Trauma is a significant health issue that not only leads to immediate death in many cases but also causes severe complications, such as sepsis, thrombosis, haemorrhage, acute respiratory distress syndrome and traumatic brain injury, among trauma patients. Target protein identification technology is a vital technique in the field of biomedical research, enabling the study of biomolecular interactions, drug discovery and disease treatment. It plays a crucial role in identifying key protein targets associated with specific diseases or biological processes, facilitating further research, drug design and the development of treatment strategies. The application of target protein technology in biomarker detection enables the timely identification of newly emerging infections and complications in trauma patients, facilitating expeditious medical interventions and leading to reduced post-trauma mortality rates and improved patient prognoses. This review provides an overview of the current applications of target protein identification technology in trauma-related complications and provides a brief overview of the current target protein identification technology, with the aim of reducing post-trauma mortality, improving diagnostic efficiency and prognostic outcomes for patients.

In preparation for an experiment with a laser-generated intense proton beam at the Laser Fusion Research Center at Mianyang to investigate the 11B(p,α)2α reaction, we performed a measurement at very low proton energy between 140 keV and 172 keV using the high-voltage platform at the Institute of Modern Physics, Lanzhou. The aim of the experiment was to test the ability to use CR-39 track detectors for cross-section measurements and to remeasure the cross-section of this reaction close to the first resonance using the thick target approach. We obtained the cross-section σ = 45.6 ± 12.5 mb near 156 keV. Our result confirms the feasibility of CR-39 type track detector for nuclear reaction measurement also in low-energy regions.

The present work investigates the linear instability of three-dimensional boundary layers in thermodynamically non-ideal regimes. As a representative fluid, we consider carbon dioxide at supercritical pressure (80 bar). The flow set-up is matched to the redesigned DLR (German Aerospace Center) experiment on cross-flow instability, with identical pressure-coefficient distribution (accelerating the flow), sweep angle and Reynolds number, at a low Mach number. The flow temperature relative to the Widom line – also known as the pseudocritical line – thus characterises the non-ideality of the flow. We consider supercritical (gas-like), subcritical (liquid-like) and transcritical (pseudoboiling) regimes, where the flow temperature remains above, below or crosses the Widom line. The stability analyses of the parabolised Navier–Stokes baseflows indicate that wall heating destabilises the flow in the supercritical regime while wall cooling stabilises both effects similar to the ideal-fluid situation but being stronger. On the contrary, wall heating/cooling exhibits reversed effects in the subcritical regime, like for an ideal liquid. In the transcritical regime, with its sharp gradients of the thermodynamic and transport properties, wall heating stabilises the flow. Most substantially, however, wall cooling provokes a changeover of the leading instability mechanism: the accelerated streamwise flow attains inflectional wall-normal profiles, and the invoked inviscid Tollmien–Schlichting instability prevails with growth rates up to one order of magnitude larger than those of the cross-flow mode. We establish a two-fold mathematical relation from the momentum equation that explains the consequence of non-ideality and wall heating/cooling. The streamwise perturbation patterns of the flows in their linear instability regime are shown by mimicking wave trains emanating from virtual point-disturbance sources. From the viewpoint of keeping laminar flows, the transcritical thermodynamic state with a cooling wall must be avoided.

Compared to the streamwise instability, the cross-flow instability in high-enthalpy flows has received relatively less attention, but the latter is of vital importance in the flow transition for practical configurations. This work aims to investigate the cross-flow primary and secondary instabilities in hypersonic and high-enthalpy boundary layers, considering thermochemical non-equilibrium (TCNE) effects. The numerical tools adopted include a high-order shock-fitting solver, nonlinear parabolized stability equations and secondary instability theory (SIT). The flow over a swept parabola is calculated at a free-stream Mach number of 16. It is found that TCNE has a destabilizing effect on the cross-flow mode with a non-catalytic wall. Two important non-dimensional parameters are summarized to explain this effect. One is the ratio between the wall and boundary-layer edge temperatures, and the other is the cross-flow Mach number. Due to nonlinear effects, the stationary cross-flow vortices evolve and exhibit the classic rollover structures as in lower-speed flows. Two different disturbance energy norms are used in the energy budget analysis to classify the secondary cross-flow instability modes. The results from SIT highlight the importance of type-IV modes in TCNE flows at the downwash region of the vortex. The type-IV modes arise with the combined contribution from the wall-normal (on top and trough of the vortex) and spanwise (in the downwash region) production terms. The type-I mode is dominant in the calorically perfect gas case with an adiabatic wall, whereas the type-IV mode has the largest growth rate in the TCNE cases irrespective of wall temperature variation.

HMGR, 3-hydroxy-3-methylglutaryl-CoA reductase, is a major rate-limiting enzyme in mevalonate (MVA) pathway for isoprenoids and subsequent tanshinone biosynthesis in the Chinese traditional bulk herbal medicine Danshen, Salvia miltiorrhiza, mainly for cardiovascular disorders. In this paper, the genomic SmHMGR genes of 38 cultivated populations of S. miltiorrhiza collected in China were for the first time sequenced to reveal the genetic diversity and phylogeny. The SmHMGR gene was shown to be intron-free, 1650~1659 bp in complete CDS with the majority being 1656 bp, and two unique populations (W-FJLY-V-1 and W-SCHY-W-1) being 1659 and 1650 bp respectively. A total of 103 SNP variation sites were detected with a variation rate of 6.22%, most of which occurred in S. miltiorrhiza f. alba population W-SCHY-W-1; a total of 25 amino acid variation sites were found, of which 19 was in W-SCHY-W-1. The same four populations, W-SCHY-W-1, V-HBAG-V-1, V-JLCC-V-1 and S-NM-V-1 could be discriminated from the remaining 34 by both the SNP fingerprints and the deduced amino acid variation sites. Other or composite DNA markers are needed for better identification. The SmHMGR gene of white flower S. miltiorrhiza f. alba population W-SCHY-W-1 is especially rich in variations and worthy of further studies. Phylogenetic trees based on both the gene and the deduced amino acid sequences showed a very similar two-clade topological structure. This research enriched the content and the genetic means for the molecular identification, genetic diversity and phylogenetic studies of the cultivated S. miltiorrhiza populations, and laid a solid foundation for further related and in-depth investigations.

The household registration (hukou) system has been widely recognized as a key contributory factor to social inequality and tensions in China yet it remains intact despite a series of institutional reforms. What explains the resilience of the system? In this study, we address this puzzle by drawing on policy documents, statistical data and interviews. We argue that the hukou system remains because it is used to protect the beneficiaries of welfare provision and to ensure pivotal groups continue to offer political support. We find that owing to the reforms, a formidable barrier has been erected between the guarded cities and other regions to protect healthcare and education resources from inbound migrant workers. Consequently, the institutional reforms of the hukou system serve as a political contrivance for the survival of the Chinese party-state regime. The findings contribute to emerging literature on China's political control by elaborating political elites’ subtle tactics through various institutions at central and local levels. We expect the new “Great Wall” established under Xi's administration to be an even stronger barrier than before for migrants during the current pandemic and in the future.

This study investigates how venture capital firms (VCs) choose syndication partners. Exponential random graph models of Chinese VC syndication networks from 2006 to 2013 show that the homophily mechanism does not always determine VCs’ partner selection. In selecting partners, VCs have to strike a balance between reducing uncertainty and mobilizing heterogeneous resources. Therefore, decisions about partners depend on institutional uncertainty and VCs’ investment preferences. While VCs that focus on traditional business in an immature market are more likely to form homogeneous syndications, their peers that prefer to invest in innovative companies and that can rely on a stable market tend to syndicate with heterogeneous partners.

This study performs global stability/receptivity analyses of hypersonic flows over a swept blunt body with infinite span. For the first time, we obtain the characteristics of the leading attachment-line mode to the variation of sweep angles from $20^{\circ }$ to $70^{\circ }$. The global eigenfunctions exhibit the characteristics of the attachment-line instability at the leading edge. At the same time, cross-flow (at small sweep angles) or second Mack mode (at larger sweep angles) dominates further downstream. We establish an adjoint-based bi-orthogonal eigenfunction system to address the receptivity problem of such flows to any external forces and boundary perturbations. The receptivity analyses indicate that the global modes are the most responsive to external forces and surface perturbations applied in the vicinity of the attachment line, regardless of the sweep angles. It is also proven that the present global extension of the bi-orthogonal eigenfunction system can be successfully applied to complex hypersonic flows.

This study aims to shed light on hypersonic attachment-line instabilities with large sweep Mach numbers. Highly swept flows over a cold cylinder that give rise to large sweep Mach numbers are studied. High-fidelity basic flows are obtained by solving full Navier–Stokes equations with a high-order shock-fitting method. Using local and global stability theories, an attachment-line mode is found to be dominant for the laminar–turbulent transition along the leading edge that agrees qualitatively with the experimental observations (Gaillard et al., Exp. Fluids, vol. 26, 1999, pp. 169–176). The behaviour of this mode explains the reason for the transition occurring earlier as the sweep Mach number is above 5. In addition, this attachment-line mode is absent if the basic flow is calculated with boundary layer assumptions, indicating that the influence of inviscid flow outside the boundary layer cannot be ignored as is normally done. It is clearly demonstrated that the global modes display the features of both attachment-line modes, as in sweep Hiemenz flow, and the second Mack modes further downstream along the surface. In the large sweep Mach number regime, the attachment-line mode is inviscid in nature and its growth rate increases with the sweep angle. In contrast, in the lower sweep Mach number regime, the attachment-line instability exhibits the features of viscous Tollmien–Schlichting waves, and the sweep angle first increases but then decreases the maximum growth rate.

The development of free-stream disturbances in flow over a vertically vibrating flat plate with a slender leading edge is investigated. The evolution of the optimal inflow perturbation that results in the maximum amplification is computed to investigate the effect of the plate vibration on the development of free-stream disturbance, secondary instability of streaks and subsequently the bypass transition to turbulence. It is observed that the plate vibration leads to periodic change of the angle of attack, shifting the free-stream disturbance to the upper or lower side of the plate. Therefore, the development of steady inflow perturbations, which receive the largest amplification, is interrupted by the vibration, and the perturbation amplification via the lift-up mechanism is weakened. The vibration brings a second peak of perturbation growth at the vibration frequency, leading to high-frequency free-stream perturbations penetrating into the base boundary layer, which is not observed in flow over a stationary plate owing to the sheltering mechanism. This resonance of the flow perturbation and the vibrating plate is explained by the staggering effect of the leading edge. Further, the direct numerical simulations with the optimal inflow perturbation imposed on the inflow boundary show that the vertical vibration of the plate leads to streamwise periodic vorticity near the edge of the boundary layer. This inhomogeneity of the streamwise vorticity brings about streamwisely localized distortion of the low-speed streaks and, thus, an intermittent secondary instability. Therefore, before the streaks break down to turbulence, they undergo several rounds of secondary instabilities, resulting in an elongated bypass transition process.

We propose an image-based flow decomposition developed from the two-dimensional (2-D) tensor empirical wavelet transform (EWT) (Gilles, IEEE Trans. Signal Process., vol. 61, 2013, pp. 3999–4010). The idea is to decompose the instantaneous flow data, or their visualisation, adaptively according to the averaged Fourier supports for the identification of spatially localised structures. The resulting EWT modes stand for the decomposed flows, and each accounts for part of the spectrum, illustrating fluid physics with different scales superimposed in the original flow. With the proposed method, decomposition of an instantaneous three-dimensional (3-D) flow becomes feasible without resorting to its time series. Examples first focus on the interaction between a jet plume and 2-D wake, where only experimental visualisations are available. The proposed method is capable of separating the jet/wake flows and their instabilities. Then the decomposition is applied to an early-stage boundary layer transition, where direct numerical simulations provided a full dataset. The tested inputs are the 3-D flow data and their visualisation using streamwise velocity and $\lambda _{2}$ vortex identification criterion. With both types of inputs, EWT modes robustly extract the streamwise-elongated streaks, multiple secondary instabilities and helical vortex filaments. Results from 2-D stability analysis justify the EWT modes that represent the streak instabilities. In contrast to proper orthogonal decomposition or dynamic modal decomposition that extract spatial modes according to energy or frequency, EWT provides a new strategy for decomposing an instantaneous flow from its spatial scales.

The North Qilian orogenic belt in North China has been defined as a subduction–collision zone between the Alxa Block and the Qilian Block. We present petrography, zircon U–Pb geochronology, major- and trace-element geochemistry, and Sr–Nd–Pb–Hf isotope analysis for the Yushigou diabase from the Longshoushan area, which is located SW of the Alxa Block, aiming to understand its petrogenetic link to subduction processes. The Yushigou diabase belongs to the tholeiite series, and shows enrichment in light rare earth and large-ion lithophile elements, and a depletion in heavy rare earth and high-field-strength elements. Laser ablation – inductively coupled plasma – mass spectrometry U–Pb zircon dating yielded an emplacement age of 414 ± 9 Ma, with an ϵHf(t) value in the range of −10.3 to 1.8. The whole-rock initial 206Pb/204Pb, 207Pb/204Pb and 208Pb/204Pb ratios of the diabase range over 16.811–17.157, 15.331–15.422 and 37.768–37.895, respectively. The (87Sr/86Sr)i ratios vary between 0.7086 and 0.7106, and ϵNd(t) values vary between −14.4 and −13.4, which are significantly higher than the ϵHf(t) value (Nd–Hf decoupling). An interpretation of the elemental and isotopic data suggests that the Yushigou diabase was derived from partial melting of an enriched mantle I (EM-I) -type lithospheric mantle in the spinel–garnet transitional zone. Based on the geochemical features and previous regional geological data, we propose that the Silurian magmatism was most likely triggered by slab break-off after the closure of the North Qilian Ocean, and ancient continental materials from the subduction slab metasomatized the overlying lithospheric mantle during exhumation.

We investigate the hydrodynamic stability of compressible boundary layers over adiabatic walls with fluids at supercritical pressure in the proximity of the Widom line (also known as the pseudo-critical line). Depending on the free-stream temperature and the Eckert number that determines the viscous heating, the boundary-layer temperature profile can be either sub-, trans- or supercritical with respect to the pseudo-critical temperature, $T_{pc}$. When transitioning from sub- to supercritical temperatures, a seemingly continuous phase change from a compressible liquid to a dense vapour occurs, accompanied by highly non-ideal changes in thermophysical properties. Using linear stability theory (LST) and direct numerical simulations (DNS), several key features are observed. In the sub- and supercritical temperature regimes, the boundary layer is substantially stabilized the closer the free-stream temperature is to $T_{pc}$ and the higher the Eckert number. In the transcritical case, when the temperature profile crosses $T_{pc}$, the flow is significantly destabilized and a co-existence of dual unstable modes (Mode II in addition to Mode I) is found. For high Eckert numbers, the growth rate of Mode II is one order of magnitude larger than Mode I. An inviscid analysis shows that the newly observed Mode II cannot be attributed to Mack’s second mode (trapped acoustic waves), which is characteristic in high-speed boundary-layer flows with ideal gases. Furthermore, the generalized Rayleigh criterion (also applicable for non-ideal gases) unveils that, in contrast to the trans- and supercritical regimes, the subcritical regime does not contain an inviscid instability mechanism.

Underground Nuclear Astrophysics in China (JUNA) will take the advantage of the ultra-low background in Jinping underground lab. High current accelerator with an ECR source and detectors were commissioned. JUNA plans to study directly a number of nuclear reactions important to hydrostatic stellar evolution at their relevant stellar energies. At the first period, JUNA aims at the direct measurements of 25Mg(p,γ)26 Al, 19F(p,α) 16 O, 13C(α, n) 16O and 12C(α,γ) 16O near the Gamow window. The current progress of JUNA will be given.

The objective of this work is to investigate linear modal and algebraic instability in Poiseuille flows with fluids close to their vapour–liquid critical point. Close to this critical point, the ideal gas assumption does not hold and large non-ideal fluid behaviours occur. As a representative non-ideal fluid, we consider supercritical carbon dioxide ($\text{CO}_{2}$) at a pressure of 80 bar, which is above its critical pressure of 73.9 bar. The Poiseuille flow is characterized by the Reynolds number ($Re=\unicode[STIX]{x1D70C}_{w}^{\ast }u_{r}^{\ast }h^{\ast }/\unicode[STIX]{x1D707}_{w}^{\ast }$), the product of the Prandtl ($Pr=\unicode[STIX]{x1D707}_{w}^{\ast }C_{pw}^{\ast }/\unicode[STIX]{x1D705}_{w}^{\ast }$) and Eckert numbers ($Ec=u_{r}^{\ast 2}/C_{pw}^{\ast }T_{w}^{\ast }$) and the wall temperature that in addition to pressure determine the thermodynamic reference condition. For low Eckert numbers, the flow is essentially isothermal and no difference with the well-known stability behaviour of incompressible flows is observed. However, if the Eckert number increases, the viscous heating causes gradients of thermodynamic and transport properties, and non-ideal gas effects become significant. Three regimes of the laminar base flow can be considered: the subcritical (temperature in the channel is entirely below its pseudo-critical value), transcritical and supercritical temperature regimes. If compared to the linear stability of an ideal gas Poiseuille flow, we show that the base flow is modally more unstable in the subcritical regime, inviscid unstable in the transcritical regime and significantly more stable in the supercritical regime. Following the principle of corresponding states, we expect that qualitatively similar results will be obtained for other fluids at equivalent thermodynamic states.

The composites were synthesized by the reaction of Bi(NO3)3·5H2O, KI, and MoS2 and were prepared with different molar ratios of Bi/Mo (1:5, 1:2, 1:1, and 4:1) by altering the amount of bismuth nitrate pentahydrate. The phase composition and chemical bonds of the composites were characterized via X-ray diffraction and FT-IR, and the morphologies of the samples were characterized via scanning electron microscopy. With the increase of lanthanum source, the lamellar structure of the sample surface became more and more obvious. The results showed that the phase composition of the composites with different ratios of Bi/Mo was different. When the Bi/Mo reached 4:1, the composite material was Bi2MoO6/BiOI. The heterojunction structure formed between Bi2MoO6 and BiOI effectively promotes the separation of photogenerated electrons and holes and improved the photocatalytic activity. Therefore, the effect of the composites on the degradation of RhB was better than pure BiOI under the irradiation of a 350-W xenon lamp.

Babesiosis is an emerging tick-transmitted zoonosis prevalent in large parts of the world. This study was designed to determine the rates of Babesia microti infection among small rodents in Yunnan province, where human cases of babesiosis have been reported. Currently, distribution of Babesia in its endemic regions is largely unknown. In this study, we cataloged 1672 small wild rodents, comprising 4 orders, from nine areas in western Yunnan province between 2009 and 2011. Babesia microti DNA was detected by polymerase chain reaction in 4·3% (72/1672) of the rodents analyzed. The most frequently infected rodent species included Apodemus chevrieri and Niviventer fulvescens. Rodents from forests and shrublands had significantly higher Babesia infection rates. Genetic comparisons revealed that Babesia was most similar to the Kobe- and Otsu-type strains identified in Japan. A variety of rodent species might be involved in the enzootic maintenance and transmission of B. microti, supporting the need for further serological investigations in humans.

Görtler vortices developed in laminar boundary layer experience remarkable changes when the flow is subjected to compressibility effects. In the present study, five $\mathit{Ma}$ numbers, covering incompressible to hypersonic flows, at $\mathit{Ma}=0.015$, 1.5, 3.0, 4.5 and 6.0 are specified to illustrate these effects. Görtler vortices in subsonic and moderate supersonic flows ($\mathit{Ma}=0.015$, 1.5 and 3.0) are governed by the conventional wall-layer mode (mode W). In hypersonic flows ($\mathit{Ma}=4.5$, 6.0), the trapped-layer mode (mode T) becomes dominant. This difference is maintained and intensifies downstream leading to different scenarios of secondary instabilities. The linear and nonlinear development of Görtler vortices which are governed by dominant modal disturbances are investigated with direct marching of the nonlinear parabolic equations. The secondary instabilities of Görtler vortices set in when the resulting streaks are adequately developed. They are studied with Floquet theory at multiple streamwise locations. The secondary perturbations become unstable downstream following the sequence of sinuous mode type I, varicose mode and sinuous mode type II, indicating an increasing threshold amplitude. Onset conditions are determined for these modes. The above three modes can each have the largest growth rate under the right conditions. In the hypersonic cases, the threshold amplitude $A(u)$ is dramatically reduced, showing the significant impact of the thermal streaks. To investigate the parametric effect of the spanwise wavenumber, three global wavenumbers ($B=0.5$, 1.0 and $2.0\times 10^{-3}$) are specified. The relationship between the dominant mode (sinuous or varicose) and the spanwise wavenumber of Görtler vortices found in incompressible flows (Li & Malik, J. Fluid Mech., vol. 297, 1995, pp. 77–100) is shown to be not fully applicable in high-speed cases. The sinuous mode becomes the most dangerous, regardless of the spanwise wavelength when $\mathit{Ma}>3.0$. The subharmonic type can be the most dangerous mode while the detuned type can be neglected, although some of the sub-dominant secondary modes reach their peak growth rates under detuned states.