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COVID-19 had the potential to dramatically increase public support for welfare. It was a time of apparent increased solidarity, of apparently deserving claimants, and of increasingly widespread exposure to the benefits system. However, there are also reasons to expect the opposite effect: an increase in financial strain fostering austerity and self-interest, and thermostatic responses to increasing welfare generosity. In this paper, we investigate the effects of the pandemic on attitudes towards working-age unemployment benefits in the UK using a unique combination of data sources: (i) temporally fine-grained data on attitudinal change over the course of the pandemic; and (ii) a novel nationally representative survey contrasting attitudes towards pandemic-era and pre-pandemic claimants (including analysis of free-text responses). Our results show that the pandemic prompted little change in UK welfare attitudes. However, we also find that COVID-era unemployment claimants were perceived as substantially more deserving than those claiming prior to the pandemic. This contrast suggests a strong degree of ‘COVID exceptionalism’ – with COVID claimants seen as categorically different from conventional claimants, muting the effect of the pandemic on welfare attitudes overall.
Rapid antigen detection tests (Ag-RDT) for SARS-CoV-2 with emergency use authorization generally include a condition of authorization to evaluate the test’s performance in asymptomatic individuals when used serially. We aim to describe a novel study design that was used to generate regulatory-quality data to evaluate the serial use of Ag-RDT in detecting SARS-CoV-2 virus among asymptomatic individuals.
Methods:
This prospective cohort study used a siteless, digital approach to assess longitudinal performance of Ag-RDT. Individuals over 2 years old from across the USA with no reported COVID-19 symptoms in the 14 days prior to study enrollment were eligible to enroll in this study. Participants throughout the mainland USA were enrolled through a digital platform between October 18, 2021 and February 15, 2022. Participants were asked to test using Ag-RDT and molecular comparators every 48 hours for 15 days. Enrollment demographics, geographic distribution, and SARS-CoV-2 infection rates are reported.
Key Results:
A total of 7361 participants enrolled in the study, and 492 participants tested positive for SARS-CoV-2, including 154 who were asymptomatic and tested negative to start the study. This exceeded the initial enrollment goals of 60 positive participants. We enrolled participants from 44 US states, and geographic distribution of participants shifted in accordance with the changing COVID-19 prevalence nationwide.
Conclusions:
The digital site-less approach employed in the “Test Us At Home” study enabled rapid, efficient, and rigorous evaluation of rapid diagnostics for COVID-19 and can be adapted across research disciplines to optimize study enrollment and accessibility.
The purpose of this study was to assess the relationship between attentional style profiles of cricketers as measured by Nideffer's (1977) Test of Attentional and Interpersonal Style (TAIS) and a performance component, playing level. A method of scoring and comparing attentional style profiles was developed. Cricket players (N = 68) at three different skill levels served as subjects. Results revealed that higher level players exhibited a higher proportion of profiles predicted to be associated with superior performance in fast-ball games, and lower proportions of inappropriate profiles, than the lowest playing levels subjects. The present results provide support for the use of attentional profile scores as a predictor of sport performance.
Cognitive reserve (CR) is a protective factor that supports cognition by increasing the resilience of an individual's cognitive function to the deleterious effects of cerebral lesions. A single environmental proxy indicator is often used to estimate CR (e.g. education), possibly resulting in a loss of the accuracy and predictive power of the investigation. Furthermore, while estimates of an individual's prior CR can be made, no operational measure exists to estimate dynamic change in CR resulting from exposure to new life experiences.
Methods:
We aimed to develop two latent measures of CR through factor analysis: prior and current, in a sample of 467 healthy older adults.
Results:
The prior CR measure combined proxy measures traditionally associated with CR, while the current CR measure combined variables that had the potential to reflect dynamic change in CR due to new life experiences. Our main finding was that the analyses uncovered latent variables in hypothesized prior and current models of CR.
Conclusions:
The prior CR model supports multivariate estimation of pre-existing CR and may be applied to more accurately estimate CR in the absence of neuropathological data. The current CR model may be applied to evaluate and explore the potential benefits of CR-based interventions prior to dementia onset.
The central serotonergic system has been implicated in the pathophysiology of panic disorder (PD) by evidence of abnormally elevated serotonin-turnover, reduced pre- and post-synaptic 5-HT1A−receptor sensitivity and binding and clinical improvement during administration of agents that enhance serotonergic transmission. Polymorphisms in genes that putatively influence serotonergic neurotransmission increase the vulnerability for developing PD specifically in males. We tested the hypotheses that serotonin transporter (5-HTT) binding is elevated in PD subjects vs. healthy controls in regions where in vivo evidence exists for both elevated 5-HTT and 5-HT1A receptor levels in PD and investigated whether the extent of this difference depends upon gender. Volunteers were out-patients with current PD (n=24) and healthy controls (n=24). The non-displaceable component of 5-HTT binding-potential (BPND) was measured using positron emission tomography and the 5-HTT selective radioligand, [11C]DASB. PD severity was assessed using the PD Severity Scale. The 5-HTT-BPND was increased in males with PD relative to male controls in the anterior cingulate cortex (F=8.96, pFDR=0.01) and midbrain (F=5.09, pFDR=0.03). In contrast, BPND did not differ between females with PD and female controls in any region examined. The finding that 5-HTT-binding is elevated in males but not in females with PD converges with other evidence suggesting that dysfunction within the central serotonergic system exists in PD, and also indicates that such abnormalities are influenced by gender. These findings conceivably may reflect a sexual dimorphism that underlies the greater efficacy of serotonin reuptake inhibitor treatment in females vs. males with PD.
This paper presents a preliminary comparison between the role of computer-aided design (CAD) and sketching in engineering through a case study of a senior design project and interviews with industry and academia. The design team consisted of four senior level mechanical engineering students each with less than 1 year of professional experience are observed while completing an industry sponsored mechanical engineering capstone design project across a 17 week semester. Factors investigated include what CAD tools are used, when in the design process they are implemented, the justification for their use from the students' perspectives, the actual knowledge gained from their use, the impact on the final designed artifact, and the contributions of any sketches generated. At each design step, comparisons are made between CAD and sketching. The students implemented CAD tools at the onset of the project, generally failing to realize gains in design efficiency or effectiveness in the early conceptual phases of the design process. As the design became more concrete, the team was able to recognize clear gains in both efficiency and effectiveness through the use of computer assisted design programs. This study is augmented by interviews with novice and experienced industry users and academic instructors to align the trends observed in the case study with industry practice and educational emphasis. A disconnect in the perceived capability of CAD tools was found between novice and experienced user groups. Opinions on the importance of sketching skills differed between novice educators and novice industry professionals, suggesting that there is a change of opinion as to the importance of sketching formed when recent graduates transition from academia to industry. The results suggest that there is a need to emphasize the importance of sketching and a deeper understanding as to the true utility of CAD tools at each stage of the design process.
This chapter talks about a 50-year-old man who was referred for dementia evaluation a few months after losing his job as head of a department in a large company. An MRI scan was initially described with white matter lesions in the temporal and parietal lobes, but no focal atrophy. A revised report also described cortical atrophy of the frontal lobes. The diagnosis of the Frontotemporal Dementia (FTD) was given based on the dominant clinical symptoms that had developed gradually over a couple of years: apathy, disinhibition, loss of social conduct, impaired empathy, stereotypic behavior, neglect of self-care, altered eating pattern, and impaired insight. Frontotemporal Lobar Degeneration (FTLD) is used here as the general label for neurodegenerative diseases involving primarily the anterior regions of the brain. The patient presented here is a prototypical example of the behavioral variant of FTLD, exhibiting most of the characteristic features of this clinical subtype.
Oilseed rape is a very undeveloped crop with regard to efficiency of production and the agronomic practice used to maximize its potential. The genetic potential to modify oilseed rape is limited by the narrow genetic base found within the breeding gene pool, resulting in limited novel variation available for exploitation. Novel variation is, however, present in wild diploid ancestors of oilseed rape and has been made available by developing synthetic Brassica napus. This is illustrated through the use of this material to develop an understanding of pod shattering which is one of the most agronomically important characteristics of the crop. Through a variety of approaches it is shown how progress has been made to understand this trait and how this understanding is being used to improve the crop such that efficiency of production will be enhanced.
The developments of two major components of a three terminal dual wavelength LED for excitation of multiple phosphors are described. Such a configuration will be novel Broadband Spectrally Dynamic Light Emitting Diode (BSDLED). First, work towards a functional tunnel junction in the GaN system is discussed. The developments of p+ and n+ GaN layers are specifically discussed in relation to their use in a buried current spreading contact layer. Second, the analysis of several phosphors and their application in a spectrally dynamic source is explored. The response to multiple wavelengths of the phosphors is analyzed to create a light source that can be tuned in “real time” to a wide range of correlated color temperatures.
Parasitic exploitation occurs within and between a wide variety of taxa in a plethora of diverse contexts. Theoretical and empirical analyses indicate that parasitic exploitation can generate substantial genetic and phenotypic polymorphism within species. Under some circumstances, parasitic exploitation may also be an important factor causing reproductive isolation and promoting speciation. Here we review research relevant to the relationship between parasitic exploitation, within species-polymorphism, and speciation in some of the major arenas in which such exploitation has been studied. This includes research on the vertebrate major histocompatibility loci, plant–pathogen interactions, the evolution of sexual reproduction, intragenomic conflict, sexual conflict, kin mimicry and social parasitism, tropical forest diversity and the evolution of language. We conclude by discussing some of the issues raised by comparing the effect of parasitic exploitation on polymorphism and speciation in different contexts.
We present an analysis of the Chandra observations of two dwarf starburst, Wolf-Rayet galaxies (NGC 4449 and NGC 5253). We have identified at least three different classes of objects within the X-ray point source populations, and we have found the diffuse emission, resulting from the stellar winds and supernova explosions of massive stars, to have a complex morphology and to consist of several components. Comparison with the Hα emission suggests the presence of ~ kpc-scale wind-blown bubbles and ruptured superbubbles.
The relationship of size to MEP-2* genotype was investigated in 0+ juvenile Atlantic salmon (Salmo salar) in the River North Esk, Scotland. Significant temperature-associated MEP-2* heterogeneity was observed among tributaries and, in the two tributaries studied, size and MEP-2* genotype were significantly associated. No size association, or heterogeneity among tributaries, was found for the other allozyme polymorphisms screened. The results suggest that the association between size and MEP-2* variation, noted by others, is likely to be widespread in wild populations, and potentially linked to habitat temperature.