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The study-to-study variability of bedload flux measurements in turbulent sediment transport borders an order of magnitude, even for idealised laboratory conditions. This uncertainty stems from physically poorly supported, empirical methods to account for channel geometry effects in the determination of the transport-driving bed shear stress, and from study-to-study grain-shape variations. Here, we derive a universal method of bed shear stress determination. It consists of a granular-physics-based definition of the bed surface and a channel sidewall correction based on linking Reynolds stress to bulk flow properties via Kolmogorov’s theory of turbulence. Application of this method to bedload transport of spherical grains – to rule out grain-shape effects – collapses data from existing laboratory measurements and grain-resolved computational fluid dynamics (CFD) and discrete element method (DEM) simulations for various channel geometries onto a single curve. In contrast, classical sidewall corrections, as well as an alternative bed surface definition, are unable to universally capture these data, especially those from shallow or very narrow channel flows. We then apply our method to an extended grain-shape-controlled data compilation, complemented by literature data for non-spherical grains and from grain-unresolved CFD-DEM simulations. This compilation covers a very diverse range of transport conditions, ranging from very narrow to infinitely wide channels, from shallow to deep channel flows, from mild to steep bed slopes, and from weak to intense transport. We generalise an existing physical bedload flux model to account for grain-shape effects, and show that it explains almost all the compiled data within a factor of only $1.3$.
Boundary slip can strongly influence the wall shear stress generated by a collapsing cavitation bubble near a solid surface. Here, we investigate this effect by systematically varying slip length $l$ and bubble stand-off distance $\gamma$. We show that boundary slip has negligible influence on bubble dynamics and jet formation prior to jet impact, but markedly alters the near-wall flow during jet spreading. Increasing $l$ substantially reduces both outward and inward peak shear stresses, suppresses flow separation during fast jet spreading and reorganises the spatio-temporal stress distribution. We derive a scaling for the maximum outward stress $\tau _m$ with $\tau _m\approx {\mu {U}_{0}{Re}^{0.5}(U_e/{U}_{0})^{1.5}}/ ({0.3R_{\textit{max}}+l(U_e {Re}/{U}_{0})^{0.5}})$, which captures the coupled effects of slip length, maximum bubble radius $R_{\textit{max}}$ and the outer-edge velocity $U_e$ of the spreading wall jet. Combined with a scaling for $U_e$ in terms of $\gamma$ and $l$, this yields a semi-empirical predictive framework for the maximum wall shear stress. These results clarify how interfacial slip regulates extreme cavitation-driven shear and offer a basis for its prediction and control.
This study employs synthetic jet actuation (SJA) to control large-scale flow separation on the suction side of a NACA0015 aerofoil at a Reynolds number of 2.1 $\times$$10^5$ and an angle of $18^\circ$. The underlying control mechanism is investigated using large-eddy simulations to resolve the dynamics of jet-induced coherent structures associated with the low-frequency actuation. During the periodic blowing and suction cycle, two distinct types of spanwise coherent vortices are identified: blowing-induced vortices (BIVs) and suction-induced vortices (SIVs), which differ significantly in spatial distribution and energy content. As these vortices are convected downstream at speeds comparable to the free-stream velocity, BIVs exhibit a significantly slower rate of energy decay, whereas SIVs dissipate rapidly, particularly near the trailing edge. Triple decomposition analysis shows that energy addition is primarily associated with the coherent velocity components. Notably, BIVs exhibit a stronger entrainment capacity, enhancing momentum exchange between the separated shear layer and outer flow via coherent Reynolds shear stresses. This intensified exchange facilitates the outward transport of low-momentum fluid, effectively enhancing aerodynamic performance and delaying flow separation. Furthermore, spectral proper orthogonal decomposition reveals distinct energy peaks centred at the actuation frequency and its harmonics. Among the two vortex types, BIVs contribute most of the coherent spectral energy, highlighting their critical role in the overall effectiveness of the flow control. These findings elucidate the flow organisation and modulation mechanisms associated with low-frequency SJA under deep-stall conditions, and provide a physical interpretation of the observed reorganisation of the separated flow.
The study of matter under extreme conditions, particularly non-repeatable ultrafast processes such as those in high-energy-density physics and inertial confinement fusion, urgently demands innovations in ultrafast imaging diagnostics. To address this, we propose a novel multi-pulse, multi-angle imaging scheme that leverages a beam-splitting design applied to a single ultra-intense laser pulse to generate multiple, precisely delayed sub-pulse beams. This method not only achieves a tunable temporal resolution range from femtoseconds to picoseconds and spatial resolution in the micrometer scale, providing a powerful tool for capturing single-shot ultrafast dynamics, but also overcomes the low repetition rate limitation in petawatt-class laser facilities, enabling previously unattainable continuous dynamic imaging. Experimental validation is scheduled on the 1 PW/0.1 Hz laser system at the Shanghai Superintense Ultrafast Laser Facility. Feasibility of the source is verified by FBPIC simulations and combined with SynchRad for radiation calculations, while Geant4 simulations demonstrate imaging performance.
The influence of hydrodynamic interactions on the schooling behaviour of fish is still poorly understood. This paper numerically investigates the collective motion of two parallel fish that move freely in both the longitudinal and lateral directions, focusing on the effects of wavelength and phase difference on their stable formations, swimming speed and energy efficiency. It is found that two parallel fish can achieve stable formations in both longitudinal and lateral directions, only via the hydrodynamic interactions. Three distinct modes are classified based on the cycle-averaged longitudinal speed, i.e. the steady slow mode, the steady fast mode and the fluctuating fast mode; which mode occurs depends on the wavelength and phase difference. Compared to a single fish, two fish in the steady slow mode swim slower, whereas they swim faster in both the steady fast and fluctuating fast modes, with a maximum speed increase of 12 % observed in the latter mode. Moreover, the fish school exhibits higher propulsive efficiency than a single fish in most cases. Furthermore, the power consumption and propulsive efficiency of each fish in different modes are discussed in detail. Finally, the mechanism behind the stable formations has been analysed. These results may shed some light on understanding the underlying mechanisms of fish schooling behaviour.
This study aimed to explore clinical characteristics and treatment efficacy in patients with posterior canal benign paroxysmal positional vertigo and different sleep qualities.
Methods
Patients with posterior canal benign paroxysmal positional vertigo were divided into high and low sleep quality groups based on Pittsburgh Sleep Quality Index scores.
Results
No significant baseline differences existed between low (n = 53) and high (n = 39) sleep quality groups. However, the proportion of cupulolithiasis was higher in the low sleep quality group (60.38 per cent vs. 35.90 per cent; p < 0.05). Additionally, the low sleep quality group had a longer median duration of upbeat nystagmus during the Dix-Hallpike test (63.50 seconds vs. 26.80 seconds; p < 0.05) and a lower cured rate in initial repositioning (9.43 per cent vs. 56.41 per cent) compared to high sleep quality group. Repositioning therapy significantly improved depressive and anxiety symptoms in all patients with posterior canal benign paroxysmal positional vertigo, with a more pronounced improvement in depressive symptoms in the low sleep quality group.
Conclusion
Poor sleep quality is associated with higher cupulolithiasis prevalence and treatment resistance, with residual symptoms mainly affecting social functioning.
Probiotics represent a promising alternative to antibiotics in livestock production. This study investigated the effects of compound probiotic fermentation (FAM, comprising Lactobacillus acidophilus and Bacillus subtilis) on nitrogen utilization and nutrient digestibility in weaned piglets. A total of 180 piglets (28 days old; initial weight: 8.21 ± 0.67 kg) were allocated to three groups: control (basal diet), FAM (basal diet + 0.1% FAM), and antibiotic (basal diet + 55 mg/kg kitasamycin + 75 mg/kg chlortetracycline). After a 30-day trial, FAM supplementation significantly increased apparent nutrient digestibility of crude protein and ether extract, enhanced duodenal and jejunal digestive enzyme activities, and reduced fecal nitrogen excretion and serum urea nitrogen levels (p < 0.05). Serum metabolomics revealed that FAM upregulated metabolites linked to energy metabolism (e.g., creatine, L-carnosine), which are metabolites of amino acid metabolism, and enriched pathways such as amino acid biosynthesis and protein digestion. These findings demonstrate that FAM improves nitrogen utilization efficiency and gut health in piglets via biosynthesis and metabolism of amino acids, offering a viable alternative to antibiotics.
An actively controllable cascaded proton acceleration driven by a separate 0.8 picosecond (ps) laser is demonstrated in proof-of-principle experiments. MeV protons, initially driven by a femtosecond laser, are further accelerated and focused into a dot structure by an electromagnetic pulse (EMP) on the solenoid, which can be tuned into a ring structure by increasing the ps laser energy. An electrodynamics model is carried out to explain the experimental results and show that the dot-structured proton beam is formed when the outer part of the incident proton beam is optimally focused by the EMP force on the solenoid; otherwise, it is overfocused into a ring structure by a larger EMP. Such a separately controlled mechanism allows precise tuning of the proton beam structures for various applications, such as edge-enhanced proton radiography, proton therapy and pre-injection in traditional accelerators.
Coherent combining of several low-energy few-cycle beams offers a reliable and feasible approach to producing few-cycle laser pulses with energies exceeding the multi-joule level. However, time synchronization and carrier-envelope phase difference (ΔCEP) between pulses significantly affect the temporal waveform and intensity of the combined pulse, requiring precise measurement and control. Here, we propose a concise optical method based on the phase retrieval of spectral interference and quadratic function symmetry axis fitting to simultaneously measure the time synchronization and ΔCEP between few-cycle pulses. The control precision of our coherent beam combining system can achieve a time delay stability within 42 as and ΔCEP measurement precision of 40 mrad, enabling a maximum combining efficiency of 98.5%. This method can effectively improve the performance and stability of coherent beam combining systems for few-cycle lasers, which will facilitate the obtaining of high-quality few-cycle lasers with high energy.
In the digital era, short videos have become a significant form of digital copyright, yet the debate over whether stronger copyright protection enhances their creation continues. To contribute to this discourse, we conducted an analysis based on a representative sample of short videos on a prominent Chinese short video platform, Douyin. Capitalizing on an external regulatory intervention, specifically the Campaign against Online Infringement and Piracy (COIP) implemented by the Chinese government, we employed the difference-in-differences (DID) method to assess the impact of reinforced copyright protection on the originality of short videos. Our findings reveal that strengthened copyright protection leads to a significant increase in the originality of short videos. Further research on creator heterogeneity shows that influencers exhibit a significantly more positive response to strengthened copyright protection than amateur creators. Finally, we present evidence explaining how external regulation works by enhancing intra-platform regulation. These results have rich implications for intellectual property protection, digital innovation management, and platform regulation.
Laser-driven inertial confinement fusion (ICF) diagnostics play a crucial role in understanding the complex physical processes governing ICF and enabling ignition. During the ICF process, the interaction between the high-power laser and ablation material leads to the formation of a plasma critical surface, which reflects a significant portion of the driving laser, reducing the efficiency of laser energy conversion into implosive kinetic energy. Effective diagnostic methods for the critical surface remain elusive. In this work, we propose a novel optical diagnostic approach to investigate the plasma critical surface. This method has been experimentally validated, providing new insights into the critical surface morphology and dynamics. This advancement represents a significant step forward in ICF diagnostic capabilities, with the potential to inform strategies for enhancing the uniformity of the driving laser and target surface, ultimately improving the efficiency of converting laser energy into implosion kinetic energy and enabling ignition.
Studying the effect of interleukin-17 (IL-17) on the mechanism of CD4+ T-cell immune regulation and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway may offer new ideas and methods for the therapy of dilated cardiomyopathy.
Methods:
Naive CD4+ T cells were isolated from mice using a magnetic bead sorting reagent and manipulated by overexpression or knockdown of IL-17. Protein levels of Janus kinase 2 (JAK2), phosphorylated JAK2 (p-JAK2), signal transducer and activator of transcription 3 (STAT3), phosphorylated STAT3 (p-STAT3), matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) were determined by Western blotting. Quantitative polymerase chain reaction was used to assess the levels of JAK2, STAT3, MMP-2, and MMP-9. Expression of tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-4 (IL-4), and interferon-gamma (IFNγ) was determined by enzyme-linked immunosorbent assay test kits. TNF-α, IL-1β, IL-4, and IFNγ secretion was measured by flow cytometry.
Results:
In CD4+ T cells, IL-17 overexpression increased TNF-α, IL-1β, IL-4, IFNγ, p-JAK2, p-STAT3, MMP-2, MMP-9 levels, and apoptosis. Knockdown of IL-17 reduced the levels of TNF-α, IL-1β, IL-4, IFNγ, p-JAK2, p-STAT3, MMP-2, and MMP-9, as well as the level of apoptosis.
Conclusion:
Through regulation of IL-17 expression in CD4+ T cells, this study reveals its crucial role in regulating the secretion of inflammatory factors, activation of the JAK/STAT signaling pathway, expression of matrix metalloproteinases, and apoptosis of CD4+ T cells.
In contemporary neuroimaging studies, it has been observed that patients with major depressive disorder (MDD) exhibit aberrant spontaneous neural activity, commonly quantified through the amplitude of low-frequency fluctuations (ALFF). However, the substantial individual heterogeneity among patients poses a challenge to reaching a unified conclusion.
Methods
To address this variability, our study adopts a novel framework to parse individualized ALFF abnormalities. We hypothesize that individualized ALFF abnormalities can be portrayed as a unique linear combination of shared differential factors. Our study involved two large multi-center datasets, comprising 2424 patients with MDD and 2183 healthy controls. In patients, individualized ALFF abnormalities were derived through normative modeling and further deconstructed into differential factors using non-negative matrix factorization.
Results
Two positive and two negative factors were identified. These factors were closely linked to clinical characteristics and explained group-level ALFF abnormalities in the two datasets. Moreover, these factors exhibited distinct associations with the distribution of neurotransmitter receptors/transporters, transcriptional profiles of inflammation-related genes, and connectome-informed epicenters, underscoring their neurobiological relevance. Additionally, factor compositions facilitated the identification of four distinct depressive subtypes, each characterized by unique abnormal ALFF patterns and clinical features. Importantly, these findings were successfully replicated in another dataset with different acquisition equipment, protocols, preprocessing strategies, and medication statuses, validating their robustness and generalizability.
Conclusions
This research identifies shared differential factors underlying individual spontaneous neural activity abnormalities in MDD and contributes novel insights into the heterogeneity of spontaneous neural activity abnormalities in MDD.
Artificial sweeteners are generally used and recommended to alternate added sugar for health promotion. However, the health effects of artificial sweeteners remain unclear. In this study, we included 6371 participants from the National Health and Nutrition Examination Survey with artificial sweetener intake records. Logistic regression and Cox regression were applied to explore the associations between artificial sweeteners and risks of cardiometabolic disorders and mortality. Mendelian randomisation was performed to verify the causal associations. We observed that participants with higher consumption of artificial sweeteners were more likely to be female and older and have above medium socio-economic status. After multivariable adjustment, frequent consumers presented the OR (95 % CI) for hypertension (1·52 (1·29, 1·80)), hypercholesterolaemia (1·28 (1·10, 1·50)), diabetes (3·74 (3·06, 4·57)), obesity (1·52 (1·29, 1·80)), congestive heart failure (1·89 (1·35, 2·62)) and heart attack (1·51 (1·10, 2·04)). Mendelian randomisation confirmed the increased risks of hypertension and type 2 diabetes. Moreover, an increased risk of diabetic mortality was identified in participants who had artificial sweeteners ≥ 1 daily (HR = 2·62 (1·46, 4·69), P = 0·001). Higher consumption of artificial sweeteners is associated with increased risks of cardiometabolic disorders and diabetic mortality. These results suggest that using artificial sweeteners as sugar substitutes may not be beneficial.
Schizophrenia is a complex and heterogeneous syndrome with high clinical and biological stratification. Identifying distinctive subtypes can improve diagnostic accuracy and help precise therapy. A key challenge for schizophrenia subtyping is understanding the subtype-specific biological underpinnings of clinical heterogeneity. This study aimed to investigate if the machine learning (ML)-based neuroanatomical and symptomatic subtypes of schizophrenia are associated.
Methods
A total of 314 schizophrenia patients and 257 healthy controls from four sites were recruited. Gray matter volume (GMV) and Positive and Negative Syndrome Scale (PANSS) scores were employed to recognize schizophrenia neuroanatomical and symptomatic subtypes using K-means and hierarchical methods, respectively.
Results
Patients with ML-based neuroanatomical subtype-1 had focally increased GMV, and subtype-2 had widespread reduced GMV than the healthy controls based on either K-means or Hierarchical methods. In contrast, patients with symptomatic subtype-1 had severe PANSS scores than subtype-2. No differences in PANSS scores were shown between the two neuroanatomical subtypes; similarly, no GMV differences were found between the two symptomatic subtypes. Cohen’s Kappa test further demonstrated an apparent dissociation between the ML-based neuroanatomical and symptomatic subtypes (P > 0.05). The dissociation patterns were validated in four independent sites with diverse disease progressions (chronic vs. first episodes) and ancestors (Chinese vs. Western).
Conclusions
These findings revealed a replicable dissociation between ML-based neuroanatomical and symptomatic subtypes of schizophrenia, which provides a new viewpoint toward understanding the heterogeneity of schizophrenia.
In recent years, the extraction of overlapping relations has received great attention in the field of natural language processing (NLP). However, most existing approaches treat relational triples in sentences as isolated, without considering the rich semantic correlations implied in the relational hierarchy. Extracting these overlapping relational triples is challenging, given the overlapping types are various and relatively complex. In addition, these approaches do not highlight the semantic information in the sentence from coarse-grained to fine-grained. In this paper, we propose an end-to-end neural framework based on a decomposition model that incorporates multi-granularity relational features for the extraction of overlapping triples. Our approach employs an attention mechanism that combines relational hierarchy information with multiple granularities and pretrained textual representations, where the relational hierarchies are constructed manually or obtained by unsupervised clustering. We found that the different hierarchy construction strategies have little effect on the final extraction results. Experimental results on two public datasets, NYT and WebNLG, show that our mode substantially outperforms the baseline system in extracting overlapping relational triples, especially for long-tailed relations.
Trauma exposure can cause post-traumatic stress symptoms (PTSS), and persistently experiencing PTSS may lead to the development of post-traumatic stress disorder (PTSD). Research has shown that PTSS that emerged within days of trauma was a robust predictor of PTSD development.
Aims
To investigate patterns of early stress responses to trauma and their associations with development of PTSD.
Method
We recruited 247 civilian trauma survivors from a local hospital emergency department. The PTSD Checklist for DSM-5 (PCL-5) and Acute Stress Disorder Scale (ASDS) were completed within 2 weeks after the traumatic event. Additionally, 3 months post-trauma 146 of these participants completed a PTSD diagnostic interview using the Clinician Administered PTSD Scale for DSM-5.
Results
We first used latent profile analysis on four symptom clusters of the PCL-5 and the dissociation symptom cluster of the ASDS and determined that a four-profile model (‘severe symptoms’, ‘moderate symptoms’, ‘mild symptoms’, ‘minimal symptoms’) was optimal based on multiple fit indices. Gender was found to be predictive of profile membership. We then found a significant association between subgroup membership and PTSD diagnosis (χ2(3) = 11.85, P < 0.01, Cramer's V = 0.263). Post hoc analysis revealed that this association was driven by participants in the ‘severe symptoms’ profile, who had a greater likelihood of developing PTSD.
Conclusions
These findings fill the knowledge gap of identifying possible subgroups of individuals based on their PTSS severity during the early post-trauma period and investigating the relationship between subgroup membership and PTSD development, which have important implications for clinical practice.
The Palaeo-Mesozoic geodynamic evolution of the Tangjia–Sumdo accretionary complex belt, which separates the North and South Lhasa Terrane, remains controversial. Moreover, the lack of geological records restricts the understanding of the evolution of the Sumdo Palaeo-Tethys Ocean from the middle Permian until the middle Triassic. Here we present zircon U–Pb geochronology, whole-rock geochemistry and Sr–Nd–Hf isotopic compositions of the Yeqing gabbro. Zircon U–Pb geochronology yields ages from 254 ± 1 to 249 ± 1 Ma. In situ Hf isotopic analyses yield ϵHf(t) values of −0.2 to +6.3. These samples have high TiO2 (3.69 wt %) and P2O5 (0.78 wt %) contents, with typical patterns like ocean island basalt (OIB). Besides, they are classified as high-Nb basalts (HNBs) based on the high content of Nb (45.3–113.5 ppm). Whole-rock Sr–Nd isotopic compositions are similar to OIB, with initial 87Sr/86Sr of 0.7047–0.7054, 143Nd/144Nd of 0.512526–0.512647 and ϵNd(t) of 0.3–2.7. These signatures suggest that the Yeqing gabbro is mainly derived from low-degree melting of the garnet lherzolite mantle. Based on field observations of HNBs intruding into the continental margin and their geochemical characteristics, we infer that the Yeqing gabbro was generated in a subduction environment. Combined with the regional geology of the subduction environment and the evolution of oceanic islands in the Sumdo Palaeo-Tethys Ocean, we propose that the Yeqing gabbro may represent a product of the asthenosphere upwelling through a slab window produced by subduction of seismic ridge in the Sumdo Palaeo-Tethys Ocean, called plume – subduction-zone interaction, during the late Permian to early Triassic.
Instrument delivery is critical part in vascular intervention surgery. Due to the soft-body structure of instruments, the relationship between manipulation commands and instrument motion is non-linear, making instrument delivery challenging and time-consuming. Reinforcement learning has the potential to learn manipulation skills and automate instrument delivery with enhanced success rates and reduced workload of physicians. However, due to the sample inefficiency when using high-dimensional images, existing reinforcement learning algorithms are limited on realistic vascular robotic systems. To alleviate this problem, this paper proposes discrete soft actor-critic with auto-encoder (DSAC-AE) that augments SAC-discrete with an auxiliary reconstruction task. The algorithm is applied with distributed sample collection and parameter update in a robot-assisted preclinical environment. Experimental results indicate that guidewire delivery can be automatically implemented after 50k sampling steps in less than 15 h, demonstrating the proposed algorithm has the great potential to learn manipulation skill for vascular robotic systems.