The crystal structures of six gem-quality pargasites and fluoro-pargasites from Mogok, Myanmar, space group C2/m, Z = 2, have been refined to R1 indices of 2.20–2.90% using MoKα X-radiation. The unit formulae were calculated from the results of electron-microprobe analysis, and were used with the refined site-scattering values and the observed mean bond lengths to assign site populations. TAl occurs at both the T(1) and T(2) sites but is strongly ordered at T(1). [6]Al is partly disordered over the M(2) and M(3) sites but does not occur at the M(1) site. ANa is split between the A(2) and A(m) sites and K occurs at the A(m) site. The infrared spectra in the principal OH-stretching region were measured and the fine structure was fit to component bands. The component bands were assigned to short-range ion arrangements over the configuration symbol M(1)M(1)M(3)–O(3)–A–O(3):T(1)T(1) using the refined site-populations and the expected frequencies from previously assigned spectra in more simple amphibole compositions, and correspond to the local arrangements: (1) MgMgMg–OH–Na–OH:SiAl; (2) MgMgMg–OH–Na–F:SiAl; (3) MgMgAl–OH–Na–OH:SiAl and (4) MgMgAl–OH–Na–F:SiAl.

U-Th isochron ages of tufas formed on shorelines suggest that the last pluvial event in Lake Lahontan and Searles Lake was synchronous at about 16,500 cal yr B.P. (equivalent to a radiocarbon age of between 14,000 and 13,500 yr B.P.), whereas the timing of this pluvial event determined by radiocarbon dating is on the order of 1000 yr younger. The timing of seven distinct periods of near desiccation in Searles Lake during late-glacial time has been reinvestigated for U-Th age determination by mass spectrometry. U-Th dating of evaporite layers in the interbedded mud and salt unit called the Lower Salt in Searles Lake was hampered by the uncertainty in assessing the initial 230Th/232Th of the samples. The resulting ages, corrected by a conservative range of initial 230Th/232Th ratios, suggest close correlation of the abrupt changes recorded in Greenland ice cores (Dansgaard-Oeschger events) and wet–dry conditions in Searles Lake between 35,000 and 24,000 cal yr B.P.

Microfluidic paper-based analytical devices (μPADs) use the passive capillary-driven flow of aqueous solutions through patterned paper channels to transport a sample fluid into distinct detection zones that contain the reagents for a chemical assay. These devices are simple, affordable, portable, and disposable; they are, thus, well suited for diagnostic applications in resource-limited environments. Adding screen-printed electrodes to the detection zones of a μPAD yields a device capable of performing electrochemical assays (an EμPAD). Electrochemical detection has the advantage over colorimetric detection that it is not affected by interference from the color of the sample and can be quantified with simple electronics. The accessibility of EμPADs, however, is limited by the requirement for an external potentiostat to power and interpret the electrochemical measurement. New developments in paper-based electronics may help loosen this requirement. This review discusses the current capabilities and limitations of EμPADs and paper-based electronics, and sketches the ways in which these technologies can be combined to provide new devices for diagnostic testing.

General practitioner activity is increasingly under pressure to monitor its performance. The involvement of service users in the development and assessment of services is said to be a key feature of this process. This article reports on the acceptability among general practitioners of a patient-completed post-consultation measure of outcome (the Patient Enablement Instrument; PEI), and its use in conjunction with two further indicators of quality, namely time spent in consultation and patients reporting knowing the doctor well. The survey was conducted using focus groups and the administration of a postal questionnaire among a group of general practices that had participated and received feedback from a large quantitative study testing these measures. The focus group study provided useful insights into general practitioners' perceptions of patient assessment of their performance and their concerns surrounding the measurement of general practice activity. The general practitioners' perceptions of the measures under the study were enmeshed within these concerns overall. The PEI was seen as being generally acceptable as a measure of patient assessment of care, and the methods of data collection were acceptable for routine use in general practice. General practitioners who performed better in terms of their feedback scores generally approved more of the proposed measures. However, these general practitioners were not comfortable with the concept of assessment of the clinical interaction by patients, and were anxious to link such assessment explicitly with clinical (disease-related) outcome. Doctors who performed ‘better’ were no more likely than those who performed less well to advocate more use of patient assessment, or to believe that patient assessment of consultations is a reliable quality indicator. These concerns need to be addressed if patients' assessments of their care are to be taken seriously.

This paper has a twofold purpose. The first is to compute the Euler characteristics of hyperbolic Coxeter groups Ws of level 1 or 2 by a mixture of theoretical and computer aided methods. For groups of level 1 and odd values of |S|, the Euler characteristic is related to the volume of the fundamental region of Ws in hyperbolic space. Secondly we note two methods of imbedding such groups in each other. This reduces the amount of computation needed to determine the Euler characteristics and also reduces the number of essentially different hyperbolic groups that need to be considered.