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This retrospective, descriptive case-series reviews the clinical presentations and significant laboratory findings of patients diagnosed with and treated for injectional anthrax (IA) since December 2009 at Monklands Hospital in Central Scotland and represents the largest series of IA cases to be described from a single location. Twenty-one patients who fulfilled National Anthrax Control Team standardized case definitions of confirmed, probable or possible IA are reported. All cases survived and none required limb amputation in contrast to an overall mortality of 28% being experienced for this condition in Scotland. We document the spectrum of presentations of soft tissue infection ranging from mild cases which were managed predominantly with oral antibiotics to severe cases with significant oedema, organ failure and coagulopathy. We describe the surgical management, intensive care management and antibiotic management including the first description of daptomycin being used to treat human anthrax. It is noted that some people who had injected heroin infected with Bacillus anthracis did not develop evidence of IA. Also highlighted are biochemical and haematological parameters which proved useful in identifying deteriorating patients who required greater levels of support and surgical debridement.
A patient was referred to us with a mass in her upper jaw. This was diagnosed to be a chondrosarcoma of the maxilla. The mass was removed surgically. We present the case here and discuss the salient features.
The disabilities following laryngectomy are well recognized. The incidence of these disabilities and the acceptability of the surgery to the patients were assessed by a questionnaire method. Sixty-five patients participated in the study. The incidence of disabilities are discussed. Total laryngectomy was felt to be a worthwhile operation by most of the patients in the study despite the disabilities they experienced afterwards.
Bismuth subnitrate, one of the constituents of BIPP is known to cause methaemoglobinaemia. Ten patients had blood estimations for methaemoglobin levels before and after nasal packing with BIPP impregnated gauze. Only one patient exhibited abnormal levels of methaemoglobin and this was most probably the result of the large quantity of BIPP used. It is unlikely that significant methaemoglobinaemia occurs during the routine use of BIPP in the nose.
New data on the production of electrical conductivity in poly (phenylene sulfide), PPS, by ion irradiation are presented. These and previously reported PPS data are investigated in the framework of a theoretical semiempirical model that relates observed conductivity to parameters associated with the deposition of energy in the polymer by the bombarding ions. It is shown that the onset of conductivity with increasing ion dose is dependent on overlap of individual ion damage regions. A straight line relationship is obtained between log of the ion stopping power and log of the effective overlap radius of the ion damage regions. Furthermore, the magnitude of the values of effective overlap radii are consistent with physical observations and theoretical predictions. At higher ion doses, the rapid increase in conductivity appears to be consistent with a multistage reaction mechanism for the production of conducting species in the polymer. A universal curve of conductivity as a function of dose above threshold dose is seen to fit all of the PPS data up to a dose of a factor of 50 above threshold. This curve and the predictable behavior of the threshold dose allow the selection of ion/dose combinations to produce a desired conductivity.
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