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Previous studies have suggested that the habenula (Hb) may be involved in the mechanism of obsessive-compulsive disorder (OCD). However, the specific role of Hb in OCD remains unclear. This study aimed to explore the structural and functional abnormalities of Hb in OCD and their relationship with the clinical symptoms.
Methods
Eighty patients with OCD and 85 healthy controls (HCs) were recruited as the primary dataset. The grey matter volume, resting-state functional connectivity (FC), and effective connectivity (EC) of the Hb were calculated and compared between OCD group and HCs. An independent replication dataset was used to verify the stability and robustness of the results.
Results
Patients with OCD exhibited smaller Hb volume and increased FC of right Hb-left hippocampus than HCs. Dynamic causal model revealed an increased EC from left hippocampus to right Hb and a less inhibitory causal influence from the right Hb to left hippocampus in the OCD group compared to HCs. Similar results were found in the replication dataset.
Conclusions
This study suggested that abnormal structure of Hb and hippocampus-Hb connectivity may contribute to the pathological basis of OCD.
In today’s fast-paced, technology-oriented business environment, anxiety among young people arising from work-related stress is a growing concern. The use of computer information processing techniques has been identified as a potential intermediary in alleviating this anxiety. Computer information processing technique has a potential mediating role in alleviating young people’s work stress and anxiety, but comprehensive intervention is still needed to integrate other factors to improve their mental health and professional life quality.
Subjects and Methods
The study involved a population of young workers exhibiting anxiety symptoms due to work-related stress. The Stanford Acute Stress Response Questionnaire (SASRQ) and the 3-min Confusion Assessment Scale (3D-CAM) were utilized to measure participants’ stress and anxiety levels pre-and-post intervention. The intervention involved the implementation of computer information processing techniques in their work routine. The outcomes were statistically analyzed using SPSS 23.0.
Results
After the application of computer information processing techniques, a significant reduction in SASRQ and 3D-CAM scores was observed, indicating decreased levels of work stress anxiety among the population. In addition, as a result of being able to manage tasks more efficiently, participants reported increased job satisfaction and improved work-life balance.
Conclusions
The results underscore the potential of computer information processing techniques in alleviating work-induced stress anxiety among young employees. Such techniques not only provide improved work efficiency but could also contribute to better mental health among the youth workforce.
Acknowledgement
Science Research Fund Project of Yunnan Education Department in 2019 (No. 2019J0999).
Schizophrenia (SCH) is a serious mental disorder of unknown aetiology, with clinical symptoms involving sensory perception, thinking, emotions, behavior, and other aspects. When symptoms occur repeatedly and the condition persists, the patient’s life and learning abilities are significantly impaired and gradually exhibiting cognitive impairment. The treatment effectiveness and rehabilitation process for SCH are often complex and diverse. This study developed a computer-aided treatment system using software engineering methods to evaluate its impact on the clinical intervention effectiveness of schizophrenia patients.
Subjects and Methods
A total of 300 patients with schizophrenia were selected for the experiment and divided into an experimental group and a control group, with 150 patients in each group. The experimental group received a 6-month intervention using a computer-aided treatment system, while the control group received traditional treatment methods. Evaluate using the Positive and Negative Symptom Scale (PANSS) and record the changes in scores before and after the intervention in both groups. The process data was analyzed using SPSS.
Results
After 6 months of treatment, the PANSS score of the experimental group significantly improved, with a statistical difference compared to the control group (P<0.05). The treatment compliance of the experimental group was also significantly improved, with higher patient satisfaction.
Conclusions
Computer-assisted therapy based on software engineering has shown positive effects in clinical interventions for schizophrenia and can serve as a beneficial supplement to traditional treatment methods. Future research needs to further improve the usability of the system and explore its applicability in different types of mental disorders and treatment stages.
Acknowledgement
Science Research Fund Project of Yunnan Education Department in 2019 (No. 2019J0999).
Separability disorder is also called hysteria, and its main manifestations are separation symptoms and conversion symptoms. Patients often have symptoms such as acute stress disorder and traumatic stress disorder. Infectious public health emergencies are unpredictable and have a wide range of impacts. In such cases, nurses are faced with intensive work, and their mental health is greatly damaged. What’s more, it will cause psychological diseases such as acute stress disorder and traumatic stress disorder. Therefore, it is necessary to organize psychological experts to form intervention teams and establish perfect intervention procedures so as to pay attention to the psychological health of nursing staff and to track and evaluate their psychological status.
Subjects and Methods
The experiment randomly selected 46 nursing staff with dissociative disorder in sudden public health events, and divided them into an experimental group (23) and a control group (23). The patients in the observation group were given routine nursing care, and the experimental group added a team of psychological experts to intervene on this basis. During the intervention, attention should be paid to the construction of a good atmosphere and the maintenance of indoor lighting, temperature, humidity, and another comfortable physical environment. After 2 months of the experiment, the SAS and SDS scores of the two groups were observed.
Results
Table 1 shows the comparison of SAS (Self-Rating Anxiety Scale) scores and SDS (Self-Rating Depression Scale) scores of patients with dissociative disorder in two groups of public health emergencies before and after the intervention. Before the intervention, there was no significant difference between the two groups (P > 0.05). After the intervention of the psychological experts, the scores of the two groups decreased, indicating that the patient’s condition had improved. However, the psychological status of patients in the experimental group was significantly better than that in the control group, and the difference was statistically significant (P < 0.05).Table 1.
Comparison of SAS and SDS scores between two groups before and after intervention ($ \overline{x}\pm s $)
Group
SAS
SDS
Before Intervention
After Intervention
Before Intervention
After Intervention
Experimental group
46.38±3.25
32.72±3.98
47.23±3.24
34.36±4.21
Control group
47.02±3.05
43.51±4.63
48.13±4.03
45.65±5.13
P
>0.05
<0.05
>0.05
<0.05
Conclusions
Nursing staff in public health emergencies are prone to suffer from separation disorder due to the particularity of their occupation. Therefore, based on the topic of psychological health of nursing staff, the experiment proposed the method of establishing a team of psychological experts to intervene in the psychological health of front-line nursing staff. The final experimental results show that this method can indeed improve the probability of separation disorder among nursing staff.
Data on average iodine requirements for the Chinese population are limited following implementation of long-term universal salt iodisation. We explored the minimum iodine requirements of young adults in China using a balance experiment and the ‘iodine overflow’ hypothesis proposed by our team. Sixty healthy young adults were enrolled to consume a sequential experimental diet containing low, medium and high levels of iodine (about 20, 40 and 60 μg/d, respectively). Each dose was consumed for 4 d, and daily iodine intake, excretion and retention were assessed. All participants were in negative iodine balance throughout the study. Iodine intake, excretion and retention differed among the three iodine levels (P < 0·01 for all groups). The zero-iodine balance derived from a random effect model indicated a mean iodine intake of 102 μg/d, but poor correlation coefficients between observed and predicted iodine excretion (r 0·538 for μg/d data) and retention (r 0·304 for μg/d data). As iodine intake increased from medium to high, all of the increased iodine was excreted (‘overflow’) through urine and faeces by males, and 89·5 % was excreted by females. Although the high iodine level (63·4 μg/d) might be adequate in males, the corresponding level of 61·6 μg/d in females did not meet optimal requirements. Our findings indicate that a daily iodine intake of approximately half the current recommended nutrient intake (120 μg/d) may satisfy the minimum iodine requirements of young male adults in China, while a similar level is insufficient for females based on the ‘iodine overflow’ hypothesis.
The decomposition mechanism of block copolymer templates inside as-synthesized mesostructured solids has been systematically studied using solid-state 1H magic angle spinning nuclear magnetic resonance spectroscopy, thermogravimetric analysis, and high-vacuum Fourier transform infrared spectrometry. It is shown that there exists hydrogen-bonding interaction between silanols and block copolymers at the inorganic–organic interface in the self-assembled as-synthesized mesostructured solids, which plays an important role in protecting the surfactants against decomposition during the high-temperature hydrothermal treatment process. Increasing silanol concentration can enhance the hydrogen-bonding interaction and thus shows better “protection” effect. Moreover, the thermal decomposition of the block copolymer in as-synthesized mesostructured solids in air commences at higher temperatures compared with that in acidic solution or in air, providing further evidence in support of the silanol protection mechanism.
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