Software implementations of traditional engineering design methods can potentially enrich the original methods. A study was conducted to better understand how concept generation can be facilitated using software. Participants of the study were asked to generate concepts using either specialized software, or by using traditional means, for applying function-means modeling and morphological matrices. A concept concretization metric was used to evaluate the results, which indicated that there are both positive and negative aspects of performing concept generation using specialized software.

In ad 872–3 a large Viking Army overwintered at Torksey, on the River Trent in Lincolnshire. We have previously published the archaeological evidence for its camp, but in this paper we explore what happened after the Army moved on. We integrate the findings of previous excavations with the outcomes of our fieldwork, including magnetometer and metal-detector surveys, fieldwalking and targeted excavation of a kiln and cemetery enclosure ditch. We provide new evidence for the growth of the important Anglo-Saxon town at Torksey and the development of its pottery industry, and report on the discovery of the first glazed Torksey ware, in an area which has a higher density of Late Saxon kilns than anywhere else in England. Our study of the pottery industry indicates its continental antecedents, while stable isotope analysis of human remains from the associated cemetery indicates that it included non-locals, and we demonstrate artefactual links between the nascent town and the Vikings in the winter camp. We conclude that the Viking Great Army was a catalyst for urban and industrial development in Torksey and suggest the need to reconsider our models for Late Saxon urbanism.

Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a frequent cause of healthcare-associated infections (HAIs). The CDC Emerging Infections Program (EIP) conducted population and laboratory-based surveillance of CRPA in selected areas in 8 states from August 1, 2016, through July 31, 2018. We aimed to describe the molecular epidemiology and mechanisms of resistance of CRPA isolates collected through this surveillance. Methods: We defined a case as the first isolate of P. aeruginosa resistant to imipenem, meropenem, or doripenem from the lower respiratory tract, urine, wounds, or normally sterile sites identified from a resident of the EIP catchment area in a 30-day period; EIP sites submitted a systematic random sample of isolates to CDC for further characterization. Of 1,021 CRPA clinical isolates submitted, 707 have been sequenced to date using an Illumina MiSeq. Sequenced genomes were classified using the 7-gene multilocus sequence typing (MLST) scheme, and a core genome MLST (cgMLST) scheme was used to determine phylogeny. Antimicrobial resistance genes were identified using publicly available databases, and chromosomal mechanisms of carbapenem resistance were determined using previously validated genetic markers. Results: There were 189 sequence types (STs) among the 707 sequenced genomes (Fig. 1). The most frequently occurring were high-risk clones ST235 (8.5%) and ST298 (4.7%), which were found across all EIP sites. Carbapenemase genes were identified in 5 (<1%) isolates. Overall, 95.6% of the isolates had chromosomal mutations associated with carbapenem resistance: 93.2% had porinD-associated mutations that decrease membrane permeability to the drugs; 24.8% had mutations associated with overexpression of the multidrug efflux pump MexAB-OprM; and 22.9% had mutations associated with overexpression of the endogenous β-lactamase ampC. More than 1 such chromosomal resistance mutation type was present in 37.8% of the isolates. Conclusions: The diversity of the sequence types demonstrates that HAIs caused by CRPA can arise from a variety of strains and that high-risk clones are broadly disseminated across the EIP sites but are a minority of CRPA strains overall. Carbapenem resistance in P. aeruginosa was predominantly driven by chromosomal mutations rather than acquired mechanisms (ie, carbapenemases). The diversity of the CRPA isolates and the lack of carbapenemase genes suggest that this ubiquitous pathogen can readily evolve chromosomal resistance mechanisms, but unlike carbapenemases, these cannot be easily spread through horizontal transfer.

Funding: None

Disclosures: None

Growing in a saline environment causes changes in important physiological processes that are directly related to plant growth and development. In this study we evaluated the effect of salinity on transpiration of sorghum plants in semi-arid conditions and found that the highest rates of transpiration were observed in the hottest hours of the day, between 10 a.m. and 3 p.m., with plants subjected to the saline environment having their transpiration reduced by up to 70% when compared to the non-saline environment. This behavior can be reflected in reductions in plant growth and development due to reduced water absorption by the roots, consequently causing an imbalance of nutrients in the plant due to low absorption rate and competition between nutrients and salts in the preferred routes of absorption in the roots.

This article examines the tombstone of Meletios II, a native of Tenedos, who was briefly Ecumenical Patriarch in 1768–9. It also offers an account of his troubled patriarchate and sketches events in the rest of his ecclesiastical career. This hitherto unknown tombstone has rested for an indeterminate number of years in the garden of North Bank, a large Victorian mansion in Pages Lane in the North London suburb of Muswell Hill. It appears to have been in the grounds of North Bank before the house became an annexe of Muswell Hill Methodist Church. It is not known where in the Ottoman Empire Meletios' grave was originally situated, nor has it been possible to establish the circumstances in which the tombstone came to North Bank. On the basis of the inscription on the tombstone it is possible to establish Meletios' previously unknown date of death, 5 January 1780. It appears to be one of the earliest known tombstones of an Ecumenical Patriarch during the period of the Tourkokratia.

New maps are presented of three internal ice-sheet radio-echo sounding (RES) layers in the region 73.5–75.75° S, 120–127° E (56 000 km2) around Dome C, central East Antarctica. These layers represent horizons of enhanced acidity resulting from volcanic aerosol deposition, identified from analogue RES data. They are continuous over the entire mapped area, and constitute deformation markers in the ice column. Internal RES layers were initially identified from discrete radar power reflection coefficient profiles and subsequently digitized directly from prints of ice-sheet cross-sections, acquired by continuous RES profiling. Georeferenced vector data are used to generate a 5 km gridcell raster of depth for each internal RES layer, as a basis for contour mapping. Ice deformation in the Dome C region is significant because this is the location of the European Project for Ice Coring in Antarctica. Since internal layers are isochronous, the one-dimensional ice-core data at Dome C can be correlated over the survey area to produce a three-dimensional context.

The upper 20—30 m of ice-rich permafrost at three sites overridden by the northwest margin of the Laurentide ice sheet in the Tuktoyaktuk Coastlands, western Arctic Canada, comprise massive ice beneath ice-rich diamicton or sandy silt. The diamicton and silt contain (1) truncated ice blocks up to 15 m long, (2) sand lenses and layers, (3) ice veins dipping at 20—30°, (4) ice lenses adjacent and parallel to sedimentary contacts, and (5) ice wedges. The massive ice is interpreted as intrasedimental or buried basal glacier ice, and the diamicton and silt as glacitectonite that has never thawed. Deformation of frozen ground was mainly ductile in character. Deformation was accompanied by sub-marginal erosion of permafrost, which formed an angular unconformity along the top of the massive ice and supplied ice clasts and sand bodies to the overlying glacitectonite. After deformation and erosion ceased, postglacial segregated ice and ice- wedge ice developed within the deformed permafrost.

In 2016 the Archaeology Data Service (ADS) was 20 years old. Since its birth the ADS has had to respond to rapid changes in technology, as well as major cultural and organizational changes in the external operating environment, from which a sustainable business model for digital preservation has emerged. This article will take a retrospective look at challenges that have been faced and will review current and future priorities for those seeking to establish digital repositories. Digital preservation and open access to research data are now much higher up the agenda of funding bodies, but there is still lack of agreement on what constitutes a core digital archive from a fieldwork project. The paper will review what the significant properties of an archaeological archive are, and how reuse can be supported, linking data and publications. It will consider the challenge of dealing with the gray literature and of avoiding creating further data silos, featuring new initiatives to provide interoperability between digital repositories. It will review the role of data and metadata standards, and consider how the profession needs to address its responsibilities over the next 20 years.

Extinctions have altered island ecosystems throughout the late Quaternary. Here, we review the main historic drivers of extinctions on islands, patterns in extinction chronologies between islands, and the potential for restoring ecosystems through reintroducing extirpated species. While some extinctions have been caused by climatic and environmental change, most have been caused by anthropogenic impacts. We propose a general model to describe patterns in these anthropogenic island extinctions. Hunting, habitat loss and the introduction of invasive predators accompanied prehistoric settlement and caused declines of endemic island species. Later settlement by European colonists brought further land development, a different suite of predators and new drivers, leading to more extinctions. Extinctions alter ecological networks, causing ripple effects for islands through the loss of ecosystem processes, functions and interactions between species. Reintroduction of extirpated species can help restore ecosystem function and processes, and can be guided by palaeoecology. However, reintroduction projects must also consider the cultural, social and economic needs of humans now inhabiting the islands and ensure resilience against future environmental and climate change.

This article presents the key results of a major survey carried out by the NEARCH project on the public perception of archaeology and heritage across Europe. The analysis focuses on three main points of significance for contemporary archaeological practice. The first is the image of archaeology and its definition in the perception of the general public. The second concerns the values that archaeology represents for the public. The third focuses on the social expectations placed on archaeologists and archaeology. The NEARCH survey clearly indicates that there is a significant public expectation by Europeans that archaeology should work comprehensively across a broad range of areas, and that cultural heritage management in general needs to engage more with different archaeological and heritage groups.