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The aim of this study was to assess the association between fish intake, n-3 PUFA, n-6 PUFA and risk of disabling dementia.
Design:
Prospective cohort.
Setting:
Municipalities within the Japan Public Health Centre-based Prospective Study.
Participants:
43 651 participants: (20 002 men and 23 649 women).
Results:
Exposure intake of fish, n-3 and n-6 PUFA was evaluated in 1995–1997. We defined disabling dementia cases as participants who were certified to receive disability care under the long-term-care insurance programme (2006–2016) in participating municipalities with a grade of activities of daily living related to dementia ≥ IIa on the dementia rating scale (range 0–IV and M). Cox proportional hazard models were applied to obtain hazard ratios (HR) and 95 % CI according to quartiles of exposures of interest. In the main analysis, we adjusted for age and area, smoking, BMI, alcohol and metabolic equivalent tasks. During 410 350 person-years of follow-up with an average follow-up of 9·4 years, 5278 cases of disabling dementia were diagnosed. Fish intake and most PUFA were not associated with the risk of disabling dementia in men. In women, n-6 PUFA showed a significant decreasing trend in risk the highest HR (95 % CI) compared with the lowest was 0·90 (0·81, 0·99) (P for trend = 0·024) and alpha-linolenic acid (ALA) was 0·91 (0·82, 1·00) (P for trend = 0·043).
Conclusions:
Our findings suggest no association with fish in general and only n-6 PUFA and ALA may be associated with a decreased risk of disabling dementia especially in women.
Although family factors are considered important for children’s language acquisition, the evidence comes primarily from affluent societies. Thus, this study aimed to examine the relations between family factors (family’s socioeconomic status [SES], home literacy activities, access to print resources, and parental beliefs) and children’s vocabulary knowledge in both urban and rural settings in China. Data from 366 children (urban group: 109, 4.85 years; rural group: 257, 4.89 years) were collected. Results showed that whereas family’s SES significantly predicted access to print resources and children’s vocabulary knowledge in the rural group, parental beliefs directly predicted children’s vocabulary knowledge in the urban group. Multigroup analysis showed that the associations of family’s SES and access to print resources with children’s vocabulary knowledge were stronger in the rural group than in the urban group. Our findings highlight the importance of considering contextual settings when conceptualising the role of family factors in children’s language acquisition.
As children advance through school, derived words become increasingly common in their reading materials. Previous studies have shown that children’s knowledge of derivational morphology develops relatively slowly, but there is more to learn about this development. This study examined differences in knowledge of the form and meaning of suffixes across grade levels (Grades 3, 5, and 8) and different types of derivational suffixes (adjectives and nominals). We assessed 309 English-speaking children on word reading and receptive vocabulary tests and two tasks designed to assess the form (orthographic knowledge) and meaning (semantic knowledge) of 28 derivational suffixes (14 adjectives and 14 nominals). Overall, our findings showed a significant improvement in identifying and understanding derivational suffixes from Grade 3 to Grade 5 and a smaller, but still significant, improvement from Grade 5 to Grade 8. Our findings regarding suffix types were mixed. While written forms of adjectives were identified more accurately than nominals across all grades, this advantage did not extend to the students’ understanding of the meaning of the suffixes. These results highlight the distinction between the identification of suffixes and the understanding of their meaning. We discuss our results in relation to suffix frequency in children’s reading materials.
Reactions between hydroxy-Al ions and orthosilicic acid as influenced by citric acid were studied at an initial Si concentration of 1.6 × 10−3 M, Si/Al molar ratios of 0.5 and 1.0, OH/Al molar ratios of 1.0-3.0, and citric acid/Al molar ratios of 0-0.3. In the absence of citric acid and at OH/A1 ratios of 1.0-2.8, imogolite (>0.01 μm) was dominant in the precipitates. At citric acid/Al ratios of 0.01-0.1, imogolite and/or pseudoboehmite were dominant in the precipitates at OH/Al ratios of 1.0 and 2.0, and imogolite and/or ill-defined aluminosilicate complexes at OH/Al ratio of 2.8. Instead of allophane or “proto-imogolite” allophane being the predominant species in the precipitates, the formation of ill-defined aluminosilicate complexes at OH/Al ratio of 3.0 was steadily promoted by increasing the solution citric acid/Al ratios from 0 to 0.3. The freeze-dried soluble products (<0.01 μ) ranged from silica gel to “proto-imogolite,” depending upon the basicity of Al and the level of citric acid of the parent solution. The amount of “proto-imogolite” increased with increasing citric acid/Al ratios from 0 to 0.1 in solution. Complexing low molecular weight organic acids, such as citric acid, impeded the formation of the short-range ordered aluminosilicates, allophanes and imogolite.
Hydroxyaluminosilicate (HAS) and hydroxyaluminum (HyA) ionic solutions having final Al concentrations ranging from 3.74 to 4.00 mM; NaOH/Al molar ratios of 1.0, 2.0 and 2.5; and Si/Al molar ratios of 0.00, 0.27–0.30, 0.51–0.56 and 0.95–1.01 were prepared through the interaction of AlCl3, or-thosilicic acid and NaOH solutions. When these solutions reacted with <2 µm sized vermiculite (Vt) and montmorillonite (Mt), varying amounts of Al and Si were fixed on Vt and Mt clays. Potassium fixation and exchange capacities of HyA/HAS (OH/Al = 1.0, 2.0 and 2.5)-Vt and HyA/HAS (OH/AI = 2.0)-Mt complexes were compared with those of untreated Vt and Mt at added K levels ranging from 21 to 319 cmolc kg−1. The untreated Vt clay showed K fixation as high as 94 cmolc kg−1, in contrast to only 16 cmolc kg−1 exchangeable K. The untreated Mt fixed a maximum of 9 cmolc K kg−1 out of a total K adsorption capacity of 67 creole kg−1. In the HyA/HAS-Vt complexes, K fixation reduced drastically in comparison to untreated Vt, and ranged from 9 to 24 cmolc kg−1 out of their total K adsorption capacities of 61 to 81 cmolc kg−1. In the HyA/HAS-Mt complexes, too, the amount of K fixed reduced to a great extent in comparison to Mt and ranged from 1.48 to 1.84 cmolc kg−1. Potassium became more exchangeable due to the presence of hydroxy-interlayers in the clays. The reduction in CEC and the well-known propping effects of hydroxy-cations’ islands in the interlayers might have hindered K fixation by the complexes. The relationships of maximum K fixing capacities of the HyA/HAS-Vt complexes with the amounts of Al, Si and Al + Si fixed on Vt were all exponential and negative. However, the amount of Al + Si or only Al fixed on Vt appeared to be the best indicator of K fixation capacities of hydroxyinterlayered Vt clay.
The purpose of this study was to examine the early growth of morphological awareness and its predictors. We followed 172 English-speaking Canadian children (82 girls, 90 boys, Mage = 75.56 months at the first assessment point) from Grade 1 to Grade 3 and assessed them on nonverbal IQ, phonological short-term memory, phonological awareness, letter knowledge, and vocabulary at the beginning of Grade 1 and on morphological awareness at the end of Grade 1, beginning and end of Grade 2, and beginning of Grade 3. Results of growth curve modeling showed different growth patterns for Word Analogy and Sentence Analogy. In addition, vocabulary and phonological awareness were associated with the initial status of morphological awareness, and phonological awareness and letter knowledge predicted the growth rate of morphological awareness. These findings suggest that code-related skills drive the development of morphological awareness during the early years of literacy instruction.
We examined the growth trajectories of reading in a consistent orthography (Greek) in two developmental periods (from Grade 1 to Grade 4 and from Grade 4 to Grade 10) and what cognitive skills predict the growth patterns. Seventy-five Greek-speaking children were assessed in Grades 1, 2, 4, 6, and 10 on word-, nonword-, and text-reading fluency. In Grades 1 and 4, they were also assessed on phonological awareness, rapid naming, phonological memory, orthographic knowledge, and articulation rate. Results of growth curve modeling showed that during the first developmental period, there was a rapid initial growth from Grade 1 to Grade 2 followed by a less rapid growth from Grade 2 to Grade 4. In the second developmental period, the slow growth continued. In both developmental periods, rapid naming and orthographic knowledge predicted the initial status of all reading outcomes and phonological memory predicted the initial status of nonword-reading fluency. Phonological awareness predicted the initial status of nonword-reading fluency in the first developmental period and the initial status of word- and text-reading fluency in the second developmental period. None of the cognitive skills predicted the growth rate in reading skills. Theoretical and practical implications of these findings are discussed.
We performed family psychoeducation for depression, and investigated the association between the education and expressed emotion of patients’ families and relapse of depression.
Methods
Of 103 patients diagnosed with major depressive disorder, and their primary family members, 53 patients and their primary family members gave consent. The patients were randomly allocated to an intervention or control group, consisting of 24 and 30 patients, respectively. The intervention group underwent 4 educational sessions and education in coping techniques. The relapse rate was compared between the intervention and control groups. In addition, the subjects were divided into high- and low-EE groups based on the EE judgment, and the effect of psychoeducation was compared in each group.
Results
The relapse rate during a 9-month period was 8.3% in the intervention group, being significantly lower than that (50%) in the control group. The relapse rate in the intervention group was slightly lower than that in the control group in the high-EE group, and significantly lower in the low-EE group. Regarding the influence of EE, in the control group, the relapse rate was 70% in the high-EE group, being significantly higher than that (40%) in the low-EE group. On multiple logistic regression analysis, psychoeducation (odds ratio: 25.53, 95% CI: 2.83-229.92) and the Hamilton score at the time of entry (odds ratio: 1.16, 95% CI: 1.045-1.298) were significantly associated with relapse.
Conclusion
It was suggested that the psychoeducation of families is very effective for the prevention of relapse in adult depressive patients.
There are no effective programs on return-to-work (RTW) despite an increase of stress related disorders. We developed an original rehabilitation program,’Ultra-short daily briefings care (USDBC)’. USDBC is based on a key concept of European Framework for Psychosocial Risk Management (PRIMA-EF; WHO, 2008) that provides the good practice guidelines at the workplace. We carried out USDBC at the worksite of Panasonic Healthcare Co., Ltd. to determine whether USDBC facilitates RTW.
Objectives:
To develop and establish the appropriate intervention that reduces depressive severity of sick-listed employees.
Aims:
The aim of the study was to determine whether USDBC strengthen the sense of coherence (SOC; Antonovsky, 1985).
Method:
We compared two groups in a cross-sectional study design: 16 depressed RTW employees (USDBC group) vs. 121 healthy employees (control group) (Fig.1). USDBC group was received the instant face-to-face rehabilitation program in every workday (Fig.2). The primary outcome was the ability to cope with stress, measured by self-reported 13-items SOC scale for Japanese (Yamazaki, 1999).
Results:
In the USDBC group, significant changes were observed between baseline and measurement point in SOC score (40.3 vs. 54.4; 95% CI (20.6 to (7.5), whereas in the control group, no significant changes were observed (58.3 vs. 57.9; 95% CI (0.1 to 0.9) (Table.1).
Conclusions:
The study suggests that USDBC strengthen the depressed employees’ SOC.
Fig. 1
Participant now climt
Flow diagram showing the selection of USDBC group and control group
Fig. 2
Intervention with USDBC
Depressive employees behave according to this flow in every workday.
Table 1
Subjects’ characteristics and SOC.
Gender
MedianAde(Range)
MeanSOC
93% CI
P-value
Male
Female
Baseline (SD)
Measurtnentpoint (SD)
USDBC group (n=l6)
12
4
39 (32 - 53)
40.3(12 4)
54.4 (8.8)
-20.6 to-7.5
< 0.001
Control group (n=121)
94
27
41 (21 - 59)
58 3(9.4)
57.9(10 1)
-0 1 to 0.9
0.10
In the USDBC goroup, significant change was found between baselne and tneasurment point. In the control group, no significant change was found.
Recently huge amount of dust Mdust ≃ 106−7M⊙ in galaxies at z = 7–8 has been discovered by ALMA observations. The suggested timescale of the dust production was a few–several×108 yr, while the stellar mass was several × 109M⊙. This amount of dust cannot be easily explained only by a supply from supernovae if we consider the dust destruction by reverse shocks. We propose that these values can be consistently explained if we take into account the grain growth in the interstellar medium (ISM). This scenario successfully reproduces the evolution of the dust mass, as well as the SFR, and stellar mass simultaneously. We conclude that even at such an early epoch of the Universe, the dust grain growth in the ISM plays a significant role in galaxies.
The spectral energy distribution (SED) model should treat the evolution of a galaxy from its birth. Dust in galaxies affects the formation and evolution of galaxies in various ways. For example, dust grains scatter and absorb stellar emitted ultraviolet (UV) photons and re-emit the radiation at infrared (IR) wavelengths. In this work, we construct a galaxy SED model based on our dust evolution model (Asano et al. 2013a,b, 2014) with a rigorous treatment of the chemical evolution. To reduce the computational cost, we adopt mega-grain approximation (MGA; (MGA; Inoue, 2005). MGA regards a high density dusty region as a huge size (10 pc) dust grain for calculating dust scattering. In this approximation, we can solve the radiative transfer easily and provide SEDs and attenuation curves of galaxies. This model can be used to fit any galaxy in the wavelength range of 10 nm-3 mm.
Recently, spectroscopic detections of O[III] 88 μm and Ly-α emission lines from the z ≍ 9.1 galaxy MACS1149-JD1 have been presented, and with these, some interesting properties of this galaxy were uncovered. One such property is that MACS1149-JD1 exhibits a significant Balmer break at around rest-frame 4000 Å, which may indicate that the galaxy has experienced large variations in star formation rate prior to z ∼ 9, with a rather long period of low star formation activity. While some simulations predict large variations in star formation activity in high-redshift galaxies, it is unclear whether the simulations can reproduce the kind of variations seen in MACS1149-JD1. Here, we utilize synthetic spectra of simulated galaxies from two simulation suites in order to study to what extent these can accurately reproduce the spectral features (specifically the Balmer break) observed in MACS1149-JD1. We show that while the simulations used in this study produce galaxies with varying star formation histories, galaxies such as MACS1149-JD1 would be very rare in the simulations. In principle, future observations with the James Webb Space Telescope may tell us if MACS1149-JD1 represents something rare, or if such galaxies are more common than predicted by current simulations.
We have developed a new SED fitting tool specialized for frontier redshift galaxies. It is a common case for high-z galaxies that the available data are restricted to rich optical to near-infrared photometry and few far-infrared (FIR) data deep enough to detect the faint object (e.g., HST/WFC3 + Spitzer/IRAC + ALMA). In such situation, one cannot perform a complicated modeling of dust emission in FIR regime. We then adopt simple treatment for the dust emission using empirical LIRG templates. Instead, we adopt a sophisticated and physically motivated modeling for stellar and nebular emission parts in rest-frame UV-to-optical regime. Our new code fits not only broad band photometry but also spectral emission line flux. There is an option to fit observed SED with two templates with different physical properties. Our new code, PANHIT, is now in public, and was already applied to some high-z frontier galaxies.
Panchromatic modeling is one of the most powerful tools at our disposal to measure reliably the physical properties of galaxies across cosmic times. We present here an entirely new implementation in python of one such tool: CIGALE. Developed along three main design principles: simplicity, modularity, and efficiency, it has proven to be a versatile code that in addition to estimating the physical properties of galaxies (or regions within galaxies), can generate arbitrary sets of theoretical models or be used as a library to build other tools. Among its defining features, it is a truly panchromatic code ranging from the far-ultraviolet to the radio that takes into account numerous physical components (including active nuclei or synchrotron emission), that can fit non-photometric data, handle upper limits, determine photometric redshifts, and even build mock catalogs.
We present ALMA detection of the [O iii] 88 μm line and 850 μm dust continuum emission in a Y-dropout Lyman break galaxy, MACS0416_Y1. The [O iii] detection confirms the object with a spectroscopic redshift to be z = 8.3118±0.0003. The 850 μm continuum intensity (0.14 mJy) implies a large dust mass on the order of 4×106M⊙. The ultraviolet-to-far infrared spectral energy distribution modeling, where the [O iii] emissivity model is incorporated, suggests the presence of a young (τage ≍ 4 Myr), star-forming (SFR ≍ 60M⊙yr−1), and moderately metal-polluted (Z ≍ 0.2Z⊙) stellar component with a stellar mass of 3 × 108M⊙. An analytic dust mass evolution model with a single episode of star formation does not reproduce the metallicity and dust mass in ≍ 4 Myr, suggesting an underlying evolved stellar component as the origin of the dust mass.
We report fourteen and twenty-eight protocluster candidates at z = 5.7 and 6.6 over 14 and 19 deg2 areas, respectively, selected from 2,230 Lyα emitters (LAEs) photometrically identified with Subaru/Hyper Suprime-Cam (HSC) deep images. Six out of the 42 protocluster candidates include at least 1 spectroscopically confirmed LAEs at redshifts up to z = 6.574. By the comparisons with the cosmological Lyα radiative transfer (RT) model reproducing LAEs with the reionization effects, we find that more than a half of these protocluster candidates might be progenitors of the present-day clusters with a mass of ≳ 1014M⊙. We also investigate the correlation between LAE overdensity and Lya rest-frame equivalent width (EW), because the cosmological Lyα RT model suggests that a slope of EW-overdensity relation is steepened towards the epoch of cosmic reionization (EoR), due to the existence of the ionized bubbles around galaxy overdensities easing the escape of Lyα emission from the partly neutral intergalactic medium. The available HSC data suggest that the slope of the EW-overdensity correlation does not evolve from the post-reionization epoch z = 5.7 to the EoR z = 6.6 beyond the moderately large statistical errors.
We present a 4.7σ detection of the [OIII] 88 μm line in a gravitationally-lensed Lyman break galaxy, RXC J2248-ID3, using the Atacama Large Millimeter/submillimeter Array (ALMA). We did not detect [CII] 158 μm and rest-frame 90 μm dust continuum emission, suggesting that the bulk of the interstellar medium (ISM) is ionized. Our two-component SED model combining the previous Hubble Space Telescope (HST) data and new photometry obtained from Very Large Telescope (VLT), Spitzer and ALMA suggests the presence of young (∼2 Myr) and mature (∼600 Myr) stellar components with the metallicity of Z = 0.2Z⊙. Our findings are in contrast with previous results claiming a very young, metal-poor stellar component.
We examined the cross-lagged relations between word reading fluency in the two orthographic systems of Japanese: phonetic (syllabic) Hiragana and morphographic Kanji. One hundred forty-two Japanese-speaking children were assessed on word reading fluency twice in Grade 1 (Times 1 and 2) and twice in Grade 2 (Times 3 and 4). Nonverbal IQ, vocabulary, phonological awareness, morphological awareness, and rapid automatized naming were also assessed in Time 1. Results of path analysis revealed that Time 1 Hiragana fluency predicted Time 2 Kanji fluency after controlling for the cognitive skills. Time 2 Hiragana fluency did not predict Time 3 Kanji fluency or vice versa after the autoregressor was controlled, but Hiragana and Kanji fluency were reciprocally related between Times 3 and 4. These findings provide evidence for a cross-script transfer of word reading fluency across the two contrastive orthographic systems, and the first evidence of fluency in a morphographic script predicting fluency development in a phonetic script within the same language.
A range of allophane samples (atomic AI/Si bulk ratios 1.1-1.9) from Silica Springs, New Zealand, has been characterized by X-ray photoelectron spectroscopy (XPS). Binding energies of Si 2s, Si 2p, Al 2p, O 1s, C 1s, and N 1s electrons, together with the kinetic energies of Al KL23L23 Auger electrons, at or near the surface of allophane aggregates, have been derived. The values for Al, Si and O electrons are similar to those for kaolinite but also to those for some framework silicates (feldspars) having 4-coordinate Al. Values for N electrons suggest that N occurs in organic structures. Comparison of XPS and bulk Al/Si ratios shows an enrichment of Al at or near the surface of allophane aggregates. The same is true for C and N. Extraction with citrate-dithionite-bicarbonate (CDB) reagent leaves the surfaces depleted in Al. The CDB extracts have higher Al/Si ratios than the bulk allophanes. Similarly, CDB treatment reduces the degree of surface enrichment of C and N. Small increases in the binding energies of Si electrons following CDB treatment suggest partial dissolution of the bulk structure though a concomitant removal of a separate phase or species cannot be ruled out. The results may be accounted for in terms of the structure previously suggested for the primary spherules of Silica Springs allophane (Childs et al., 1990) though the composition of the spherules at or near the surface of the allophane aggregates is different from those of the bulk.
To investigate whether adverse childhood experiences (ACEs) modify the impact of exposure to a natural disaster (the 2011 Great East Japan earthquake and tsunami) on the occurrence of posttraumatic stress disorder (PTSD) among older people.
Methods.
Data were collected as part of the Japan Gerontological Evaluation Study (JAGES), which is an on-going epidemiological survey investigating social determinants of health among older people across Japan. Information on PTSD symptoms based on the Screening Questionnaire for Disaster Mental Health, traumatic exposure to the earthquake (i.e., house damage and loss of relatives/friends during the earthquake/tsunami) and ACEs was obtained from 580 participants aged 65 or older living in Iwanuma City, Miyagi Prefecture, which suffered severe damage as a result of the earthquake and the subsequent tsunami in March 2011. Associations were examined using Poisson regression analysis with a robust variance estimator after adjusting for covariates.
Results.
The prevalence of PTSD was 9.7% in this population; compared to those with no traumatic experience, the prevalence of PTSD was approximately two times higher among those who experienced the loss of close friends/relatives (PR = 1.84, 95% CI = 1.11–3.03, p = 0.018), or whose house was damaged (PR = 2.15, 95% CI = 1.07–4.34, p = 0.032). ACE was not significantly associated with PTSD. Stratified analyses by the presence of ACE showed that damage due to the earthquake/tsunami was associated with PTSD only among those without ACEs; more specifically, among non-ACE respondents the PR of PTSD associated with house damage was 6.67 (95% CI = 1.66–26.80), while for the loss of a relative or a close friend it was 3.56 (95% CI = 1.18–10.75). In contrast, no statistically significant associations were observed among those with ACEs.
Conclusion.
Following the Great East Japan earthquake/tsunami in 2011 a higher risk of developing PTSD symptoms was observed in 2013 especially among older individuals without ACEs. This suggests that ACEs might affect how individuals respond to subsequent traumatic events later in life.