Clozapine remains the gold standard intervention for treatment-resistant schizophrenia; however, it remains underused, especially for some minority groups. A significant impediment is concern about propensity to neutropenia. The aim of this article is to provide an update on current knowledge relating to: the pattern and incidence of severe blood dyscrasias; the effectiveness of current monitoring regimes in reducing harm; the mechanisms of and the distinctions between clozapine-induced neutropenia and agranulocytosis; benign ethnic neutropenia; and changes to the monitoring thresholds in the USA and other international variations. These all have implications for the practical use of clozapine; specifically, how barriers to initiating, maintaining and restarting clozapine can be understood and in many cases overcome, especially for patients from minority groups, potentially with simpler approaches than the use of lithium or G-CSF.

Beginning in 1856 and ending in 1876, Portuguese colonial authorities in Mozambique registered almost 55,000 enslaved and freed Africans (libertos). The sources for these twinned registration processes are located in the national archives of Portugal and Mozambique. Fragments of the originals survive for only six of the ten districts of the colony, but contemporary copies exist for nearly all districts. Combined, they provide a unique opportunity to understand both the extent of slavery — as opposed to the export slave trade — and the process of abolition in late-nineteenth-century Mozambique. In this article we first describe the registers themselves, then focus on the registration of enslaved and freed Africans, the resistance of slaveholders, and the kinds of information that we can glean from the registers. We also explore the ways in which freed Africans were employed after registration and the extent to which being a liberto implied ‘freedom’. Finally, we consider how the registration led to new laws and policies in Portuguese Africa, opening a new era of European colonialism and imperial expansion.

We prove two main results on Denjoy–Carleman classes: (1) a composite function theorem which asserts that a function $f(x)$ in a quasianalytic Denjoy–Carleman class ${\mathcal{Q}}_{M}$, which is formally composite with a generically submersive mapping $y=\unicode[STIX]{x1D711}(x)$ of class ${\mathcal{Q}}_{M}$, at a single given point in the source (or in the target) of $\unicode[STIX]{x1D711}$ can be written locally as $f=g\circ \unicode[STIX]{x1D711}$, where $g(y)$ belongs to a shifted Denjoy–Carleman class ${\mathcal{Q}}_{M^{(p)}}$; (2) a statement on a similar loss of regularity for functions definable in the $o$-minimal structure given by expansion of the real field by restricted functions of quasianalytic class ${\mathcal{Q}}_{M}$. Both results depend on an estimate for the regularity of a ${\mathcal{C}}^{\infty }$ solution $g$ of the equation $f=g\circ \unicode[STIX]{x1D711}$, with $f$ and $\unicode[STIX]{x1D711}$ as above. The composite function result depends also on a quasianalytic continuation theorem, which shows that the formal assumption at a given point in (1) propagates to a formal composition condition at every point in a neighbourhood.

Many ethical dilemmas in medicine are associated with highly unusual clinical situations and are an almost daily challenge for mental health teams. We describe the ethical issues that arose in relation to a significant difference of opinion between team members about using nasogastric clozapine in the treatment of a severely ill patient. We discuss how conflicting emotions and perspectives within teams acquire ethical significance and how negotiation and reflection are essential for good-quality ethical reasoning to take place.

A peat core from southern Greenland provided a rare opportunity to investigate human-environment interactions, climate change and atmospheric pollution over the last ~ 700 years. X-ray fluorescence, gas chromatography-combustion, isotope ratio mass spectrometry, peat humification and fourier-transform infrared spectroscopy were applied and combined with palynological and archaeological evidence. Variations in peat mineral content seem to be related to soil erosion linked with human activity during the late Norse period (13th–14th centuries AD) and the modern era (20th century). Cooler conditions during the Little Ice Age (LIA) are reflected by both slow rates of peat growth and carbon accumulation, and by low bromine (Br) concentrations. Spörer and Maunder minima in solar activity may be indicated by further declines in Br and enrichment in easily degradable compounds such as polysaccharides. Peat organic matter composition was also influenced by vegetation changes at the end of the LIA when the expansion of oceanic heath was associated with polysaccharide enrichment. Atmospheric lead pollution was recorded in the peat after ~ AD 1845, and peak values occurred in the 1970s. There is indirect support for a predominantly North American lead source, but further Pb isotopic analysis would be needed to confirm this hypothesis.

The main purpose of this panel discussion was to encourage conversation around potential collaborations between the IAU Office of Astronomy for Development (OAD) and IAU Divisions. The discussion was facilitated by the OAD and the conversation revolved mainly around two questions: (i) What should the OAD be doing to enhance the work of the Divisions? (ii) What could the Divisions (both members and respective scientific discipline in general) contribute towards the implementation of the IAU strategic plan?

In Professional Ethics and Civic Morals, Emile Durkheim (1957: 50) explains that the state is the organ of a particular form of collective consciousness. This consciousness is not