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Edited by
Allan Young, Institute of Psychiatry, King's College London,Marsal Sanches, Baylor College of Medicine, Texas,Jair C. Soares, McGovern Medical School, The University of Texas,Mario Juruena, King's College London
This chapter focuses on how recent advances in neuroimaging methods have increased our understanding of a key treatment for bipolar disorder, lithium. Structural magnetic resonance imaging (sMRI) studies suggest that lithium normalises both global and regional reductions in grey matter volume associated with bipolar disorder, while diffusion-weighted imaging (dMRI) studies have shed light on lithium’s potential to rectify abnormalities in white matter integrity. We describe the advent of direct imaging of lithium distribution in the brain using multinuclear MRI techniques (7Li-MRI) which is the first report of noninvasive imaging of a psychoactive drug in its target organ. The spatially heterogenous distribution of the 7Li-MR signal may suggest that lithium directly influences brain structure and function based on lithium tissue concentrations and initial work combining 7Li-MRI and dMRI support this hypothesis. Future directions of research are discussed, including harnessing the potential of multi-modal imaging and longitudinal study designs to develop combined biomarkers or biosignatures of response to treatment. Using lithium as an example, technological and scientific advances in brain imaging can facilitate treatment development and a personalised medicine approach in bipolar disorder.
Population-wide restrictions during the COVID-19 pandemic may create barriers to mental health diagnosis. This study aims to examine changes in the number of incident cases and the incidence rates of mental health diagnoses during the COVID-19 pandemic.
Methods
By using electronic health records from France, Germany, Italy, South Korea and the UK and claims data from the US, this study conducted interrupted time-series analyses to compare the monthly incident cases and the incidence of depressive disorders, anxiety disorders, alcohol misuse or dependence, substance misuse or dependence, bipolar disorders, personality disorders and psychoses diagnoses before (January 2017 to February 2020) and after (April 2020 to the latest available date of each database [up to November 2021]) the introduction of COVID-related restrictions.
Results
A total of 629,712,954 individuals were enrolled across nine databases. Following the introduction of restrictions, an immediate decline was observed in the number of incident cases of all mental health diagnoses in the US (rate ratios (RRs) ranged from 0.005 to 0.677) and in the incidence of all conditions in France, Germany, Italy and the US (RRs ranged from 0.002 to 0.422). In the UK, significant reductions were only observed in common mental illnesses. The number of incident cases and the incidence began to return to or exceed pre-pandemic levels in most countries from mid-2020 through 2021.
Conclusions
Healthcare providers should be prepared to deliver service adaptations to mitigate burdens directly or indirectly caused by delays in the diagnosis and treatment of mental health conditions.
Physical activity (PA) may help maintain brain structure and function in aging. Since the intensity of PA needed to effect cognition and cerebrovascular health remains unknown, we examined associations between PA and cognition, regional white matter hyperintensities (WMH), and regional cerebral blood flow (CBF) in older adults.
Method:
Forty-three older adults without cognitive impairment underwent magnetic resonance imaging (MRI) and comprehensive neuropsychological assessment. Waist-worn accelerometers objectively measured PA for approximately one week.
Results:
Higher time spent in moderate to vigorous PA (MVPA) was uniquely associated with better memory and executive functioning after adjusting for all light PA. Higher MVPA was also uniquely associated with lower frontal WMH volume although the finding was no longer significant after additionally adjusting for age and accelerometer wear time. MVPA was not associated with CBF. Higher time spent in all light PA was uniquely associated with higher CBF but not with cognitive performance or WMH volume.
Conclusions:
Engaging in PA may be beneficial for cerebrovascular health, and MVPA in particular may help preserve memory and executive function in otherwise cognitively healthy older adults. There may be differential effects of engaging in lighter PA and MVPA on MRI markers of cerebrovascular health although this needs to be confirmed in future studies with larger samples. Future randomized controlled trials that increase PA are needed to elucidate cause-effect associations between PA and cerebrovascular health.
Air dispersal of respiratory viruses other than SARS-CoV-2 has not been systematically reported. The incidence and factors associated with air dispersal of respiratory viruses are largely unknown.
Methods:
We performed air sampling by collecting 72,000 L of air over 6 hours for pediatric and adolescent patients infected with parainfluenza virus 3 (PIF3), respiratory syncytial virus (RSV), rhinovirus, and adenovirus. The patients were singly or 2-patient cohort isolated in airborne infection isolation rooms (AIIRs) from December 3, 2021, to January 26, 2022. The viral load in nasopharyngeal aspirates (NPA) and air samples were measured. Factors associated with air dispersal were investigated and analyzed.
Results:
Of 20 singly isolated patients with median age of 30 months (range, 3 months–15 years), 7 (35%) had air dispersal of the viruses compatible with their NPA results. These included 4 (40%) of 10 PIF3-infected patients, 2 (66%) of 3 RSV-infected patients, and 1 (50%) of 2 adenovirus-infected patients. The mean viral load in their room air sample was 1.58×103 copies/mL. Compared with 13 patients (65%) without air dispersal, these 7 patients had a significantly higher mean viral load in their NPA specimens (6.15×107 copies/mL vs 1.61×105 copies/mL; P < .001). Another 14 patients were placed in cohorts as 7 pairs infected with the same virus (PIF3, 2 pairs; RSV, 3 pairs; rhinovirus, 1 pair; and adenovirus, 1 pair) in double-bed AIIRs, all of which had air dispersal. The mean room air viral load in 2-patient cohorts was significantly higher than in rooms of singly isolated patients (1.02×104 copies/mL vs 1.58×103 copies/mL; P = .020).
Conclusion:
Air dispersal of common respiratory viruses may have infection prevention and public health implications.
The absence of observable innovation data for a firm often leads us to exclude or classify these firms as non-innovators. We assess the reliability of six methods for dealing with unreported innovation using several different counterfactuals for firms without reported R&D or patents. These tests reveal that excluding firms without observable innovation or imputing them as zero innovators and including a dummy variable can lead to biased parameter estimates for observed innovation and other explanatory variables. Excluding firms without patents is especially problematic, leading to false-positive results in empirical tests. Our tests suggest using multiple imputation to handle unreported innovation.
We developed two leafy spurge bacterial artificial chromosome (BAC)
libraries that together represent approximately 5× coverage of the leafy
spurge genome. The BAC libraries have an average insert size of
approximately 143 kb, and copies of the library and filters for
hybridization-based screening are publicly available through the Arizona
Genomics Institute. These libraries were used to clone full-length genomic
copies of an AP2/ERF transcription factor of the A4
subfamily of DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEINS
(DREB) known to be differentially expressed in crown buds of
leafy spurge during endodormancy, a DORMANCY ASSOCIATED
MADS-BOX (DAM) gene, and several
FLOWERING LOCUS T (FT) genes.
Sequencing of these BAC clones revealed the presence of multiple
FT genes in leafy spurge. Sequencing also provided
evidence that two different DAM transcripts expressed in
crown buds of leafy spurge during endo- and eco-dormancy result from
alternate splicing of a single DAM gene. Sequence data from
the FT promoters was used to identify several conserved
elements previously recognized in Arabidopsis, as well as potential novel
transcription factor binding sites that may regulate FT.
These leafy spurge BAC libraries represent a new genomics-based tool that
complements existing genomics resources for the study of plant growth and
development in this model perennial weed. Furthermore, phylogenetic
footprinting using genes identified with this resource demonstrate the
usefulness of studying weedy species to further our general knowledge of
agriculturally important genes.
The formal commissioning of the IRWG occurred at the 1991 Buenos Aires General Assembly, following a Joint Commission meeting at the IAU GA in Baltimore in 1988 that identified the problems with ground-based infrared photometry. The meeting justification, papers, and conclusions, can be found in Milone (1989). In summary, the challenges involved how to explain the failure to achieve the milli-magnitude precision expected of infrared photometry and an apparent 3% limit on system transformability. The proposed solution was to redefine the broadband Johnson system, the passbands of which had proven so unsatisfactory that over time effectively different systems proliferated, although bearing the same “JHKLMNQ” designations; the new system needed to be better positioned and centered in the spectral windows of the Earth's atmosphere, and the variable water vapour content of the atmosphere needed to be measured in real time to better correct for atmospheric extinction.
The formal origin of the IRWG occured at the Buenos Aires General Assembly, following a Joint Commission meeting at the IAU GA in Baltimore in 1988 that identified the problems with ground-based infrared photometry. The situation is summarized in Milone (1989). In short, the challenges involved how to explain the failure to achieve the milli-magnitude precision expected of infrared photometry and an apparent 3% limit on system transformability. The proposed solution was to redefine the broadband Johnson system, the passbands of which had proven so unsatisfactory that over time effectively different systems proliferated, although bearing the same JHKLMNQ designations; the new system needed to be better positioned and centered in the atmospheric windows of the Earth's atmosphere, and the variable water vapour content of the atmosphere needed to be measured in real time to better correct for atmospheric extinction.
We show that the ℵ0-categorical structures produced by Hrushovski's predimension construction with a control function fit neatly into Shelah's SOPn hierarchy: if they are not simple, then they have SOP3 and NSOP4. We also show that structures produced without using a control function can be undecidable and have SOP.
Vitamin D is essential for Ca absorption, prevention of falls and fracture, and maintenance of muscle strength and balance. Lack of awareness of the importance of vitamin D in bone health is common in Asia.
Objective
To define key statements, objectives and actions for improving osteoporosis management and vitamin D inadequacy in Asia.
Results and conclusion
This declaration was jointly produced by specialists at the Asia Metaforum on the Role of Vitamin D and the Management of Osteoporosis, held in September 2006 in Hong Kong, to define actions to prevent vitamin D insufficiency in Asia. Although developed specifically for Asia, some or all of these statements may be applicable to other regions of the world.
Two patients are described with sudden death as the first presenting symptom of Kawasaki disease. The first patient died of cardiac tamponade as a result of rupture of a coronary arterial aneurysm at the age of three months and nineteen days. The second patient, one and half years old, developed acute myocardial infarction secondary to coronary arterial aneurysm and thrombosis. The true nature of their underlying disease was realized only after postmortem examination. Their clinical signs and symptoms of Kawasaki disease might be so mild as to escape recognition. A high index of suspicion should be exercised by the clinician in order not to miss this condition, especially in places where Kawasaki disease is uncommon.
This paper presents the findings of a study of the support and service needs of older Chinese people in Brisbane, the capital city of Queensland, Australia. There were two specific objectives: to ascertain the problems encountered by older Chinese-Australians in their daily lives and social activities; and to develop policy and service development recommendations, with a view to mitigating their problems, meeting their unmet needs, improving their quality of life, and enhancing their participation in Australian society. The study used multiple methods, including a literature review, focus group meetings, and a community survey. The findings indicate that older Chinese people, and particularly women, experience significant restrictions in their activity patterns, social isolation and loneliness. Their lack of proficiency in the English language, and the difficulties they have in accessing language-support and interpretation services, limit their autonomous mobility and make them heavily dependent on their adult children, not least for transport. Their physical and psychological wellbeing is affected further by strained relations with their adult children, and these are compounded by financial concerns. The implications of the findings for welfare policy and practice are discussed at the end of the paper.
Renewed interest in nuclear power in the United States has prompted investigations into new reactor designs, resulting in a need to gain a greater understanding of the properties of the materials which are proposed for use in next generation nuclear reactors. This presentation will focus on preliminary results of large-scale empirical potential atomistic studies into the generation of point defect clusters in 3C SiC by particle irradiation and the evolution from point defect clusters to ‘voids’ on the atomic scale. Our working definition of ‘void’ will be explained in the context of small length-scale simulations. The determination of interstitial and vacancy diffusivities for the empirical potential employed and its impact on defect coalescence will be discussed. The characterization of initial damage states for given irradiation conditions will be presented and compared to previous work on ceramics and ceramic-composites.
We have completed a grid of spherically symmetric AGB star atmospheres using the state of the art spectral synthesis code PHOENIX. Models are constructed for stars with masses of 1 M⊙ and 1.5 M⊙, spanning the range 10 to 3300 L⊙ in luminosity and 2500 to 5200 K in effective temperature. We find that grains of Al2O3 and CaTiO3 among other species form in atmospheres cooler than Teff = 3000 K. In the coolest models the grains cause a weakening of the TiO absorption features in the red and near infrared of up to 30% through both a depression of the continuum and a depletion of the TiO number abundance. We use spectrophotometric observations from a number of catalogs to determine effective temperature – spectral class and effective temperature – color relationships. We also compare synthetic colors calculated from our models with observations of M giants on Wing's 8-color narrow-band system of classification photometry.
Comprehensive data on the developmental history and
current behaviours of a large sample
of high-functioning individuals with diagnoses of autism, Asperger's
syndrome, or other
related disorder were collected via parent interviews. This provided the
basis for a taxonomic
analysis to search for subgroups. Most participants also completed theory
of mind tasks.
Three clusters or subgroups were obtained; these differed on theory of
mind performance
and on verbal abilities. Although subgroups were identified which bore
some relationship to
clinical differentiation of autistic, Asperger syndrome, and Pervasive
Developmental
Disorder Not Otherwise Specified (PDD-NOS) cases, the nature of the differences
between
them appeared strongly related to ability variables. Examination of the
kinds of behaviours
that differentiated the groups suggested that a spectrum of autistic disorders
on which
children differ primarily in term of degrees of social and cognitive impairments
could explain
the findings.
Spectra are presented in the J band (7400 to 9700 cm-1) for four Miras ranging in spectral type from M through C. All the program stars have been observed near minimum light. The program stars cover a considerable range in C/0 and the spectral features exhibit a progression as a function of C/0. The S-type stars contain strong bands not previously reported. Especially striking are two sets of triple-headed bands in the J-band spectrum of the S-type Mira R And. The bandheads, which are degraded to longer wavelengths, are at 7877, 7957, 8030 cm-1 and 8379, 8459, 8530 cm-1. The former triplet, which is the stronger of the two, also is present in the mild S star × Cyg but not in the M star R Cas. Additional heads are found in R And at 7477 cm-1, near the short wavelength edge of strong telluric absorption, and at 8968, 9031, 9063 cm-1. The bands are identified as the Δv = -1, 0, 1, and 2 sequences of a predicted (3II-3Δ) transition of ZrS. Additional conspicuous features in the spectra of × Cyg and R Cas are identified with V0, TiO, and H20 bands. These observations provide additional evidence that ZrS is responsible for the majority of the Keenan-Wing bands in the near infrared (0.7-1.1 μ). With additional laboratory work, the ZrS bands will provide an opportunity to measure sulfur abundances in late-type stellar photospheres.
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