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This study aims to evaluate the impact of low-carbohydrate diet, balanced dietary guidance and pharmacotherapy on weight loss among individuals with overweight or obesity over a period of 3 months. The study involves 339 individuals with overweight or obesity and received weight loss treatment at the Department of Clinical Nutrition at the Second Affiliated Hospital of Zhejiang University, School of Medicine, between 1 January 2020 and 31 December 2023. The primary outcome is the percentage weight loss. Among the studied patients, the majority chose low-carbohydrate diet as their primary treatment (168 (49·56 %)), followed by balanced dietary guidance (139 (41·00 %)) and pharmacotherapy (32 (9·44 %)). The total percentage weight loss for patients who were followed up for 1 month, 2 months and 3 months was 4·98 (3·04, 6·29) %, 7·93 (5·42, 7·93) % and 10·71 (7·74, 13·83) %, respectively. Multivariable logistic regression analysis identified low-carbohydrate diet as an independent factor associated with percentage weight loss of ≥ 3 % and ≥ 5 % at 1 month (OR = 0·461, P < 0·05; OR = 0·349, P < 0·001). The results showed that a low-carbohydrate diet was an effective weight loss strategy in the short term. However, its long-term effects were comparable to those observed with balanced dietary guidance and pharmacotherapy.
In producing linguistic variation, language users display a tendency to reuse the same variant. This paper compares the empirical properties of different types of repetitiveness in a single case study: locative variation in Chengdu Mandarin. Using conversational data from sociolinguistic interviews, we ask whether within-speaker repetitiveness (persistence) and cross-speaker repetitiveness (convergence) behave similarly with respect to (1) their sensitivity to the linguistic similarity of the prime and target, and (2) their tendency to decline with greater temporal distance between the prime and target. Our results suggest that intraspeaker persistence and interspeaker convergence behave similarly in both respects. We therefore propose that repetitiveness has a common underlying mechanism within and across speakers and encourage future work aimed at testing this hypothesis across other variables and varieties.
To date, there is limited evidence for health care providers regarding the determinants of early assessment of poor outcomes of adult in-patients due to earthquakes. This study aimed to explore factors related to early assessment of adult earthquake trauma patients (AETPs).
Methods:
The data on 29,933 AETPs in the West China Earthquake Patients Database (WCEPD) were analyzed retrospectively. Then, 37 simple variables that could be obtained rapidly upon arrival at the hospital were collected. The least absolute shrinkage and selection operator (LASSO) regression analyses were performed. A nomogram was then constructed.
Results:
Nine independent mortality-related factors that contributed to AETP in-patient mortality were identified. The variables included age (OR:1.035; 95%CI, 1.027-1.044), respiratory rate ([RR]; OR:1.091; 95%CI, 1.050-1.133), pulse rate ([PR]; OR:1.028; 95%CI, 1.020-1.036), diastolic blood pressure ([DBP]; OR:0.96; 95%CI, 0.950-0.970), Glasgow Coma Scale ([GCS]; OR:0.666; 95%CI, 0.643-0.691), crush injury (OR:3.707; 95%CI, 2.166-6.115), coronary heart disease ([CHD]; OR:4.025; 95%CI, 1.869-7.859), malignant tumor (OR:4.915; 95%CI, 2.850-8.098), and chronic kidney disease ([CKD]; OR:5.735; 95%CI, 3.209-10.019).
Conclusions:
The nine mortality-related factors for ATEPs, including age, RR, PR, DBP, GCS, crush injury, CHD, malignant tumor, and CKD, could be quickly obtained on hospital arrival and should be the focal point of future earthquake response strategies for AETPs. Based on these factors, a nomogram was constructed to screen for AETPs with a higher risk of in-patient mortality.
This study evaluates the effectiveness of our game-based pedagogical technique by comparing the learning, enjoyment, interest, and motivation of medical students who learned about best practices for patient surge in a natural disaster with a novel game-based computer application, with those of medical students who learned about it with a traditional lecture.
Methods:
We conducted our study by modifying an existing optional course in disaster medicine that we taught at Sichuan University. More specifically, in 2017, while our application was still in development, we taught this course by lecture. In this iteration, 63 third-grade medical students voluntarily joined our course as our ‘lecture group.’ Once our application was complete in 2018, 68 third-grade medical students voluntarily joined this course as the ‘game group.’ We examined the different effects of these learning methods on student achievement using pre -, post -, and final tests.
Results:
Both teaching methods significantly increased short-term knowledge and there was no statistical difference between the 2 methods (p > 0.05). However, the game group demonstrated significantly higher knowledge retention than the traditional lecture group (p < 0.05).
Conclusion:
Our game-based computer application proved to be an effective tool for teaching medical students best practices for caring for patient surge in a natural disaster.
Little is known about the trend and predictors of 21-year mortality and suicide patterns in persons with schizophrenia.
Aims
To explore the trend and predictors of 21-year mortality and suicide in persons with schizophrenia in rural China.
Method
This longitudinal follow-up study included 510 persons with schizophrenia who were identified in a mental health survey of individuals (≥15 years old) in 1994 in six townships of Xinjin County, Chengdu, China, and followed up in three waves until 2015. Kaplan–Meier survival analysis and Cox hazard regressions were conducted.
Results
Of the 510 participants, 196 died (38.4% mortality) between 1994 and 2015; 13.8% of the deaths (n = 27) were due to suicide. Life expectancy was lower for men than for women (50.6 v. 58.5 years). Males consistently showed higher rates of mortality and suicide than females. Older participants had higher mortality (hazard ratio HR = 1.03, 95% CI 1.01–1.05) but lower suicide rates (HR = 0.95, 95% CI 0.93–0.98) than their younger counterparts. Poor family attitudes were associated with all-cause mortality and death due to other causes; no previous hospital admission and a history of suicide attempts independently predicted death by suicide.
Conclusions
Our findings suggest there is a high mortality and suicide rate in persons with schizophrenia in rural China, with different predictive factors for mortality and suicide. It is important to develop culture-specific, demographically tailored and community-based mental healthcare and to strengthen family intervention to improve the long-term outcome of persons with schizophrenia.
In this study, we aimed to evaluate the correlation between the trauma score of individuals wounded in the Lushan earthquake and emergency workload for treatment. We further created a trauma score-emergency workload calculation model.
Methods:
We included data from patients wounded in the Lushan earthquake and treated at West China Hospital, Sichuan University. We calculated scores per the following models separately: Revised Trauma Score (RTS), Prehospital Index (PHI), Circulation Respiration Abdominal Movement Speech (CRAMS), Therapeutic Intervention Scoring System (TISS-28), and Nursing Activities Score (NAS). We assessed the association between values for CRAMS, PHI, and RTS and those for TISS-28 and NAS. Subsequently, we built a trauma score-emergency workload calculation model to quantitative workload estimation.
Results:
Significant correlations were observed for all pairs of trauma scoring models with emergency workload scoring models. TISS-28 score was significantly associated with PHI score and RTS; however, no significant correlation was observed between the TISS-28 score and CRAMS score.
Conclusions:
CRAMS, PHI, and RTS were consistent in evaluating the injury condition of wounded individuals; TISS-28 and NAS scores were consistent in evaluating the required treatment workload. Dynamic changes in emergency workload in unit time were closely associated with wounded patient visits.
A simple evaluation tool for patients with novel coronavirus disease 2019 (COVID-19) could assist the physicians to triage COVID-19 patients effectively and rapidly. This study aimed to evaluate the predictive value of 5 early warning scores based on the admission data of critical COVID-19 patients.
Methods:
Overall, medical records of 319 COVID-19 patients were included in the study. Demographic and clinical characteristics on admission were used for calculating the Standardized Early Warning Score (SEWS), National Early Warning Score (NEWS), National Early Warning Score2 (NEWS2), Hamilton Early Warning Score (HEWS), and Modified Early Warning Score (MEWS). Data on the outcomes (survival or death) were collected for each case and extracted for overall and subgroup analysis. Receiver operating characteristic curve analyses were performed.
Results:
The area under the receiver operating characteristic curve for the SEWS, NEWS, NEWS2, HEWS, and MEWS in predicting mortality were 0.841 (95% CI: 0.765-0.916), 0.809 (95% CI: 0.727-0.891), 0.809 (95% CI: 0.727-0.891), 0.821 (95% CI: 0.748-0.895), and 0.670 (95% CI: 0.573-0.767), respectively.
Conclusions:
SEWS, NEWS, NEWS2, and HEWS demonstrated moderate discriminatory power and, therefore, offer potential utility as prognostic tools for screening severely ill COVID-19 patients. However, MEWS is not a good prognostic predictor for COVID-19.
We present an experimental study on controlling the number of vortices and the torque in a Taylor–Couette flow of water for Reynolds numbers from 660 to 1320. Different flow states are achieved in the annulus of width $d$ between the inner rotating and outer stationary cylinders through manipulating the initial height of the water annulus. We show that the torque exerted on the inner cylinder of the Taylor–Couette system can be reduced by up to 20 % by controlling the flow at a state where fewer than the nominal number of vortices develop between the cylinders. This flow state is achieved by starting the system with an initial water annulus height $h_0$ (which nominally corresponds to $h_0/d$ vortices), then gradually adding water into the annulus while the inner cylinder keeps rotating. During this filling process the flow topology is so persistent that the number of vortices does not increase; instead, the vortices are greatly stretched in the axial (vertical) direction. We show that this state with stretched vortices is sustainable until the vortices are stretched to around 2.05 times their nominal size. Our experiments reveal that by manipulating the initial height of the liquid annulus we are able to generate different flow states and demonstrate how the different flow states manifest themselves in global momentum transport.
Translations are generally assumed to share universal features that distinguish them from texts that are originally written in the same language. Thus, we can argue that these translations constitute their own variety of a language, often called translationese. However, translations are also influenced by their source languages and thus show different characteristics depending on the source language. Consequently, we argue that these variants constitute different “dialects” of translations into the same target language. Studies using machine learning techniques on Indo-European languages have investigated the universal characteristics of translationese and how translations from various source languages differ. However, for typologically very different languages such as Chinese, there are only few corpus studies that tap into the intricate relation between translations and the originals, as well as into the relations among translations themselves. In this contribution, we investigate the following questions: (1) What are the characteristics of Chinese translationese, both in general and with respect to different source languages? (2) Can we find differences not only at the lexical but also on the syntactic level? and (3) Based on the characteristics found in the previous questions, which of the proposed laws and universals can we corroborate based on our evidence from Chinese? We use machine learning to operationalize determining the importance of different characteristics and comparing their importance for our Chinese dataset with characteristics previously reported in studies on English. In addition, our methodology allows us to add syntactic features, which have rarely been used to study translations into Chinese. Our results show that Chinese translations as a whole can be reliably distinguished from non-translations, even based on only five features. More interestingly, typological traces from the source languages can often be found in their translations, therefore creating what we call dialects of translationese. For instance, translations from two Altaic languages exhibit more noun repetition and less frequent use of pronouns. Additionally, some characteristics that are not discriminative for English work well for Chinese, possibly because the distance between Chinese and the source languages is greater than that in English studies.
Isolated gametes can be used to investigate fertilization mechanisms, and probe distant hybridization between different species. Pollen grains of wheat and Setaria viridis are tricellular, containing sperm cells at anthesis. Sperm from these plants were isolated by breaking open pollen grains in a osmotic solution. Wheat ovules were digested in an enzyme solution for 20 min, and then transferred to an isolation solution without enzymes to separate egg cells from ovules. The fusion of wheat egg cells with wheat and S. viridis sperm was conducted using an electro-fusion apparatus. Under suitable osmotic pressure (10% mannitol), calcium concentration of 0.001% (CaCl2·2H2O), and a 30–35 V alternating electric field for 15 s, egg cells and sperm adhered to each other and became arranged in a line. Electroporation of the plasma membrane of egg cells and sperm using a 300–500 V direct-current electric field (45 µs amplitude pulse) caused them to fuse.
Currently, Technical Advisors of the World Health Organization’s (WHO) Emergency Medical Teams (EMT) Secretariat are conducting standardized verification work for international emergency medical teams in various countries and organizations. However, a uniform and standard training course for an International EMT is lacking.
Aim:
To design a training course model based on knowledge structure, teaching, and evaluation methods for an International EMT.
Methods:
The first and second level catalogue defined as chapters and sections for the International EMT training curriculum were drafted based on literature and summaries of fragmentary experience. The teaching syllabus with the method of teaching and evaluation was initially outlined. The expert consultation form was designed and validated. Experts from International EMTs from various countries were consulted and investigated. The Delphi method was used, and the chapters and sections were adjusted and weighed according to experts’ advice through the Analytic Hierarchy Process. The teaching and evaluation methods for each knowledge module were obtained based on suggestions from experts.
Results:
A total of 25 experts were consulted. By 2 rounds of consultation with a Kendall coordination coefficient W value of 0.210 and chi-square value of 78.61 (p<0.05), consensus about the knowledge structure for the curriculum was achieved, which consisted of 6 chapters: (1) introduction of International EMT, (2) Disaster medicine, (3) Global health, (4) Care in austere condition, (5) Medical technology, (6) Field training, with the weights of 0.1415, 0.1584, 0.1536, 0.1827, 0.1728, and 0.1909, respectively, and 32 sections. Teaching methods for different knowledge modules were determined, which included lecture, demonstration, discussion, drills, and tabletop simulation. The evaluation methods were affirmed via a quiz, written examination, skill test, and teamwork test assessed by intra-group and inter-group evaluation.
Discussions:
Through scientific investigation of experts from International EMTs, a training course model for International EMT was established.
Classroom instruction of disaster medicine for medical students is complicated and lacks attraction. Nowadays a novel method, which is named Game-Based Learning (GBL), has been used in other fields and received good feedback.
Aim:
To apply GBL to the teaching process of disaster medicine and discuss the effect of its application.
Methods:
A computer game was devised based on a syllabus of disaster medicine and employed it in classes of disaster medicine for medical students. Then a questionnaire about the application of GBL in education was used inquiring the demands of medical students for the designing of GBL in disaster medicine, including their platform and game mode preferences. Feedback was collected and data was analyzed after the class.
Results:
201 questionnaires were issued, and the valid rate was 100%. From the responses, 77% of medical students considered the application of GBL in education on disaster medicine was necessary, and 73% of the respondents thought it was practical. Furthermore, over 90% of medical students expressed their expectation for the adoption of GBL. According to another survey of 51 medical students we conducted, after attending a class about knowledge of injury classification with one board game adopted, most of the students believed GBL was better than traditional methods of teaching.
Discussion:
There is a high approbation degree among medical students to the adoption of GBL in the teaching process of disaster medicine, which suggests a great possibility for the application of GBL in medical education. It is concluded that GBL can be used in the teaching process of disaster medicine.
Currently, there is no uniform and standard disaster medicine course for students in medical school.
Aim:
To design a disaster medicine course model based on knowledge structure, teaching and evaluation methods according to experts’ advice and interest of undergraduates majoring in clinical medicine.
Methods:
The first and second level catalog defined as chapters and sections for the disaster medicine curriculum were drafted based on literature and summary of fragmentary experience. The teaching syllabus with methods of teaching and evaluation was initially outlined. The expert consultation form and student questionnaire were designed and validated. Experts in disaster medicine in China were consulted and students in our medical school were investigated. Delphi Methods was used and the chapters and sections were adjusted and weighed according to experts’ advice through the Analytic Hierarchy Process. The teaching and evaluation methods for each knowledge module were obtained based on suggestions from experts and students.
Results:
A total of 31 experts were consulted. 320 students were inquired. By two rounds of consultation with Kendall coordination coefficient W value 0.207, chi-square value 128.781(p=0.01), consensus about the knowledge structure for the curriculum were achieved, which consisted of 6 chapters (as Introduction to disaster medicine, incident command, medical knowledge and skills in disaster, public health, ethics in disaster, information management, with the weights of 0.1486, 0.1999, 0.4209, 0.0785, 0.0748, 0.0774 respectively)and 25 sections. Teaching methods for different knowledge module were determined, which included lecture, demonstration, case discussion, drill and sand table simulation. And the evaluation methods were affirmed as a quiz, written examination, skill test and teamwork test assessed by intra-group and inter-group evaluation.
Discussion:
Through scientific investigation of experts in disaster rescue and undergraduates majoring in clinical medicine, a disaster medicine course model for clinical medical students was established.
Compared with traditional START Triage Method, the Sacco Triage Method is a new way to access death risk in disaster scenes. However, due to the difficulties in disaster medical research, there is still no evidence to prove which one is more effective.
Aim:
To assess and compare the value of START Triage Method and Sacco Triage Method in the death risk assessment of transport and the one-month death risk assessment of the earthquake mass trauma patients.
Methods:
A retrospective analysis was conducted on 1,612 patients who were transferred to the West China Hospital by assigning to different triage levels by Sacco Triage Method and START Triage Method respectively. Both of the triage methods were evaluated based on death cases on either during transport or in the emergency department, using the area under the receiver-operator curve.
Results:
For death during the transport and in the emergency department, the receiver-operator curve of two groups reflected as 0.721 and 0.649. For death in a consequence, the receiver-operator curve of the two groups was revealed as 0.667 and 0.519.
Discussion:
As an accurate triage method, the Sacco Triage Method may be used in a mass casualty incident. It is a more effective way than the START Triage Method for the evaluation of death risk assessment of the mass trauma patients.
First aid in a short time is the key to saving lives. As undergraduates step into society, they should have enough ability to save others. As a result, first aid knowledge and training are essential for them.
Aim:
To investigate the cognition level of the first aid knowledge among undergraduates, and to improve the training for undergraduates.
Methods:
A questionnaire was designed for this study. It includes the basic information of the test subjects, attitude towards first aid, level of first aid knowledge, etc. The subjects of the questionnaire were mainly undergraduates in Sichuan province.
Results:
There were 302 valid questionnaires. The percent correct of the first aid basic knowledge quiz was only 47.62%. Using Chi-Square tests to analyze, medical education can make a significant difference in the level of first aid knowledge. (Chi-Square=251.004, P<0.01) Additionally, 78.81% of undergraduates thought it was significant to learn and master first aid knowledge, and the most common way to learn first aid knowledge was through university (81.46%).
Discussion:
Universities should strengthen the training for undergraduates to improve their first aid skills. This is a feasible approach to promote a public level of first aid knowledge.
The effect of SiCp on the aging behavior of the extruded SiCp/AZ91 composite fabricated by stir casting was investigated in detail. The necklace-type distribution of the particles in the cast SiCp/AZ91 composite was destroyed, and the extrusion bands consisting of SiCp and small dynamic recrystallized grains formed aligning along the extrusion direction. Addition of SiCp could accelerate the aging kinetics of the AZ91 matrix because of the overlapped particle plastic zone. The improved particle distribution and refined grains caused by the recrystallization could affect the aging behavior of the SiCp/AZ91 composite. The Mg17A112 discontinuous precipitates preferred to nucleate at the SiC/Mg interfaces and the grain boundaries within the extrusion bands and then expanded into the particle-free region. Moreover, the promoted discontinuous precipitates would suppress the continuous intragranular precipitates with respect to the unreinforced AZ91 alloy.