Gravitational waves from coalescing neutron stars encode information about nuclear matter at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced by the presence of tides, which depend on the neutron star equation of state. Neutron star mergers are expected to often produce rapidly rotating remnant neutron stars that emit gravitational waves. These will provide clues to the extremely hot post-merger environment. This signature of nuclear matter in gravitational waves contains most information in the 2–4 kHz frequency band, which is outside of the most sensitive band of current detectors. We present the design concept and science case for a Neutron Star Extreme Matter Observatory (NEMO): a gravitational-wave interferometer optimised to study nuclear physics with merging neutron stars. The concept uses high-circulating laser power, quantum squeezing, and a detector topology specifically designed to achieve the high-frequency sensitivity necessary to probe nuclear matter using gravitational waves. Above 1 kHz, the proposed strain sensitivity is comparable to full third-generation detectors at a fraction of the cost. Such sensitivity changes expected event rates for detection of post-merger remnants from approximately one per few decades with two A+ detectors to a few per year and potentially allow for the first gravitational-wave observations of supernovae, isolated neutron stars, and other exotica.

Restoration in Mediterranean-climate grasslands is strongly impeded by lack of native propagules and competition with exotic grasses and forbs. We report on a study testing several methods for exotic plant control combined with planting native grasses to restore prairies in former agricultural land in coastal California. Specifically we compared tarping (shading out recently germinated seedlings with black plastic) once, tarping twice, topsoil removal, herbicide (glyphosate), and a control treatment in factorial combinations with or without wood mulch. Into each treatment we planted three native grass species (Elymus glaucus, Hordeum brachyantherum, and Stipa pulchra) and monitored plant survival and cover for three growing seasons. Survival of native grass species was high in all treatments, but was slightly lower in unmulched soil removal and control treatments in the first 2 yr. Mulching, tarping, and herbicide were all effective in reducing exotic grass cover and enhancing native grass cover for the first 2 yr, but by the third growing season cover of the plant guilds and bare ground had mostly converged, primarily because of the declining effects of the initial treatments. Mulching and tarping were both considerably more expensive than herbicide treatment. Topsoil removal was less effective in increasing native grass cover likely because soil removal altered the surface hydrology in this system. Our results show that several treatments were effective in enhancing native grass establishment, but that longer term monitoring is needed to evaluate the efficacy of restoration efforts. The most appropriate approach to controlling exotics to restore specific grassland sites will depend not only on the effectiveness, but also on relative costs and site constraints.

Neuropsychiatric symptoms are common features in patients with neurodegenerative diseases, and have important clinical implications for both patients and caregivers. This study used the Neuropsychiatric Inventory (NPI) to measure symptomatology in 120 patients drawn from five disease groups: Parkinson's disease (PD), Alzheimer's disease (AD), dementia associated with Lewy bodies (DLB), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Ninety per cent of the patient group reported experiencing at least one symptom, with the most prevalent symptoms being depression and apathy. However, a differential pattern of symptomatology was reported across the disease groups, a finding which has diagnostic and treatment implications. Furthermore, this provides additional evidence that a broad cortical–subcortical distinction cannot be supported.

The levels of erythrocyte membrane sialic acid from 17 patients with Plasmodium falciparum malaria and 1 with Plasmodium vivax malaria, in Papua New Guinea, have been compared with 9 uninfected controls. The amounts of radioactivity incorporated into the major erythrocyte glycoproteins by the periodate/NaB3H4 or galactose oxidase plus neuraminidase/NaB3H4 methods were unchanged by malaria infection. The electrophoretic mobilities of these proteins also were unaffected. Several new glycoprotein bands with molecular weights (mol. wt) of 160000, 89000, 46000, 42000 and 33000 Daltons were labelled on the surface of erythrocytes from infected individuals; however, none of these bands appeared in all malarious samples. Sialic acid levels on the erythrocyte membrane were also measured by exhaustive neuraminidase treatment and quantitative assay of released sialic acid. The amount of sialic acid was raised in 1 infected individual, within the normal range for Europeans in 4 others, and below this range with 3 patients. Apparently, extensive removal or modification of sialic acid on the surface of uninfected erythrocytes does not occur in human malaria, in contrast to the results obtained in earlier studies with the lethal murine malarias.

Three handbooks have been developed, in conjunction with a wide range of stakeholders toassist in the management of contaminated food production systems, inhabited areas anddrinking water following a radiological incident. The handbooks are aimed at national andlocal authorities, central government departments and agencies, emergency services,radiation protection experts, the agriculture and food production sectors, industry andothers who may be affected. The handbooks include management options for application inthe different phases of an incident. Sources of contamination considered in the handbooksinclude nuclear accidents and radiological dispersion devices; the most relevantradionuclides are included. The handbooks are divided into several sections which providesupporting scientific and technical information; an analysis of the factors influencingrecovery; compendia of comprehensive, state-of-the-art datasheets for around 100management options and guidance on planning in advance. A decision-aiding frameworkcomprising colour coded selection tables, look-up tables and decision trees and severalworked examples are also included. The handbooks can be used as a preparatory tool, undernon-crisis conditions, to engage stakeholders and to develop local and regional plans. Thehandbooks can also be applied as part of the decision-aiding process to develop a recoverystrategy following an incident. In addition, the handbooks are useful for trainingpurposes and during emergency exercises. To realise their full potential, the handbooksshould be customised at national, regional and local levels.

Snails, provisionally identified as Bulinus tropicus, on the basis of chromosome number, egg protein profile, AcP and 118DH enzymes of the digestive gland, and radular morphology, from Lochinvar National Park, Zambia have been demonstrated to transmit Schistosoma margrebowiei naturally. The identification of the unpaired male schistosomcs was confirmed by PGM and AcP analyses. The observations confirm earlier epidemiological predictions, and add another species of mollusc to the two, B. forskalii and B. scalaris, known to be natural intermediate hosts of S. margrebowiei.

There is general international acceptance of the need to demonstrate that the environment is protected from ionising radiation. In some countries requirements and guidelines for the protection of non-human biota are already in place. As a consequence a number of models and approaches have been proposed for the estimation of the exposure of non-human biota to ionising radiation. The IAEA EMRAS programme's Biota Working Group has conducted the most comprehensive intercomparison of the predictions of these approaches to date. In this paper, we present an overview of the activities of the Biota Working Group concentrating on its conclusions and recommendations.

Putting down a revolt always risks seeing the legitimate use of force degenerate into an excessive and discredited repression, here called domestic state violence. Sergio Cotta's analytical model of the difference between force and violence helps to reveal the significance of various cycles of revolt and repression over three centuries of French history. Oscillations between measured coercive force and domestic state violence divide these three centuries into six stages: early absolutist (1594–1639), Louisquatorzian (1640–75), themistocratic (1675–1789), revolutionary (1792–5), late republican (1797–1802), and liberal authoritarian (1802–71). Continuities existed across all of these stages, such as the recourse to regular troops and summary justice; however, periods of rapid socio-political realignment caused the use of force to become domestic state violence. In order to overcome the alienation this produced, the state created new means of restricting its use of force while still protecting the new social order. The years 1797–1802 constituted the pivotal phase of this process because this was when so many methods of repression developed during the era between early absolutism and the Terror were revived, only now wrapped in the restraints of legal-rational authority. The resulting ‘liberal authoritarianism’ persisted until the 1880s without substantial changes other than growth in the sheer magnitude of repression.

The Basic Trauma Life Support (BTLS) course was developed to teach prehospital providers a rapid, prioritized approach to assess and manage the trauma victim. Little data currently are available relative to the retention of the cognitive and psychomotor skilk taught in the course. To examine this question, thirteen paramedics were retested on identically moulaged trauma scenarios and written examinations 14–16 months after initial training in BTLS. No advanced notification of the re-test was given. Written test scores decreased from an initial mean of 93.0±6.6 to a mean of 64.9±11.8 (p<0.001) 14–16 months later. Similarly, the trauma scenario test scores declined from 71.6±10.4 to 61.3±16.2 (p<0.05). The results suggest that there is significant loss of both didactic information and practical skills from the BTLS course 14–16 months after training. Frequent BTLS refresher training in the form of supplemental readings, lectures, and repeated exposures to trauma simulations is needed.