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6 results

  • 2137 Percentage of viable tumor Versus radiation treatment effect in surgical specimens is not associated with outcomes in recurrent glioblastoma

  • Robert D. Schwab, Stephen Bagley, Zev Binder, Robert Lustig, Donald O’Rourke, Steven Brem, Arati S. Desai, MacLean Nasrallah
  • Journal:
    Journal of Clinical and Translational Science / Volume 2 / Issue S1 / June 2018
    Published online by Cambridge University Press:
    21 November 2018, p. 45
    • Article
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  • OBJECTIVES/SPECIFIC AIMS: In patients with recurrent glioblastoma (GBM) who undergo a second surgery following standard chemoradiotherapy, histopathologic examination of the resected tissue often reveals a combination of viable tumor and treatment-related inflammatory changes. However, it remains unclear whether the degree of viable tumor Versus “treatment effect” in these specimens impacts prognosis. We sought to determine whether the percentage of viable tumor Versus “treatment effect” in recurrent GBM surgical samples, as assessed by a trained neuropathologist and quantified on a continuous scale, is associated with overall survival. METHODS/STUDY POPULATION: We reviewed the records of 47 patients with histopathologically confirmed GBM who underwent surgical resection as the first therapeutic modality for suspected radiographic progression following standard radiation therapy and temozolomide. The percentage of viable tumor Versus “treatment effect” in each specimen was estimated by one neuropathologist who was blinded to patient outcomes. RESULTS/ANTICIPATED RESULTS: After adjusting for other known prognostic factors in a multivariate Cox proportional hazards model, there was no association between the degree of viable tumor and overall survival (HR 0.83; 95% CI, 0.20–3.4; p=0.20). DISCUSSION/SIGNIFICANCE OF IMPACT: These results suggest that, in patients who undergo resection for recurrent GBM following standard first-line chemoradiotherapy, histopathologic quantification of the degree of viable tumor Versus “treatment effect” present in the surgical specimen has limited prognostic influence and clinical utility.

  • 19 - Unpacking the effectivity paradox of strategy workshops: do strategy workshops produce strategic change?

  • Edited by Damon Golsorkhi, Linda Rouleau, David Seidl, Universität Zürich, Eero Vaara
  • Book:
    Cambridge Handbook of Strategy as Practice
    Published online:
    05 October 2012
    Print publication:
    26 August 2010, pp 291-309

  • Summary

    Introduction

    The recent turn of strategy research towards practice-based theorizing (Balogun et al. 2007; Johnson et al. 2003, 2007; Whittington 1996, 2006) has increased interest in the everyday micro-activities of strategy practitioners. Strategy, it is argued, is better conceptualized as something people do rather than something that firms in their markets have. The interest in what managers actually do has a long tradition in the field of strategy process, starting with the seminal studies of Mintzberg (1973). Yet, in contrast to earlier research on organizational practices (Dalton 1959; Kotter 1982; Mintzberg, 1973), which emphasized the informal side of managerial work, the Strategy as Practice approach – whilst acknowledging the importance of emergence – calls for a reappreciation of the role of formal strategic practices. As Whittington (2003, p. 118) argued, formal practices deserve our particular attention for two reasons: not only are they pervasive phenomena in organizational life – a large part of organizational activity is in some way concerned with formal practices – but they also inflict considerable costs on the respective organizations. Responding to such calls, several researchers have looked into the organizational effects of various formal practices such as different administrative routines (Jarzabkowski 2003, 2005; Jarzabkowski and Wilson 2002) or strategy meetings (Jarzabkowski and Seidl 2008), discussing their role in organizational strategizing.

    More recently, attention has begun to centre on the role of strategy workshops as a particular formal strategic practice.

  • Global Ethics and Global Peace

  • Donald A. MacLean
  • Journal:
    The Review of Politics / Volume 5 / Issue 4 / October 1943
    Published online by Cambridge University Press:
    05 August 2009, pp. 517-523

  • World peace, the greatest natural good mankind can possess, is a universal global responsibility. In its attainment all peoples, nations and states should share. Sacrifice, generosity and good will are its vital concomitants.

    A necessary and urgent requirement for guaranteeing the ordered tranquility of mankind is the creation of a sound, reliable, and effective peace program. To this must be coupled such practical, juridical, international institutions as are necessary to ensure the application of the program to the realities of the present world crisis. This constitutes for peoples and states their major ethical obligation.