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Maternal syphilis and congenital syphilis (CS) have been increasing globally, but there are limited data from Fiji. We performed secondary analysis of clinical trial data of intrapartum azithromycin given to pregnant women to determine the prevalence of maternal syphilis and estimate the incidence of probable CS. Healthy, pregnant women at a tertiary hospital were routinely tested for syphilis, and their infants, were enrolled between July 2019 and January 2022. World Health Organisation case definitions for maternal and CS were used. Of the 2112 women enrolled, 2073 (98.2%) were tested for syphilis; 82.7% (n = 1715) were iTaukei (indigenous Fijians), and the median age was 27 years (interquartile range [IQR] 23–32). The maternal syphilis prevalence was 6.6% (n = 137). The majority (85.4%, n = 117) of women with positive serological result received at least one dose of benzathine penicillin 30 days prior to delivery. There were 139 infants born to mothers with positive serological results. The 2.5-year pooled incidence of probable CS was 212 per 100000 livebirths. Confirmation of CS was not possible as results of polymerase chain reaction test of cerebrospinal fluid were not available. Fiji has a substantial burden of maternal and CS. To eliminate mother-to-child transmission, improvements in testing and follow-up are needed, along with comprehensive data and confirmatory testing to accurately determine disease burden.
The content learned in paediatric cardiology fellowship is variable depending on the socio-economic and geographic setting in which training takes place and may result in knowledge gaps. We highlight the key lessons learned from a recent case-based learning session, hosted by Heart University, between two programmes from different geographic and resource settings.
Historically, there are inconsistencies in the calculation of whole-grain intake, particularly through use of highly variable whole-grain food definitions. The current study aimed to determine the impact of using a whole-grain food definition on whole-grain intake estimation in Australian and Swedish national cohorts and investigate impacts on apparent associations with CVD risk factors. This utilised the Australian National Nutrition and Physical Activity Survey 2011–2012, the Swedish Riksmaten adults 2010–2011 and relevant food composition databases. Whole-grain intakes and associations with CVD risk factors were determined based on consumption of foods complying with the Healthgrain definition (≥30 % whole grain (dry weight), more whole than refined grain and meeting accepted standards for ‘healthy foods’ based on local regulations) and compared with absolute whole-grain intake. Compliance of whole-grain containing foods with the Healthgrain definition was low in both Sweden (twenty-nine of 155 foods) and Australia (214 of 609 foods). Significant mean differences of up to 24·6 g/10 MJ per d of whole-grain intake were highlighted using Swedish data. Despite these large differences, application of a whole-grain food definition altered very few associations with CVD risk factors, specifically, changes with body weight and blood glucose associations in Australian adults where a whole-grain food definition was applied, and some anthropometric measures in Swedish data where a high percentage of whole-grain content was included. Use of whole-grain food definitions appears to have limited impact on measuring whole-grain health benefits but may have greater relevance in public health messaging.
To determine the impacts of using a whole grain food definition on measurement of whole grain intake compared with calculation of total grams of intake irrespective of the source.
Design:
The Australian whole grain database was expanded to identify foods that comply with the Healthgrain whole grain food definition (≥30 % whole grains on a dry weight basis, whole grain ingredients exceeds refined grain and meeting accepted standards for healthy foods based on local regulations). Secondary analysis of the National Nutrition and Physical Activity Survey (NNPAS) 2011–2012 dietary intake data included calculation of whole grain intakes based on intake from foods complying with the Healthgrain definition. These were compared with intake values where grams of whole grain in any food had been included.
Setting:
Australia.
Participants:
Australians (≥2 years) who participated in the NNPAS 2011–2012 (n 12 153).
Results:
Following expansion of the whole grain database, 214 of the 609 foods containing any amount of whole grain were compliant with the Healthgrain definition. Significant mean differences (all P < 0·05) of 2·84–6·25 g/d of whole grain intake (5·91–9·44 g/d energy adjusted) were found when applying the Healthgrain definition in comparison with values from foods containing any whole grain across all age groups.
Conclusions:
Application of a whole grain food definition has substantial impact on calculations of population whole grain intakes. While use of such definitions may prove beneficial in settings such as whole grain promotion, the underestimation of total intake may impact on identification of any associations between whole grain intake and health outcomes.
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