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The aim of this project is to study to which extent salience alterations influence the severity of psychotic symptoms. However, rather than studying them individually, we decided to focus on their interplay with two additional variables, that is: observing their effect in a vulnerability phase (adolescence) and with another added, well-recognized risk factor (cannabis use).
The reason for this study design lies in the fact that, in our opinion, it is fundamental to observe the trajectory of psychotic symptoms over a continuum; however, rather than adopting a longitudinal approach, we decided to structure it as a cross-sectional study confronting patients from two age brackets - adolescence and adulthood.
Objectives
The primary purpose of this study was to assess a difference between THC-abusing and non-abusing patients in adolescent and adult cohorts, using the Italian version of the psychometric scale “Aberrant Salience Inventory” (ASI), and the possible correlation with more severe psychotic symptoms. The employment of several different psychometric scales and the inclusion of a variegated cohort allowed to pursue multiple secondary objectives.
Methods
We recruited 192 patients, subsequently divided into six subgroups based on age and department of recruitment (whether adolescent or adult psychiatric or neurologic units - the latter serving as controls). Each individual was administered a set of questionnaires and a socio-demographic survey; the set included: Aberrant Salience Inventory (ASI), Community Assessment of Psychic Experiences (CAPE), Positive and Negative Syndrome Scale (PANSS), Montgomery-Asberg Depression Rating Scale (MADRS), Mania Rating Scale (MRS), Hamilton Anxiety Scale (HAM-A), Association for Methodology and Documentation in Psychiatry (AMDP) and Cannabis Experience Questionnaire (CEQ).
Results
The data analysis showed statistically significant (p<0.05) differences between adolescents and adults with psychotic symptoms in all of the three scales of PANSS and in MADRS. These two groups were homogenous for both cannabis use and ASI score. The intra-group comparison (either adolescent or adult) showed a hierarchical pattern in the scores of psychometric scales according to the diagnostic subgroup of allocation: patients with psychotic symptoms showed an higher level of psychopathology in all measures when compared to patients from the psychiatric unit without psychotic symptoms, which in turn scored higher than the patients from the neurologic unit.
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Conclusions
The results of the present study may suggest that when salience alterations occur in adolescents with cannabis exposure, we might observe worsened positive and negative psychotic symptoms; their influence might be relevant also in other domains, especially regarding the depressive and anxiety spectrums.
Evolution of Learning and Memory Mechanisms is an exploration of laboratory and field research on the many ways that evolution has influenced learning and memory processes, such as associative learning, social learning, and spatial, working, and episodic memory systems. This volume features research by both outstanding early-career scientists as well as familiar luminaries in the field. Learning and memory in a broad range of animals are explored, including numerous species of invertebrates (insects, worms, sea hares), as well as fish, amphibians, birds, rodents, bears, and human and nonhuman primates. Contributors discuss how the behavioral, cognitive, and neural mechanisms underlying learning and memory have been influenced by evolutionary pressures. They also draw connections between learning and memory and the specific selective factors that shaped their evolution. Evolution of Learning and Memory Mechanisms should be a valuable resource for those working in the areas of experimental and comparative psychology, comparative cognition, brain–behavior evolution, and animal behavior.
The capacity to learn and remember exists in most known animal species, which raises fascinating questions about the role of evolutionary processes. Logic suggests that processing and storing information for future use is likely to be fundamental for an animal’s survival and reproductive success. Foraging for food requires capacities to respond to cues that signal its availability and location, and store memories for future excursions; successful reproduction requires capacities to locate and choose a suitable mate; and, evading predators requires learning about and remembering cues associated with survival threats, such as the presence and location of predators; all of these capacities, either directly or indirectly, enhance reproductive success. Although logical deduction plays an important role in science, empirical tests are needed to confirm, in this case, evolutionary hypotheses about learning and memory. This book is about the ways in which evolutionary hypotheses inform the design of experiments on learning and memory, the empirical methods and tests that have been developed, and the knowledge derived from research programs that reveal relationships between learning, memory, and evolution. The contributors to each chapter provide unique insights into how evolution has influenced a broad array of learning and memory mechanisms across a diverse representation of invertebrate and vertebrate species.
Let X be a real Banach space. The rectangular constant
$\mu (X)$
and some generalisations of it,
$\mu _p(X)$
for
$p \geq 1$
, were introduced by Gastinel and Joly around half a century ago. In this paper we make precise some characterisations of inner product spaces by using
$\mu _p(X)$
, correcting some statements appearing in the literature, and extend to
$\mu _p(X)$
some characterisations of uniformly nonsquare spaces, known only for
$\mu (X)$
. We also give a characterisation of two-dimensional spaces with hexagonal norms. Finally, we indicate some new upper estimates concerning
$\mu (l_p)$
and
$\mu _p(l_p)$
.
We characterize diametrically maximal and constant width sets in $C(K)$, where $K$ is any compact Hausdorff space. These results are applied to prove that the sum of two diametrically maximal sets needs not be diametrically maximal, thus solving a question raised in a paper by Groemer. A characterization of diametrically maximal sets in $\ell _{1}^{3}$ is also given, providing a negative answer to Groemer's problem in finite dimensional spaces. We characterize constant width sets in ${{c}_{0}}\left( I \right)$, for every $I$, and then we establish the connections between the Jung constant of a Banach space and the existence of constant width sets with empty interior. Porosity properties of families of sets of constant width and rotundity properties of diametrically maximal sets are also investigated. Finally, we present some results concerning non-reflexive and Hilbert spaces.
the interplay between the behaviour of approximately convex (and approximately affine) functions on the unit ball of a banach space and the geometry of banach $k$-spaces is studied.
Given a Banach space X, we investigate the behaviour of the metric projection PF onto a subset F with a bounded complement.
We highlight the special role of points at which d(x, F) attains a maximum. In particular, we consider the case of X as a Hilbert space: this case is related to the famous problem of the convexity of Chebyshev sets.
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