American Muslims’ increased societal salience has led to greater scrutiny of their political and social attitudes. Yet, systematic analyses of this population remain rare and tend to aggregate findings at a level that masks the community's diverse backgrounds and experiences. As a partial corrective, our paper provides a comprehensive demographic analysis of American Muslim political participation. Our conclusions, first, complement previous efforts to elaborate the influence of minority status on the core determinants of political participation. Second, they highlight the differential impact of these determinants within key American Muslim demographic subgroups, revealing the moderating effects of denomination, racial or ethnic background, and gender. As scholars and practitioners seek to better understand Muslims in America, our research suggests that there are myriad circumstances when this community's presumed cohesion gives way to meaningfully diverse perspectives and behaviors.