We present the design, construction and initial experimental validation of the Northwestern Polytechnical University Taylor–Couette (NPU-TC) apparatus, specifically developed to explore turbulent Taylor–Couette flows under conditions relevant to ultra-high-speed rotating machinery. The apparatus features an inner cylinder capable of rotating at speed of up to 10 000 rpm, corresponding to a Taylor number $Ta = 6.4 \times 10^8$, with an exceptionally narrow annular gap of 2.8 mm, yielding a radius ratio ($\eta$) of 0.98. Axial-scanning particle image velocimetry is employed here for the first time in air-based TC flows at such extreme conditions, which enables detailed velocity measurements without intrusive disturbances. Our velocity measurements demonstrate the absence of large-scale coherent flow structures, indicating a transition into the ultimate turbulence regime characterised by very thin boundary layers and nearly uniform velocity distributions in the bulk region. The NPU–TC apparatus thus represents a significant advance in experimental capabilities, providing critical insights into turbulent flow behaviour in high-speed rotating machinery.

Prior research suggests that low-carbohydrate diets may reduce the frequency of headache attacks in individuals with migraine. However, the association between dietary carbohydrate intake and migraine in adults remains unclear. Given migraine’s significant public health burden and the modifiable nature of diet, understanding this relationship is vital for prevention. This study therefore investigated whether carbohydrate intake is associated with severe headache or migraine in a nationally representative sample of US adults. Using National Health and Nutrition Examination Survey (NHANES) data (1999–2004), this study examined the association between dietary carbohydrate intake and severe headache or migraine in adults aged over 20. Multivariable logistic regression was used, adjusting for demographics, socioeconomic status, lifestyle factors, and comorbidities. The study surveyed 10,413 participants, with 2062 reporting severe headache or migraine. Analysis of carbohydrate energy percentage revealed: compared to Q1 (≤42.7%), odds ratios (ORs) for severe headache or migraine were 1.04 for Q2 (42.7% to ≤50.5%, P = 0.642), 1.13 for Q3 (50.5% to ≤58.0%, P = 0.176), and 1.32 for Q4 (>58.0%, P = 0.008). A non-linear association was found between dietary carbohydrate intake and severe headache or migraine among U.S. adults (P for non-linearity = 0.002). The group with carbohydrate intake ≥51.1% of total energy had an OR of 1.22 (95% CI: 1.09–1.38, P = 0.002) compared to those below this level. The data suggest a significant association, with an important inflection point occurring at approximately 51.1%. This research uncovered a non-linear link between carbohydrate intake from diet and the chance of suffering from severe headache or migraine among American adults.

At the low-coherence Kunwu laser facility with a 0.6% bandwidth, we experimentally studied the laser absorption efficiency of laser–target coupling at intensities of (3–5) × 1014 W cm–2. To characterize side scattering across a wide angular range, we developed a novel radiochromic film-based diagnostic system, which enables continuous spatial mapping over approximately π steradians for the first time. The results indicate a substantial reduction in total loss rate (by more than three times) when compared to a monochromatic laser. We focused on analyzing the influence of laser bandwidth on stimulated Brillouin scattering and stimulated Raman scattering (SRS). Notably, we found that the broadband laser enhances SRS at high intensities, which is contrary to the results obtained at low intensities. These results highlight the role of bandwidth as a quantitative control parameter for improving laser–plasma coupling, which is of particular significance for advancing direct-drive inertial confinement fusion.

A lattice Boltzmann method is adopted to investigate the breakup of surfactant-free and surfactant-laden droplets in both regular and irregular T-junction microchannels. During droplet neck contraction, the neck thinning shifts from inertia dominated to interfacial tension dominated, causing spontaneous rapid neck collapse due to Rayleigh–Plateau instability. For the regular rectangular microchannels, we find that the prerequisite for the spontaneous breakup of a surfactant-free droplet is that the local capillary pressure in the triggering area exceeds the Laplace pressure difference between the inside and outside of the droplet neck. Results show that the critical neck thickness $\delta _\textit{cr}^{*}$ for the droplet spontaneous breakup increases with increasing height-to-width ratio $\chi$ of the microchannel in both surfactant-free and surfactant-laden systems. The presence of surfactants decreases $\delta _\textit{cr}^{*}$ at the identified $\chi$, while the surfactant effects are gradually enhanced as $\chi$ increases. Subsequently, a constriction section is incorporated into the upper microchannel wall to establish an irregular microchannel. As constriction depth (length) increases, $\delta _\textit{cr}^{*}$ linearly decreases (increases) in the surfactant-free system, while $\delta _\textit{cr}^{*}$ exponentially decreases (linearly increases) in the surfactant-laden system. Four empirical formulas are proposed to predict the values of $\delta _\textit{cr}^{*}$ under varying constriction depths and lengths in the two systems.

Visual exploration is a task in which a camera-equipped robot seeks to efficiently visit all navigable areas of an environment within the shortest possible time. Most existing visual exploration methods rely on a static camera fixed to the robot’s body to control its own movements. However, coupling the orientation of camera with robot’s body limits the extra degrees of freedom to obtain more visual information. In this work, we adjust the camera orientation during robot motion by using a novel camera view planning (CVP) policy to improve the exploration efficiency. Specifically, we reformulate the CVP problem as a reinforcement learning problem. However, two new challenges need to be addressed: 1) determining how to learn an effective CVP policy in complex indoor environments and 2) figuring out how to synchronize it with the robot motion. To solve the above issues, we create a reward function considering factors such as exploration area, observed semantic objects, and the motion conflicts between the camera and the robot’s body. Moreover, to better coordinate the policies of the camera and the robot’s body, the CVP policy takes the body actions and the egocentric 2D spatial maps with exploration, occupancy, and trajectory information into account to make motion decisions. Experimental results show that after using the proposed CVP policy, the exploration area is expanded by 21.72% and 25.6% on average in the small-scale indoor scene with few structured obstacles and large-scale indoor scene with cluttered obstacles, respectively.

As international exploration of the Meso-Neoproterozoic continues, these layers have become a key target for deep oil and gas field exploration. The Ordos Basin exhibits considerable sedimentary thicknesses within the Meso-Neoproterozoic. However, significant hydrocarbon discoveries have not been forthcoming, primarily due to the complex tectonic evolution. This paper focuses on the southern Ordos Basin, utilizing logging-seismic calibration to interpret seismic data and elucidate Meso-Neoproterozoic tectonic features. By comparing ancient and modern tectonic patterns, based on palaeotectonic maps retrieved through the impression method and combining these with tectonic evolution profiles, the study clarifies the history of tectonic modification. Under the control of two fracture systems – basin-controlling fractures at the margin and trough-controlling fractures – the Changchengian exhibits two categories (single-fault and double-fault) and five sub-categories of fault depression combinations. The study highlights significant differences between ancient and modern tectonics in the Meso-Neoproterozoic, which are attributed to various tectonic stages, including the trough-uplift depositional differentiation stage during the early rift-late depression of the Changchengian, the basin-margin subsidence stage of the southwestern depression of the Jixianian, the uplift and denudation stage of the Sinian basin’s main body and the four-stage tectonic remodelling stage of differential uplift-subsidence in the Palaeoproterozoic. This study employs the ancient-present tectonic pattern as a point of departure, thereby enhancing the theoretical understanding of deep-seated tectonics in the Ordos Basin. It offers novel insights into the exploration of Meso-Neoproterozoic gas reservoirs from a tectonic remodelling perspective.

Eotetranychus kankitus is an important pest on several agricultural crops, and its resistance to pesticides has promoted the exploration of biological control strategies. Beauveria bassiana and Neoseiulus barkeri have been identified as potential agents for suppressing spider mites. This study aimed to investigate the pathogenicity of B. bassiana on E. kankitus and its compatibility with N. barkeri. Results showed that among the five tested strains of B. bassiana, Bb025 exhibited the highest level of pathogenicity on E. kankitus. Higher application rates (1 × 108 conidia/mL) of Bb025 led to a higher mortality rate of E. kankitus (90.402%), but also resulted in a 15.036% mortality of N. barkeri. Furthermore, preference response tests indicated that both E. kankitus and N. barkeri actively avoided plants sprayed with Bb025 compared to the control group that was sprayed with Tween-80. In a no-choice test, we observed that N. barkeri actively attacked Bb025-treated E. kankitus with no adverse effect on its predatory capacities. Furthermore, N. barkeri laid more eggs when fed on Bb025-treated E. kankitus compared to Tween-80-treated E. kankitus, but the subsequent generation of surviving individuals fed on Bb025-treated E. kankitus was reduced. These findings demonstrate that the Bb025 strain of B. bassiana is highly virulent against E. kankitus while causing less harm to N. barkeri. Consequently, a promising strategy for controlling E. kankitus could involve the sequential utilisation of Bb025 and N. barkeri at appropriate intervals.

Compacted bentonite, used as an engineering barrier for permanent containment of high-level radioactive waste, is susceptible to mineral evolution resulting in compromise of the expected barrier performance due to alkaline–thermal chemical interaction in the near-field. To elucidate the mineral-evolution mechanisms within bentonite and the transformation of the nuclide adsorption properties during that period, experimental evolution of bentonite was conducted in a NaOH solution with a pH of 14 at temperatures ranging from 60 to 120°C. The results showed that temperature significantly affects the stability of minerals in bentonite under alkali conditions. The dissolution rate of fine-grained cristobalite in bentonite exceeds that of smectite, with the phase-transition products of smectite being temperature-dependent. As the temperature rises, smectite experiences a three-stage transformation: initially, at 60°C, the lattice structure thins due to the collapse of the octahedral sheets; at 80°C, the lattice disintegrates and reorganizes into a loose framework akin to albite; and by 100°C, it further reorganizes into a denser framework resembling analcime. The adsorption properties of bentonite exhibit a peak inflection point at 80°C, where the dissolution of the smectite lattice eliminates interlayer pores and exposes numerous polar or negatively charged sites which results in a decrease in specific surface area and an increase in cation exchange capacity and adsorption capacity of Eu3+. This research provides insights into the intricate evolution of bentonite minerals and the associated changes in radionuclide adsorption capacity, contributing to a better understanding of the stability of bentonite barriers and the effective long-term containment of nuclear waste.

Artificial sweeteners are generally used and recommended to alternate added sugar for health promotion. However, the health effects of artificial sweeteners remain unclear. In this study, we included 6371 participants from the National Health and Nutrition Examination Survey with artificial sweetener intake records. Logistic regression and Cox regression were applied to explore the associations between artificial sweeteners and risks of cardiometabolic disorders and mortality. Mendelian randomisation was performed to verify the causal associations. We observed that participants with higher consumption of artificial sweeteners were more likely to be female and older and have above medium socio-economic status. After multivariable adjustment, frequent consumers presented the OR (95 % CI) for hypertension (1·52 (1·29, 1·80)), hypercholesterolaemia (1·28 (1·10, 1·50)), diabetes (3·74 (3·06, 4·57)), obesity (1·52 (1·29, 1·80)), congestive heart failure (1·89 (1·35, 2·62)) and heart attack (1·51 (1·10, 2·04)). Mendelian randomisation confirmed the increased risks of hypertension and type 2 diabetes. Moreover, an increased risk of diabetic mortality was identified in participants who had artificial sweeteners ≥ 1 daily (HR = 2·62 (1·46, 4·69), P = 0·001). Higher consumption of artificial sweeteners is associated with increased risks of cardiometabolic disorders and diabetic mortality. These results suggest that using artificial sweeteners as sugar substitutes may not be beneficial.

To date, a comprehensive understanding of the influence of the Prandtl number ($Pr$) on flow topology in turbulent Rayleigh–Bénard convection (RBC) remains elusive. In this study, we present an experimental investigation into the evolution of flow topology in quasi-two-dimensional turbulent RBC with $7.0 \leq Pr \leq 244.2$ and $2.03\times 10^{8} \leq Ra \leq 2.81\times 10^{9}$. Particle image velocimetry (PIV) measurements reveal the flow transitions from multiple-roll state to single-roll state with increasing $Ra$, and the transition is hindered with increasing $Pr$, i.e. the transitional Rayleigh number $Ra_t$ increases with $Pr$. We mapped out a phase diagram on the flow topology change on $Ra$ and $Pr$, and identified the scaling of $Ra_t$ on $Pr$: $Ra_t \sim Pr^{0.93}$ in the low $Pr$ range, and $Ra_t \sim Pr^{3.3}$ in the high $Pr$ range. The scaling in the low $Pr$ range is consistent with the model of balance of energy dissipation time and plume travel time that we proposed in our previous study, while the scaling in the high $Pr$ range implies a new governing mechanism. For the first time, the scaling of $Re$ on $Ra$ and $Pr$ is acquired through full-field PIV velocity measurement, $Re \sim Ra^{0.63}\,Pr^{-0.87}$. We also propose that increasing horizontal velocity promotes the formation of the large-scale circulation (LSC), especially for the high $Pr$ case. Our proposal was verified by achieving LSC through introducing horizontal driving force $Ra_H$ by tilting the convection cell with a small angle.

Human cystic echinococcosis (CE) is a zoonotic disorder triggered by the larval stage of Echinococcus granulosus (E. granulosus) and predominantly occurred in the liver and lungs. The M2 macrophage level is considerably elevated among the liver of patients with hepatic CE and performs an integral function in liver fibrosis. However, the mechanism of CE inducing polarisation of macrophage to an M2 phenotype is unknown. In this study, macrophage was treated with E. granulosus cyst fluid (EgCF) to explore the mechanism of macrophage polarisation. Consequently, the expression of the M2 macrophage and production of anti-inflammatory cytokines increased after 48 h treatment by EgCF. In addition, EgCF promoted polarisation of macrophage to an M2 phenotype by inhibiting the expression of transcriptional factor hypoxia-inducible factor 1-alpha (HIF-1α), which increased the expression of glycolysis-associated genes, including hexokinase 2 (HK2) and pyruvate kinase 2 (PKM2). The HIF-1α agonist ML228 also inhibited the induction of macrophage to an M2 phenotype by EgCF in vitro. Our findings indicate that E. granulosus inhibits glycolysis by suppressing the expression of HIF-1α.

HIV-1 molecular surveillance provides a new approach to explore transmission risks and targeted interventions. From January to June 2021, 663 newly reported HIV-1 cases were recruited in Zhaotong City, Yunnan Province, China. The distribution characteristics of HIV-1 subtypes and HIV-1 molecular network were analysed. Of 542 successfully subtyped samples, 12 HIV-1 strains were identified. The main strains were CRF08_BC (47.0%, 255/542), CRF01_AE (17.0%, 92/542), CRF07_BC (17.0%, 92/542), URFs (8.7%, 47/542), and CRF85_BC (6.5%, 35/542). CRF08_BC was commonly detected among Zhaotong natives, illiterates, and non-farmers and was mostly detected in Zhaoyang County. CRF01_AE was frequently detected among married and homosexual individuals and mostly detected in Weixin and Zhenxiong counties. Among the 516 pol sequences, 187 (36.2%) were clustered. Zhaotong natives, individuals aged ≥60 years, and illiterate individuals were more likely to be found in the network. Assortativity analysis showed that individuals were more likely to be genetically associated when stratified by age, education level, occupation, and reporting area. The genetic diversity of HIV-1 reflects the complexity of local HIV epidemics. Molecular network analyses revealed the subpopulations to focus on and the characteristics of the risk networks. The results will help optimise local prevention and control strategies.

The new mineral tennantite-(Ni), Cu6(Cu4Ni2)As4S13, has been discovered from the Luobusa Chromitite, Tibet, southwestern China. Tennantite-(Ni) occurs as anhedral grains ranging from 2 to 20 μm in size. In reflected light microscopy, tennantite-(Ni) is isotropic and appears yellow-greenish grey. Reflectance data for Commission on Ore Mineralogy wavelengths in air for tennantite-(Ni) are: 31.0 (470 nm), 29.6 (546 nm), 29.6 (589 nm) and 29.3 (650 nm). Electron microprobe analysis for holotype material gave the empirical formula (on basis of total cations = 16 apfu): M(2)Cu6 M(1)[Cu4.00(Ni0.97Cu0.53Fe0.50)Σ2.00]Σ6.00X(3)(As2.94Sb1.06)Σ4S12.77. Tennantite-(Ni) is cubic, with space group I$\bar{ 4}$3m (#217), a =10.2957(9) Å, V = 1091.4(3) Å3 and Z = 2. By using single-crystal X-ray diffraction, the crystal structure has been determined and refined to a final R1 = 0.0423 on the basis of 163 independent reflections [Fo > 4σ (Fo)]. The calculated seven strongest powder X-ray diffraction lines [d in Å (I) (hkl)] are: 2.972 (100) (222), 1.820 (83) (440), 2.574 (28) (400), 1.552 (18) (622), 3.640 (10) (220), 1.880 (10) (521) and 1.287 (7) (800). Tennantite-(Ni) is isostructural with other tetrahedrite-group minerals, and nickel is hosted at the tetrahedrally coordinated M(1) site, along with Cu and minor Fe. The mineral and its name have been approved by the Commission on New Minerals, Nomenclature and Classification of the International Mineralogical Association (IMA2021-018).

The resurgence and outbreaks of mumps occur frequently in many countries worldwide in recent years, even in countries with high vaccination coverage. In this study, a descriptive and spatiotemporal clustering analysis at the township level was conducted to explore the dynamic spatiotemporal aggregation and epidemiological characteristics of mumps in Wuhan. During 2005 and 2019, there were 40 685 cases reported in Wuhan, with an average annual morbidity of 28.11 per 100 000 populations. The morbidity showed a fluctuating tendency, and peaked in 2010 and 2018. Bimodal seasonality was found, with a large peak between May and July, and a mild peak from November to January in the following year. Male students aged 5–9-year-old were the main risk group of mumps infection. Significant global spatial auto-correlation was detected except in 2007, 2009 and 2015. The spatial and temporal scan statistics indicated that the hot-spots mainly located at the western and southern areas of Wuhan with variations almost every year. Our findings could assist the public health authorities to develop and improve targeted health strategies, and allocate health resources rationally.

Extensive evidence has demonstrated that bilinguals non-selectively activate lexicons of both languages when reading or hearing words in one language. Here, we further investigated the electrophysiological roles of cross-linguistic orthography and phonology in the processing of L2 spoken words in unbalanced Chinese (L1)–English (L2) bilinguals in a cross-modal situation. Relative to unrelated control, the recognition of auditory L2 words showed behavioral interference effects when paired with orthographic or phonological neighbors of the correct translations of L2 words. Moreover, the lexical effects were also exhibited in the electrophysiological data, as reflected by marginally less positive late positive component (500–800 ms) amplitudes in the frontal region. Importantly, the orthographic rather than phonological translation neighbor condition elicited less negative N400 (300–500 ms) amplitudes in the parietal–occipital regions, suggesting that this orthographic translation neighbor condition facilitated the co-activation of spoken L2 words. Taken together, these findings indicate that cross-linguistic orthographic and phonological activation have different temporal dynamics with both bottom-up parallel cross-linguistic activation and the top-down inhibitory control mechanism governing the two-language lexical organization in L2 spoken word recognition.