Published online by Cambridge University Press:
- 25 April 2016, pp. 261-262
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We give a progress report on a programme of observations to obtain flux densities at 8.4 GHz for a large sample of radio sources selected from the Parkes 2700 MHz Survey. So far, about 1000 flux measurements have been made with a typical accuracy of 10%.
Deep-sea ostracods from the South Atlantic sector of the Southern Ocean during the last 370,000 years
- Moriaki Yasuhara, Thomas M. Cronin, Gene Hunt, David A. Hodell
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- Journal of Paleontology / Volume 83 / Issue 6 / November 2009
- Published online by Cambridge University Press:
- 14 July 2015, pp. 914-930
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We report changes of deep-sea ostracod fauna during the last 370,000 yr from the Ocean Drilling Program (ODP) Hole 704A in the South Atlantic sector of the Southern Ocean. The results show that faunal changes are coincident with glacial/interglacial-scale deep-water circulation changes, even though our dataset is relatively small and the waters are barren of ostracods until mid-MIS (Marine Isotope Stage) 5. Krithe and Poseidonamicus were dominant during the Holocene interglacial period and the latter part of MIS 5, when this site was under the influence of North Atlantic Deep Water (NADW). Conversely, Henryhowella and Legitimocythere were dominant during glacial periods, when this site was in the path of Circumpolar Deep Water (CPDW). Three new species (Aversovalva brandaoae, Poseidonamicus hisayoae, and Krithe mazziniae) are described herein. This is the first report of Quaternary glacial/interglacial scale deep-sea ostracod faunal changes in the Southern and South Atlantic Oceans, a key region for understanding Quaternary climate and deep-water circulation, although the paucity of Quaternary ostracods in this region necessitates further research.
Contributors
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- By Nic Beech, Chris Bilton, Alan Bradshaw, Stephen Broad, Shiona Chillas, Martin Cloonan, Kevina Cody, Christine Coupland, Stephen Cummings, Ann Cunliffe, Chris Cusack, Jane Donald, Martin Dowling, Michael Downes, Celia Duffy, Charlotte Gilmore, Lance Green, Gail Greig, Elizabeth Gulledge, Chris Hackley, Martin John Henry, Paul Hibbert, Casper Hoedemaekers, R. M. Hubbert, John Hunt, Peter Keenan, Nod Knowles, Gretchen Larsen, Johnny Lynch, Raymond MacDonald, Robert MacIntosh, Katy MacKintosh, Donald MacLean, Katy J. Mason, Alan McCusker-Thompson, Lloyd Meredith, Louise Mitchell, Davide Nicolini, Daragh O’Reilly, Jill O’Sullivan, Cliff Oswick, Marco Panagopoulos, Jim Prime, Jenny Reeve, Simon Rose, Michael Saren, David Sims, Ian Smith, Duglas T. Stewart, Chris Stout, Dimitrinka Stoyanova Russell, Antonio Strati, Ben Talbot Dunn:, Robyn Thomas, Lori Watson, Simon Webb, Richard Wigley, Sierk Ybema, Matthew Young, Carlo Zanotti
- Edited by Nic Beech, University of Dundee, Charlotte Gilmore, University of Edinburgh
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- Book:
- Organising Music
- Published online:
- 05 January 2015
- Print publication:
- 05 February 2015, pp xii-xxviii
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- By Naila A. Ahmad, Dua M. Anderson, Jennifer Aunspaugh, Sabrina T. Bent, Adam Broussard, Staci Cameron, Rahul Dasgupta, Ravinder Devgun, Ofer N. Eytan, Sean H. Flack, Terry G. Fletcher, Charles James Fox, Mary Elise Fox, Scott Friedman, Louise K. Furukawa, Sonja Gennuso, Stanley M. Hall, Hani Hanna, Jacob Hummel, James E. Hunt, Ranu Jain, Joe R. Jansen, Deepa Kattail, Alan David Kaye, David J. Krodel, Gregory J. Latham, Sungeun Lee, Michael G. Levitzky, Alexander Y. Lin, Carl Lo, Hoa N. Luu, Camila Lyon, Kelly A. Machovec, Lizabeth D. Martin, Maria Matuszczak, Patrick S. McCarty, Brenda C. McClain, J. Grant McFadyen, Helen Nazareth, Dolores B. Njoku, Christina M. Pabelick, Shannon M. Peters, Amit Prabhakar, Michael Richards, Kasia Rubin, Joel A. Saltzman, Lisgelia Santana, Gabriel Sarah, Katherine Stammen, John Stork, Kim M. Strupp, Lalitha V. Sundararaman, Rosalie F. Tassone, Douglas R. Thompson, Nicole C. P. Thompson, Paul A. Tripi, Jacqueline L. Tutiven, Navyugjit Virk, Stacey Watt, B. Craig Weldon, Maria Zestus
- Edited by Alan David Kaye, Louisiana State University, Charles James Fox, Tulane University School of Medicine, Louisiana, James H. Diaz, Louisiana State University
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- Book:
- Essentials of Pediatric Anesthesiology
- Published online:
- 05 November 2014
- Print publication:
- 16 October 2014, pp ix-xii
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Dimensions of improvement in a clinical trial of N-acetyl cysteine for bipolar disorder
- Pedro V. Magalhães, Olivia M. Dean, Ashley I. Bush, David L. Copolov, Gin S. Malhi, Kristy Kohlmann, Susan Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Michael Berk
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- Acta Neuropsychiatrica / Volume 23 / Issue 2 / April 2011
- Published online by Cambridge University Press:
- 24 June 2014, pp. 87-88
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S cones: Evolution, retinal distribution, development, and spectral sensitivity
- DAVID M. HUNT, LEO PEICHL
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- Visual Neuroscience / Volume 31 / Issue 2 / March 2014
- Published online by Cambridge University Press:
- 29 July 2013, pp. 115-138
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S cones expressing the short wavelength-sensitive type 1 (SWS1) class of visual pigment generally form only a minority type of cone photoreceptor within the vertebrate duplex retina. Hence, their primary role is in color vision, not in high acuity vision. In mammals, S cones may be present as a constant fraction of the cones across the retina, may be restricted to certain regions of the retina or may form a gradient across the retina, and in some species, there is coexpression of SWS1 and the long wavelength-sensitive (LWS) class of pigment in many cones. During retinal development, SWS1 opsin expression generally precedes that of LWS opsin, and evidence from genetic studies indicates that the S cone pathway may be the default pathway for cone development. With the notable exception of the cartilaginous fishes, where S cones appear to be absent, they are present in representative species from all other vertebrate classes. S cone loss is not, however, uncommon; they are absent from most aquatic mammals and from some but not all nocturnal terrestrial species. The peak spectral sensitivity of S cones depends on the spectral characteristics of the pigment present. Evidence from the study of agnathans and teleost fishes indicates that the ancestral vertebrate SWS1 pigment was ultraviolet (UV) sensitive with a peak around 360 nm, but this has shifted into the violet region of the spectrum (>380 nm) on many separate occasions during vertebrate evolution. In all cases, the shift was generated by just one or a few replacements in tuning-relevant residues. Only in the avian lineage has tuning moved in the opposite direction, with the reinvention of UV-sensitive pigments.
List of contributors
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- By Anthony Atala, Karl W. Broman, Irene Cervelló, David K. Gardner, Caroline E. Gargett, Nicolás Garrido, Ellen Goossens, Jennifer R. Gruhn, Alexandra J. Harvey, Terry J. Hassold, Patricia A. Hunt, Orkan Ilbay, Irina Klimanskaya, Tippi C. MacKenzie, Ana M. Martínez-Arroyo, Jose V. Medrano, Heidi Mertes, Marcos Meseguer, Sergio Mora, Sean V. Murphy, Hong P.T. Nguyen, Amar Nijagal, Takehiko Ogawa, Guido Pennings, Joy Rathjen, Angel Raya, Renee A. Reijo Pera, Rocío Rivera, Emre Seli, Carlos Simón, Herman Tournaye, Agustín G. Zapata
- Edited by Carlos Simón, Antonio Pellicer, Renee Reijo Pera
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- Stem Cells in Reproductive Medicine
- Published online:
- 05 July 2013
- Print publication:
- 04 July 2013, pp vii-viii
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Science and Evidence-based Considerations for Fulfilling the SALT Triage Framework—Lerner et al Reply
- E. Brooke Lerner, Richard B. Schwartz, Phillip L. Coule, Eric S. Weinstein, David C. Cone, Richard C. Hunt, Scott M. Sasser, J. Marc Liu, Nikiah G. Nudell, Ian S. Wedmore, Jeffrey Hammond, Eileen M. Bulger, Jeffrey P. Salomone, Teri L. Sanddal, Graydon C. Lord, David Markenson, Robert E. O'Connor
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- Journal:
- Disaster Medicine and Public Health Preparedness / Volume 4 / Issue 1 / March 2010
- Published online by Cambridge University Press:
- 08 April 2013, p. 12
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Mass Casualty Triage: An Evaluation of the Science and Refinement of a National Guideline
- E. Brooke Lerner, David C. Cone, Eric S. Weinstein, Richard B. Schwartz, Phillip L. Coule, Michael Cronin, Ian S. Wedmore, Eileen M. Bulger, Deborah Ann Mulligan, Raymond E. Swienton, Scott M. Sasser, Umair A. Shah, Leonard J. Weireter, Jr, Teri L. Sanddal, Julio Lairet, David Markenson, Lou Romig, Gregg Lord, Jeffrey Salomone, Robert O'Connor, Richard C. Hunt
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- Disaster Medicine and Public Health Preparedness / Volume 5 / Issue 2 / June 2011
- Published online by Cambridge University Press:
- 08 April 2013, pp. 129-137
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Mass casualty triage is the process of prioritizing multiple victims when resources are not sufficient to treat everyone immediately. No national guideline for mass casualty triage exists in the United States. The lack of a national guideline has resulted in variability in triage processes, tags, and nomenclature. This variability has the potential to inject confusion and miscommunication into the disaster incident, particularly when multiple jurisdictions are involved. The Model Uniform Core Criteria for Mass Casualty Triage were developed to be a national guideline for mass casualty triage to ensure interoperability and standardization when responding to a mass casualty incident. The Core Criteria consist of 4 categories: general considerations, global sorting, lifesaving interventions, and individual assessment of triage category. The criteria within each of these categories were developed by a workgroup of experts representing national stakeholder organizations who used the best available science and, when necessary, consensus opinion. This article describes how the Model Uniform Core Criteria for Mass Casualty Triage were developed.
(Disaster Med Public Health Preparedness. 2011;5:129-137)
Mass Casualty Triage: Universal Versus Specific: Lerner et al reply
- E. Brooke Lerner, Richard B. Schwartz, Philip L. Coule, Eric S. Weinstein, David C. Cone, Richard C. Hunt, Scott M. Sasser, J Marc Liu, Nikiah G. Nudell, Ian S. Wedmore, Jeffrey Hammond, Eileen M. Bulger, Jeffrey P. Salomone, Teri L. Sanddal, Graydon C. Lord, David Markenson, Robert E. O’Connor
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- Disaster Medicine and Public Health Preparedness / Volume 3 / Issue 2 / June 2009
- Published online by Cambridge University Press:
- 08 April 2013, p. 72
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Mass Casualty Triage: An Evaluation of the Data and Development of a Proposed National Guideline
- E. Brooke Lerner, Richard B. Schwartz, Phillip L. Coule, Eric S. Weinstein, David C. Cone, Richard C. Hunt, Scott M. Sasser, J Marc Liu, Nikiah G. Nudell, Ian S. Wedmore, Jeffrey Hammond, Eileen M. Bulger, Jeffrey P. Salomone, Teri L. Sanddal, Graydon C. Lord, David Markenson, Robert E. O'Connor
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- Journal:
- Disaster Medicine and Public Health Preparedness / Volume 2 / Issue S1 / September 2008
- Published online by Cambridge University Press:
- 08 April 2013, pp. S25-S34
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Mass casualty triage is a critical skill. Although many systems exist to guide providers in making triage decisions, there is little scientific evidence available to demonstrate that any of the available systems have been validated. Furthermore, in the United States there is little consistency from one jurisdiction to the next in the application of mass casualty triage methodology. There are no nationally agreed upon categories or color designations. This review reports on a consensus committee process used to evaluate and compare commonly used triage systems, and to develop a proposed national mass casualty triage guideline. The proposed guideline, entitled SALT (sort, assess, life-saving interventions, treatment and/or transport) triage, was developed based on the best available science and consensus opinion. It incorporates aspects from all of the existing triage systems to create a single overarching guide for unifying the mass casualty triage process across the United States. (Disaster Med Public Health Preparedness. 2008;2(Suppl 1):S25–S34)
First record of the mandarin dogfish Cirrhigaleus barbifer (Chondrichthyes: Squalidae) from Western Australia
- Ryan M. Kempster, David M. Hunt, Brett A. Human, Channing A. Egeberg, Shaun P. Collin
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- Marine Biodiversity Records / Volume 6 / 2013
- Published online by Cambridge University Press:
- 22 February 2013, e25
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- 2013
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The mandarin dogfish, Cirrhigaleus barbifer, is the only species in this genus found in Western Australia, and represents a significant range extension and first record in Australia. Most Cirrhigaleus sharks are clearly separable from other squalid sharks by the presence of conspicuous barbels on the anterior nasal flaps. Cirrhigaleus barbifer may be distinguished from its close relative C. australis by the structure of the CO1 gene and key measurements. In addition, this is only the second record of a gravid female of C. barbifer, with pups in an advanced stage of development. New data on the reproductive biology and range of C. barbifer are included.
Contributors
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- By Phillip L. Ackerman, Soon Ang, Susan M. Barnett, G. David Batty, Anna S. Beninger, Jillian Brass, Meghan M. Burke, Nancy Cantor, Priyanka B. Carr, David R. Caruso, Stephen J. Ceci, Lillia Cherkasskiy, Joanna Christodoulou, Andrew R. A. Conway, Christine E. Daley, Janet E. Davidson, Jim Davies, Katie Davis, Ian J. Deary, Colin G. DeYoung, Ron Dumont, Carol S. Dweck, Linn Van Dyne, Pascale M. J. Engel de Abreu, Joseph F. Fagan, David Henry Feldman, Kurt W. Fischer, Marisa H. Fisher, James R. Flynn, Liane Gabora, Howard Gardner, Glenn Geher, Sarah J. Getz, Judith Glück, Ashok K. Goel, Megan M. Griffin, Elena L. Grigorenko, Richard J. Haier, Diane F. Halpern, Christopher Hertzog, Robert M. Hodapp, Earl Hunt, Alan S. Kaufman, James C. Kaufman, Scott Barry Kaufman, Iris A. Kemp, John F. Kihlstrom, Joni M. Lakin, Christina S. Lee, David F. Lohman, N. J. Mackintosh, Brooke Macnamara, Samuel D. Mandelman, John D. Mayer, Richard E. Mayer, Martha J. Morelock, Ted Nettelbeck, Raymond S. Nickerson, Weihua Niu, Anthony J. Onwuegbuzie, Jonathan A. Plucker, Sally M. Reis, Joseph S. Renzulli, Heiner Rindermann, L. Todd Rose, Anne Russon, Peter Salovey, Scott Seider, Ellen L. Short, Keith E. Stanovich, Ursula M. Staudinger, Robert J. Sternberg, Carli A. Straight, Lisa A. Suzuki, Mei Ling Tan, Maggie E. Toplak, Susana Urbina, Richard K. Wagner, Richard F. West, Wendy M. Williams, John O. Willis, Thomas R. Zentall
- Edited by Robert J. Sternberg, Oklahoma State University, Scott Barry Kaufman, New York University
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- The Cambridge Handbook of Intelligence
- Published online:
- 05 June 2012
- Print publication:
- 30 May 2011, pp xi-xiv
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- By Saleh H. Alwasel, Susan P. Bagby, David J. P Barker, Richard Boyd, Robert Boyd, Graham Burdge, Graham J Burton, Anthony M Carter, Irene Cetin, Zoe Cole, Cyrus Cooper, Hilary Critchley, Elaine Dennison, Susie Earl, Johan G Eriksson, Caroline H. D Fall, Anne C. Ferguson-Smith, Tom P. Fleming, Alison J. Forhead, Abigail L. Fowden, Dino Giussani, Laura Goodfellow, Nicholas Harvey, Christopher Holroyd, Joan Hunt, Alan A. Jackson, Thomas Jansson, Eric Jauniaux, Rosalind John, Eero Kajantie, Michelle Lampl, Karen Lillycrop, Charlie Loke, Samantha Louey, Per Magnus, Ashley Moffett, Lorna G. Moore, Terry Morgan, Clive Osmond, Perrie F. O'Tierney, Robert Pijnenborg, Lucilla Poston, Theresa L. Powell, Elizabeth J. Radford, Tessa J. Roseboom, Amanda Sferruzzi-Perri, Colin P. Sibley, Gordon C. S. Smith, Emanuela Taricco, Kent Thornburg, Benjamin Tycko, Owen R. Vaughan, Lisbeth Vercruysse
- Edited by Graham J. Burton, David J. P. Barker, Ashley Moffett, Kent Thornburg
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- Book:
- The Placenta and Human Developmental Programming
- Published online:
- 04 February 2011
- Print publication:
- 16 December 2010, pp vii-x
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. 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- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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The physiological control of gene action in the eyeless and eyegone mutants of Drosophila melanogaster
- David M. Hunt
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- Genetical Research / Volume 17 / Issue 3 / June 1971
- Published online by Cambridge University Press:
- 14 April 2009, pp. 195-208
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The effect of dietary supplements of individual l-amino acids on the expression of the eyegone and eyelessK mutants of Drosophila melanogaster are compared. In both mutants, eye size is reduced by excess levels of tryptophan, phenylalanine and methionine, and in each case the effects are independent of metabolic competition for pyridoxal phosphate. A dietary interaction involving methionine and UNA can be demonstrated in the eyK strain, but the mechanism of action of this amino acid is obscure. Tryptophan metabolism is examined in detail. Although both tryptamine and serotonin have significant effects, the action of tryptophan on eye development is largely independent of its metabolic products. Conversely, the effect of dietary supplements of certain catecholamines is consistent with the action of phenylalanine. The action of certain metabolic inhibitors provides additional support for the suggestion that the catecholamines have an important effect on morphogenesis in the eye imaginai disks. Eye development is also affected by increasing concentrations of γ-amino-butyric acid, and this, taken together with the effect of the catecholamines and indolalkylamines, suggests that physiological control of the action of the mutant genes on eye development involves a group of compounds characteristically associated with nervous tissue. Eye development in the eyK strain may be influenced by the availability of acetyl CoA, which would be expected to affect acetylcholine biosynthesis. Possible mechanisms of action of the effective dietary treatments are discussed, together with a tentative hypothesis regarding the mode of action of the mutant genes on eye development.