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This chapter offers what Franco Moretti has called a “distant reading” of popular fictional narrative in the 1860s. That is, it concerns itself predominantly with charting changes in the larger units of generic form and publishing format, rather than attempting a close analysis of a limited set of canonical texts. The focus tends to fall on serial rather than volume publication, while the early career of Mary Elizabeth Braddon provides the subject of a specific case study. Such a procedure of course depends on the availability of comprehensive data sets, so that the chapter also touches on the recent growth in virtual archives and associated developments in the academic field of digital humanities, including the use of analytical methods owing more to book history than literary criticism.
Sleep curtailment is common in the Westernised world and coincides with an increase in the prevalence of type 2 diabetes mellitus (T2DM). This review considers the recently published evidence for whether sleep duration is involved in the development of T2DM in human subjects and whether sleep has a role to play in glucose control in people who have diabetes. Data from large, prospective studies indicate a U-shaped relationship between sleep duration and the development of T2DM. Smaller, cross-sectional studies also support a relationship between short sleep duration and the development of both insulin resistance and T2DM. Intervention studies show that sleep restriction leads to insulin resistance, with recent sleep extension studies offering tantalising data showing a potential benefit of sleep extension on glucose control and insulin sensitivity. In people with established diabetes the published literature shows an association between poor glucose control and both short and long sleep durations. However, there are currently no studies that determine the causal direction of this relationship, nor whether sleep interventions are likely to offer benefit for people with diabetes to help them achieve tighter glucose control.
Despite evidence for the effectiveness of structured psychological
therapies for bipolar disorder no psychological interventions have been
specifically designed to enhance personal recovery for individuals with
recent-onset bipolar disorder.
Aims
A pilot study to assess the feasibility and effectiveness of a new
intervention, recovery-focused cognitive–behavioural therapy (CBT),
designed in collaboration with individuals with recent-onset bipolar
disorder intended to improve clinical and personal recovery outcomes.
Method
A single, blind randomised controlled trial compared treatment as usual
(TAU) with recovery-focused CBT plus TAU (n = 67).
Results
Recruitment and follow-up rates within 10% of pre-planned targets to
12-month follow-up were achieved. An average of 14.15 h (s.d. = 4.21) of
recovery-focused CBT were attended out of a potential maximum of 18 h.
Compared with TAU, recovery-focused CBT significantly improved personal
recovery up to 12-month follow-up (Bipolar Recovery Questionnaire mean
score 310.87, 95% CI 75.00–546.74 (s.e. = 120.34), P =
0.010, d=0.62) and increased time to any mood relapse
during up to 15 months follow-up (χ2 = 7.64,
P<0.006, estimated hazard ratio (HR) = 0.38, 95%
CI 0.18–0.78). Groups did not differ with respect to medication
adherence.
Conclusions
Recovery-focused CBT seems promising with respect to feasibility and
potential clinical effectiveness. Clinical- and cost-effectiveness now
need to be reliably estimated in a definitive trial.
Las Cumbres Observatory Global Telescope Network (LCOGT) is currently building a new kind of general-purpose astronomical facility: a fully robotic network of telescopes of 2m, 1m and 0.4m apertures and homogeneous instrumentation. A pan-network approach to scheduling (rather than per individual telescope) offers redundancy in the event of poor weather or technical failure, as well as the ability to observe a target around the clock. Here we describe the network design and instrumentation under development, together with the main science programmes already being lead by LCOGT staff.
This book examines how national and ethnic identities are being reforged in the post-Soviet borderland states. The first chapter provides a conceptual and theoretical context for examining national identities, drawing in particular upon post-colonial theory. The rest of the book is divided into three parts. In Part I, the authors examine how national histories of the borderland states are being rewritten especially in relation to new nationalising historiographies, around myths of origin, homeland, and descent. Part II explores the ethnopolitics of group boundary construction and how such a politics has led to nationalising policies of both exclusion and inclusion. Part III examines the relationship between nation-building and language, especially with regard to how competing conceptions of national identity have informed the thinking of both political decision-takers and nationalising intellectuals, and the consequences for ethnic minorities. Such perspectives on nation-building are illustrated with substantive studies drawn from the Baltic states, Ukraine, and Belarus, Transcaucasia, and Central Asia.
This study assessed the prescription of potentially nephrotoxic non-steroidal anti-inflammatory drugs (NSAIDs) to patients with chronic kidney disease (CKD) in general practice.
Background
CKD poses a considerable disease burden in the UK. Guidelines state that caution should be exercised when prescribing NSAIDs to CKD patients, due to increased risk of rapid kidney disease progression.
Methods
We reviewed the medical records of 1427 patients with CKD Stages 3–5 in seven general practices in West Yorkshire.
Findings
A total of 792 (55.5%) were prescribed NSAIDs; 128 (9%) of these were prescribed NSAIDs excluding low-dose aspirin. Twenty-three (20.2%) patients who were prescribed NSAIDs had no record of CKD monitoring in the preceding year.
Conclusion
Prescription of NSAIDs is likely to be contributing to unnecessary renal impairment.
The ‘Sea Empress’ oil tanker grounded outside Milford Haven (Wales, UK) in February 1996, spilling ~70,000 tonnes of crude oil and contaminating over 100 km of coastline, causing mass mortalities and standings of at least 11 mollusc species. Intensive field monitoring commenced after the spill, examining immunity and hydrocarbon levels in the mussel, Mytilus edulis (Mollusca: Bivalvia), a commercially-harvested species which can accumulate contaminants. Comparisons of mussels from oiled and reference sites revealed significant modulations in cell-mediated immunity. Elevations in blood cell (haemocyte) numbers and decreases in superoxide generation and phagocytosis were identified in contaminated animals. The immune response of contaminated mussels gradually improved and generally showed no significant differences compared with clean mussels after 11 weeks. By then, total hydrocarbon content in contaminated mussels had declined by 70–90%, while polycyclic aromatic hydrocarbon content had decreased by over 90%.
This chapter concerns changing patterns of serial publication, a term which covers two related practices: the publishing of periodicals with miscellaneous contents, including both magazines and newspapers, and the issuing of unified texts at intervals in independent fascicles or parts. Piecemeal publication blurred generic distinctions between news and fiction, but also between new print, revised print and reprint editions, and between serialisation, book, sequel and series. Publication of original novels in fascicles lost ground in the face of the new wave of literary miscellanies, whether monthly or weekly, which sold at lower prices once knowledge taxes were abolished and mechanical improvements cheapened book production and distribution. Primary developments in serialisation included both the expansion of the mass periodical and newspaper market and the segmentation of the market into diversely identified readerships. The chapter discusses the long-anticipated demise of the multi-volume first edition in the mid-1890s and the regulation of price discounting through the Net Book Agreement established in January 1900.
The defining moment of Wilkie Collins's career occurred at the turn of the 1860s with the runaway success of The Woman in White. The novel's striking combination of respectable settings and illicit events launched the fashion for 'sensation fiction' which prevailed through much of the next two decades, thus marking a breakthrough in the marketing of fiction as a commodity form. Running as a serial in Charles Dickens's new family weekly All the Year Round from November 1859, the narrative aroused wide interest with its eerily enigmatic opening and deft manipulation of suspense, causing queues on publication day and raising the circulation into six figures. When the novel appeared from Sampson Low in three volumes for the lending libraries in mid-August 1860, it was widely advertised, sold 1,350 copies within the week and received its eighth impression before the end of the year. When the single-volume edition appeared from the same publisher in April 1861, embellished with a signed likeness of the author, Collins had to sit several times for the photographer to keep pace with the demand.
As the dust of the immediate post-Soviet transition settles, we are now better placed to begin to examine how national identities are being reforged in the fourteen borderland states of what up until December 1991 constituted the non-Russian union republics of the former Soviet Union. Having secured sovereign spaces following the collapse of the world's largest multiethnic federation, the borderland states are now embarking upon nation-building. And herein lies the paradox. The post-colonial desire to recreate national identities can facilitate solidarity, play a positive role in state-making and form a basis for popular participation in politics. A politics defined in relation to a particular national community may not in itself be incompatible with processes of democratisation. The problem arises when national or ethnic identity is predicated on a form of imagined community that reifies the importance of national or ethnic boundaries to the detriment of the wider political community. In this regard, there is as yet only limited evidence to suggest that the post-Soviet borderland states are on the threshold of entering such a post-national era in which national and ethnic identities have been superseded by understandings of cultural difference based on a broader and more inclusive vision of political community. Rather, although the scale of inter-ethnic violence as witnessed in TransDniester, Nagorno-Karabakh and Georgia in the late 1980s and the first half of the 1990s has now diminished, national identities continue to be caught up in power struggles, leadership elections, legislative acts and in the state distribution of social goods.
Following the break-up of the Soviet Union, one of the most urgent questions to emerge from the critical confusion was how the newly emerging polities would set about creating convincing identities for themselves and their citizens. It was perhaps a foregone conclusion that Russia would inherit the lion's share of the symbols and the history of the USSR and the tsarist empire; on the other hand, it was unclear what resources nation-builders in the fourteen borderland states would have to draw upon. What new tensions would arise out of the choice of symbols and myths, and which old ones would be exacerbated, or alternatively suppressed? Which of the heady mix of religion, language, ethnicity and homeland would come to the fore in any given region? The elusive, ever-shifting nature of the answers to these questions, the separate elements rearranging themselves kaleidoscopically in the very moment when a coherent pattern seemed to be emerging, has become dismayingly plain in the years since 1991. And yet the more complex the picture, the greater the urgency of the task of understanding it.
It is clearly impossible for any one individual to be conversant not only with the languages, histories and diverse political and social cultures of the fourteen new or restored borderland states, but also with the disparate academic disciplines required to arrive at a balanced picture of the changes now underway.