To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The propagation of detonations in a non-uniform mixture exhibits notable distinctions from that in a uniform mixture. This study first delves into the analytical analysis of the one-dimensional shock transmission problem and the two-dimensional shock propagation in a mixture with temperature non-uniformity. Additionally, the research extends to the numerical simulation of the propagation of shocks and detonations, building upon the insights garnered from the analytical analysis. The numerical results indicate that introducing a temperature interface in a non-uniform gas creates a discrete flow field and wavefront, resulting in oblique shocks that connect hot and cold layers. A competitive mechanism between the transverse waves and non-uniformity is responsible for the detonation propagation. The temperature amplitude tends to inhibit the propagation of transverse waves. In contrast, the wavelengths primarily affect the spacing and strength of these transverse waves, especially during the early stages of propagation. In a Zel’Dovich–von Neumann–Döring detonation, the non-uniformities distort the detonation front, creating transverse wave spacings comparable to the wavelength and reducing the front velocity. However, the detonation can recover its Chapman–Jouguet velocity and approach a steady states as intrinsic instabilities come into play. In the steady state, the cell sizes are found to be determined by the temperature amplitude. When the temperature amplitude is sufficiently high, the detonation cells effectively disappear.
A flexible power assistive exoskeleton is proposed in this study to overcome limitations in range of motion, assistance, and comfort existing in current exoskeletons. The flexible power assistive exoskeleton is made of three springs that store energy from shoulder movements to provide assistance. It uses biomechanical models to simulate muscle forces. It is highly portable and comfortable, with only 83.29 g weight. A theoretical model was established to address the relationship between body work and output force. An evaluation system is proposed to assess the comfort effect of the assistive exoskeleton. Results show that the assistive exoskeleton can support all ranges of motion for the human upper limbs. It can offer up to 14.2% assistance. It also has a mass-to-assistance value of 120. For a comforting evaluation, its satisfaction rate reaches 93.4%. In summary, we present a highly flexible power-assisted exoskeleton with a large motion range, noticeable assistance effect, and high comfortability. This work contributes to the development of flexible assistive exoskeletons and comforting evaluation strategies for wearable devices.
Recent research on zoonotic diseases has increasingly focused on tick-borne illnesses due to their high prevalence in northwestern China. This study aimed to determine the prevalence of tick-borne pathogens in yaks (Bos grunniens) within Qinghai Province. A total of 299 blood samples were collected from yaks in Xining City of Qinghai Province and analysed using polymerase chain reaction. Results indicated the absence of several significant zoonotic pathogens, including Borrelia burgdorferi sensu lato, Anaplasma spp. and Coxiella burnetii. However, rickettsiae were detected in the sampled yaks. The overall prevalence of spotted fever group rickettsiae was 46·5%, with a significant difference between females (68·3%) and males (9·09%). Age was also identified as a significant factor influencing infection rates. Furthermore, sequencing analysis revealed that the obtained rickettsial sequences shared 99·04–100% nucleotide identity with Rickettsia raoultii, a species endemic to Qinghai, China. Phylogenetic analysis based on the ompA and gltA genes confirmed that these sequences clustered within the R. raoultii clade. This study demonstrates a high prevalence of R. raoultii infection in yaks from Qinghai. Consequently, the implementation of preventive and therapeutic measures for yaks is recommended to mitigate the risk of transmission. This study did not collect tick samples simultaneously, so the transmission vector cannot be identified. Additionally, uneven sample distribution across some age groups may affect the representativeness of the results.
Remote injury assessment during natural disasters poses major challenges for healthcare providers due to the inaccessibility of disaster sites. This study aimed to explore the feasibility of using artificial intelligence (AI) techniques for rapid assessment of traumatic injuries based on gait analysis.
Methods
We conducted an AI-based investigation using a dataset of 4500 gait images across 3 species: humans, dogs, and rabbits. Each image was categorized as either normal or limping. A deep learning model, YOLOv5—a state-of-the-art object detection algorithm—was trained to identify and classify limping gait patterns from normal ones. Model performance was evaluated through repeated experiments and statistical validation.
Results
The YOLOv5 model demonstrated high accuracy in distinguishing between normal and limp gaits across species. Quantitative performance metrics confirmed the model’s reliability, and qualitative case studies highlighted its potential application in remote, fast traumatic assessment scenarios.
Conclusions
The use of AI, particularly deep convolutional neural networks like YOLOv5, shows promise in enabling fast, remote traumatic injury assessment during disaster response. This approach could assist healthcare professionals in identifying injury risks when physical access to patients is restricted, thereby improving triage efficiency and early intervention.
This article proposes a dielectric waveguide bandpass filter (BPF) with good stopband suppression based on different kinds of dielectric waveguide resonators (DWRs). Three distinct types of DWRs are modified from the traditional rectangular DWR, i.e., one with a metallized blind hole, one with a metallized U-shaped slot and another one with a pair of parallel ridges. These resonators are designed that their fundamental mode frequencies are basically the same and their higher-order modes are staggered. As a result, the higher-order modes can be suppressed to a certain extent when conducting BPF designs. For verification, a sixth-order BPF with an operating frequency band ranging from 3.4 to 3.5 GHz is designed, fabricated and measured. It is composed of the above three distinct types of DWRs, with a deliberate arrangement that prevents the DWRs of the same type from being adjacent to each other, guaranteeing that the harmonics are well suppressed. In measurement, the in-band return loss is better than 12 dB, the minimum in-band insertion loss is about 1.0 dB. Besides, the 20 dB out-of-band suppression reaches 6.9 GHz, which is almost twice the center frequency.
Magnetohydrodynamic turbulence with Hall effects is ubiquitous in heliophysics and plasma physics. Direct numerical simulations reveal that, when the forcing scale is comparable to the ion inertial scale, the Hall effects induce remarkable cross-helicity. It then suppresses the cascade efficiency, leading to the accumulation of large-scale magnetic energy and helicity. The process is accompanied by the disruption of current sheets through the entrainment by vortex tubes or the excitation of whistler waves. Using the solar wind data from the Parker Solar Probe, the numerical findings are separately confirmed. These findings provide new insights into the emergence of large-scale solar wind turbulence driven by helical fields and Hall effects.
Objectives: The recent experience of the COVID-19 pandemic emphasized the critical need for a surveillance system to alert healthcare facilities about the admission of patients with emerging infectious diseases (EID), thereby preventing nosocomial transmissions. Methods: Tan Tock Seng Hospital, an 1800-bed acute tertiary-care hospital in Singapore, transitioned to a new- generation electronic medical record system, Epic, in August 2022. Leveraging the system’s capabilities, we developed an algorithm to generate the line-list of suspected Middle East Respiratory Syndrome (MERS) patients, in alignment with the screening guidelines provided by Singapore’s Ministry of Health. The algorithm first identifies patients who presented within 14 days (maximum incubation period) of their travel to Arabic peninsular countries. This information is documented by the emergency department’s triage nurses. Additionally, patients with suspected MERS indicated in the problem list or diagnosis by attending clinicians, particularly emergency-medicine physicians or infectious-disease physicians, are included. Furthermore, patients who are ordered for a MERS- Coronavirus polymerase chain reaction test, are identified. The algorithm can also be further modified as and when the case definition of the EID changes. Results: The surveillance report constructed with Epic algorithm can be scheduled for daily generation or generated on demand within a few minutes. This newer approach is more time- and resource-efficient compared to the manual surveillance process, which necessitates at least three staff members to engage in a series of prolonged manual processes. The report, by extracting information directly from Epic in near real-time, also minimizes the likelihood of errors that may occur during the manual process. Subsequently, the team of epidemiologists identifies the suspected MERS patients form the generated report and efficiently follow up them until a diagnosis of MERS is excluded. Conclusions: Harnessing Epic’s capabilities, we constructed an algorithm to efficiently and swiftly identify suspected MERS patients, enabling the timely implementation of infection prevention strategies to prevent nosocomial transmission.
Objectives: The recent experience of the COVID-19 pandemic emphasized the critical need for a surveillance system to alert healthcare facilities about the admission of patients with emerging infectious diseases (EID), thereby preventing nosocomial transmissions. Methods: Tan Tock Seng Hospital, an 1800-bed acute tertiary-care hospital in Singapore, transitioned to a new- generation electronic medical record system, Epic, in August 2022. Leveraging the system’s capabilities, we developed an algorithm to generate the line-list of suspected Middle East Respiratory Syndrome (MERS) patients, in alignment with the screening guidelines provided by Singapore’s Ministry of Health. The algorithm first identifies patients who presented within 14 days (maximum incubation period) of their travel to Arabic peninsular countries. This information is documented by the emergency department’s triage nurses. Additionally, patients with suspected MERS indicated in the problem list or diagnosis by attending clinicians, particularly emergency-medicine physicians or infectious-disease physicians, are included. Furthermore, patients who are ordered for a MERS- Coronavirus polymerase chain reaction test, are identified. The algorithm can also be further modified as and when the case definition of the EID changes. Results: The surveillance report constructed with Epic algorithm can be scheduled for daily generation or generated on demand within a few minutes. This newer approach is more time- and resource-efficient compared to the manual surveillance process, which necessitates at least three staff members to engage in a series of prolonged manual processes. The report, by extracting information directly from Epic in near real-time, also minimizes the likelihood of errors that may occur during the manual process. Subsequently, the team of epidemiologists identifies the suspected MERS patients form the generated report and efficiently follow up them until a diagnosis of MERS is excluded. Conclusions: Harnessing Epic’s capabilities, we constructed an algorithm to efficiently and swiftly identify suspected MERS patients, enabling the timely implementation of infection prevention strategies to prevent nosocomial transmission.
As international exploration of the Meso-Neoproterozoic continues, these layers have become a key target for deep oil and gas field exploration. The Ordos Basin exhibits considerable sedimentary thicknesses within the Meso-Neoproterozoic. However, significant hydrocarbon discoveries have not been forthcoming, primarily due to the complex tectonic evolution. This paper focuses on the southern Ordos Basin, utilizing logging-seismic calibration to interpret seismic data and elucidate Meso-Neoproterozoic tectonic features. By comparing ancient and modern tectonic patterns, based on palaeotectonic maps retrieved through the impression method and combining these with tectonic evolution profiles, the study clarifies the history of tectonic modification. Under the control of two fracture systems – basin-controlling fractures at the margin and trough-controlling fractures – the Changchengian exhibits two categories (single-fault and double-fault) and five sub-categories of fault depression combinations. The study highlights significant differences between ancient and modern tectonics in the Meso-Neoproterozoic, which are attributed to various tectonic stages, including the trough-uplift depositional differentiation stage during the early rift-late depression of the Changchengian, the basin-margin subsidence stage of the southwestern depression of the Jixianian, the uplift and denudation stage of the Sinian basin’s main body and the four-stage tectonic remodelling stage of differential uplift-subsidence in the Palaeoproterozoic. This study employs the ancient-present tectonic pattern as a point of departure, thereby enhancing the theoretical understanding of deep-seated tectonics in the Ordos Basin. It offers novel insights into the exploration of Meso-Neoproterozoic gas reservoirs from a tectonic remodelling perspective.
High gain greater than 106 is crucial for the preamplifiers of joule-class high-energy lasers. In this work, we present a specially designed compact amplifier using 0.5%Nd,5%Gd:SrF2 and 0.5%Nd,5%Y:SrF2 crystals. The irregular crystal shape enhances the gain length of the laser beam and helps suppress parasitic oscillations. The amplified spontaneous emission (ASE) induced by the high gain is analyzed through ray tracing. The balance between gain and ASE is estimated via numerical simulation. The gain spectral characteristics of the two-stage two-pass amplifier are examined, demonstrating the advantages of using different crystals, with bandwidths up to 8 nm and gains over 106. In addition, the temperature and stress distributions in the Nd,Gd:SrF2 crystal are simulated. This work is expected to contribute to the development of high-peak-power ($\ge$terawatt-class) high-energy (joule-class) laser devices.
Tumour immunotherapy holds great promise as a treatment for cancer, which ranks as the second highest cause of mortality worldwide. This therapeutic approach can be broadly categorized into two main types: active immunotherapy and passive or adoptive immunotherapy. Active immunotherapy, such as cancer vaccines, stimulates the patients’ immune system to target tumour cells. On the other hand, adoptive immunotherapy involves supplying in vitro activated immune cells, such as T cells, natural killer cells and macrophages, to the patient to combat the tumour. Induced pluripotent stem cells are extensively utilized in both active and adoptive tumour immunotherapy due to their pluripotency and ease of gene editing. They can be differentiated into various types of immune cells for direct cancer treatment and can also function as tumour vaccines to elicit an immune response against the tumour. Importantly, iPSCs can be leveraged to develop off-the-shelf allogenic immunotherapy products.
Conclusion
This article provides a comprehensive review of the application of iPSCs in tumor immunotherapy, along with a discussion of the opportunities and challenges in this evolving field.
To address the problems of accuracy degradation, localization drift, and even failure of Simultaneous Localization and Mapping (SLAM) algorithms in unstructured environments with sparse geometric features, such as outdoor parks, highways, and urban roads, a multi-metric light detection and ranging (LiDAR) SLAM system based on the fusion of geometric and intensity features is proposed. Firstly, an adaptive method for extracting multiple types of geometric features and salient intensity features is proposed to address the issue of insufficient sparse feature extraction. In addition to extracting traditional edge and planar features, vertex features are also extracted to fully utilize the geometric information, and intensity edge features are extracted in areas with significant intensity changes to increase multi-level perception of the environment. Secondly, in the state estimation, a multi-metric error estimation method based on point-to-point, point-to-line, and point-to-plane is used, and a two-step decoupling strategy is employed to enhance pose estimation accuracy. Finally, qualitative and quantitative experiments on public datasets demonstrate that compared to state-of-the-art pure geometric and intensity-assisted LiDAR SLAM algorithms, our proposed algorithm achieves superior localization accuracy and mapping clarity, with an ATE accuracy improvement of 28.93% and real-time performance of up to 62.9 ms. Additionally, test conducted in real campus environments further validates the effectiveness of our approach in complex, unstructured scenarios.
We study density properties of orbits for a hypercyclic operator T on a separable Banach space X, and show that exactly one of the following four cases holds: (1) every vector in X is asymptotic to zero with density one; (2) generic vectors in X are distributionally irregular of type $1$; (3) generic vectors in X are distributionally irregular of type $2\frac {1}{2}$ and no hypercyclic vector is distributionally irregular of type $1$; (4) every hypercyclic vector in X is divergent to infinity with density one. We also present some examples concerned with weighted backward shifts on $\ell ^p$ to show that all the above four cases can occur. Furthermore, we show that similar results hold for $C_0$-semigroups.
Coherent beam combining (CBC) of laser arrays is increasingly attracting attention for generating free-space structured light, unlocking greater potential in aspects such as power scaling, editing flexibility and high-quality light field creation. However, achieving stable phase locking in a CBC system with massive laser channels still remains a great challenge, especially in the presence of heavy phase noise. Here, we propose an efficient phase-locking method for a laser array with more than 1000 channels by leveraging a deep convolutional neural network for the first time. The key insight is that, by elegantly designing the generation strategy of training samples, the learning burden can be dramatically relieved from the structured data, which enables accurate prediction of the phase distribution. We demonstrate our method in a simulated tiled aperture CBC system with dynamic phase noise and extend it to simultaneously generate orbital angular momentum (OAM) beams with a substantial number of OAM modes.
This paper introduces a novel ray-tracing methodology for various gradient-index materials, particularly plasmas. The proposed approach utilizes adaptive-step Runge–Kutta integration to compute ray trajectories while incorporating an innovative rasterization step for ray energy deposition. By removing the requirement for rays to terminate at cell interfaces – a limitation inherent in earlier cell-confined approaches – the numerical formulation of ray motion becomes independent of specific domain geometries. This facilitates a unified and concise tracing method compatible with all commonly used curvilinear coordinate systems in laser–plasma simulations, which were previously unsupported or prohibitively complex under cell-confined frameworks. Numerical experiments demonstrate the algorithm’s stability and versatility in capturing diverse ray physics across reduced-dimensional planar, cylindrical and spherical coordinate systems. We anticipate that the rasterization-based approach will pave the way for the development of a generalized ray-tracing toolkit applicable to a broad range of fluid simulations and synthetic optical diagnostics.
We aimed to validate in-body bioelectrical impedance analysis (BIA) measures with dual-energy X-ray absorptiometry (DXA) as reference and describe the body composition (BC) profiling of Tibetan adults.
Design:
This cross-sectional study included 855 participants (391 men and 464 women). Correlation and Bland–Altman analyses were performed for method agreement of in-body BIA and DXA. BC were described by obesity and metabolic status.
Setting:
In-body BIA and DXA have not been employed to characterise the BC of the Tibetan population living in the Qinghai–Tibet Plateau.
Participants:
A total of 855 Tibetan adults, including 391 men and 464 women, were enrolled in the study.
Results:
Concordance correlation coefficient for total fat mass (FM) and total lean mass (LM) between in-body BIA and DXA were 0·91 and 0·89. The bias of in-body BIA for percentages of total FM and total LM was 0·91 % (2·46 %) and –1·74 % (–2·80 %) compared with DXA, respectively. Absolute limits of agreement were wider for total FM in obese men and women and for total LM in overweight men than their counterparts. Gradience in the distribution of total and regional FM content was observed across different BMI categories and its combinations with waist circumference and metabolic status.
Conclusions:
In-body BIA and DXA provided overall good agreement at the group level in Tibetan adults, but the agreement was inferior in participants being overweight or obese.
We conduct direct numerical simulations to investigate the synchronisation of Kolmogorov flows in a periodic box, with a focus on the mechanisms underlying the asymptotic evolution of infinitesimal velocity perturbations, also known as conditional leading Lyapunov vectors. This study advances previous work with a spectral analysis of the perturbation, which clarifies the behaviours of the production and dissipation spectra at different coupling wavenumbers. We show that, in simulations with moderate Reynolds numbers, the conditional leading Lyapunov exponent can be smaller than a lower bound proposed previously based on a viscous estimate. A quantitative analysis of the self-similar evolution of the perturbation energy spectrum is presented, extending the existing qualitative discussion. The prerequisites for obtaining self-similar solutions are established, which include an interesting relationship between the integral length scale of the perturbation velocity and the local Lyapunov exponent. By examining the governing equation for the dissipation rate of the velocity perturbation, we reveal the previously neglected roles of the strain rate and vorticity perturbations, and uncover their unique geometrical characteristics.
An important parameter characterising the synchronisation of turbulent flows is the threshold coupling wavenumber. This study investigates the relationship between the threshold coupling wavenumber and the leading Lyapunov vector using large eddy simulations and the SABRA model. Various subgrid-scale stress models, Reynolds numbers and different coupling methods are examined. A new scaling relation is identified for the leading Lyapunov exponents in large eddy simulations, showing that they approximate those of filtered direct numerical simulations. This interpretation provides a physical basis for results related to the Lyapunov exponents of large eddy simulations, including those related to synchronisation. Synchronisation experiments show that the peak wavenumber of the energy spectrum of the leading Lyapunov vector coincides with the threshold coupling wavenumber, in large eddy simulations of box turbulence with standard Smagorinsky or dynamic mixed models as well as in the SABRA model, replicating results from direct numerical simulations of box turbulence. Although the dynamic Smagorinsky model exhibits different behaviour, the totality of the results suggests that the relationship is an intrinsic property of a certain class of chaotic systems. We also confirm that conditional Lyapunov exponents characterise the synchronisation process in indirectly coupled systems as they do in directly coupled ones, with their values insensitive to the nature of the master flow. These findings advance the understanding of the role of the Lyapunov vector in the synchronisation of turbulence.
Spin coating is the process of generating a uniform coating film on a substrate by centrifugal forces during rotation. In the framework of lubrication theory, we investigate the axisymmetric film evolution and contact-line dynamics in spin coating on a partially wetting substrate. The contact-line singularity is regularized by imposing a Navier slip model. The interface morphology and the contact-line movement are obtained by numerical solution and asymptotic analysis of the lubrication equation. The results show that the evolution of the liquid film can be classified into two modes, depending on the rotational speed. At lower speeds, the film eventually reaches an equilibrium state, and we provide a theoretical description of how the equilibrium state can be approached through matched asymptotic expansions. At higher speeds, the film exhibits two or three distinct regions: a uniform thinning film in the central region, an annular ridge near the contact line, and a possible Landau–Levich–Derjaguin-type (LLD-type) film in between that has not been reported previously. In particular, the LLD-type film occurs only at speeds slightly higher than the critical value for the existence of the equilibrium state, and leads to the decoupling of the uniform film and the ridge. It is found that the evolution of the ridge can be well described by a two-dimensional quasi-steady analysis. As a result, the ridge volume approaches a constant and cannot be neglected to predict the variation of the contact-line radius. The long-time behaviours of the film thickness and the contact radius agree with derived asymptotic solutions.
While both simultaneous and sequential contests are mechanisms used in practice such as crowdsourcing, job interviews and sports contests, few studies have directly compared their performance. By modeling contests as incomplete information all-pay auctions with linear costs, we analytically and experimentally show that the expected maximum effort is higher in simultaneous contests, in which contestants choose their effort levels independently and simultaneously, than in sequential contests, in which late entrants make their effort choices after observing all prior participants’ choices. Our experimental results also show that efficiency is higher in simultaneous contests than in sequential ones. Sequential contests’ efficiency drops significantly as the number of contestants increases. We also discover that when participants’ ability follows a power distribution, high ability players facing multiple opponents in simultaneous contests tend to under-exert effort, compared to theoretical predictions. We explain this observation using a simple model of overconfidence.