We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Autism spectrum disorder (ASD) affects 20–30% of adults with intellectual disability. This group are vulnerable to challenging behaviour and mental health problems.
Objectives:
To explore the extent to which ASD affects challenging behaviour among specialist mental health service users with intellectual disability.
Aims:
To identify predictors of challenging behaviour among adults who have intellectual disability.
Methods:
A cross-sectional study of 92 participants from a specialist mental health service for adults with intellectual disability in the UK. The presence/absence of ASD was confirmed using the Autism Diagnostic Observation Schedule. Challenging behaviour was assessed using the Developmental Behaviour Checklist (DBC).
Results:
Participants with ASD (N=48) had higher total DBC scores than those without ASD (N=44; mean=54.2 vs. 29.2). ASD, severity of intellectual disability, age, presence of psychiatric disorder and total number of needs were entered as independent variables into a linear regression. The model accounted for 51% of the variance and was statistically significant (F(5,91)=18.1, p<0.001). Presence of ASD and total number of needs were the only significant predictors of challenging behaviour. Presence of ASD had the highest standardised coefficient (β=0.56).
Conclusion:
Participants with ASD had significantly higher levels of challenging behaviour than those without ASD. Challenging behaviour was also independently associated with total number of needs. Understanding which service users with intellectual disability have higher levels of challenging behaviour than others despite receiving psychiatric treatment, and the extent to which having ASD is a contributing factor, should inform the development of more effective services and lead to improved outcomes.
Lysergic acid diethylamide (LSD) is a potent serotonergic hallucinogen or psychedelic that modulates consciousness in a marked and novel way. This study sought to examine the acute and mid-term psychological effects of LSD in a controlled study.
Method
A total of 20 healthy volunteers participated in this within-subjects study. Participants received LSD (75 µg, intravenously) on one occasion and placebo (saline, intravenously) on another, in a balanced order, with at least 2 weeks separating sessions. Acute subjective effects were measured using the Altered States of Consciousness questionnaire and the Psychotomimetic States Inventory (PSI). A measure of optimism (the Revised Life Orientation Test), the Revised NEO Personality Inventory, and the Peter's Delusions Inventory were issued at baseline and 2 weeks after each session.
Results
LSD produced robust psychological effects; including heightened mood but also high scores on the PSI, an index of psychosis-like symptoms. Increased optimism and trait openness were observed 2 weeks after LSD (and not placebo) and there were no changes in delusional thinking.
Conclusions
The present findings reinforce the view that psychedelics elicit psychosis-like symptoms acutely yet improve psychological wellbeing in the mid to long term. It is proposed that acute alterations in mood are secondary to a more fundamental modulation in the quality of cognition, and that increased cognitive flexibility subsequent to serotonin 2A receptor (5-HT2AR) stimulation promotes emotional lability during intoxication and leaves a residue of ‘loosened cognition’ in the mid to long term that is conducive to improved psychological wellbeing.
In the 1930s, Walter Benjamin described Paris as ‘the capital of the nineteenth century’, the hub of cultural transformations precipitated by the rise of industrial capitalism. For good reasons, Jewish historians have followed suit in identifying Paris as the focal point for studies of political, social, cultural, demographic and economic change in France during the nineteenth and twentieth centuries. Moreover, native French Jewish religious and cultural administrative structures, implemented during Napoleon I's reign and further entrenched by reforms in the Third Republic, are centred in Paris. These conditions have rendered an abundance of source material documenting the rest of the country from the centre, a phenomenon that places even more weight on the capital as a locus for national processes that occur in its image.
This paper presents an overview of the first broad coverage grammatical description of Danish in a Typed Feature Structure (TFS) based unification formalism inspired by HPSG. These linguistic specifications encompass phenomena within inflectional morphology, phrase structure and predicate argument structure, and have been developed with a view to implementation. The emphasis on implementability and re-usability of the specifications has led to the adoption of a rather leaner formal framework than that underlying HPSG. However, the paper shows that the adoption of such a framework does not lead to a loss of expressibility, but in fact enables certain phenomena, such as the interface between morphology and syntax and local discontinuities, to be treated in a simple and elegant fashion.
One of the commonest grasses found in hedges and thickets in this country, more especially on the lighter soils, is the Tall Oat Grass (Arrhenatherum avenaceum, Beauvais). In meadows it is generally present, abundantly on some soils, while occasionally it forms part of the “seeds” mixture put down for temporary or permanent pasture. In some localities a form of this grass known as “Onion Couch” becomes a dangerous weed on the arable land—this plant is identical in outward appearance with the Tall Oat Grass except at the base of the stems where the nodes swell and form chains of bulbs each of which is capable of breaking off and giving rise to a new plant. This habit of growth together with a liberal supply of seeds formed in June and July make it a very difficult weed to eradicate. Its occurrence is usually reported from the lighter soils, but in the West of England the heavy land is equally badly affected.
A sol-gel derived organosilica material that energetically swells when exposed to organic molecules was tested as a means to extract dissolved organic species from water. Swellable organically modified silica (SOMS) was demonstrated to be effective at removing butanol, methyl t-butyl ether (MTBE), tetrachloroethylene, trichloroethylene, ethanol, and toluene from lab grade water, salt water, and natural waters. Partition coefficients for the absorption of organic species from water by SOMS ranged from 2.8�105 – 1.0�102, and vary depending on polarity of the contaminant, concentration, and the total mass of contaminant absorbed. Absorption of organic species to SOMS appears to be enhanced by matrix expansion of nanometer sized pores leading to non-selective capture of organics beyond what could be attributed to physisorption.
We appreciate the effort and thought that Stewart-Oaten (2008) has put into his comment on our paper in Environmental Conservation (Bulleri et al. 2007). Clearly, the philosophical and methodological approaches used in ecological impact assessments (EIAs) warrant much further attention and discussion by ecologists. We would like, however, to clarify that the goals of our comment were far from summarizing available procedures and, even more, from expressing an opinion about which among these should be retained or rejected. This is quite well reflected by the contents of our paper (Bulleri et al. 2007). Our ‘main purpose’ (to quote Stewart-Oaten 2008) was to point out that the degree of naturalness of a site is irrelevant to whether or not some proposed disturbance causes an impact and that all disturbances potentially cause negative impacts.
The Derm Imaging Center uses various light and electron microscopic techniques to determine meaningful morphologic differences in skin samples received from multiple investigators. Qualitative comparisons required laborious hand measurements, which, in time gave way to computer assisted image capture, enhancement and analysis. The ability to attach a numerical value to a morphologic observation has made quantification an expected component of the experimental results. Laboratory personnel are now spending more time in front of computers than microscopes. This fact prompted a reevaluation of our current methods resulting in a faster, user-friendly computer assisted imaging system.
One software program that has become ubiquitous within the field of scientific imaging is Adobe® Photoshop®. Although a multitude of different image capture and analysis software programs are in use, a version of Photoshop® can invariably be found residing in most laboratories involved in imaging. A disadvantage of many image analysis software programs is the lack of image enhancement capability that we have grown to know and love within the Photoshop® environment.
This paper describes the work carried out at the Center for
Sprogteknologi in Copenhagen to
validate the LE evaluation methodology developed by the LRE project TEMAA.
TEMAA has
developed a framework for the evaluation of LE products, implemented in
a Parameterisable
Testbed (PTB). The framework allows for a modular, formal and exible description
of user
requirements and objects of evaluation, it accommodates test methods of
various kind and
provides a methodology for assessing test results in the light of the requirements
expressed by
different user types. While the fundamentals of the TEMAA framework are
meant to apply to
adequacy evaluation of LE products in general, a detailed methodology has
been worked out
for the evaluation of spelling and grammar checkers, and applied to the
concrete evaluation
of Danish and Italian spelling checkers. The main focus of this paper is
on showing that
the general methodology provides a valid model for designing and carrying
out a concrete
evaluation, as in the case study on Danish spelling checkers.
X-ray absorption and glancing angle reflectivity measurements in the energy range of the Nitrogen K-edge and Gallium M2,3 edges are reported. Linear muffin-tin orbital band-structure and spectral function calculations are used to interpret the data. Polarization effects are evidenced for the N-K-edge spectra by comparing X-ray reflectivity in s- and p-polarized light.
In many applications, x-ray mulhilayer mirrors are exposed to high peak fluxes of x-rays with subsequent damage to the mirror. Mirror damage is a particularly severe problem with the use of multilayers as cavity optics for short wavelength x-ray lasers. Intense optical and x-ray radiation, from the x-ray laser plasma amplifier, often damages the multilayer mirror on time scales of hundreds of picoseconds. The phenomenon of multilayer mirror damage by pulsed xray emission has been studied using short duration (500 psec) bursts of soft x-rays from a laser produced gold plasma. The results of the experiments will be compared with some simple models and the possibility of increasing the damage thresholds of short wavelength multilayer mirrors will be discussed.
In English history, 1688 is best remembered as the year of the Glorious Revolution. But that same year also witnessed the death of John Bunyan (1628–1688), the Nonconformist Bedford minister widely known as the author of The Pilgrim's Progress (1678; part two, 1684) and a preacher capable of drawing 3,000 persons to Sunday sermons in London. In subsequent centuries his fame increased, and, partly through translations into numerous languages, his story of Christian's pilgrimage became known in nearly every region of the world. In our own time his life and work have drawn the attention of many scholars from several fields, and the publication in modern editions of all of his sixty printed works has been undertaken. In 1988 the tercentenary of his death has been observed by a variety of activities including scholarly conferences and publications.
X-ray microscopy is a field that has developed rapidly in recent years. Two different approaches have been used. Zone plates have been employed to produce focussed beams with sizes as low as 0.07 pm for x-ray energies below 1 keV. Images of biological materials and elemental maps for major and minor low Z have been produced using above and below absorption edge differences. At higher energies collimators and focussing mirrors have been used to make small diameter beams for excitation of characteristic K— or L-x rays of all elements in the periodic
table.