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Social Network Analysis is a method of analyzing coauthorship networks or relationships through graph theory. Institutional Development Award (IDeA) Networks for Clinical and Translational Research (IDeA-CTR) was designed to expand the capability for clinical and translational research to enhance National Institutes of Health funding.
Methods:
All publications from a cohort of clinical and translational scientists in Oklahoma were collected through a PubMed search for 2014 through 2021 in October 2022. For this study’s bibliometric portion, we pulled the citations from iCite in November of 2022.
Results:
There were 2,391 articles published in 1,019 journals. The number of papers published by year increased from 56 in 2014 to 448 in 2021. The network had an average of 6.4 authors per paper, with this increasing by year from 5.3 in 2014 to 6.9 in 2021. The average journal impact factor for the overall network was 7.19, with a range from 0.08 to 202.73. The Oklahoma Shared Clinical and Translational Resources (OSCTR) network is a small world network with relatively weak ties.
Conclusions:
This study provides an overview of coauthorship in an IDeA-CTR collaboration. We show the growth and structure of coauthorship in OSCTR, highlighting the importance of understanding and fostering collaboration within research networks.
Already by the time our volume Vikings in Scotland: An Archaeological Survey came to fruition in 1998, it was becoming clear that even two authors could not fully encompass the range of developing evidence. Scientific endeavours, new methodologies and the explosion of environmental data, with burgeoning analysis, were beginning to dominate research agendas beyond our specialisms. During the succeeding decades, these aspects have developed into commonly applied approaches, complementing the study of antiquarian sources, place-names and historical documentation. Taken together, all these aspects provide a unique suite of interdisciplinary tools. The contents of this current – and most timely – volume highlight both the richness of the evidence and the results of a collegiate approach within our discipline as a whole.
Several different approaches are already enabling a much fuller – and potentially more accurate – understanding of the Scandinavians in Scotland. In combination with more commonly applied methods, new approaches and new scientific methodologies are already integrated, and all are providing a much wider platform for discussion. Commencing with a reassessment of accepted narratives, a number of issues can be addressed. Making use of new refinements in C14 determinations, artefactual studies (for example, Ashby on combs, this volume) and isotopic/ aDNA studies, it is becoming more likely that we will be able to establish more clearly the dating of the arrival of the Vikings on our shores, as well as the nature of that arrival and interaction between native and incoming populations. The thorny issue of whether this was peaceful or violent is less commonly dictating the agenda now, being replaced with a more nuanced understanding of regional variations and continuing regimes of landscape exploitation (see, for example, Dockrill and Bond, and Macniven, this volume). The nature of this potential population replacement is informed through isotopic examination where the origin of individuals can be interrogated. The consideration of ethnic identities and their expression in newly settled areas has fascinating potential.
Major datasets ripe for reinterpretation and amplification include little- understood early settlement excavations, markedly Jarlshof in Shetland. As an oft-cited archaeological sequence of developing farmsteads, the issues with the stratigraphy and associated (or otherwise) artefact groups have cast a long shadow over the interpretation of many artefact assemblages from broadly contemporary sites. Items are uncritically considered to be securely dated in the Jarlshof sequence and are cited as datable parallels, when in fact the stratigraphical sequence is problematic.
Spinal muscular atrophy (SMA) is a devastating rare disease that affects individuals regardless of ethnicity, gender, and age. The first-approved disease-modifying therapy for SMA, nusinursen, was approved by Health Canada, as well as by American and European regulatory agencies following positive clinical trial outcomes. The trials were conducted in a narrow pediatric population defined by age, severity, and genotype. Broad approval of therapy necessitates close follow-up of potential rare adverse events and effectiveness in the larger real-world population.
Methods:
The Canadian Neuromuscular Disease Registry (CNDR) undertook an iterative multi-stakeholder process to expand the existing SMA dataset to capture items relevant to patient outcomes in a post-marketing environment. The CNDR SMA expanded registry is a longitudinal, prospective, observational study of patients with SMA in Canada designed to evaluate the safety and effectiveness of novel therapies and provide practical information unattainable in trials.
Results:
The consensus expanded dataset includes items that address therapy effectiveness and safety and is collected in a multicenter, prospective, observational study, including SMA patients regardless of therapeutic status. The expanded dataset is aligned with global datasets to facilitate collaboration. Additionally, consensus dataset development aimed to standardize appropriate outcome measures across the network and broader Canadian community. Prospective outcome studies, data use, and analyses are independent of the funding partner.
Conclusion:
Prospective outcome data collected will provide results on safety and effectiveness in a post-therapy approval era. These data are essential to inform improvements in care and access to therapy for all SMA patients.
Non-typhoidal Salmonella (NTS) serovars, sequences types and antimicrobial susceptibility profiles have specific associations with animal and human infections in Vietnam. Antimicrobial resistance may have an effect on the manifestation of human NTS infections, with isolates from asymptomatic individuals being more susceptible to antimicrobials than those associated with animals and human diarrhoea.
Commercially available cabinet sprayers are not well suited for making low volume applications (<30 L/ha) of herbicides to woody forest species that can be up to 1.5 m tall. A simple, inexpensive laboratory sprayer that overcomes some limitations of commercial cabinet sprays can be built from materials readily available at local building and electronic suppliers. The only specialized equipment required is a positive displacement pump and a rotary disk atomizer. The atomizer is attached to the end of a variable height arm mounted on a laboratory cart. A positive displacement pump ensures controlled flow. The operator pushes the cart along a metal rub rail which keeps the cart tracking in a straight line. Travel speed is regulated by the operator following a marker on a clothesline-like loop of fishing line and is driven by a variable-speed drill attached to a variable voltage power supply.
The geochemistry, petrography, and distribution of the Jarvis Creek Ash (Péwé, 1965, 1975a) indicate that this tephra from the lower Delta River area of central Alaska is correlative with vol volcanic ash from sites in south-central Alaska near Tangle Lakes (upper Delta River area) and the Cantwell ash from Hayes volcano found in the upper Nenana River area (Riehle et al., 1990). Volcanic glass compositions of distal Jarvis Creek and Tangle Lakes tephra samples are compositionally restricted, while several discrete glass populations are present in some samples are compositionally collected nearer Hayes volcano. These correlations extend the known distribution of Hayes volcano tephras across the Alaska Range and into central Alaska, a distance of more than 650 km. New geochronologic data for the Jarvis Creek Ash suggest it was deposited ca. 3660 ± 125 yr B.P., consistent with previous age estimates of tephra eruptions at the Hayes volcano. The name “Jarvis Creek Ash” has well-established priority with respect to “Cantwell ash” or other local names for this tephra layer from the Hayes volcano.
Head injury is an important cause of morbidity and mortality in pediatrics. Comprehensive studies on outcome are scarce despite significant clinical concern that multiple areas of functioning may be impaired following moderate to severe head injury. The literature suggests that sequelae include not only medical problems but also impairments in cognitive functioning.
Methods:
Aretrospective medical and psychology chart review of patients, age 1-18 years, admitted to the Children's Hospital of Eastern Ontario with moderate (Glasgow Coma Scale [GCS] 9-12) or severe head injury (GCS ≤ 8) from November 1, 1993 until December 31, 1998 was conducted. Correlations were performed between medical variables (i.e., GCS, Pediatric Risk of Mortality [PRISM] III score, duration of ICU and hospital stay) and measures of intelligence and memory functioning.
Results:
Eighty-three children age 1 to 18 were included. Seventy percent of the children were classified as having a severe head injury. There was a mortality rate of thirteen percent. Younger age at injury, lower GCS, and higher PRISM III scores predicted higher mortality. Medical complications were documented systematically. Forty-four patients underwent at least one cognitive assessment and 17 of these children had intelligence testing at three points in time: baseline (< four months), early recovery (five to 15 months) and follow-up (16 to 38 months). The mean intelligence and memory scores fell within the average range at the latest point in follow-up. For those children who underwent three serial assessments, the mean verbal and performance IQ fell within the low average range at baseline improving significantly to fall within the average range by early recovery. Continued improvements were apparent in verbal memory beyond early recovery, with the mean obtained at follow-up falling within 1 SD of the normative mean. Despite the return to normal ranges for the group means the proportion of scores falling below 1.5 standard deviations from the mean was greater than population norms for verbal IQ, performance IQ and verbal memory. Lower GCS scores and longer duration of stay in ICU or hospital were predictive of lower nonverbal intelligence. Lower GCS was also predictive of lower visual memory scores.
Conclusions:
This study describes a population of Canadian children who suffered moderate or severe traumatic brain injury. Initial GCS was the best predictor of mortality and cognitive outcome. These children demonstrated a temporal improvement in intelligence and memory functioning, with their mean performance on these cognitive measures falling within the average range at 16 to 38 months postinjury, although there was considerable variability in the outcomes between individuals.
Allotment food gardens represent important sources of food security for urban residents. Since urban gardeners rarely receive formal agricultural education and have extremely limited space, they may be relying on readily available gardening advice (e.g., seed packet instructions), inventing cultural strategies that consider inter-specific competitive dynamics, or making poor planting decisions. Knowledge of garden crop diversity and planting arrangements can aid in designing strategies for productive urban gardens and food systems. We surveyed 96 individual plots in 10 allotment gardens in the Toronto region, assessed crop diversity within gardens and recorded planting practices used by urban gardeners by measuring the proximity of individual plants relative to similar or different crop species. We also compared planting densities used by urban gardeners with those recommended by major seed distributers. Collectively, Toronto urban agriculture contributes substantially to urban plant diversity (108 crops), but each plot tends to be relatively depauperate. Carrots and lettuce were three to five times more likely to be planted in clusters than intermingled with other crops (P < 0.05); whereas gardeners did not appear to use consistent planting arrangements for tomatoes or zucchini. Gardeners tended to plant tomatoes and zucchini 56–62.5% more densely than recommended by seed distributers (P < 0.001), whereas they planted 147 times fewer carrots in a given area than recommended (P < 0.05). Furthermore, neither crop planting density nor crop diversity changed with plot size. The planting arrangements we have documented suggest gardeners using allotment plots attempt plant densely in extremely limited space, and are employing cultural strategies that intensify competitive dynamics within gardens. Future research should assess the absolute and relative effect of altered cultural practices on yield, such that any modifications can be prioritized by their impact on yield.
Variation in human cognitive ability is of consequence to a large number of health and social outcomes and is substantially heritable. Genetic linkage, genome-wide association, and copy number variant studies have investigated the contribution of genetic variation to individual differences in normal cognitive ability, but little research has considered the role of rare genetic variants. Exome sequencing studies have already met with success in discovering novel trait-gene associations for other complex traits. Here, we use exome sequencing to investigate the effects of rare variants on general cognitive ability. Unrelated Scottish individuals were selected for high scores on a general component of intelligence (g). The frequency of rare genetic variants (in n = 146) was compared with those from Scottish controls (total n = 486) who scored in the lower to middle range of the g distribution or on a proxy measure of g. Biological pathway analysis highlighted enrichment of the mitochondrial inner membrane component and apical part of cell gene ontology terms. Global burden analysis showed a greater total number of rare variants carried by high g cases versus controls, which is inconsistent with a mutation load hypothesis whereby mutations negatively affect g. The general finding of greater non-synonymous (vs. synonymous) variant effects is in line with evolutionary hypotheses for g. Given that this first sequencing study of high g was small, promising results were found, suggesting that the study of rare variants in larger samples would be worthwhile.
Increased dietary Na intake and decreased dietary K intake are associated with higher blood pressure. It is not known whether the dietary Na:K ratio is associated with all-cause mortality or stroke incidence and whether this relationship varies according to race. Between 2003 and 2007, the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort enrolled 30 239 black and white Americans aged 45 years or older. Diet was assessed using the Block 98 FFQ and was available on 21 374 participants. The Na:K ratio was modelled in race- and sex-specific quintiles for all analyses, with the lowest quintile (Q1) as the reference group. Data on other covariates were collected using both an in-home assessment and telephone interviews. We identified 1779 deaths and 363 strokes over a mean of 4·9 years. We used Cox proportional hazards models to obtain multivariable-adjusted hazard ratios (HR). In the highest quintile (Q5), a high Na:K ratio was associated with all-cause mortality (Q5 v. Q1 for whites: HR 1·22; 95 % CI 1·00, 1·47, P for trend = 0·084; for blacks: HR 1·36; 95 % CI 1·04, 1·77, P for trend = 0·028). A high Na:K ratio was not significantly associated with stroke in whites (HR 1·29; 95 % CI 0·88, 1·90) or blacks (HR 1·39; 95 % CI 0·78, 2·48), partly because of the low number of stroke events. In the REGARDS study, a high Na:K ratio was associated with all-cause mortality and there was a suggestive association between the Na:K ratio and stroke. These data support the policies targeted at reduction of Na from the food supply and recommendations to increase K intake.