Two new species of the genus Allocreadium were isolated from the intestines of the Lake minnow Rhynchocypris percnura caught in the backwater of the Komissarovka River in the South of the Russian Far East. The morphology of A. anastasii n. sp. corresponds to that of Allocreadium sp. from Lake Khar (Mongolia) and Allocreadium sp. Belous, 1952 from the Primorsky region of Russia except for the preacetabular anterior border of the vitelline follicles in A. anastasii n. sp. from the Komissarovka River vs. at anterior half of ventral sucker in Allocreadium sp. Genetic analysis revealed the identity of A. anastasii n. sp. to Allocreadium sp. 1 from the Nezhinka River and Lake Khar. Allocreadium macrolecithum n. sp. was differentiated from Palaearctic Allocreadium spp. by having the following features: respectively large vitelline follicles extending from posterior extremity to anterior margin of the ventral sucker; relatively short caeca reaching the border of middle and posterior thirds of hindbody; and small testes in the middle of hindbody. Interspecific genetic p-distances between Allocreadium spp. were 0.16–7.23% in 28S gene and 18.62–31.54% in Cox1 mtDNA gene. In the phylogenetic tree reconstructed with Maximum parsimony and Bayesian Inference methods, A. anastasii n. sp. and A. macrolecithum n. sp. were nested into different species groups of the genus Allocreadium – sister to A. khankaiense and A. bursense, respectively. Modified dichotomous keys were prepared for 31 Palaearctic species of Allocreadium including A. crassum, A. dogieli, A. papilligerum, A. bursense, A. anastasii n. sp., and A. macrolecithum n. sp.

High premature adult deaths in developing countries are gaining attention, as recent studies show their increasing impact on overall mortality rates. This paper has twofold objectives: firstly, it investigates the long-term trends and patterns of adult mortality between 1970 and 2018 in India. Secondly, it attempts to detect age, period, and cohort (APC) effects on adult mortality decline over time. Data on age-specific mortality rates and disease-adjusted life years for adult age groups (15–59 years) were collected from the Sample Registration System and the Global Burden of Disease study, respectively. The trends in age-standardized mortality rates were presented graphically, and critical change points were highlighted using a change-point analysis. The intrinsic estimator model was applied to estimate the independent effects of APC on adult mortality. The findings revealed that adult mortality declined between 1970 and 2018 with multiple critical change points. The APC effects showed a notable decline in adult mortality during 2005–2018 and for the recent birth cohorts, 1980–2004. However, the rate of mortality declined slowly over time. Results also indicated that mortality started increasing from mid-adult ages and peaked in older adult ages due to the age effects and provided evidence of a rise in adult life loss due to non-communicable diseases in recent years. Overall, the study underscores the importance of implementing health policies aimed at reducing life loss in the most economically active ages that can have long-term negative implications for the country’s economic growth.

The 7th edition of the Canadian Stroke Best Practice Recommendations (CSBPR) is a comprehensive summary of current evidence-based recommendations, appropriate for use by healthcare providers and system planners, and intended to drive healthcare excellence, improved outcomes and more integrated health systems. This edition includes a new module on the management of cerebral venous thrombosis (CVT). Cerebral venous thrombosis is defined as thrombosis of the veins of the brain, including the dural venous sinuses and/or cortical or deep veins. Cerebral venous thrombosis is a rare but potentially life-threatening type of stroke, representing 0.5–1.0% of all stroke admissions. The reported rates of CVT are approximately 10–20 per million and appear to be increasing over time. The risk of CVT is higher in women and often associated with oral contraceptive use and with pregnancy and the puerperium. This guideline addresses care for adult individuals who present to the healthcare system with current or recent symptoms of CVT. The recommendations cover the continuum of care from diagnosis and initial clinical assessment of symptomatic CVT, to acute treatment of symptomatic CVT, post-acute management, person-centered care, special considerations in the long-term management of CVT, including pregnancy and considerations related to CVT in special circumstances such as trauma and vaccination. This module also includes supporting materials such as implementation resources to facilitate the adoption of evidence into practice and performance measures to enable monitoring of uptake and effectiveness of recommendations.

Faecal examinations for helminth eggs were performed on 1869 people from two riverside localities, Vientiane Municipality and Saravane Province, along the Mekong River, Laos. To obtain adult flukes, 42 people positive for small trematode eggs (Opisthorchis viverrini, heterophyid, or lecithodendriid eggs) were treated with a 20–30 mg kg−1 single dose of praziquantel and purged. Diarrhoeic stools were then collected from 36 people (18 in each area) and searched for helminth parasites using stereomicroscopes. Faecal examinations revealed positive rates for small trematode eggs of 53.3% and 70.8% (average 65.2%) in Vientiane and Saravane Province, respectively. Infections with O. viverrini and six species of intestinal flukes were found, namely, Haplorchis taichui, H. pumilio, H. yokogawai, Centrocestus caninus, Prosthodendrium molenkampi, and Phaneropsolus bonnei. The total number of flukes collected and the proportion of fluke species recovered were markedly different in the two localities; in Vientiane, 1041 O. viverrini (57.8 per person) and 615 others (34.2 per person), whereas in Saravane, 395 O. viverrini (21.9 per person) and 155207 others (8622.6 per person). Five people from Saravane harboured no O. viverrini but numerous heterophyid and/or lecithodendriid flukes. The results indicate that O. viverrini and several species of heterophyid and lecithodendriid flukes are endemic in these two riverside localities, and suggest that the intensity of infection and the relative proportion of fluke species vary by locality along the Mekong River basin.

Tamalia (Hemiptera: Aphididae: Tamaliinae), a Nearctic aphid genus, is associated with galls on woody plants in the family Ericaceae (Arctostaphylos spp., Arbutus arizonica, and Comarostaphylis diversifolia). Tamalia cruzensis Miller and Pike, n. sp., Tamalia glaucensis Miller and Pike, n. sp., and Tamalia moranae Miller and Pike, n. sp. are described and illustrated. Two of these, T. cruzensis and T. moranae, represent host plant records for Tamalia on genera other than Arctostaphylos spp. Character measurements, comparisons, and descriptions; DNA cytochrome oxidase subunit 1 sequences; geographic distributions; seasonal occurrence; biology; and host plant associations are provided, along with diagnoses and a key to the known species based on the gall-inhabiting apterous adult stage.

Collective wind farm flow control, where wind turbines are operated in an individually suboptimal strategy to benefit the aggregate farm, has demonstrated potential to reduce wake interactions and increase farm energy production. However, existing wake models used for flow control often estimate the thrust and power of yaw-misaligned turbines using simplified empirical expressions that require expensive calibration data and do not extrapolate accurately between turbine models. The thrust, wake velocity deficit, wake deflection and power of a yawed wind turbine depend on its induced velocity. Here, we extend classical one-dimensional momentum theory to model the induction of a yaw-misaligned actuator disk. Analytical expressions for the induction, thrust, initial wake velocities and power are developed as a function of the yaw angle ($\gamma$) and thrust coefficient. The analytical model is validated against large eddy simulations of a yawed actuator disk. Because the induction depends on the yaw and thrust coefficient, the power generated by a yawed actuator disk will always be greater than a $\cos ^3(\gamma )$ model suggests. The power lost due to yaw misalignment depends on the thrust coefficient. An analytical expression for the thrust coefficient that maximizes power, depending on the yaw, is developed and validated. Finally, using the developed induction model as an initial condition for a turbulent far-wake model, we demonstrate how combining wake steering and thrust (induction) control can increase array power, compared to either independent steering or induction control, due to the joint dependence of the induction on the thrust coefficient and yaw angle.

We investigate the interaction of an aqueous polymeric droplet with a tuneable continuous laser in an acoustically levitated environment. The effect of laser irradiation intensity and polymeric concentration on various spatio-temporal parameters is unearthed using high-speed shadowgraphy and theoretical scaling analysis. We observe four temporal phases: droplet evaporation, vapour bubble growth followed by membrane inflation, bubble/membrane rupture through hole nucleation and droplet breakup. During the initial droplet evaporation phase, concentration build-up at the droplet surface beyond a critical limit leads to the formation of a skin layer. It is revealed that, at a given location inside the droplet, hot spots occur, and the maximum temperature at the hot spots scales linearly with irradiation intensity until a bubble nucleates. The low-intensity laser interaction leads to symmetric membrane inflation that eventually forms holes at droplet poles and cracks on the shell surface. On the contrary, high intensity causes early bubble nucleation followed by asymmetric membrane inflation that eventually ruptures through multiple hole formation. Furthermore, the growth and rupture of the membrane is followed by a catastrophic breakup of the droplet. Two dominant atomization modes are reported at significantly high irradiation intensities: stable sheet collapse and unstable sheet breakup. The evolution of droplets into a stable/unstable sheet follows universally observed ligament and hole dynamics. A regime map is shown to describe the influence of polymer concentration and irradiation intensity on the strength and mode of droplet atomization.

We investigate experimentally the outflow that occurs when a plume of dense fluid strikes a sloping permeability jump in a saturated two-layered porous medium of finite extent. Contact of the plume with the jump results in a pair of leaky (primary) gravity currents that propagate up- and downdip. Previous studies have considered a thin or thick lower layer; here, we identify the non-trivial dynamics that arises for the intermediate thickness case. For instance, the primary gravity currents become arrested when the volume supplied by the plume matches that lost by basal draining. However, fluid draining into the lower layer will eventually contact the bottom boundary leading to the formation of secondary gravity currents. As these secondary gravity currents propagate left and right, they ‘tug’ upon the primary gravity currents causing remobilization. Of course, the motion of the primary and secondary gravity currents must eventually become impeded by the sidewall boundaries leading, thereafter, to layer filling. We categorize the overall filling process as either simultaneous (upper and lower layers fill concurrently) or sequential (lower layer fills first). Factors influencing the filling mode include the permeability jump angle and the plume source conditions/location. Owing to the asymmetric manner in which the upper layer fills, the plume, originally vertical, must become deflected. We categorize this deflection and identify scenarios where, somewhat counterintuitively, the plume bends towards the lower (lower permeability) layer. The significance of our measurements relative to real geophysical flows is highlighted with particular attention paid to geological sequestration and storage.