This is a collection of original articles on diverse vulnerable populations in Japan in the wake of the new coronavirus pandemic. The effects of COVID-19 are felt differently, with some among us at much greater risk of infection due to preexisting health and welfare conditions. For others, perhaps more than the risk of infection, it is the precautions taken to mitigate the risk for the whole population, such as lockdowns and business closures, that have pulled away the already fragile safety net of state and civil society organization (CSO) support, leading to increased marginalization and social exclusion. The goal of this set of papers is to document the conditions of those that have been most directly affected by the virus and to provide background on the conditions that made them vulnerable in the first place, notably chronic conditions that are brought into more obvious relief in light of emergency measures. Each of the authors had a pre-established relationship with those affected populations and employed various ethnographic approaches, some face to face, others digitally via Zoom interviews and SNS exchanges. In this moment of what appears to be relative calm, we hope that our collection, quickly compiled in an attempt to capture the ever-changing situation, will give some insight into how those most vulnerable are faring in this time of crisis and provide information that will allow us to prepare better before the next wave comes our way.

Of the many populations at risk in these corona times, the homeless are among the most vulnerable. Without shelter, having to do without personal protective equipment, often without health insurance and unable to limit contact with strangers, the risk of infection is very high. The emergency measures taken by the Tokyo Metropolitan Government included the closure of many public spaces, indoors and out, depriving them of access to the few spaces of survival. . This ethnographic article outlines how an older group of homeless men responded to the risk of infection and inconsistent government efforts to address this issue. Finally, we examine the response of civil society organizations to compensate for weakness of the government’s response.

Recently, young people have been out on the Tokyo streets and in the mass media in opposition to Prime Minister Abe's efforts to pass the State Secrecy Acts, the “reinterpretation” of Article 9 of the Constitutions and the Security Bills. None have garnered more interest or exerted more influence than SEALDs, Students Emergency Action for Liberal Democracy. They are worthy of attention for various reasons, but we should note at the start they are the first college-based social movement in 50 years to have drawn such attention in their efforts to directly address the Japanese government's policy. They are speaking out in favor of constitutional democracy, due process and respect for popular opinion; for peace in Asia and social eguality within Japan.

In the context of the global increase in displaced people, spiking to nearly 80 million in these corona times, Japan has also seen a dramatic increase in the number of applications for refugee asylum since 2010. Despite increasing numbers of applications, Japan has not increased its refugee recognition rate. Unable to return home to sure persecution when rejected, many refugees end up in Japanese detention centers once their visa expires. Like jails, hospitals and detention centers everywhere, detention centers in Japan are crowded and dangerous and unable to protect the detainees inside. Japan has been slower than many other countries to take precautions, including temporary release. This paper outlines some of the policy shifts that have led to this dangerous situation, the conditions of anxiety inside the detention centers themselves in Tokyo and Ibaraki and the problematic situation of “provisional release” of some detainees into a corona-infested Japan without any safety net or protection. We hope to not only point out the immediate danger of infection under COVID-19, but also the larger dynamic of using detention to manage a refugee asylum system that has proven to be ineffective and unjust.

The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.

In comparative-historical analysis, countries are always different places before critical junctures set them on divergent pathways. By comparing the legacies of politicized ethnic diversity for the construction of state infrastructural power in Latin America and Southeast Asia, we elaborate the methodological and substantive importance of these “critical antecedents.” The critical antecedent in each region was the inheritance at independence of a sharp indigenous cleavage. This indigenous inheritance shaped threat perceptions and state-society coalitions in both regions in similarly powerful path-dependent ways—yet in intriguingly divergent directions. A salient indigenous cleavage hindered but did not preclude state building in nineteenth-century Peru, while fostering but not predestining state building in post–World War II Malaysia. Divergent levels of postcolonial state infrastructural power thus exhibit deep if indirect foundations in the identity cleavages inherited from preindependence eras. This cross-region comparative exploration highlights the analytical leverage gained from systematically incorporating preexisting cross-case differences into critical juncture accounts.

Greenland's marine-terminating glaciers may be sensitive to oceanic heat, but the fjord processes controlling delivery of this heat to glacier termini remain poorly constrained. Here we use a three-dimensional numerical model of Kangerdlugssuaq Fjord, East Greenland, to examine controls on fjord/shelf exchange. We find that shelf-forced intermediary circulation can replace up to ~25% of the fjord volume with shelf waters within 10 d, while buoyancy-driven circulation (forced by subglacial runoff from marine-terminating glaciers) exchanges ~10% of the fjord volume over a 10 d period under typical summer conditions. However, while the intermediary circulation generates higher exchange rates between the fjord and shelf, the buoyancy-driven circulation is consistent over time hence more efficient at transporting water along the full length of the fjord. We thus find that buoyancy-driven circulation is the primary conveyor of oceanic heat to glaciers during the melt season. Intermediary circulation will however dominate during winter unless there is sufficient input of fresh water from subglacial melting. Our findings suggest that increasing shelf water temperatures and stronger buoyancy-driven circulation caused the heat available for melting at Kangerdlugssuaq Glacier to increase by ~50% between 1993–2001 and 2002–11, broadly coincident with the onset of rapid retreat at this glacier.

Methylation of the fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary positioned fragile X related epigenetic element 2 (FREE2), reveals skewed X-chromosome inactivation (XCI) in fragile X syndrome full mutation (FM: CGG > 200) females. XCI skewing has been also linked to abnormal X-linked gene expression with the broader clinical impact for sex chromosome aneuploidies (SCAs). In this study, 10 FREE2 CpG sites were targeted using methylation specific quantitative melt analysis (MS-QMA), including 3 sites that could not be analysed with previously used EpiTYPER system. The method was applied for detection of skewed XCI in FM females and in different types of SCA. We tested venous blood and saliva DNA collected from 107 controls (CGG < 40), and 148 FM and 90 SCA individuals. MS-QMA identified: (i) most SCAs if combined with a Y chromosome test; (ii) locus-specific XCI skewing towards the hypomethylated state in FM females; and (iii) skewed XCI towards the hypermethylated state in SCA with 3 or more X chromosomes, and in 5% of the 47,XXY individuals. MS-QMA output also showed significant correlation with the EpiTYPER reference method in FM males and females (P < 0.0001) and SCAs (P < 0.05). In conclusion, we demonstrate use of MS-QMA to quantify skewed XCI in two applications with diagnostic utility.

Background: Environmental factors have been associated with psychosis but there is little qualitative research looking at how the ongoing interaction between individual and environment maintains psychotic symptoms. Aims: The current study investigates how people with persecutory delusions interpret events in a virtual neutral social environment using qualitative methodology. Method: 20 participants with persecutory delusions and 20 controls entered a virtual underground train containing neutral characters. Under these circumstances, people with persecutory delusions reported similar levels of paranoia as non-clinical participants. The transcripts of a post-virtual reality interview of the first 10 participants in each group were analysed. Results: Thematic analyses of interviews focusing on the decision making process associated with attributing intentions of computer-generated characters revealed 11 themes grouped in 3 main categories (evidence in favour of paranoid appraisals, evidence against paranoid appraisals, other behaviour). Conclusions: People with current persecutory delusions are able to use a range of similar strategies to healthy volunteers when making judgements about potential threat in a neutral environment that does not elicit anxiety, but they are less likely than controls to engage in active hypothesis-testing and instead favour experiencing “affect” as evidence of persecutory intention.

Using first principles techniques we have examined the relative physisorption/chemisorption energetics of neutral molecular water and oxygen at the most thermodynamically stable surface (110) of tin dioxide. We find that water binds more strongly to the perfect surface at 5 co- ordinate tin sites than oxygen. However, binding of both water and oxygen at bridging oxygen vacancies in the defective surface is comparable. In the context of gas-sensing behaviour at moderate temperatures (∼300K), we propose that the Mars and van Krevelen [1] re-oxidation reaction will slow when the partial pressure of water is high, since the number of favourable adsorption sites will effectively decrease. In addition, one would expect that the surface conductivity will increase, since the re-oxidation reaction will be hindered.