Dyslipidaemia is associated with chronic low-grade inflammation and immune dysfunction, but the immunological effects of dietary phytosterols in humans remain unclear. We conducted a secondary analysis of an outcome-assessor-blinded, randomised controlled feeding trial to evaluate the effects of a high-phytosterol (HPS) diet, using phytosterol-enriched corn–wheat germ blended oil (CWGO), compared with a low-phytosterol (LPS) diet using peanut oil, on systemic inflammatory markers, humoural immune markers and peripheral blood lymphocyte subsets in Chinese adults with dyslipidaemia. After a 2-week run-in period, 104 participants were randomised to the HPS group (n 52) or the LPS group (n 52) for 12 weeks. In intention-to-treat analyses, the HPS group had a higher CD4+:CD8+ ratio at 12 weeks than the LPS group (adjusted mean difference: 0·561; 95 % CI 0·060, 1·063; P = 0·03) and a lower CD8+ T-cell count (adjusted mean difference: −116·315 cells/μl; 95 % CI −215·781, –16·849; P = 0·02). No significant between-group differences were observed for systemic inflammatory markers, humoral immune markers or most other lymphocyte subset outcomes. In per-protocol analyses, the difference in CD4+:CD8+ ratio remained significant, whereas the reduction in CD8+ T-cell count was attenuated. These exploratory findings suggest that a 12-week phytosterol-enriched CWGO intervention may be associated with changes in T-cell subset balance in adults with dyslipidaemia, although the results should be interpreted cautiously given the exploratory nature of this secondary analysis.

The traditional design of laser drivers for inertial confinement fusion (ICF) is highly dependent on coherent laser light fields, which have significant advantages in achieving harmonic conversion and enhancing amplification efficiency. However, they also bring the core challenge of achieving uniform irradiation. This paper investigates the dynamic evolution process of uniform irradiation of multi-mode spatiotemporal light fields and analyzes the influence mechanism of spatiotemporal coherence on irradiation uniformity with different integration times. By balancing the relationship between the spatiotemporal coherence of the light field and uniform irradiation, we explore a possible scheme to alleviate the beam smoothing problem while satisfying the basic requirements of laser amplification and high-efficiency harmonic conversion. Based on this scheme, the overall architecture of the ICF laser driver is constructed.

Orthopaedic inpatients have distinct clinical traits. This study aimed to quantify the burden of nosocomial infections (NIs) on orthopaedic patients. A nested case–control study (2022–2024) at the China National Orthopaedic Medical Center compared orthopaedic inpatients with and without NIs and matched cases and controls 1:3 to evaluate the burden of NIs. A national economic burden analysis was subsequently conducted under various scenarios. Among 120,764 eligible patients, 338 (0.28%) developed NIs. A total of 321 cases were matched with 916 controls. The economic and temporal burdens of NIs are US$2,100 and 5 days per case respectively. Haematologic NIs had the highest additional cost (US$4,295) and the second longest extended stay (9 days). In terms of initial hospitalisations and readmissions, surgical site infections extended hospital stays by 20 days and increased costs by US$4,881. The top three diagnosis-related groups (DRGs) with high burdens are ZC11, ZJ15, and IE21 for costs and ZJ15, IE21, and IB19 for duration. In the mixed-region scenario, orthopaedic specialty hospitals nationwide incur US$5.23 million in direct medical costs annually because of NIs. These findings indicate that NIs significantly affect orthopaedic patients both individually and nationally, necessitating focused prevention and control for high-burden DRGs and specific infections.

Unmanned aerial vehicles (UAVs) tracking one moving target in an oilfield environment with dynamic obstacles has been studied. Firstly, the UAV tracking one target is modeled mathematically, including the oilfield environment, the UAV kinematic model, the moving target model and so on. Considering the oilfield environment with dynamic obstacles, the chance-constraint method is incorporated into the distributed model predictive control (DMPC) to realise the target tracking and avoid the obstacles in the environment. Secondly, to obtain high-quality control-input sequences, the improved salp swarm algorithm (ISSA) is designed as the solver for the chance-constraint DMPC, integrating the sine-tent-cosine chaotic mapping in the initialisation, the differential mutation operation in the leader-position updating and the nonlinear adaptive inertia weights in the follower-position updating. Finally, the simulation results show that the proposed method has great performance in tracking the moving target in an oilfield environment with dynamic obstacles.

To determine values for the digestible indispensable amino acid score (DIAAS), it is recommended that ileal amino acid (AA) digestibility values obtained in growing pigs are used to characterise protein quality in different foods. Therefore, an experiment was conducted to determine the standardised ileal digestibility (SID) of AA in eight energy ingredients (barley, sorghum, wheat, brown rice, rice bran, wheat bran, cassava and paddy rice) fed to pigs, where SID values in pigs can be used to calculate approximate DIAAS values in humans. Among the data obtained for all energy ingredients, significant variations (P < 0·01) in CP and AA composition were observed. Rice bran and wheat bran had the highest CP (16·43 % and 18·16 %, respectively) and DIAAS scores of 81–88 for adult, qualifying as ‘good’ protein sources (> 75). Cassava, with the lowest CP (2·74 %), was limited by sulphur amino acid (54). Lysine (Lys) was the first-limiting AA in barley (74), sorghum (51) and wheat (49), with SID values lowest in wheat (71·04 %). Brown rice and paddy rice showed higher SIDLys (87·51 % and 78·13 %, respectively). These findings highlight the potential of bran-based ingredients and Lys fortification to improve protein quality in grain-dependent diets, providing the scientific basis to combat protein malnutrition.

African swine fever (ASF) is a highly contagious animal disease caused by African swine fever virus (ASFV). It is listed by the World Organization for Animal Health (WOAH) as an animal disease subject to statutory reporting. ASFV, a large, enveloped double-stranded DNA virus with high genomic complexity, exhibits a case fatality rate of up to 100%, posing a significant threat to the global pig industry and food safety. To date, the absence of a safe commercial ASFV vaccine primarily stems from challenges in identifying immunogenic viral antigens, insufficient characterization of ASFV pathogenesis, and limited understanding of the virus’s immune evasion mechanisms. Here, we review the pathogenic characteristics (morphological structure, clinical symptoms, and epidemiological characteristics), molecular biological characteristics, and infection mechanism of ASFV, as well as the immune response mechanism, vaccine research, and the latest information on ASFV in other areas. This review will be in favour of understanding the current state of knowledge of ASF and developing effective vaccines to control this disease.

Understanding the flow behaviour of wet granular materials is essential for comprehending the dynamics of numerous geological and physical phenomena, but remains a significant challenge, especially the transition of these flow regimes. In this study, we perform a series of rotating drum experiments to systematically investigate the dynamic observables and flow regimes of wet mono-dispersed particles. Two typical continuous flows including rolling and cascading regimes are identified and analysed, concentrating on the impact of fluid density and rotation speed. The probability density functions of surface angles, $\theta _{\textit{top}}$ and $\theta _{\textit{lo}w\textit{er}}$, reveal distinct patterns for these two flow regimes. A morphological parameter thus proposed, termed angle divergence, is used to characterise the rolling–cascading regime transition quantitatively. By integrating quantitative observables, we construct the flow phase diagram and flow curve to delineate the transition rules governing these regimes. Notably, the resulting nonlinear phase boundary demonstrates that higher fluid densities significantly enhance the likelihood of the system transitioning into the cascading regime. This finding is further supported by corresponding variations in flow fluctuations. Our results provide new insights into the fundamental dynamics of wet granular matter, offering valuable implications for understanding the complex rheology of underwater landslides and related phenomena.

This study reports potassium (K) isotope compositions of diamondiferous kimberlites. Altered kimberlite samples exhibit δ41K values ranging from −1.293 ± 0.052 (2SD) to −0.114 ± 0.029 ‰, showing covariations with chemical indicators of alteration. This is consistent with the geochemical dynamics of K isotopes in hydrothermal fluid-related processes. In contrast, pristine kimberlite samples display restricted K isotope compositions, with δ41K values between −0.494 ± 0.057 and −0.270 ± 0.048 ‰. Notably, the δ41K values of these pristine kimberlite samples correlate well with K2O and Rb contents, suggesting that approximately ∼0.2 ‰ of K isotope fractionation is induced by phlogopite crystallization, as indicated by quantitative modelling. The estimated δ41K values of −0.458 ‰ for the primary kimberlite melt and of −0.414 ‰ for the kimberlite source imply a potential link to the bulk silicate Earth. These new measurements, along with literature data from various rocks, indicate that the K isotope composition in the deep mantle (>150 km) is more homogenous than in shallow regions, likely reflecting the efficiency of convection flow and K behaviour during subduction. In addition, the K isotope data reveal temporal variations in mantle-derived magmas from the Palaeozoic to the Cenozoic, highlighting the geological history and lithospheric destruction of the North China Craton. This study underscores the significance of K isotopes in enhancing our understanding of mantle dynamics, crustal recycling and the geochemical evolution of the Earth’s interior.

Objectives: Data on primary care antibiotic prescription practices for children in Southeast Asia, which are essential for policy, quality improvement and patient safety, are lacking. We aimed to describe this gap and to benchmark prescription practices against international standards. Methods: Antibiotic prescriptions for children (age <18 years) who visited six public primary care clinics in Singapore between 2018 and 2021 were extracted and categorized according to the World Health Organization Access, Watch, Reserve (WHO AWaRe) classification. Quality indicators from the European Surveillance of Antimicrobial Consumption Network (ESAC- Net) and National Institute for Health and Care Excellence (NICE) guidelines were used as a measure of appropriateness of antibiotic prescribing. Descriptive statistics and T-test was used to compare prescription rates pre- and post-COVID-19 pandemic. Results: 19,325 and 20,692 oral and topical antibiotics were prescribed for 831,669 visits, with a prescription rate of 2.3% and 2.5% respectively. Mean antibiotic prescriptions fell significantly post-pandemic (2020–2021), compared to pre-pandemic numbers (1062.8 to 604.5 prescriptions per month) (p <0.001). The majority (95.8%) of prescriptions belonged to the Access group. Watch group antibiotics constituted 6.1% of the total antibiotics prescribed for respiratory conditions (n = 562). While prescriptions were low (4.1%) and well within EASC-Net quality indicator limits of 0-20% for respiratory infections, prescriptions for otitis media were significantly high (56.6%). Approximately 1 in 2 children received antibiotics as recommended by NICE guidelines for both respiratory infections (n=4,622, 51.5%) and otitis media (n=204, 51.8%). Conclusions: Primary care antibiotic prescriptions for children in Singapore decreased post- COVID-19. However, high rates of otitis media prescriptions and only 50% appropriateness for respiratory infections and otitis media emphasize the need for targeted improvements in these areas.