The motion of a spherical particle along a rough bed in a simple shear viscous flow is studied experimentally for a wide range of parameters, varying the particle size and density, the fluid viscosity and the shear rate γ. The instantaneous particle velocity is calculated in the stream, transverse and vertical directions, using a high-speed video imaging system. It is found that the normalized streamwise mean particle velocity U/US, where US is the Stokes settling velocity, depends only on the dimensionless shear rate μ γ/(Δ ρ g d), this relationship being independent of the particle Reynolds number Rep. This result holds for small Rep, which was the case in our experiments (Rep < 10). The characteristic amplitude and frequency of the velocity fluctuations are also given and discussed. A model is then proposed for the mean streamwise velocity, based on ideas of Bagnold (Proc. R. Soc. Lond. A, vol. 332, 1973, p. 473) and calculations of Goldman et al. (Chem. Engng Sci., vol. 22, 1967b, p. 653) for the velocity of a particle close to a smooth plane. From this model an equivalent bed roughness and an effective friction coefficient are deduced.

Panic attacks can be observed in a wide range of situations, but most common are those providing complex and unstructured stimulations, suggesting an impairment in attentional processing of visuo-spatial information. This study evaluated agoraphobics’ attentional processing of neutral (i.e., not anxiety-provoking) visuo-spatial stimulation. Twelve patients suffering from panic attacks with agoraphobia were compared with 22 normal controls on a computerized visual target discrimination task specifically designed for this study. Psychometric measures assessed the phobic avoidance, the level of depression and anxiety. The numbers of errors and reaction times were analysed with a three-way ANOVA (Group x target modality x number of stimulations). No between-group significant difference was found for the reaction time performance and the mean number of detection errors. However, an interaction effect was observed for this last variable depending on the target modality: agoraphobic patients made fewer omission errors than control subjects when the target was present among distractors, while they made more commission errors when the target was absent. Outcomes are discussed in terms of attentional hyperactivation related to anxiety and perseverative decision process in agoraphobic patients.

Unsteadiness in separated shock–boundary layer interactions have been previously analysed in order to propose a scenario of entrainment–discharge as the origin of unsteadiness. It was assumed that the fluid in the separated zone is entrained by the free shear layer formed at its edge, and that this layer follows the properties of the canonical mixing layer. This last point is addressed by reanalysing the velocity measurements in an oblique shock reflection at a nominal Mach number of 2.3 and for two cases of flow deviation ($8^{\circ }$ and $9.5^{\circ }$). The rate of spatial growth of this layer is evaluated from the spatial growth of the turbulent stress profiles. Moreover, the entrainment velocity at the edge of the layer is determined from the mean velocity profiles. It is shown that the values of turbulent shear stress, spreading rate and entrainment velocity are consistent, and that they follow the classical laws for turbulent transport in compressible shear layers. Moreover, the measurements suggest that the vertical normal stress is sensitive to compressibility, so that the anisotropy of turbulence is affected by high Mach numbers. Dimensional considerations proposed by Brown & Roshko (J. Fluid Mech., vol. 64, 1974, 775–781) are reformulated to explain this observed trend.

In this contribution, we report progress in the preparation of superconducting materials made by Spark Plasma Sintering (SPS). On the one hand, the fabrication process was optimized in order to improve the texturing of Bi2Ca2Sr2CuO8 superconductor ceramics. The new process is referred to as “Spark Plasma Texturing” (SPT). During SPT, the bulk material is free to deform itself. As a result, an inter-grain preferential crystallographic orientation is generated, while materials processed by conventional SPS are usually quasi-isotropic. The crystallographic orientation causes a strong anisotropy in the magnetic properties of the Bi2Ca2Sr2CuO8 bulk.

On the other hand, superconducting MgB2 discs were consolidated using the rapid SPS process. MgB2 has not been yet been seriously considered as a superconductor that could be used for magnetic levitation. Here we present trapped field measurements as a function of the distance to the superconductor and field cooled levitation force measurements that suggests that it presents interesting characteristics for this application.

The impact of nutrition and energy reserves on the fertility of ruminants has been extensively described. However, the metabolic factors and the molecular mechanisms involved in the interactions between nutrition and ovarian function are still poorly understood. These factors could be hormonal (either reproductive and/or metabolic) and/or dietary and metabolic (glucose, amino acids and fatty acids). In this review, we briefly summarize the impact of those nutrients (fatty acids, glucose and amino acids) and metabolic hormones (insulin/IGF-I, growth hormone, T3/4, ghrelin, apelin and the adipokines (leptin, adiponectin and resistin)) implicated in the development of ovarian follicles, oocytes and embryos in ruminants. We then discuss the current hypotheses on the mechanisms of action of these factors on ovarian function. We particularly describe the role of some energy sensors including adenosine monophosphate-activated kinase and peroxisome proliferator-activated receptors in the ovarian cells.

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.

The kalipyrochlore (K,Sr,Na,Ca,H2O)2−m(Nb,Ti)2−xO6−wY1−n, with (0<m<0.8, x∼0.2, w = 0 and 0.2<n<1) from Lueshe, Zaire is a defect pyrochlore species whose A-site weakly depleted. The measured powder diffraction is presented with a calculated figure of merit F(30) = 74.7(0.010,39). The structure has been refined by single-crystal from X-ray diffraction data collected on a Huber four-circle diffractometer and by Rietveld analysis from X-ray powder diffraction data. The slightly weathered crystal (studied by single crystal) has a cubic pyrochlore-type structure with the same atomic positions and a unit-cell parameter a = 10.603(5) Å, space group (S.G.): Fd3m. The highly weathered crystal (studied by Rietveld) has the same cubic pyrochlore-type structure except for the oxygen position. The oxygen moved from the 48f position with x, y, z equal to 0.284, 0, 0 to x = 0.308(5), y = 0.024(6) and z = –0.028(9). The cell parameter is a = 10.569(6)±0.0007 Å. These modifications of positions induce a distortion of the A-site into an hexagonal bipyramid and an elongation of the B-site along the c axis of the octahedron.

A model based on mass conservation properties is developed for shock-wave/boundary-layer interactions (SWBLIs), aimed at reconciling the observed great diversity in flow organization documented in the literature, induced by variations in interaction geometry and aerodynamic conditions. It is the basis for a scaling approach for the interaction length that is valid independent of the geometry of the flow (considering compression corners and incident-reflecting shock interactions). As part of the analysis, a scaling argument is proposed for the imposed pressure jump that depends principally on the free-stream Mach number and the flow deflection angle. Its interpretation as a separation criterion leads to a successful classification of the separation states for turbulent SWBLIs (attached, incipient or separated). In addition, the dependence of the interaction length on the Reynolds number and the Mach numbers is accounted for. A large compilation of available data provides support for the validity of the model. Some general properties on the state of the flow are derived, independent of the geometry of the flow and for a wide range of Mach numbers and Reynolds numbers.

Improvement of reproduction in dairy cows has become a major challenge in dairy production. We have recently shown that dairy cows carrying the ‘fertil−’ haplotype for one quantitative trait locus (QTL), affecting female fertility and located on the bovine chromosome 3, had a significantly lower conception rate after the first artificial insemination than cows carrying the ‘fertil+’ haplotype. The objective of this paper was to study other phenotypic modifications linked to this QTL. In the present study, 23 ‘fertil+’ and 18 ‘fertil−’ cows were characterized for live weight, milk production, food intake, eating behaviour and plasma metabolites. These parameters were measured during the first lactation, from calving to 40 weeks postpartum (wkpp). In the first 7 weeks of lactation, ‘fertil+’ primiparous cows had a significantly higher live BW and milk production than ‘fertil−’ cows. Dry matter intake tended to be slightly higher for ‘fertil+’ than for ‘fertil−’ primiparous cows in this period. However, energy balance was similar for the two haplotypes in the whole lactation, except in the first wkpp, and consequently, could not explain their different fertility. The major observation concerned the eating behaviour. ‘Fertil+’ primiparous cows had a significantly lower eating rate than ‘fertil−’ cows during the 40 weeks of lactation. In parallel, ‘fertil+’ cows spent significantly more time at the feeder for a similar number of visits than ‘fertil−’ cows. Furthermore, no differences in plasma concentrations of non-esterified fatty acids and insulin were observed between the two haplotypes. Plasma glucose was significantly lower in ‘fertil+’ than in ‘fertil−’ cows in the second wkpp. Taken together, our results show that ‘fertil+’ and ‘fertil−’ dairy cows, with different fertility, have also different eating behaviour without any variation in energy balance, except in the first week of lactation.

The diagnosis of cows' milk protein allergy (CMPA) requires first the suspicion of diagnosis based on symptoms described in the medical history, and, second, the elimination of cows' milk proteins (CMP) from the infant's diet. Without such rigorous analysis, the elimination of CMP is unjustified, and sometimes harmful. The elimination diet should be strictly followed, at least until 9–12 months of age. If the child is not breast fed or the mother cannot or no longer wishes to breast feed, the first choice is an extensively hydrolysed formula (eHF) of CMP, the efficacy of which has been demonstrated by scientifically sound studies. If it is not tolerated, an amino acid-based formula is warranted. A rice protein-based eHF can be an alternative to a CMP-based eHF. Soya protein-based infant formulae are also a suitable alternative for infants >6 months, after establishing tolerance to soya protein by clinical challenge. CMPA usually resolves during the first 2–3 years. However, the age of recovery varies depending on the child and the type of CMPA, especially whether it is IgE-mediated or not, with the former being more persistent. Once the child reaches the age of 9–12 months, an oral food challenge is carried out in the hospital ward to assess the development of tolerance and, if possible, to allow for the continued reintroduction of CMP at home. Some children with CMPA will tolerate only a limited daily amount of CMP. The current therapeutic options are designed to accelerate the acquisition of tolerance thereof, which seems to be facilitated by repeated exposure to CMP.

A model to explain the low-frequency unsteadiness found in shock-induced separation is proposed for cases in which the flow is reattaching downstream. It is based on the properties of fluid entrainment in the mixing layer generated downstream of the separation shock whose low-frequency motions are related to successive contractions and dilatations of the separated bubble. The main aerodynamic parameters on which the process depends are presented. This model is consistent with experimental observations obtained by particle image velocimetry (PIV) in a Mach 2.3 oblique shock wave/turbulent boundary layer interaction, as well as with several different configurations reported in the literature for Mach numbers ranging from 0 to 5.

The work presented here focuses on the analysis of a turbulent boundary layer saturated with saltating particles. Experiments were carried out in a wind tunnel 15m long and 0.6m wide at the University of Aarhus in Denmark with sand grains 242 μm in size for wind speeds ranging from the threshold speed to twice its value. The saltating particles were analysed using particle image velocimetry (PIV) and particle-tracking velocimetry (PTV), and vertical profiles of particle concentration and velocity were extracted. The particle concentration was found to decrease exponentially with the height above the bed, and the characteristic decay height was independent of the wind speed. In contrast with the logarithmic profile of the wind speed, the grain velocity was found to vary linearly with the height. In addition, the measurements indicated that the grain velocity profile depended only slightly on the wind speed. These results are shown to be closely related to the features of the splash function that characterizes the impact of the saltating particles on a sandbed. A numerical simulation is developed that explicitly incorporates low-velocity moments of the splash function in a calculation of the boundary conditions that apply at the bed. The overall features of the experimental measurements are reproduced by simulation.

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008

The still ever increasing demand for sedation and/or analgesia for diagnostic and therapeutic procedures puts high pressure on anaesthesia care providers all over Europe. Since the capacity to provide that service by anaesthetists is limited in most European countries, guidelines for non-anaesthetist doctors who want to sedate patients on a high-quality level and especially in a safe way are mandatory. This paper, produced by a working party of the European Board of Anaesthesiology of the European Union of Medical Specialists (EUMS/UEMS), gives direction to those practitioners who feel responsibilities in this area of medicine. Close cooperation with anaesthesiologists seems mandatory to achieve and sustain a high-quality standard for our patients undergoing medical or surgical procedures under sedation.

The raffinose family of oligosaccharides (RFO) is present in relatively high levels in grain legume seeds. They are considered to be antinutritional compounds because they are, at least in part, believed to be responsible for causing flatulence in humans, which is the single most important factor in deterring people from including more legume seeds in their diet. The RFO also have important functions within the plant. They serve as transport metabolites in many legumes and have been proposed to play a positive role in cold acclimatisation and in conferring desiccation tolerance during seed maturation. These responses to environmental stresses are believed to result from the RFO acting as protecting agents for membrane bound-proteins. We have screened 70 pea lines from the test array of the John Innes Pisum germplasm collection, and lines were selected which had unusual RFO composition. The soluble sugars within these lines were quantified using High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection (HPAEC-PAD), and variants were identified which were deficient in verbascose and one with a reduced level of raffinose. These selected lines are being used in a crossing programme designed to study the genetics of the RFO pathway and to produce new material to test the effect of specific RFO on the plant’s responses to the environment and on the diets of humans and animals.