The World Cancer Research Fund and the American Institute for Cancer Research recommend a plant-based diet to cancer survivors, which may reduce chronic inflammation and excess adiposity associated with worse survival. We investigated associations of plant-based dietary patterns with inflammation biomarkers and body composition in the Pathways Study, in which 3659 women with breast cancer provided validated food frequency questionnaires approximately 2 months after diagnosis. We derived three plant-based diet indices: overall plant-based diet index (PDI), healthful plant-based diet index (hPDI) and unhealthful plant-based diet index (uPDI). We assayed circulating inflammation biomarkers related to systemic inflammation (high-sensitivity C-reactive protein [hsCRP]), pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) and anti-inflammatory cytokines (IL-4, IL-10, IL-13). We estimated areas (cm2) of muscle and visceral and subcutaneous adipose tissue (VAT and SAT) from computed tomography scans. Using multivariable linear regression, we calculated the differences in inflammation biomarkers and body composition for each index. Per 10-point increase for each index: hsCRP was significantly lower by 6·9 % (95 % CI 1·6%, 11·8%) for PDI and 9·0 % (95 % CI 4·9%, 12·8%) for hPDI but significantly higher by 5·4 % (95 % CI 0·5%, 10·5%) for uPDI, and VAT was significantly lower by 7·8 cm2 (95 % CI 2·0 cm2, 13·6 cm2) for PDI and 8·6 cm2 (95 % CI 4·1 cm2, 13·2 cm2) for hPDI but significantly higher by 6·2 cm2 (95 % CI 1·3 cm2, 11·1 cm2) for uPDI. No significant associations were observed for other inflammation biomarkers, muscle, or SAT. A plant-based diet, especially a healthful plant-based diet, may be associated with reduced inflammation and visceral adiposity among breast cancer survivors.

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists (RAs) mimic naturally occurring GLP-1 and GIP and are highly effective anti-diabetic and anti-obesity agents. In addition to their robust acute and long-term effects on weight, metabolism, and blood pressure, these agents also reduce cardiovascular mortality as well as stroke risk and associated consequences. A replicated and convergent body of preclinical evidence also indicates that incretin receptor agonists activate molecular effectors critical to neuroplasticity, neuroprotection, and anti-apoptosis. Herein, we propose that GLP-1 RAs and GIP RAs are promising transdiagnostic mechanistically informed therapeutics in the treatment and prevention of multiple domains of psychopathology, including general cognitive, reward, and motivation systems and mental disorders. Major neurocognitive disorders (eg, Alzheimer’s Disease, Parkinson’s Disease), alcohol and substance use disorders, traumatic brain injury, and depressive disorders are near-term therapeutic targets. In addition, GLP-1 RAs and GIP RAs have robust effects on comorbidities that differentially affect persons with mental disorders (eg, cardiovascular, cerebrovascular, and metabolic disorders) and psychotropic drug-related weight gain.

There is growing interest in lifestyle interventions as stand-alone and add-on therapies in mental health care due to their potential benefits for both physical and mental health outcomes. We evaluated lifestyle interventions focusing on physical activity, diet, and sleep in adults with severe mental illness (SMI) and the evidence for their effectiveness. To this end, we conducted a meta-review and searched major electronic databases for articles published prior to 09/2022 and updated our search in 03/2024. We identified 89 relevant systematic reviews and assessed their quality using the SIGN checklist. Based on the findings of our meta-review and on clinical expertise of the authors, we formulated seven recommendations. In brief, evidence supports the application of lifestyle interventions that combine behavioural change techniques, dietary modification, and physical activity to reduce weight and improve cardiovascular health parameters in adults with SMI. Furthermore, physical activity should be used as an adjunct treatment to improve mental health in adults with SMI, including psychotic symptoms and cognition in adults with schizophrenia or depressive symptoms in adults with major depression. To ameliorate sleep quality, cognitive behavioural informed interventions can be considered. Additionally, we provide an overview of key gaps in the current literature. Future studies should integrate both mental and physical health outcomes to reflect the multi-faceted benefits of lifestyle interventions. Moreover, our meta-review highlighted a relative dearth of evidence relating to interventions in adults with bipolar disorder and to nutritional and sleep interventions. Future research could help establish lifestyle interventions as a core component of mental health care.

Yellow and knotroot foxtail are two common weed species infesting turfgrass and pastures in the southeastern region of the United States. Yellow and knotroot foxtail share morphological similarities and are frequently misidentified by weed managers, thus leading to confusion in herbicide selection. Greenhouse research was conducted to evaluate the response of yellow and knotroot foxtail to several turfgrass herbicides: pinoxaden (35 and 70 g ai ha−1), sethoxydim (316 and 520 g ai ha−1), thiencarbazone + dicamba + iodosulfuron (230 g ai ha−1), nicosulfuron + rimsulfuron (562.8 g ai ha−1), metribuzin (395 g ha−1), sulfentrazone (330 g ai ha−1), sulfentrazone + imazethapyr (504 g ai ha−1), and imazaquin (550 g ai ha−1). All treatments controlled yellow foxtail >87% with more than 90% reduction of the biomass. By comparison, only sulfentrazone alone controlled knotroot foxtail 90% and completely reduced aboveground biomass. Sethoxydim (520 g ai ha−1), metribuzin, and imazaquin controlled knotroot foxtail >70% at 28 d after application. In a rate response evaluation, nonlinear regression showed that yellow foxtail was approximately 8 times more susceptible to pinoxaden and 2 times more susceptible to sethoxydim than knotroot foxtail based on log (WR50) values, which were 50% reduction in fresh weight. Our research indicates that knotroot foxtail is more difficult to control across a range of herbicides, making differentiation of these two species important before herbicides are applied.

In the course of the project ‘Pottery Production and Distribution of Bronze Age Settlements of Mycenaean Greece and the Aegean’ in 1996, Mycenaean pottery from Boeotia in the Archaeological Museum of Thebes was sampled with a view to investigation by neutron activation analysis (NAA). The NAA results were published and analysed in 2002. Ongoing work with new samples and re-evaluation of pre-existing ones, in both cases deriving from several sites of the Mycenaean world, resulted in the reappraisal of the NAA results concerning the Theban material. The present work aims at the archaeological assessment of the sampled material (152 samples from 148 examples) organised into three sections according to their exact findspot: (a) the chamber tomb cemeteries at Agia Anna area (Kolonaki and Mikro Kolonaki hills) and at Ismenion Hill; (b) the House of Kadmos; and (c) habitation areas at the lower south-east and north-west part of Kadmeia Hill. This classification corresponds roughly to the chronology of the examples dated to Middle Helladic and Late Helladic II to Late Helladic IIIC Late. The bulk of the pottery sampled is Mycenaean. A few examples of Handmade Burnished Pottery are included as well as four fragments of rooftiles, an uninscribed fragment of a Linear B tablet and a clay lump intended for a tablet. Twenty-one chemical groups/subgroups/pairs have been identified. The groups assigned to Boeotia comprise numerous examples excavated mainly at the habitation areas and dated to the subphase Late Helladic IIIB2 Late. Imports from the Peloponnese, Euboea and Crete, as well as one from Corfu, have been recognised, as have pieces of unknown provenance and loners. In conclusion, five chemical groups of pottery (TheA, TanA, TheB, ThBC, TheF) are associated with varying degrees of certainty with Boeotian pottery production. Imports came mainly from the north-eastern Peloponnese in Early Mycenaean times and from Euboea in the late palatial and post-palatial periods.

Mitochondrial dysfunction is a common feature of brain disorders. Mitochondria play a central role in oxidative phosphorylation; thus changes in energy metabolism in the brain have been reported in conditions such as Alzheimer’s disease, Parkinson’s disease, and stroke. In addition, mitochondria regulate cellular responses associated with neuronal damage such as the production of reactive oxygen species (ROS), opening of the mitochondrial permeability transition pore (mPTP), and apoptosis. Therefore, interventions that aim to protect mitochondria may be effective against brain disorders. Fucoxanthin is a marine carotenoid that has recently gained recognition for its neuroprotective properties. However, the cellular mechanisms of fucoxanthin in brain disorders, particularly its role in mitochondrial function, have not been thoroughly discussed. This review summarises the current literature on the effects of fucoxanthin on oxidative stress, neuroinflammation, and apoptosis using in vitro and in vivo models of brain disorders. We further present the potential mechanisms by which fucoxanthin protects mitochondria, with the objective of developing dietary interventions for a spectrum of brain disorders. Although the studies reviewed are predominantly preclinical studies, they provide important insights into understanding the cellular and molecular functions of fucoxanthin in the brain. Future studies investigating the mechanisms of action and the molecular targets of fucoxanthin are warranted to develop translational approaches to brain disorders.

Aspect-based sentiment analysis (ABSA) provides an opportunity to systematically generate user's opinions of specific aspects to enrich the idea creation process in the early stage of product/service design process. Yet, the current ABSA task has two major limitations. First, existing research mostly focusing on the subsets of ABSA task, e.g. aspect-sentiment extraction, extract aspect, opinion, and sentiment in a unified model is still an open problem. Second, the implicit opinion and sentiment are ignored in the current ABSA task. This article tackles these gaps by (1) creating a new annotated dataset comprised of five types of labels, including aspect, category, opinion, sentiment, and implicit indicator (ACOSI) and (2) developing a unified model which could extract all five types of labels simultaneously in a generative manner. Numerical experiments conducted on the manually labeled dataset originally scraped from three major e-Commerce retail stores for apparel and footwear products indicate the performance, scalability, and potentials of the framework developed. Several directions are provided for future exploration in the area of automated aspect-based sentiment analysis for user-centered design.

This article presents the results of Neutron Activation Analysis (NAA) of, altogether, 145 pottery and clay samples deriving from five sites located in the Thessalian region of Magnesia: Dimini, Nea Ionia, Kastro/Palaia (Volos), Pefkakia and Velestino. Chronologically, the sampled pottery covers the entire Late Bronze Age (LBA), with a few samples dating to the Middle Bronze Age. Within this broad chronological range, Mycenaean-type pottery dominates, the majority of it being decorated, with an addition of fine unpainted pottery and such used for transport and cooking. Pottery of non-Mycenaean derivation is represented by a variety of types belonging to the early LBA as well as two classes of the early post-palatial period (i.e. after 1200 BC): Handmade Burnished Ware and Grey Ware. Importantly, samples associated with two pottery kilns at Dimini and Velestino were included in the project, although no kiln wasters were identified. Results of the analysis provide important insights into both local Thessalian pottery production and inter- and intra-regional pottery exchange. Local production utilising clay beds around Dimini is best evidenced, with a distribution of its products reaching beyond Thessaly. Two further chemical patterns appear to be associated with Velestino, while an additional two small chemical groups are likely Thessalian as well. In terms of identified imports, the Argolid stands out as the major source of non-local pottery from the beginning of the LBA until the end of the palatial period. Other regions and production localities play a significantly smaller role as sources of supply. On the basis of the study, for the first time the local production as well as importation of pottery in the region of Magnesia is documented by scientific means, opening new research perspectives and strengthening the region's standing as part of the Mycenaean world.

An early form of eurypterids (Chelicerata), Archopterus anjiensis n. gen. n. sp., is described from the uppermost Ordovician Wenchang Formation of Anji County, Zhejiang Province, South China. It is the earliest record of eurypterids in China and likely the oldest representative of the Adelophthalmidae. The species, represented by a single specimen, is diagnosed by a ventrally preserved prosoma with a parabolic carapace, Hughmilleria-type prosomal appendages, a short vase-shaped metastoma, and a three-segmented type A (female) genital appendage. The specimen is preserved, together with diverse sponges, graptolites and occasional nautiloids, in a 10 m thick shale of marine deep-water setting. This finding extends the stratigraphic range of adelophthalmids from the previously recorded early Silurian into the Late Ordovician (some 10 million years older) and supports an earlier cryptic phase of eurypterid evolution in Gondwana.

UUID: http://zoobank.org/a2d090e5-1a15-40b6-8e2a-dda45b01e94d

In South Korea, government regulations constrain the resources of higher (tertiary) education, especially non-STEM (science, technology, engineering, and mathematics) departments. Resource constraints, in turn, reinforce a culturally Confucian hierarchy that restricts the participation of lower-rank members (e.g., high school and undergraduate students). This more-regulated, formal-education sector does not reflect the increasingly diverse cultural preferences (e.g., utilitarian and expressive) of Korean students. Many students, acting as consumers, exit to alternative sectors, including formal-educational institutions abroad and informal, private supplemental education at home, which offer more student research opportunities. This article develops and illustrates three theoretical propositions with relevant literature and secondary data as well as participant observations and interviews with Korea-based students. Arguably, our propositions and findings are relevant to other countries with gaps between formal education and consumer preferences and with consumer exit options.

Pigmented microalgae inhabiting snow and ice environments lower the albedo of glacier and ice-sheet surfaces, significantly enhancing surface melt. Our ability to accurately predict their role in glacier and ice-sheet surface mass balance is limited by the current lack of empirical data to constrain their representation in predictive models. Here we present new empirical optical properties for snow and ice algae and incorporate them in a radiative transfer model to investigate their impact on snow and ice surface albedo. We found ice algal cells to be more efficient absorbers than snow algal cells, but their blooms had comparable impact on surface albedo due to the different photic conditions of their habitats. We then used the model to reconstruct the effect of ice algae on bare ice albedo spectra collected at our field site in southern Greenland, where blooms dropped the albedo locally by between 3 and 43%, equivalent to 1–10 L m$^{-2}$ d$^{-1}$ of melted ice. Using the newly parametrized model, future studies could investigate biological albedo reduction and algal quantification from remote hyperspectral and multispectral imagery.

We describe a large outbreak of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) involving an acute-care hospital emergency department during December 2020 and January 2021, in which 27 healthcare personnel worked while infectious, resulting in multiple opportunities for SARS-CoV-2 transmission to patients and other healthcare personnel. We provide recommendations for improving infection prevention and control.

Paleoperspectives of climate provide important information for understanding future climate, particularly in arid regions such as California, where water availability is uncertain from year to year. Here, we present a record from Barley Lake, California, focusing on the interval spanning the Younger Dryas (YD) to the early Holocene (EH), a period of acute and rapid global climate change. Twelve radiocarbon dates constrain the timing between 12.9 and 8.1 ka. We combine a variety of sediment analyses to infer changes in lake productivity, relative lake level, and runoff dynamics. In general, the lake is characterized by two states separated by a <200-year transition: (1) a variably deep, lower-productivity YD lake; and (2) a two-part variably shallow, higher-productivity EH lake. Inferred EH winter-precipitation runoff reveals dynamic multidecadal-to-centennial-scale variability, in agreement with the EH lake-level data. The Barley Lake archive captures both hemispheric and regional signals of climate change across the transition, suggesting a role for both ocean-atmosphere and insolation forcing. Our paleoperspective emphasizes California's sensitivity to climate change and how that change can generate abrupt shifts in limnological regimes.

Physical activity (PA) may be therapeutic for people with severe mental illness (SMI) who generally have low PA and experience numerous life style-related medical complications. We conducted a meta-review of PA interventions and their impact on health outcomes for people with SMI, including schizophrenia-spectrum disorders, major depressive disorder (MDD) and bipolar disorder. We searched major electronic databases until January 2018 for systematic reviews with/without meta-analysis that investigated PA for any SMI. We rated the quality of studies with the AMSTAR tool, grading the quality of evidence, and identifying gaps, future research needs and clinical practice recommendations. For MDD, consistent evidence indicated that PA can improve depressive symptoms versus control conditions, with effects comparable to those of antidepressants and psychotherapy. PA can also improve cardiorespiratory fitness and quality of life in people with MDD, although the impact on physical health outcomes was limited. There were no differences in adverse events versus control conditions. For MDD, larger effect sizes were seen when PA was delivered at moderate-vigorous intensity and supervised by an exercise specialist. For schizophrenia-spectrum disorders, evidence indicates that aerobic PA can reduce psychiatric symptoms, improves cognition and various subdomains, cardiorespiratory fitness, whilst evidence for the impact on anthropometric measures was inconsistent. There was a paucity of studies investigating PA in bipolar disorder, precluding any definitive recommendations. No cost effectiveness analyses in any SMI condition were identified. We make multiple recommendations to fill existing research gaps and increase the use of PA in routine clinical care aimed at improving psychiatric and medical outcomes.

Miargyrite is the low-temperature monoclinic derivative of a high temperature cubic galena/halite structure. The essential features of its crystal structure (Knowles, 1959) were confirmed, but the details of the bonding changed [new space group C121; a 12.824(1), b 4.4060(3), c 13.193(1) Å, β 98.567(6)°]. The octahedral connectivity of galena/halite is severely distorted: Ag(1), 2S each at 2.53, 2.66 & 3.39 Å; Ag(2), 2 each at 2.54, 2.62 and 3.44; Ag(3), 2.38, 2.40, 3.05, 3.05, 3.53, 3.58; Sb(1), 2.45, 2.50, 2.51, 3.22 3.28, 3.41; Sb(2), 2.45, 2.50, 2.51, 3.22, 3.28, 3.41. The short distances define the following coordinations: very distorted tetrahedral Ag(1) and (2); near-linear Ag(3) at 178.9(2)° trigonal-pyramidal Sb(1) and (2) at 92.0, 93.6 and 96.8°. The ten shortest S-S distances range from 3.61 to 3.77 Å.