To detect modest associations of dietary intake with disease risk, observational studies need to be large and control for moderate measurement errors. The reproducibility of dietary intakes of macronutrients, food groups and dietary patterns (vegetarian and Mediterranean) was assessed in adults in the UK Biobank study on up to five occasions using a web-based 24-h dietary assessment (n 211 050), and using short FFQ recorded at baseline (n 502 655) and after 4 years (n 20 346). When the means of two 24-h assessments were used, the intra-class correlation coefficients (ICC) for macronutrients varied from 0·63 for alcohol to 0·36 for polyunsaturated fat. The ICC for food groups also varied from 0·68 for fruit to 0·18 for fish. The ICC for the FFQ varied from 0·66 for meat and fruit to 0·48 for bread and cereals. The reproducibility was higher for vegetarian status (κ > 0·80) than for the Mediterranean dietary pattern (ICC = 0·45). Overall, the reproducibility of pairs of 24-h dietary assessments and single FFQ used in the UK Biobank were comparable with results of previous prospective studies using conventional methods. Analyses of diet–disease relationships need to correct for both measurement error and within-person variability in dietary intake in order to reliably assess any such associations with disease in the UK Biobank.

Steps required for proper acquisition and processing of laser Doppler velocimetry data for turbomachinery research applications are addressed. Turbomachinery applications are difficult due to the small internal passages, high-frequency fluctuations, large turbulence intensities, and strong secondary flows resulting in low overall signal-to-noise ratios and narrowband noise sources that cannot be removed by simple band-pass filters. Special aspects that must be considered for successful and accurate laser Doppler velocimetry studies to be conducted in turbomachinery are discussed. Specifically, the design of the measurement volume size, reflection mitigation, engineering of seed particle size and injection schema, and alignment of the traverse mechanism are addressed in terms of their importance (from literature sources) and the solutions implemented by the authors. These techniques have been applied to successfully obtain three-component, unsteady velocity data in a high-speed centrifugal compressor for aeroengine application. Processing techniques are also presented including a novel mixture-model-based statistical method for narrowband noise isolation developed by the authors. The method, validation steps, and example results are presented, showing the successful rejection of noise with high accuracy, a low failure rate, and a significant reduction in required manual inspection. This newly developed method elucidated flow features that were not clear prior to the noise removal.

Measurements of the incident solar radiation taken during the Antarctic Remote Ice Sensing Experiment (ARISE) aboard the R/V Aurora Australis in the Southern Ocean and springtime Antarctic ice pack are analyzed together with all-sky cloud imagery to determine the incident shortwave cloud radiative forcing at the surface. For most solar zenith angles (Z<82˚) in this dataset, the primary shortwave cloud effect is to induce cooling of the surface; as the sun approaches the horizon, however, the shortwave effects become negligible or even positive. The clear-sky atmospheric transmissivity over the length of the cruise is 0.91, a value comparable to those derived from measurements taken at various locations in the Arctic during daylight periods. Although the presence of clouds has a great effect on the surface heat budget and provides a negative shortwave feedback that may stabilize the polar atmosphere, the effect on the photosynthetically active radiation available to ice algae is relatively small in comparison to the effects of even small amounts of snow on sea ice.

Recent cases of acute kidney injury due to Seoul hantavirus infection from exposure to wild or pet fancy rats suggest this infection is increasing in prevalence in the UK. We conducted a seroprevalence study in England to estimate cumulative exposure in at-risk groups with contact with domesticated and wild rats to assess risk and inform public health advice. From October 2013 to June 2014, 844 individual blood samples were collected. Hantavirus seroprevalence amongst the pet fancy rat owner group was 34.1% (95% CI 23·9–45·7%) compared with 3·3% (95% CI 1·6–6·0) in a baseline control group, 2·4% in those with occupational exposure to pet fancy rats (95% CI 0·6–5·9) and 1·7% with occupational exposure to wild rats (95% CI 0·2–5·9). Variation in seroprevalence across groups with different exposure suggests that occupational exposure to pet and wild rats carries a very low risk, if any. However incidence of hantavirus infection among pet fancy rat owners/breeders, whether asymptomatic, undiagnosed mild viral illness or more severe disease may be very common and public health advice needs to be targeted to this at-risk group.

Wave action causes ablation in a narrow zone around an iceberg’s waterline, at up to 0.3 m per day, in water of −1°C with waves up to 0.4 m high. Subsequent subaerial calving of ice from iceberg sides takes place up to a similar rate. Submarine melting is an order of magnitude slower than wave action but acts over the largest part of an iceberg. Ablation rates derived theoretically or statistically elsewhere for comparable environmental conditions, are in reasonable agreement with those measured here. Drifting icebergs trail a plume of mixed, slightly cooled and diluted sea-water in their wake.

Fish consumption is the major dietary source of EPA and DHA, which according to rodent experiments may reduce body fat mass and prevent obesity. Only a few human studies have investigated the association between fish consumption and body-weight gain. We investigated the association between fish consumption and subsequent change in body weight. Women and men (n 344 757) participating in the European Prospective Investigation into Cancer and Nutrition were followed for a median of 5·0 years. Linear and logistic regression were used to investigate the associations between fish consumption and subsequent change in body weight. Among women, the annual weight change was 5·70 (95 % CI 4·35, 7·06), 2·23 (95 % CI 0·16, 4·31) and 11·12 (95 % CI 8·17, 14·08) g/10 g higher total, lean and fatty fish consumption per d, respectively. The OR of becoming overweight in 5 years among women who were normal weight at enrolment was 1·02 (95 % CI 1·01, 1·02), 1·01 (95 % CI 1·00, 1·02) and 1·02 (95 % CI 1·01, 1·04) g/10 g higher total, lean and fatty consumption per d, respectively. Among men, fish consumption was not statistically significantly associated with weight change. Adjustment for potential over- or underestimation of fish consumption did not systematically change the observed associations, but the 95 % CI became wider. The results in subgroups from analyses stratified by age or BMI at enrolment were not systematically different. In conclusion, the present study suggests that fish consumption has no appreciable association with body-weight gain.

The fast ignitor concept for inertial confinement fusion relies on the generation of hot electrons, produced by a short-pulse ultrahigh intensity laser, which propagate through high-density plasma to deposit their energy in the compressed fuel core and heat it to ignition. In preliminary experiments designed to investigate deep heating of high-density matter, we used a 20 joule, 0.5–30 ps laser to heat solid targets, and used emission spectroscopy to measure plasma temperatures and densities achieved at large depths (2–20 microns) away from the initial target surface. The targets consisted of an Al tracer layer buried within a massive CH slab; H-like and He-like line emission was then used to diagnose plasma conditions. We observe spectra from tracer layers buried up to 20 microns deep, measure emission durations of up to 200 ps, measure plasma temperatures up to Te=650 eV, and measure electron densities above 1023 cm−3. Analysis is in progress, but the data are in reasonable agreement with heating simulations when space-charge induced inhibition is included in hot-electron transport, and this supports the conclusion that the deep heating is initiated by hot electrons.

Biological specimen collection is an integral part of many longitudinal epidemiological studies. It is important to achieve high participant satisfaction for continuing involvement, and high sample quality for accurate biomarker measurement. We conducted a study to evaluate these issues on the sample collection proposed for the Canadian Longitudinal Study on Aging (CLSA). There were 85 participants recruited, and 65 attended either a hospital laboratory or private laboratory. Approximately 100 mL of blood and a random urine specimen were collected from each participant for a total of 2,108 sample aliquots. Quality standards were met for more than 90 per cent of samples and were similar for samples collected in both laboratories. More than 90 per cent of participants rated satisfaction with the collection as being good or excellent, and 84 per cent would be willing to repeat the collection in one to three years.

Recombining plasmas produced by picosecond laser pulses are characterized by measuring ratio of intensities of resonance lines of H- and He-like ions in the plasmas. It is found that the rapidly recombining plasmas produced by picosecond laser pulses are suitable for highgain operation.

Recent experiments to study the laser driven compression of CH shell targets and the effects of increasing aspect ratio using x-ray shadowgraph techniques are described. This work has been carried out at the Rutherford Appleton Laboratory's Central Laser Facility with 12 beam, 0·53 μm, 1·0 ns irradiation. X-ray shadowgraphy techniques have been used with a frame time of ∼100ps and spatial resolution of 5 to lOμm to obtain density profiles for the compressed targets. A systematic study of 150–200 μm targets with aspect ratios from ∼7 to ∼20 has been performed. The x-ray shadowgraphy techniques used are described, results in the form of x-radiographs presented and a discussion of preliminary results given.

Emission-line observations made with the Spitzer Space Telescope are used to test the predicted ionizing spectral energy distributions of various stellar atmosphere models.

This paper presents a novel MEMS Ultrasound Electro-Magnetic transducer. With advances in CMOS MEMS fabrication processes [2] we can explore and build miniature devices which could only be designed till a few years back. As our understanding in MEMS evolved, we explored the use of Electro-Magnetism as an effective way to produce ultrasound waves. Thus we can use a highly efficient and inexpensive fabrication technique to fabricate transducers with a fairly good capability to produce and detect ultrasound waves.

The transducer consists of 2 concentric spiral coils, one carrying an AC current (which is tethered to the substrate at one end and free to vibrate at the other, also called the “Flapper”) and other coil carrying DC current (enveloping the inner coil, fixed and called “Stator”). The force arising from the interaction of the coupled magnetic fields induces a mechanical vibration of the flapper structure. The transducer serves as an actuator or a sensor (where we simply apply a pressure force on the flapper and note the frequency response of the flapper).

The current mode helps to associate the transducer with front-end electronics, which is one of the most critical components of ultrasound imaging systems

Advantages of this approach as compared to traditional PZT ceramics and capacitative micromachined devices are explored.

Different dimensions of the transducer to accommodate the limitations in the processes are explored and a comparison of the parameters is presented.

Potential uses and future challenges are discussed.