Sleep is essential for the health of midlife women, yet the barriers (factors that impede) and facilitators (factors that support) to achieving adequate sleep, particularly among working-class women in Mexico City and broader Latin American contexts, remains insufficiently understood. This study aims to provide a nuanced understanding of the factors influencing sleep among working-class midlife women in Mexico City. A mixed-methods approach, combining quantitative data (epidemiologic measures) and qualitative data (ethnographic interviews), was employed among women enrolled in a Mexico City cohort. We used epidemiologic data to describe sleep and its correlates in a sample of 120 women, incorporating both self-reported (questionnaires and sleep diaries) and behavioral (actigraphy-based) measures of sleep. A subset of 30 women participated in in-depth ethnographic interviews to explore determinants of sleep, including barriers, facilitators and coping strategies to compensate for sleep loss. Our findings reveal that many women experienced poor sleep, with 43% reporting insomnia-related difficulties and 53% experiencing short sleep duration. Barriers included family-related stress, particularly caregiving responsibilities, economic instability, and mental health challenges. In response to sleep loss, women often resorted to coping mechanisms, such as caffeine consumption and napping, and the use of natural remedies. This study highlights the critical role social factors, including family dynamics and caregiving roles, in shaping sleep health outcomes. Sleep, as an inherently social behavior, is strongly influenced by these contextual factors. These findings underscore the importance of considering psychosocial and cultural contexts in interventions aimed at promoting healthy sleep in midlife women.