Healthcare facilities in the U.S. are well positioned to assist with measles control by timely identification and isolation of suspected or confirmed cases and, as measles is nationally notifiable, by informing local health departments about both suspected and confirmed cases. However, responding to measles cases in acute healthcare settings presents unique challenges, is disruptive, and requires an intense outlay of resources before, during, and afterward primarily due to exposure investigations. We describe our measles preparedness efforts to improve identification of measles cases, facilitate appropriate isolation, reduce exposures, and provide timely post-exposure prophylaxis.